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基于行程时间可靠性的车辆优化调度(英文)

交通运输系统工程与信息 2005年第5期5卷 121-134,F0003页

作者：林兴强陈驰陈景新任爱珠香港理工大学土木及结构工程学系清华大学土木工程系北京100084

行程时间的不确定性是影响货运车队路径选择的一个重要因素,特别是对于要求货物准时送达的配送任务(例如商品混凝土的配送).提出了在车辆调度中考虑由拥挤路段交通流量波动引起的行程时间不确定性的方法,建立了考虑行程时间可靠性要求... 详细信息

行程时间的不确定性是影响货运车队路径选择的一个重要因素,特别是对于要求货物准时送达的配送任务(例如商品混凝土的配送).提出了在车辆调度中考虑由拥挤路段交通流量波动引起的行程时间不确定性的方法,建立了考虑行程时间可靠性要求的车辆优化调度数学模型,给出了相应的启发式算法.通过算例介绍了该模型和算法的应用.结果表明配送总成本随行程时间可靠性要求的提高而增加.

关键词：车辆调度运输问题行程时间可靠性

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Impact of exercise on neuro-cognitive function and hippocampal plasticity in early psychosis—a preliminary data analysis

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Impact of exercise on neuro-cognitive function and hippocamp...

关于动脉粥样硬化性肾动脉狭窄积极药物治疗和因心、脑或肾损伤置入肾动脉支架的前瞻性评估

中华医学会精神病学分会第九次全国学术会议

作者： LIN Jing-xia,~1 May Mei-Ling Lam,~1 Kit-Wa Chan,~1 Wing-Chung Chang,~1 glen Joe,~2 gloria Hoi-Yan Wong,~1 Cindy Pui-Yu Chiu,~1 Pek-Lan Khong,~3 william g Honer,Wayne Su,~4 Cecilia Lai-Wan Chan,~5 Kwok-Fai So,~6 Michael Tse~2 and Eric Yu-Hai Chen~1 1 Department of Psychiatry,the University of Hong Kong 2 Institute of Human Performance,the University of Hong Kong 3 Department of Diagnostic Radiology,the University of Hong Kong 4 Department of Psychiatry,University of British Columbia,Vancouver,Canada 5 Department of Social Work and Social Administration,the University of Hong Kong 6 Department of Anatomy,the University of Hong Kong

Objectives Hippocampal volume is lower in schizophrenic patients than in normal *** present study aimed to investigate whether physical exercise would increase hippocampal volume in patients with early psychosis,and whether this effect would be related to improved neuro-cognitive functions. Methods A total of 60 female psychosis patients aged 18-55 years old with less than 5 years illness duration were

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 41-42页

作者： Hanzel g. Balon H. Wong O. R.D. Safian 徐永城 Division of Cardiology William Beaumont Hospital Royal Oak MI United States Dr.

Sixty-six patients with atherosclerotic renal artery stenosis(RAS) and serum creatinine ≤2.0 mg/dl were treated with antihypertensive therapy, a statin, and aspirin. Renal stenting was reserved for patients with injuries to the heart, b rain, or kidneys. The primary end point was stenotic kidney glomerular filtratio n rate(gFR) at 21 months; secondary end points included major adverse clinical e vents, serum creatinine, total gFR, and blood pressure(BP). After baseline evalu ation, 26 of 66 patients underwent renal stenting because of injuries to the hea rt, brain, or kidneys. After 21 months, 6 medical patients required renal stenti ng, and 5 patients experienced late clinical events(2 medical patients, 3 stent patients). There was no difference in final BP between groups. Whereas medical p atients experienced 6%and 8%decreases in total and stenotic kidney gFR, stent patients experienced 7%and 11%increases in total kidney(p=0.006) and stenotic kidney(p=0.02) gFR. There was no difference in final serum creatinine. In conclu sion, patients with atherosclerotic RAS and baseline creatinine ≤2.0 mg/dl can be safely managed with aggressive medical therapy, with a small decrease in gFR. For patients who develop injuries to the heart, brain, or kidneys, renal artery stenting may further reduce hypertension and improve renal function.

关键词：肾动脉支架患者肾损伤动脉粥样硬化性肾动脉狭窄置入药物治疗

HSPA1A启动子荧光素酶报告基因Hepg2细胞体系在评价焦炉逸散物毒性中的应用

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中华劳动卫生职业病杂志 2012年第12期30卷 883-887页

作者：信丽丽李晓海邓华欣旷聃戴霞云黄素丽王峰何美安 R.williamCurrie 邬堂春华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系环境与健康教育部重点实验室武汉430030 加拿大Dalhousie大学香港中文大学

目的探讨利用含HSPA1A（HSPT0．1）启动子荧光素酶报告基因质粒的稳定转染Hepg2/HSPA1A细胞评价焦炉逸散物毒性的可行性。方法构建含HSPA1A启动子的pgL4．17／HSPA1A重组质粒并转染人Hepg2细胞，建立稳定细胞株Hepg2／HSPA1A。用不同浓... 详细信息

