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Optoelectronics Letters 2024年第10期20卷 623-628页

作者： PING Haoyu ma yongjie ZHU Guangya ZHANG Jiaqi School of Physics and Electronic Engineering Northwest Normal University

To address traffic congestion, this study improves Mobile Netv2-you only look once version 4(YOLOv4) target detection algorithm(Mobile Netv2-YOLOv4-K++F) and introduces an embedded traffic information processing solution based on edge computing. We transition models initially designed for large-scale graphics processing units(GPUs) to edge computing devices, maximizing the strengths of both deep learning and edge computing technologies. This approach integrates embedded devices with the current traffic system, eliminating the need for extensive equipment updates. The solution enables real-time traffic flow monitoring and license plate recognition at the edge, synchronizing instantaneously with the cloud, allowing for intelligent adjustments of traffic signals and accident forewarnings, enhancing road utilization, and facilitating traffic flow optimization. Through on-site testing using the RK3399PRO development board and the Mobile Netv2-YOLOv4-K++F object detection algorithm, the upgrade costs of this approach are less than one-tenth of conventional methods. Under favorable weather conditions, the traffic flow detection accuracy reaches as high as 98%, with license plate recognition exceeding 80%.

关键词： A

Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients

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Stroke & Vascular Neurology 2024年第1期9卷 18-29页

作者： yongjie ma Zihao Song Yinqing Wang Jiachen Wang Chuan He Guilin Li Peng Zhang Tao Hong Liyong Sun Peng Hu Ming Ye Hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing China

Background Craniocervical junction(CCJ)arteriovenous fistulas(AVFs)are *** current treatment strategies for AVFs with different angioarchitecture need to be *** present study aimed to analyse the correlation between angioarchitecture and clinical characteristics,share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage(SAH)and poor *** A total of 198 consecutive patients with CCJ AVFs from our neurosurgical centre were retrospectively *** patients were grouped according to their clinical manifestations,and their baseline clinical characteristics,angioarchitecture,treatment strategies and outcomes were *** The patients’median age was 56 years(IQR 47–62 years).The majority of patients were men with 166(83.8%)*** most common clinical manifestation was SAH(52.0%),followed by venous hypertensive myelopathy(VHM)(45.5%).The most common CCJ AVFs type was dural AVF,with 132(63.5%)*** most frequent fistula location was C-1(68.7%)and dural branch of vertebral artery(70.2%)was the most involved arterial feeders for *** most common direction of venous drainage was descending intradural drainage(40.9%),followed by ascending intradural drainage(36.5%).Microsurgery was the most common treatment strategy applied for 151(76.3%)patients,15(7.6%)patients were treated with interventional embolisation only,and 27(13.6%)received both interventional embolisation and microsurgical *** learning curve for microsurgery only was analysed by cumulative summation method,and the turning point was the 70th case,and blood loss in post-group was lower than that in pre-group(p=0.034).At the last follow-up,there were 155(78.3%)patients with favourable outcomes(modified Rankin Scale(mRS)manifestation(OR 4.102,95%CI 2.108 to 7.982,p<0.001)and pretreatment mRS≥3(OR 3.127,95%CI 1.617 to 6.047,p<0

关键词： patients treatment hypertensive

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou Xinhui Huang Chunmei Zhang yongjie ma Jinqiu Hu Xiaoyan Bi Junyu ma Mengyao Li Dong Lu Liang Hu Jiahua Fan Fuli Ya Department of Nutrition， School of Public Health， Dali University Department of Laboratory Teaching Center， School of Public Health， Dali University Department of Health management， Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine School of Integrative Medicine， Shanghai University of Traditional Chinese Medicine School of Public Health， Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases， Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

关键词：

多重压力下青海湖国家公园内牧户生计脆弱性评价

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经济地理 2024年第3期44卷 169-177,217页

作者：仲俊涛马勇洁米文宝石建丽蒋鑫西安科技大学测绘科学与技术学院陕西西安710054 青海师范大学地理科学学院青海西宁810008 宁夏大学地理科学与规划学院宁夏银川750021

文章以青海湖国家公园为例,运用参与式农村评估法(PRA)进行生计普查,基于调整的VSD框架构建多重压力下牧户生计脆弱性评估分析框架,从“敏感性、适应性”2个维度选取体现青海湖国家公园牧户生计脆弱性的变量,测算不同生态功能分区牧户... 详细信息

