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Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

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International Journal of Oral Science 2024年第3期16卷 448-459页

作者： Kang Li caihua Zhang Ruoxing Zhou ma.sheng Cheng Rongsong Ling Gan Xiong Jieyi ma.Yan Zhu Shuang Chen Jie Chen Demeng Chen Liang Peng State Key Laboratory of Oncology in South China Department of Oral and Maxillofacial SurgeryInstitute of Precision MedicineCenter for Translational MedicineThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Hospital of Stoma.ology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhouChina Senior Department of Oncology The Fifth Medical Center of PLA General HospitalBeijingChina

Head and neck squamous cell carcinoma.HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is *** is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a crucial,synergistic role in tumor ***,little is known about the role TIL-Bs play in immune microenvironment and the way TIL-Bs affect the outcome of immune checkpoint *** single-cell RNA sequencing(scRNA-seq)data from the Gene Expression Omnibus(GEO)database,the study identified distinct gene expression patterns in *** samples were categorized into TIL-Bs inhibition and TIL-Bs activation groups using unsupervised *** classification was further validated with TCGA HNSCC data,correlating with patient prognosis,immune cell infiltration,and response to *** found that the B cells activation group exhibited a better prognosis,higher immune cell infiltration,and distinct immune checkpoint levels,including elevated PD-L1.A prognostic model was also developed and validated,highlighting four genes as potential bioma.kers for predicting survival outcomes in HNSCC ***,this study provides a foundational approach for B cells-based tumor classification in HNSCC,offering insights into targeted treatment and immunotherapy strategies.

关键词： prognosis elevated offering

青岛鳌山湾2019年浒苔绿潮灾害损失价值评估

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海洋湖沼通报 2024年第1期46卷 167-175页

作者：马彩华尚静马伟伟游奎中国海洋大学山东青岛266100 大连理工大学辽宁盘锦124221

浒苔绿潮在青岛爆发多年,对沿海居民生活、生产及生态环境造成不同程度影响。本文拟以鳌山湾浒苔绿潮灾害为研究对象,采用调研实证方法进行损失价值评估;运用指标体系方法计算其损失价值共计15 743.36万元,其中养殖业损失、生物资源损... 详细信息

浒苔绿潮在青岛爆发多年,对沿海居民生活、生产及生态环境造成不同程度影响。本文拟以鳌山湾浒苔绿潮灾害为研究对象,采用调研实证方法进行损失价值评估;运用指标体系方法计算其损失价值共计15 743.36万元,其中养殖业损失、生物资源损失、生态服务损失、应急处置费分别为6 864.00、105.09、8 398.85、375.42万元。该研究结果为后续相关利益方生态补偿提供参考标准,也为更好地进行生态文明建设,实现人与自然和谐相处奠定理论基础。

关键词：浒苔绿潮灾害损失价值评估青岛鳌山湾

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中国心房颤动流行病学20年

中华心血管病杂志 2024年第2期52卷 220-226页

作者：高明阳何柳杜昕桑才华马长生首都医科大学附属北京安贞医院心内科、国家心血管疾病临床医学研究中心北京100029

心房颤动(房颤)是临床上最常见的持续性心律失常,也是缺血性卒中的重要病因。过去20年,随着人口结构老龄化进程加速以及危险因素的累积,我国房颤相关疾病负担呈上升趋势,但知晓率和综合管理率还处于较低水平。随着房颤检测设备的进步与... 详细信息

心房颤动(房颤)是临床上最常见的持续性心律失常,也是缺血性卒中的重要病因。过去20年,随着人口结构老龄化进程加速以及危险因素的累积,我国房颤相关疾病负担呈上升趋势,但知晓率和综合管理率还处于较低水平。随着房颤检测设备的进步与普及、筛查策略的优化,房颤检出率将进一步提高,有利于诊断治疗关口前移,改善房颤患者生活质量和预后。面对有限的医疗资源和庞大的患者数量,借助移动互联网、人工智能技术实现高质量、高效率的远程管理将发挥巨大价值,是解决这一矛盾的重要途径。

关键词：心房颤动疾病负担患者管理

User space transforma.ion in deep learning based recommendation

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Journal of Systems Engineering and Electronics 2020年第4期31卷 674-684页

作者： WU caihua ma.Jianchao ZHANG Xiuwei XIE Dang Radar Non-Commissioned Officer School Air Force Early Warning AcademyWuhan 430345China

