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Comparison of paclitaxal vs. sirolimus eluting stents with bio-degradable polymer for the treatment of coronary bifurcation lesions： subgroup analysis from DKCRUSH-I and DKCRUSH-II studies

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Chinese Medical Journal 2012年第19期125卷 3382-3387页

作者： CHEN Shao-liang Gary Mintz Teguh Santoso ZHANG Jun-jie YE Fei XU Ya-wei FU Qiang KAN Jing Chitprapai Paiboon ZHOU Yong DING shi-qin tak W Kwan Department of Cardiology Nanjing hrst Hospital NanjlngMedical University Nanjing 210006 China Cardiovascular Research Foundation New York NY US Department of Cardiology Medistra Hospital University ofIndonesia Medical School Jakarta Indonesia Department of Cardiology Shanghai 10th People's HospitalShanghai 200072 China Department of Cardiology Xuzhou Central Hospital XuzhouJiangsu 221009 China Department of Cardiology Bangkok General Hospital BangkokThailand Department of Cardiology Zhangjiagang People's HospitalZhangjiagang Jiangsu 215600 China Department of Cardiology Huainan Xinhua Hospital HuainanAnhui 232038 China Department of Cardiology Beth Israel Hospital NewYork USA

Background The difference in clinical outcome between paclitaxal-eluting stents （PES） and sirolimus-eluting stents with bio-degradable polymer （SES-BDP） for bifurcation lesions remains unclear. The present study aimed to investigate the one-year clinical outcome after DK crush stenting using PES （maxusTM） MS. SES-BDP （ExcelTM） from our database. Methods A total of 275 patients （90 from the DKCRUSH-I and 185 from the DKCRUSH-II study） were studied. The primary endpoint was the occurrence of major adverse cardiac events （MACE） at 12 months; including cardiac death, myocardial infarction （MI）, or target vessel revascularization （TVR）. The rate of binary restenosis and stent thrombosis served as secondary endpoints. Results At follow-up, minimal luminal diameter （MLD） in the Taxus group was （2.11＋0.66） mm, with resultant increased target lesion revascularization （TLR） 12.2% and TVR 14.4%, significantly different from the Excel group; （2.47±0.56） mm, P 〈0.001, 3.2%, P=0.006, 4.9%, P=0.019, respectively. As a result there was a significant difference in MACE between the Taxus （20.0%） and Excel （10.3%, P=0.038） groups. Overall stent thrombosis was monitored in 11 patients （4.0%）, with five in the Excel group （2.7%） and six in the Taxus group （6.7%）. All stent thrombosis in the Excel group was classified as early, and all were defined as late in the Taxus group. Conclusion The Excel stent had lower rate of stent thrombosis, TLR, TVR, and composite MACE at 12-month after an indexed stenting procedure, compared to the Taxus stent.

关键词： paclitaxal-eluting stent sirolimus-eluting stent bio-degradable polymer," coronary bifurcation lesions

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饲粮添加姜黄粉对黄羽肉鸡生产性能和免疫性能的影响

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动物营养学报 2024年第4期36卷 2303-2317页

作者：贺智曼孟繁颀张世忠代学凯史鸿飞郑博瀚黄小红林昭妍福建农林大学动物科学学院福州350002 福建农林大学中西兽医结合与动物保健福建省高校重点实验室福建省兽医中药与动物保健重点实验室福州350002 福建省农业科学院畜牧兽医研究所福州350002

本试验旨在研究饲粮添加姜黄粉对黄羽肉鸡生产性能和免疫性能的影响。试验选用320羽1日龄黄羽肉鸡,随机分成4组,每组8个重复,每个重复10羽。对照组饲喂基础饲粮,试验组分别在基础饲粮中添加150 mg/kg姜黄素(姜黄素组)、5 g/kg姜黄粉(0.5... 详细信息