文章以青海湖国家公园为例,运用参与式农村评估法(PRA)进行生计普查,基于调整的VSD框架构建多重压力下牧户生计脆弱性评估分析框架,从“敏感性、适应性”2个维度选取体现青海湖国家公园牧户生计脆弱性的变量,测算不同生态功能分区牧户生计脆弱性,并应用障碍度模型识别生计脆弱性形成的主要因子。结果表明:(1)自然灾害、草/耕地退化、衣食住行、退牧还草是对青海湖国家公园牧户生计安全影响最剧烈的生计压力。(2)核心保护区牧户生计敏感性强,适应能力弱,生计脆弱性高;一般控制区牧户生计敏感性弱,适应能力强,生计脆弱性低。(3)不同区域牧户生计脆弱性在各维度的主要促成因子具有高度趋同性,食品自给度、湖水上涨、旅游市场萎缩、固定资产、牲畜数量、草地面积和家庭收入等分别从不同维度促进了生计脆弱性的形成。

关键词：牧户生计脆弱性多重压力参与式农村评估方法(PRA) 青海湖国家公园

国际空间站 10项在期刊发表的创新性科学成果

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航天员 2024年第3期 71-75页

作者：马永洁(编译) 不详

作为一个大型研究性的在轨实验室,至2023年国际空间站已经进入了运营的第25个年头。20多年来,国际空间站为科学家们提供了独特的实验平台,科研人员开展了各个领域的科学实验,取得了许多有意义的科研成果,发表了多篇学术论文。据统计,202... 详细信息

作为一个大型研究性的在轨实验室,至2023年国际空间站已经进入了运营的第25个年头。20多年来,国际空间站为科学家们提供了独特的实验平台,科研人员开展了各个领域的科学实验,取得了许多有意义的科研成果,发表了多篇学术论文。据统计,2023年度有200多篇与国际空间站研究相关的论文在期刊发表。

关键词：国际空间站科研人员科研成果实验平台科学成果学术论文科学实验研究性

基于剩余寿命预测信息的风电场动态成组维护策略研究

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电力系统保护与控制 2024年第16期52卷 178-187页

作者：黄玲玲马永杰应飞祥王全德刘璐洁海上风电技术教育部工程研究中心(上海电力大学) 上海200090 上海电力大学电气工程学院上海200090

现有的风电场成组维护优化研究中,较少考虑维护时间窗内的部件实时状态信息动态变化影响,针对此问题,提出了一种考虑剩余寿命预测信息动态更新的风电场成组维护策略。首先,利用实时状态信息获得各部件剩余寿命预测结果,基于实时剩余寿... 详细信息

现有的风电场成组维护优化研究中,较少考虑维护时间窗内的部件实时状态信息动态变化影响,针对此问题,提出了一种考虑剩余寿命预测信息动态更新的风电场成组维护策略。首先,利用实时状态信息获得各部件剩余寿命预测结果,基于实时剩余寿命预测结果优化最小平均维修成本,构建单部件最优维修时间窗。其次,考虑风电机组部件结构相关性及部件备件库存约束,以节省维修成本最大为目标,建立风电场成组维护模型,并采用遗传算法进行成组维护策略优化。最后,采用滚动时间窗模型实时更新机组部件的剩余寿命预测信息,动态调整原有维修方案。一个实际风电场案例的分析结果表明,所提策略能够实时更新风电场维修计划,实现维修计划的动态优化,有助于降低维修成本。

关键词：风电场剩余寿命预测相关性动态成组维护遗传算法

表面改性密网支架治疗合并系统性红斑狼疮多发颅内动脉瘤一例

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中国脑血管病杂志 2024年第4期21卷 257-260页

作者：丁前进马永杰张鸿祺河南省新乡市中心医院神经外科 453000 首都医科大学宣武医院神经外科

合并系统性红斑狼疮(SLE)的多发颅内动脉瘤病例临床较为罕见,尽管SLE与颅内多发动脉瘤发生之间的相关性暂不明确,但是对于合并SLE的颅内动脉瘤患者,其动脉瘤通常具有增长快速和极易破裂的特点,如何对其动脉瘤进行破裂风险评估并制定治... 详细信息

合并系统性红斑狼疮(SLE)的多发颅内动脉瘤病例临床较为罕见,尽管SLE与颅内多发动脉瘤发生之间的相关性暂不明确,但是对于合并SLE的颅内动脉瘤患者,其动脉瘤通常具有增长快速和极易破裂的特点,如何对其动脉瘤进行破裂风险评估并制定治疗策略尤为重要。该文报道1例表面改性密网支架置入治疗合并SLE多发颅内动脉瘤患者,并进行相关文献复习,希望为临床医师诊疗该疾病提供帮助。