目的探讨利用含HSPA1A（HSPT0．1）启动子荧光素酶报告基因质粒的稳定转染Hepg2/HSPA1A细胞评价焦炉逸散物毒性的可行性。方法构建含HSPA1A启动子的pgL4．17／HSPA1A重组质粒并转染人Hepg2细胞，建立稳定细胞株Hepg2／HSPA1A。用不同浓度的炉底、炉侧和炉顶焦炉逸散物染毒Hepg2／HSPA1A细胞24h，分别测定细胞的相对荧光素酶活力、存活率、丙二醛（MDA）含量、Olive尾距和微核率。结果与对照组相比，炉底焦炉逸散物染毒组细胞的相对荧光素酶活力明显升高，差异有统计学意义（P〈0．01）。且在0．15μg/L时，细胞的相对荧光素酶活力最高，为对照组的1．4倍。细胞的相对荧光素酶活力分别随着炉侧和炉顶焦炉逸散物浓度的增加而逐渐增加．差异均有统计学意义（P〈0．01）。且在最高浓度时（65．4μg／L，202μg／L）细胞的相对荧光素酶活力分别为对照组的2．1和5-3倍。仅炉底焦炉逸散物染毒后细胞的相对荧光素酶活力与MDA浓度呈正相关。差异有统计学意义（r=0．404，P〈0．05）。炉底、炉侧和炉顶焦炉逸散物染毒后，Hepg2／HSPA1A细胞的相对荧光素酶活力均与Olive尾距、微核率呈正相关（r尾距分别为0．476、0．940、0．788，r微校率分别为0．580、0．649、0．432），P〈0．05。结论Hepg2／HSPA1A细胞的相对荧光素酶活力可以敏感地反映焦炉逸散物的毒性效应，该细胞可用于快速评估职业环境复合污染物的综合毒性效应。

关键词： HSPA1A启动子荧光素酶报告基因焦炉逸散物毒性评估

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Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions

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World Journal of gastrointestinal Endoscopy 2022年第6期14卷 402-415页

作者： Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mogawer Ayman Yosry Magdy Elserafy Eman Medhat Hanaa Khalaf Magdy Fouad Tamer Elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y william ghada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed galal Wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah Mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir Mohamed El-Nady Department of Internal Medicine and Hepatogastroenterology Kasr Al-Aini HospitalsCairo UniversityKasr Al-Aini HospitalsCairo UniversityCairo 11451Egypt Department of Endemic Diseases Cairo UniversityCairo 11451Egypt Department of Tropical Medicine and gastroenterology Minia UniversityMinia 61511Egypt Department of Internal Medicine Kasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of gastroenterology Armed forces College of MedicineCairo 11451Egypt Endoscopy and Internal Medicine Consultant at Dr/Ahmed galal Endoscopy Center Alexandria 35516Egypt Department of Internal Medicine Faculty of MedicineAssuit UniversityAssuit 71111Egypt Department of gastroenterology and Hepatology Mansoura UniversityMansoura 35511Egypt Department of gastroenterology and Hepatology Theodor Bilharz Research InstituteCairo 11451Egypt Department of Microbiology and Immunology Faculty of Medicine for girls Al-Azhar UniversityCairo 11451Egypt Department of Internal Medicine Faculty of MedicineAin shams UniversityCairo 11451Egypt Department of Internal Medicine Bani-suef UniversityBani-suefBani-suef 62511Egypt Department of Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Environmental Medicine&Clinical Pathology National Research CentreCairo 11451Egypt

BACKgROUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diagnosis of these lesions are crucial to avoid unnecessary treatment of benign lesions and missed opportunities for early treatment of potentially malignant *** To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antigens [e.g., cancer antigen(CA)19-9, CA72-4], carcinoembryonic antigen(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial growth factor A(VEgF-A), and prostaglandin E2(PgE2)], amylase, and mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign *** This study included 76 patients diagnosed with PCLs using different imaging modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling of different *** The mean age of studied patients was 47.4 ± 11.4 years, with a slight female predominance(59.2%). Mucin stain showed high statistical significance in predicting malignancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and negative predictive value of 93.1% and 91.49%, respectively(P glucose, SPINK1, amylase, and CEA levels had high statistical significance(P gF-A, VEgFR2, and PgE2 did not show any statistical significance. Univariate regression analysis for prediction of malignancy in PCLs showed a statistically significant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. Meanwhile, logistic multivariable regression analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malignancy in cystic pancreatic *** EUS examination of cyst morphology with cytopathological analysis and cyst fluid ana

关键词： Pancreatic cystic neoplasm Mucinous cystic neoplasm Intraductal papillary mucinous neoplasm Mucin stain Amylase