本试验旨在研究饲粮添加姜黄粉对黄羽肉鸡生产性能和免疫性能的影响。试验选用320羽1日龄黄羽肉鸡,随机分成4组,每组8个重复,每个重复10羽。对照组饲喂基础饲粮,试验组分别在基础饲粮中添加150 mg/kg姜黄素(姜黄素组)、5 g/kg姜黄粉(0.5%姜黄粉组)和10 g/kg姜黄粉(1.0%姜黄粉组),其中姜黄粉组饲粮用姜黄粉替代等量的谷壳糠。试验期70 d。结果表明:1)与对照组相比,姜黄粉组肉鸡29~70日龄料重比显著降低(P0.05)。2)与对照组相比,0.5%姜黄粉组肉鸡肌肉必需氨基酸、总氨基酸和总脂肪酸含量显著提高(Ptak1)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)mRNA相对表达量(P<0.05)。综上所述,饲粮添加姜黄粉能降低黄羽肉鸡料重比,促进其生长;提高肉品质,提升其营养价值;调节NF-κB信号通路相关基因的表达,减轻炎症,调节黄羽肉鸡免疫性能,提高其生产性能。

关键词：姜黄粉黄羽肉鸡生产性能免疫性能 NF-κB信号通路

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基于1DCNN-DACLSTM模型的风电超短期功率预测方法

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电子器件 2024年第1期47卷 194-200页

作者：时志雄朱峰刘舒符杨田书欣国网上海市电力公司上海200122 上海电力大学电气工程学院上海200090 国网上海市电力公司电力科学研究院上海200437

风电超短期功率预测是电网运行态势感知的重要基础。针对风电随机波动性将给电网带来高动态扰动的问题,利用同步相量测量装置(PMU)的高频采样能力,提出一种融合一维卷积(1DCNN)和双重注意力卷积长短时记忆网络(DACLSTM)模型的风电超短... 详细信息

风电超短期功率预测是电网运行态势感知的重要基础。针对风电随机波动性将给电网带来高动态扰动的问题,利用同步相量测量装置(PMU)的高频采样能力,提出一种融合一维卷积(1DCNN)和双重注意力卷积长短时记忆网络(DACLSTM)模型的风电超短期功率预测方法。首先,基于具有高精度高密集采样的PMU装置对风电超短期功率进行实时量测。然后,利用1DCNN在特征提取和时间卷积减少计算复杂度方面的优势,充分挖掘由PMU采样得到的风电功率及相关因素量测数据关键特征,进而结合DACLSTM模型自主分析风电功率数据与输入特征间的关联关系,实现基于1DCNN-DACLSTM组合模型的风电超短期功率高动态变化趋势预测。最后以已配置PMU的某实际风电场为例,验证所提方法的可行性和有效性。

关键词：风电功率同步相量测量装置相关因素 1DCNN-DACLSTM模型随机波动性

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新建本科院校构建教育教学质量保障体系的探索与实践——以新疆工程学院为例

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乌鲁木齐职业大学学报 2024年第1期33卷 48-51页

作者：张玉珍石枚梅张丹王东新疆工程学院新疆乌鲁木齐830023

教育部《关于加快建设高水平本科教育全面提高人才培养能力的意见》中指出:要“强化高校质量保障主体意识,完善高校自我评估制度,健全内部质量保障体系。”本文以新疆工程学院为例,以学校教育教学质量管理工作为基础,通过完善机制构建... 详细信息

教育部《关于加快建设高水平本科教育全面提高人才培养能力的意见》中指出:要“强化高校质量保障主体意识,完善高校自我评估制度,健全内部质量保障体系。”本文以新疆工程学院为例,以学校教育教学质量管理工作为基础,通过完善机制构建质量保障闭环管理、培育良性生态质量保障体系、加强质量保障体系队伍建设、细化日常监控及运行环节、重视反馈和持续改进工作五个方面的实践与探索,培育出适合新建本科院校教育教学质量保障体系的“良性生态”,构建起新疆工程学院教育教学质量保障体系并得到有效运行。

关键词：新建本科院校教育教学质量保障体系

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cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1203-1215页

