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Unraveling the complexity of polycystic ovary syndrome with animal models

Journal of Genetics and Genomics 2024年第2期51卷 144-158页

作者： Huanju Liu Mixue Tu Zhiyong Yin Dan Zhang jun ma Feng He Center for Genetic Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Key Laboratory of Women's Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology Women's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Zhejiang Provincial Clinical Research Center for Child Health Women's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Clinical Research Center on Birth Defect Prevention and Intervention of Zhejiang Province HangzhouZhejiang 310006China Institute of Genetics Zhejiang University International School of MedicineHangzhouZhejiang 310058China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorder HangzhouZhejiang 310058China

Polycystic ovary syndrome (PCOS) is a highly familial and heritable endocrine disorder. Over half of the daughters born to women with PCOS may eventually develop their own PCOS-related symptoms. Progress in the treatment of PCOS is currently hindered by the complexity of its clinical manifestations and incomplete knowledge of its etiopathogenesis. Various animal models, including experimentally induced, naturally occurring, and spontaneously arising ones, have been established to emulate a wide range of phenotypical and pathological traits of human PCOS. These studies have led to a paradigm shift in understanding the genetic, developmental, and evolutionary origins of this disorder. Furthermore, emerging evidence suggests that animal models are useful in evaluating state-of-the-art drugs and treatments for PCOS. This review aims to provide a comprehensive summary of recent studies of PCOS in animal models, highlighting the power of these disease models in understanding the biology of PCOS and aiding high-throughput approaches.

关键词： Polycystic ovary syndrome Animal model Genetc manipulation Developmnental progtanning Drug screening

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Oxidation Resistance of In Situ Reaction/Hot Pressing Synthesized Ti_(2)AlC-20%TiB_(2) Composite at 600-900℃in Air

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 739-748页

作者： Wenting Wang Jingjun Xu jun Zuo Ke ma Yang Li Guangqi He Meishuan Li Shengyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of materials Science and Engineering University of Science and Technology of ChinaShenyang110016China

The oxidation behavior and kinetics of Ti_(2)AlC-20vol.%TiB_(2) composite at 600-900℃ in air were *** results showed that the oxidation kinetics of the composite followed a logarithmic law within the given temperature range,which indicated that the composites had excellent oxidation *** selective oxidation of Al in Ti_(2)AlC was greatly enhanced,which facilitated the formation of a continuous and dense protective layer of Al_(2)O_(3).Meanwhile,the existence of molten B_(2)O_(3) inhibited the outward diffusion of Ti and inward diffusion of oxygen,which prevented the growth of anatase TiO_(2) at 600℃ and rutile TiO_(2) at 700-900℃.Therefore,the incorporation of TiB_(2) completely inhibited the abnormally rapid oxidation of bulk Ti_(2)AlC at 600℃ and improved its oxidation resistance at 700-900℃.

关键词： maX phase Ti_(2)AlC-TiB_(2)composite Intermediate temperature oxidation Oxidation kinetics

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Paeoniflorin,the main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU jun RUAN An-min ma Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

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Knockout of a rice K5.2 gene increases Ca accumulation in the grain

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Journal of Integrative Plant Biology 2024年第2期66卷 252-264页

作者： Peitong Wang Naoki Yamaji Namiki Mitani-Ueno jun Ge Jian Feng ma National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China Institute of Plant Science and Resources Okayama UniversityKurashiki 710-0046Japan

Rice is a staple food for half of the world’s population,but it is a poor dietary source of calcium(Ca)due to the low *** is an important issue to boost Ca concentration in this grain to improve Ca deficiency risk,but the mechanisms underlying Ca accumulation are poorly ***,we obtained a rice(Oryza sativa)mutant with high shoot Ca *** mutant exhibited 26%-53% higher Ca in shoots than did wild-type rice(WT)at different Ca *** concentration in the xylem sap was 36% higher in the mutant than in the *** was no difference in agronomic traits between the WT and mutant,but the mutant showed 25% higher Ca in the polished grain compared with the ***-based cloning combined with a complementation test revealed that the mutant phenotype was caused by an 18-bp deletion of a gene,OsK5.2,belonging to the Shaker-like K+channel ***5.2 was highly expressed in the mature region of the roots and its expression in the roots was not affected by Ca levels,but upregulated by low *** showed that OsK5.2 was mainly expressed in the pericycle of the *** together,our results revealed a novel role for OsK5.2 in Ca translocation in rice,and will be a good target for Ca biofortification in rice.