Deep learning based recommendation methods, such as the recurrent neural network based recommendation method(RNNRec) and the gated recurrent unit(GRU) based recommendation method(GRURec), are proposed to solve the problem of time heterogeneous feedback recommendation. These methods out-perform several state-of-the-art methods. However, in RNNRec and GRURec, action vectors and item vectors are shared among users. The different meanings of the same action for different users are not considered. Similarly, different user preference for the same item is also ignored. To address this problem, the models of RNNRec and GRURec are modified in this paper. In the proposed methods, action vectors and item vectors are transformed into the user space for each user firstly, and then the transformed vectors are fed into the original neural networks of RNNRec and GRURec. The transformed action vectors and item vectors represent the user specified meaning of actions and the preference for items, which ma.es the proposed method obtain more accurate recommendation results. The experimental results on two real-life datasets indicate that the proposed method outperforms RNNRec and GRURec as well as other state-of-the-art approaches in most cases.

关键词： recommender system collaborative filtering time heterogeneous feedback recurrent neural network gated recurrent unit(GRU) user space transforma.ion

考虑土-结构相互作用的超高层结构地震非线性分析

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建筑结构学报 2024年第6期45卷 25-38页

作者：潘玉华王翠坤时继瑞陈才华邱盛源马明崔明哲董皓中建研科技股份有限公司北京100013 国家建筑工程技术研究中心北京100013

目前,对于超高层结构进行动力弹塑性分析时,大多采用刚性地基假定,并忽略土-结构相互作用的影响。为了研究土-结构相互作用对超高层结构的影响,建立精细化的土体-地下室-上部结构三维非线性有限元模型,并对一栋高度366 m超高层塔楼进行... 详细信息

目前,对于超高层结构进行动力弹塑性分析时,大多采用刚性地基假定,并忽略土-结构相互作用的影响。为了研究土-结构相互作用对超高层结构的影响,建立精细化的土体-地下室-上部结构三维非线性有限元模型,并对一栋高度366 m超高层塔楼进行了罕遇地震动力弹塑性分析。首先根据工程场地条件进行了一维等效线性化分析,以获取土层的地震反应。然后,利用波动法解决了在三维土层地震波动输入的问题,并验证了所采用方法的准确性。计算结果表明:与刚性地基假定相比,考虑土-结构相互作用会增加塔楼的自振周期;在预估的罕遇地震作用下,考虑土-结构相互作用后,塔楼的整体地震反应减小;塔楼层间位移角在低区增大,在高区减小,高区最大层间位移角减小,呈现变形向底部转移的趋势;塔楼高区墙体损伤减轻,结构整体刚度退化程度减小,同时基底剪力和倾覆弯矩降低;塔楼巨柱个别位置的内力增大,忽略土-结构相互作用的影响可能会导致设计结果偏于不安全;所提出的方法能够全面考虑场地土的影响,较为真实地模拟超高层结构的地震响应。

关键词：超高层结构土-结构相互作用一维场地分析黏弹性边界弹塑性分析

Prima.y Discussion of a Carbon Sink in the Oceans

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Journal of Ocean University of China 2015年第2期14卷 284-292页

作者： ma.caihua YOU Kui JI Dechun ma.Weiwei LI Fengqi Ocean University of China Woods Hole Oceanographic Institution Dalian University of Technology

As a consequence of global warming and rising sea levels, the oceans are becoming a ma.ter of concern for more and more people because these changes will impact the growth of living organisms as well as people＇s living standards. In particular, it is extremely important that the oceans absorb ma.sive amounts of carbon dioxide. This paper takes a pragma.ic approach to analyzing the oceans with respect to the causes of discontinuities in oceanic variables of carbon dioxide sinks. We report on an application of chemical, physical and biological methods to analyze the changes of carbon dioxide in oceans. Based on the relationships among the oceans, land, atmosphere and sediment with respect to carbon dioxide, the foundation of carbon dioxide in shell-building and ocean acidification, the changes in carbon dioxide in the oceans and their impact on clima.e change, and so on, a vital conclusion can be drawn from this study. Specifically, under the condition that the oceans are not disturbed by external forces, the oceans are a large carbon dioxide sink. The result can also be inferred by the formula： C=A-B and G=E＋F when the ma.ine ecosystem can keep a natural balance and the amount of carbon dioxide emission is limited within the calrying capacity of the oceans.