关键词：颅内动脉瘤系统性红斑狼疮血管内治疗表面改性密网支架

球囊辅助Onyx胶栓塞前颅底硬脑膜动静脉瘘的效果分析

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中华神经外科杂志 2024年第1期40卷 54-59页

作者：高振忠苏新马永杰宋子豪张鸿祺叶明张鹏首都医科大学宣武医院神经外科北京100053 海南医学院第一附属医院神经外科海口570102

目的探讨经不同供血动脉行球囊辅助栓塞前颅底硬脑膜动静脉瘘(DAVF)的安全性和有效性。方法回顾性分析2002年1月至2022年12月首都医科大学宣武医院神经外科采用球囊辅助栓塞的9例前颅底DAVF患者的临床资料。9例患者分别经蝶腭动脉、眼... 详细信息

目的探讨经不同供血动脉行球囊辅助栓塞前颅底硬脑膜动静脉瘘(DAVF)的安全性和有效性。方法回顾性分析2002年1月至2022年12月首都医科大学宣武医院神经外科采用球囊辅助栓塞的9例前颅底DAVF患者的临床资料。9例患者分别经蝶腭动脉、眼动脉、脑膜中动脉进行球囊辅助Onyx胶栓塞,共10例次。术中以栓塞剂完全闭塞近端引流静脉为即刻治愈性栓塞标准。根据患者的并发症情况评估手术的安全性。术后行临床随访,采用改良Rankin量表评分(mRS)评估患者的临床疗效。通过数字减影血管造影(DSA)检查进行影像学随访,以明确病变有无复发。结果9例患者中,7例达到治愈性栓塞,2例为近全闭塞。9例患者中,1例患者经眼动脉途径栓塞后出现视网膜中央动脉缺血症状,其余8例患者无并发症发生。所有患者均完成临床随访,随访时间为59~127个月。末次随访时mRS为0分7例,1分2例。6例患者完成影像学随访,随访时间为6~71个月,其中1例近全闭塞的患者在血管内治疗3个月余后瘘口自行闭塞;其余5例患者在达到治愈性栓塞后行DSA复查,无一例出现复发。结论对于前颅底DAVF,当微导管难以到达瘘口时,经球囊辅助Onyx胶栓塞是一种可行、有效的治疗方法,且并发症轻微。

关键词：动静脉瘘硬膜颅窝,前血管内操作治疗结果安全性 Onyx

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青鳉鱼的首次太空繁殖实验

航天员 2024年第2期 70-73页

作者：马永洁赵海豹不详

1994年夏天,作为国际微重力实验室2号(IML-2/STS-65)进行的空间生物学实验之一,有4条青鳉鱼(Oryzias latipes)进行了15天的太空旅行。这4条青鱼作为脊椎动物首次在太空中成功交配,此外,它们产下的卵在太空中正常发育,还孵化出了鱼苗。... 详细信息

1994年夏天,作为国际微重力实验室2号(IML-2/STS-65)进行的空间生物学实验之一,有4条青鳉鱼(Oryzias latipes)进行了15天的太空旅行。这4条青鱼作为脊椎动物首次在太空中成功交配,此外,它们产下的卵在太空中正常发育,还孵化出了鱼苗。这次实验由日本科学家井上宪一(Kenichi jiri)负责设计并组织完成。由于交配实验对饲养条件要求较高,当时完成这个实验花费了研究人员很大的精力和投入。本文将对青鳉鱼在太空中的这次繁殖实验进行回顾。

关键词：太空旅行青鳉鱼繁殖实验空间生物学微重力正常发育实验室饲养条件

Enhancement of the efficiency of PEI/liposome transfection by magnetofectins formed via electrostatic self-assembly

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Chinese Science Bulletin 2012年第31期57卷 4005-4011页

作者： ma yongjie WANG XiaoLiang GU HongChen Nano Biomedical Research Center School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China

One of the major challenges for successful gene therapy is improving the transfection efficiency of non-viral vectors. magnetic nanoparticles (MNPs) have been developed as enhancers of non-viral vehicles. We prepared MNPs and modified them with polyethyleneimine (PEI), citric acid (CA) or carboxylmethyl-dextran (CMD). Both positively charged MNPs (MNPs@PEI) and negatively charged MNPs (MNPs@CA, MNPs@CMD) could spontaneously form transfection complexes (magnetofectins) with plasmid DNA and PEI/liposome via electrostatic self-assembly. Our results showed as-prepared magnetofectins apparently enhanced PEI/liposome transfection efficiency and/or gene expression level into COS-7 cells with reduced transfection time from 4 h to 15 min under a magnetic field in vitro. Meanwhile, the effect of magnetofection was cell line-dependant. These results suggest that charged MNPs could improve transfection efficiency for non-viral vectors by simply mixing with them and by exerting a magnetic force. Thus such MNPs provide a convenient platform for further applications of gene delivery.

关键词：脂质体转染静电自组装 PEI 效率增强 COS-7细胞非病毒载体转染效率磁性纳米粒子