作者： Yuhui Gao shi Yu Mengdan Chen Xun Wang Lei Pan Bin Wei Guangxun Meng School of Life Sciences Shanghai UniversityShanghai200444China The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghai200031China Shanghai Blood Center Shanghai200051China Pasteurien College Soochow UniversitySuzhou215006JiangsuChina Nanjing Advanced Academy of Life and Health Nanjing211135JiangsuChina Department of Basic Research Guangzhou LaboratoryGuangzhou International Bio-lslandGuangzhou 510o05 GuangdongChina

The innate immune responses,including inflammasome activation,are paramount for host defense against pathogen *** contrast to canonical and noncanonical inflammasome activation,in this study,heat-killed gram-negative bacteria(HK bacteria)were identified as single-step stimulators of the NLRP3 inflammasome in human monocytes,and they caused a moderate amount of IL-1βto be released from *** course experiments showed that this alternative inflammasome response was finished within a few *** analysis showed that the intrinsically limited NLRP3 inflammasome activation response was due to the negative regulation of caspase-8 by the short isoform of cFLIP(cFLIPs),which was activated by NF-κ*** contrast,overexpressed cFLIPS,but not overexpressed cFLIPL,inhibited the activation of caspase-8 and the release of IL-1βin response to HK bacteria infection in human ***,we demonstrated that tak1 activity mediated the expression of cFLIPs and was upstream and essential for the caspase-8 cleavage induced by HK bacteria in human *** functional specificity of cFLIPs and tak1 revealed unique responses of human monocytes to a noninvasive pathogen,providing novel insights into an alternative regulatory pathway of NLRP3 inflammasome activation.

关键词： cFLIPS gram-negative bacteria NLRP3 inflammasome human monocyte

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Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway

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Chinese Journal of Integrative Medicine 2022年第2期28卷 153-161页

作者： BU Yu LI Wen-shuang LIN Ji WEI Yu-wei SUN Qiu-ying ZHU shi-jie TANG Zhong-sheng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Department of Hematology the Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang(550025)China

Objective:To investigate whether electroacupuncture(EA)alleviates cognitive impairment by suppressing the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)signaling pathway,which triggers immune-inflammatory responses in the hippocampus of rats with vascular dementia(VaD).Methods:The experiments were conducted in 3 parts and in total the Sprague-Dawley rats were randomly divided into 8 groups by a random number table,including sham,four-vessel occlusion(4-VO),4-VO+EA,4-VO+non-EA,sham+EA,4-VO+lipopolysaccharide(LPS),4-VO+LPS+EA,and 4-VO+tak-242 *** VaD model was established by the 4-VO *** days later,rats were treated with EA at 5 acupoints of Baihui(DV 20),Danzhong(RN 17),Geshu(BL 17),Qihai(RN 6)and Sanyinjiao(SP 6),once per day for 3 consecutive *** subsets,lymphocyte transformation rates,and inflammatory cytokines interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were measured to assess immune function and inflammation in VaD *** electron microscopy was used to observe the ultrastructure of nerve cells in the *** levels of TLR4,MyD88,IL-6,and TNF-αwere detected after EA ***4/MyD88 signaling and cognitive function were also assessed after intracerebroventricular injection of TLR4 antagonist tak-242 or TLR4 agonist LPS with or without ***:Compared with the 4-VO group,EA notably improved immune function of rats in the 4-VO+EA group,inhibited the protein and mRNA expressions of TLR4 and MyD88 in the hippocampus of rats,reduced the expressions of serum IL-6 and TNF-α(all Ptak-242 and 4-VO+EA groups(P>0.05).Conclusions:EA attenuated cognitive impairment associated with immune inflammation by inhibition of the TLR4/MyD88 signaling ***,EA may be a promising alternative therapy for the treatment of VaD.