关键词： biological ecosystems Carbon Dioxide sinks ma.ine carrying capacity

An approach to error elimination for multi-axis CNC ma.hining and robot ma.ipulation

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Science China(Technological Sciences) 2007年第5期50卷 560-574页

作者： XIONG caihua School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

The geometrical accuracy of a ma.hined feature on a workpiece during ma.hining processes is ma.nly affected by the kinema.ic chain errors of multi-axis CNC ma. chines and robots, locating precision of fixtures, and datum errors on the work- piece. It is necessary to find a way to minimize the feature errors on the workpiece. In this paper, the kinema.ic chain errors are transformed into the displacements of the workpiece. The relationship between the kinema.ic chain errors and the dis- placements of the position and orientation of the workpiece is developed. A ma.- ping model between the displacements of workpieces and the datum errors, and adjustments of fixtures is established. The suitable sets of unit basis twists for each of the commonly encountered types of feature and the corresponding locating di- rections are analyzed, and an error elimination (EE) method of the ma.hined feature is formulated. A case study is given to verify the EE method.

关键词： error elimination, multi-axis ma.hine, robot ma.ipulation, kinema.ic chain, twist

A Study on ma.ine Region Carrying Capacity and Eco-compensation

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Journal of Ocean University of China 2012年第2期11卷 253-256页

作者： ma.caihua YOU Kui ma.Weiwei XIE Jun LI Fengqi Ocean University of China Qingdao 266003P.R.China

With the using up of land resources, people are beginning to pay attention to the exploitation of the ocean and the use of ma.ine resources is becoming more and more intense. Whether and how the ocean can be sustainably exploited as it is being exploited is an academic hot topic. This question is addressed in this paper based on the theories of carrying capacity of a ma.ine region and ma.ine eco-compensation, and the amount of the loss is calculated by the method of Time Value of Capital. This thesis covers the study of eco-compensation between two specific subjects with clear compensation objects, and as a defined approach and standard, the proposed method has good operability and positive practical significance in the good use of the ocean.

关键词： carrying capacity of ma.ine region ma.ine eco-compensation time value of capital

采用可穿戴设备连续光电容积脉搏波算法检测心房颤动的临床价值

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中华心血管病杂志 2024年第5期52卷 513-518页

作者：李起帆左嵩赖一炜李思彤桑才华杜昕董建增马长生首都医科大学附属北京安贞医院心内科北京100029

目的评估连续光电容积脉搏波算法应用于可穿戴设备时,检出心房颤动(房颤)和评估房颤负荷的准确性。方法本研究是一项自身对照的前瞻性队列研究,连续纳入2022年9至11月于首都医科大学附属北京安贞医院心内科住院治疗的254例房颤患者。所... 详细信息

目的评估连续光电容积脉搏波算法应用于可穿戴设备时,检出心房颤动(房颤)和评估房颤负荷的准确性。方法本研究是一项自身对照的前瞻性队列研究,连续纳入2022年9至11月于首都医科大学附属北京安贞医院心内科住院治疗的254例房颤患者。所有受试者同时佩戴2种设备:(1)心电手表,用于采集光电容积脉搏波(W-PPG)和心电图(W-ECG);(2)心电贴,用于采集心电图(P-ECG)。分别以30 s数据片段和受试者个体为单位,将心电手表得出的测量结果与心电图专家判读心电贴结果相对比,采用受试者工作特征曲线评估其敏感度和特异度。按照房颤负荷比例均分为4个分段,计算由房颤分析软件得出的房颤负荷与心电图专家判别心电贴结果得出的房颤负荷差值。结果254例受试者的年龄为(63.04±11.04)岁,99例(38.98%)为女性,持续性房颤患者97例(38.19%)。以心电图专家判读心电贴的结果为标准,以片段为单位时,P-ECG算法的敏感度为94.86%(95%CI:94.81%~94.91%),特异度为99.30%(95%CI:99.28%~99.31%),W-PPG算法的敏感度为96.07%(95%CI:95.97%~96.18%),特异度为98.62%(95%CI:98.59%~98.65%);以个体为单位时,P-ECG算法的敏感度为92.55%(95%CI:87.57%~95.71%),特异度为96.39%(95%CI:93.45%~98.09%),W-PPG算法的敏感度为93.71%(95%CI:88.75%~96.67%),特异度为89.62%(95%CI:85.61%~92.65%);以单次采集W-ECG记录为单位时,W-ECG算法的敏感度为92.04%(95%CI:88.14%~94.78%),特异度为96.19%(95%CI:94.35%~97.47%)。房颤负荷评估方面,各负荷分布区间内W-PPG分析结果与心电图专家判读心电贴结果相差均小于2%。结论连续PPG算法应用于可穿戴设备检测房颤是一种可行策略。以心电图专家判读心电贴的结果为标准,通过智能手表连续监测PPG对于房颤诊断具有较高的准确性,同时也可有效地完成房颤负荷评估。

关键词：心房颤动心房颤动负荷光电容积脉搏波心电图智能手表可穿戴设备算法连续监测