Intra-host Ebola viral adaption during human infection

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Biosafety and Health 2019年第1期1卷 14-24页

作者： william JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu gary Wong Chengchao Chen Chunyu geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong guizhen Wu george F.gao Yuelong Shu NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shandong Universities Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases Taishan Medical UniversityTaian 271000China Institute of Disease Control and Prevention Academy of Military Medical SciencesBeijing 100071China State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China BgI-Shenzhen Shenzhen 518083China Sierra Leone Ministry of Health and Sanitation FreetownSierra Leone Special Pathogens Program National Microbiology LaboratoryPublic Health Agency of CanadaWinnipegCanada Chinese Center for Disease Control and Prevention Beijing 102206China Public Health School(Shenzhen) Sun Yat-sen UniversityShenzhen 510006China

The onsite next generation sequencing(NgS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this ***,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the *** surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical *** genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC ***,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge *** addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated *** study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions.

关键词： Ebola virus Intra-host Nucleotide Variation Adaptation genome sequencing Clinical manifestations Blood biochemistry

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Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, Christopher Rodman, Mariella g. Filbin, Cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave gennert, Rahul Satija, Todd R. golub, Miguel N. Rivera, gad getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella g. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. John Iafrate, Matthew P. Frosch, Miguel N. Rivera, gad getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop P. Patel, Brian V. Nahed, william T. Curry, Robert L. Martuza Daniel P. Cahill Christopher Mount Michelle Monje Mariella g. Filbin Todd R. golub Joshua M. Francis Todd R. golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

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牛皮纸浆的糖化与同步糖化及发酵

农业工程技术(新能源产业) 2012年第5期 46-46页

作者： Nichole A. Bauer william R. gibbons 吴卓晶王应宽 Biology-Microbiology Department South Dakota State University Brookings SD 57007 USA

酶在生产纤维素乙醇过程中是一项重要支出,只要保证乙醇的产量和生产力不降低,减少酶的使用将是有价值的。该项研究旨在评估酶剂量对纤维素向乙醇转化过程的影响。牛皮纸浆,是纸生产过程的一种中间产物,用来代表分离出来的纤维素原料。... 详细信息

酶在生产纤维素乙醇过程中是一项重要支出,只要保证乙醇的产量和生产力不降低,减少酶的使用将是有价值的。该项研究旨在评估酶剂量对纤维素向乙醇转化过程的影响。牛皮纸浆,是纸生产过程的一种中间产物,用来代表分离出来的纤维素原料。实验在一个5L(工作体积为2-3L)的流动式生物反应器中进行,并以80～900r/min范围内不断变化的搅拌速度使之充分混合。通过查阅文献,计算出纤维素酶的平均剂量为每克葡聚糖34FPU和β-葡糖苷酶的平均剂量为每克葡聚糖135CBU,并将之设定为100%剂量。实验选用了酶剂量分别为1%,7%,13%,33%,67%,100%,133%,在干重为4.8%的牛皮纸浆悬浮液中使用纤维素酶NovozymeCelluclast1.5L和β-葡糖苷酶Novozyme188。Novozyme酶的剂量选用其推荐范围的最低值:在浓度为12g/g的葡聚糖中加入Celluclast1.5L35%的剂量,在浓度为1.2g/g的葡聚糖中加入Novozyme1880.9%的剂量。在50℃时的糖化实验显示了一个典型的剂量反应:酶剂量为133%时糖浓度达到最高(约每升葡萄糖59克),糖化速度为2.45g/L/h,该条件下出现一个特定的糖化速度为每小时每个酶单位2.2×10-4克葡萄糖。然而,酶剂量为13%时最高的糖化速度为每小时每个酶单位2.9×10-4克葡萄糖。在35℃时进行同步糖化发酵实验,用酿酒酵母或假丝酵母比较33%,67%,100%,和133%的酶剂量。酶剂量为67%时或多于文献中的平均酶剂量时,乙醇浓度和生产率相似,然而在酶剂量为33%时乙醇浓度和生产率更低。因此,在保证乙醇的产量和生产率不降低的情况下,酶剂量可显著降低至文献中引用的典型水平以下,但不能降低到制造商推荐的水平。

关键词：纤维质乙醇发酵糖化再生能源

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark gregory W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. grotta gary Houser Tudor g. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudiger von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen william A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten g. Lansberg Lawrence L. Latour Ting-Yim Lee Richard Leigh Weili Lin Patrick Lyden grant Mair Bijoy IC Menon Patrik Michel Robert Mikulik Raul g. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schellinger georgios Tsivgoulis Lawrence R. Wechsler Philip M. White greg Zaharchuk Osama O. Zaidat Stephen M. Davis geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell Vincent N. Thijs gotz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImagingResearchgroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImagingResearchgroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国