关键词： electroacupuncture vascular dementia immune-inflammation toll-like receptor 4/myeloid differentiation factor 88 signaling pathway

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Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities

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World Journal of Pediatrics 2018年第5期14卷 482-491页

作者： Kam Lun Hon Yan Min Bao Kate C.Chan Kin Wai Chau Rong-Shan Chen Kun Tat Gary Cheok Wa Keung Chiu Li Deng Chun-Hui He Kin Mui Ieong Jeng Sum C.Kung Ping Lam Shu Yan David Lam Qun Ui Lee So Lun Lee Ting Fan Leung Theresa N.H.Leung Lei shi Ka Ka Siu Wei-Ping Tan Maggie Haitian Wang tak Wai Wong Bao-Jing Wu Ada Y.F.Yip Yue-Jie Zheng Daniel K.Ng Department of Pediatrics The Chinese University of Hong Kong 6/F Prince of Wales HospitalRoom 84042ShatinN.THong Kong SARChina Department ofR espiratory Diseases Shenzhen Children’s HospitalShenzhen 518026China Hong Kong Society of P ediatric Respirology and Aller gy Hong K ong S ARChina Pediatric Respiratory andSleep Disorders Center Room 1315DArgyle Centre Phase 1688 Nathan RoadMongkokKowloonHong K ong S ARChina Department of R espiration Guangzhou Women and Children’s Medical CenterGuangzhou 510623China Department of P ediatrics Kiang Wu HospitalMacaoChina Department of P ediatrics and A dolescent Medicine United Christian Hospital130Hip Wo StreetKwun TongHong K ong S ARChina Department of P ediatrics Central Hospital Conde S.JanuarioMacaoChina Department of P ediatrics and A dolescent Medicine Caritas Medical Center111Wing Hong StreetSham Shui PoHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Tuen Mun Hospital23 Tsing Chung Koon RoadTuen MunNewT erritoriesHongK ongS ARChina Department of P ediatrics and A dolescent Medicine Princess Margaret Hospital2-10 Princess Margaret Hospital RoadLai Chi KokKowloonHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Queen Mary Hospital102Pokfulam RoadHong K ong S ARChina Department of P ediatrics and A dolescent Medicine The University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescent Medicine Pamela Youde Nethersole Eastern Hospital3Lok Man RoadChaiwanHong K ong S ARChina Department of P ediatrics The University of Hong Kong-Shenzhen Hospital1Haiyuan 1st RoadFutianShenzhenChina Department of P ediatrics and A dolescent Medicine Kwong Wah Hospital25 Waterloo RoadKLN Hong K ong S ARChina Department of P ediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong K ong S ARChina Department of P ediatrics and A dolescen

Background Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. Methods The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macao hos-pitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ). Acceptability of a treatment is graded as very good/good/fair/poor. Results Good asthma control was only reported in 80% subjects in Hong Kong, but higher in sister cities (85–94%, P<0.001). Allergic rhinitis, 'incense burning', and 'smoker in family' were prevalent among the four cities. Logistic regres-sion showed better control of asthma was associated with better PADQLQ (B=?0.029, P < 0.001), better acceptability of bronchodilator (B=?1.488, P = 0.025), negatively with 'smoker in family' (B=?0.83, P = 0.015) and various PADQLQ domains. Conversely, worse PADQLQ was associated with allergic rhinitis severity (B=4.77, P <0.001), poor control of asthma (B=7.56, P <0.001), increased frequency of traditional Chinese medicine use (B=1.7, P < 0.05), increased fre-quency of bronchodilator usage (B=1.05, P < 0.05), 'smoker in family' (B=4.05, P < 0.05), and incense burning at home (B=3.9, P < 0.05). Conclusions There are some clinical and cultural differences among the four southern Chinese cities within the Guangdong province. This study identifies potentially modifiable environmental and treatment factors associated with poor asthma control and QoL for health-care interventions. Having a smoker in the family is independently associated with poor asthma control and QoL.

关键词： Asthma Complementary and alternative medicine Control Inhaled bronchodilator Inhaled corticosteroid Pediatric Allergic Disease Quality of Life Questionnaire Smoking Traditional Chinese medicine

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驱动力矩对汽车转向驱动分岔的影响分析

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汽车工程 2017年第10期39卷 1176-1186,1216页

作者：王宪彬施树明东北林业大学交通学院哈尔滨150040 吉林大学交通学院长春130025

为研究驱动力矩对汽车动力学稳定性的影响,以引入驱动力矩的5自由度汽车二维非线性动力学模型为基础,利用前轮转角作为中间变量,建立了相应的7自由度自治系统模型,分析了不同驱动方式下,驱动力矩对汽车转向驱动分岔的动力学特征的影响... 详细信息

为研究驱动力矩对汽车动力学稳定性的影响,以引入驱动力矩的5自由度汽车二维非线性动力学模型为基础,利用前轮转角作为中间变量,建立了相应的7自由度自治系统模型,分析了不同驱动方式下,驱动力矩对汽车转向驱动分岔的动力学特征的影响。以前轮驱动汽车为例,利用相空间、状态变量时间序列、功率谱密度和李雅普诺夫指数分析了驱动力矩对转向驱动分岔特征影响的动力学演变过程。结果表明:驱动力矩的大小将直接影响汽车动力学系统的分岔特征,在分析汽车的动力学分岔特征时应同时考虑前轮转角和驱动力矩两个分岔参数的影响。

关键词：汽车非线性动力学驱动力矩转向驱动耦合工况分岔混沌

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tak1 Deficiency in Macrophages Increases Host Susceptibility to Leishmania Infection

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感染微生物与疾病(英文) 2023年第3期5卷 127-136页

作者： Xiankai Cao Kossiwa C.Kokou shi Yu Mengdan Chen Junling Niu HervéLecoeur Eric Prina Gerald F.Späth Guangxun Meng The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyUniversity of Chinese Academy of SciencesShanghaiChina Institute Pasteur Paris City UniversityINSERM U1201Molecular Parasitology and Signalling UnitParisFrance Pasteurien College Soochow UniversitySuzhouChina Nanjing Advanced Academy of Life and Health NanjingChina.

Leishmania parasites mainly infect macrophages and may cause severe immunopathologies in their host,which are called *** the current work,we infected human and mouse macrophages in vitro with Leishmania major,an etiological agent of cu-taneous leishmaniasis,and found that inhibition or deletion of the transforming growth factorβ–activated kinase 1(tak1)gene re-sulted in increased parasite *** vivo,following a challenge with ***,mice with a macrophage-specific deletion of tak1 showed increased clinical signs and higher parasite loads compared with wild-type ***1 deficiency in mouse macro-phages led to biased Th2 cell responses during the acute stage of infection,characterized by a decrease in interferon-γexpression,and increased expression of IL-4,IL-5 and ***,we found that,in the late stage of *** infection,excessive Th2-related cytokines led to high arginase 1 expression in mouse tissues and a significant reduction of NO production both locally and system-ically,resulting in compromised control of *** findings suggest that tak1 plays a vital role in host resistance to Leish-mania infection.

关键词： tak1 macrophage Leishmania major arginase 1 nitric oxide

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Motion-Inspired Real-Time Garment Synthesis with Temporal-Consistency

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Journal of Computer Science & Technology 2023年第6期38卷 1356-1368页

作者：魏育坤石敏冯文科朱登明毛天露 School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China

Synthesizing garment dynamics according to body motions is a vital technique in computer ***-based simulation depends on an accurate model of the law of kinetics of cloth,which is time-consuming,hard to implement,and complex to *** data-driven approaches either lack temporal consistency,or fail to handle garments that are different from body *** this paper,we present a motion-inspired real-time garment synthesis workflow that enables high-level control of garment *** a sequence of body motions,our workflow is able to gen-erate corresponding garment dynamics with both spatial and temporal *** that end,we develop a transformer-based garment synthesis network to learn the mapping from body motions to garment ***-level attention is employed to capture the dependency of garments and body ***,a post-processing procedure is further tak-en to perform penetration removal and ***,textured clothing animation that is collision-free and tempo-rally-consistent is *** quantitatively and qualitatively evaluated our proposed workflow from different *** experiments demonstrate that our network is able to deliver clothing dynamics which retain the wrinkles from the physics-based simulation,while running 1000 times ***,our workflow achieved superior synthesis perfor-mance compared with alternative *** stimulate further research in this direction,our code will be publicly available soon.

关键词： clothing animation computer graphics transformer temporal consistency

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