关键词： accumulation biofortification calcium OsK5.2 pericycle rice translocation

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Clinical efficacy and pathological outcomes of transanal endoscopic intersphincteric resection for low rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 933-944页

作者： Zhi-Wen Xu Jing-Tao Zhu Hao-Yu Bai xue-jun Yu Qing-Qi Hong jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361000Fujian ProvinceChina

BACKGROUND Transanal endoscopic intersphincteric resection(ISR)surgery currently lacks sufficient clinical research and *** To investigate the clinical effectiveness of transanal endoscopic ISR,in order to promote the clinical application and development of this *** This study utilized a retrospective case series *** and pathological data of patients with lower rectal cancer who underwent transanal endoscopic ISR at the First Affiliated Hospital of Xiamen University between may 2018 and may 2023 were *** patients underwent transanal endoscopic ISR as the surgical *** conducted this study to determine the perioperative recovery status,postoperative complications,and pathological specimen charac-teristics of this group of *** This study included 45 eligible patients,with no perioperative *** overall incidence of early complications was 22.22%,with a rate of 4.44%for Clavien-Dindo grade≥III *** patients(4.4%)developed anastomotic leakage after surgery,including one case of grade A and one case of grade *** pathological examination confirmed negative circumferential resection margins and distal resection margins in all *** mean distance between the tumor lower margin and distal resection margin was found to be 2.30±0.62 *** transanal endoscopic ISR procedure consistently yielded high quality pathological *** Transanal endoscopic ISR is safe,feasible,and provides a clear anatomical *** is associated with a low incidence of postoperative complications and favorable pathological outcomes,making it worth further research and application.

关键词： Intersphincteric resection Transanal Rectal cancer Complications Endoscopic

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Bose–Einstein distribution temperature features of quasiparticles around magnetopolaron in Gaussian quantum wells of alkali halogen ions

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Chinese Physics B 2024年第9期33卷 521-526页

作者： Xin Zhang Sarengaowa Shuang Han Ran An Xin-xue Zhang Xin-Ying Ji Hong-Xu Jiang Xin-jun ma Pei-Fang Li Yong Sun College of Physics and Electronic Information Inner Mongolia Minzu UniversityTongliao028000China Institute of Condensed matter Physics Inner Mongolia Minzu UniversityTongliao 028000China

We have applied strong coupling unitary transformation method combined with Bose–Einstein statistical law to investigate magnetopolaron energy level temperature effects in halogen ion crystal quantum *** obtained results showed that under magnetic field effect,magnetopolaron quasiparticle was formed through the interaction of electrons and surrounding *** the same time,magnetopolaron was influenced by phonon temperature statistical law and important energy level shifts down and binding energy *** revealed that lattice temperature and magnetic field could easily affect magnetopolaron and the above results could play key roles in exploring thermoelectric conversion and conductivity of crystal materials.

关键词： temperature effect quantum well asymmetric Gaussian potential magnetopolaron

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long ma xue-Yan Feng Li-Na ma Department of Infectious Disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Infectious Disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(Pmatory factors(Pmatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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L^(p)-solutions of Multi-dimensional Oblique Reflected BSDEs and Optimal Switching Problem on Finite or Infinite Time Horizon

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Acta mathematicae Applicatae Sinica 2024年第4期40卷 1127-1146页

作者： xue-jun SHI Qun FENG Long JIANG School of mathematics and Statistics Shandong Normal UniversityJinan 250358China School of management Science and Engineering University of JinanJinan 250002China School of mathematics China University of Mining and TechnologyXuzhou 221116China

In this paper,we study mulit-dimensional oblique reflected backward stochastic differential equations(RBSDEs)in a more general framework over finite or infinite time horizon,corresponding to the pricing problem for a ... 详细信息

关键词： multi-dimensional oblique reflected BSDE optimal switching and stopping problem finite or infinite time horizon uniformly continuous generators

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Sustainable electrochemical dearomatization for the synthesis of diverse 2,3-functionalized indolines

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Green Synthesis and Catalysis 2024年第1期5卷 25-30页

作者： jun Chen Rong Zhang Caiyan ma Peng Zhang Yonghong Zhang Bin Wang Fei xue Weiwei Jin Yu Xia Chenjiang Liu Urumqi Key Laboratory of Green Catalysis and Synthesis Technology Key Laboratory of Oil and Gas Fine ChemicalsMinistry of Education&Xinjiang Uygur Autonomous RegionState Key Laboratory of Chemistry and Utilization of Carbon Based Energy ResourcesCollege of ChemistryCollege of Future TechnologyXinjiang UniversityUrumqi 830017China

Herein,we achieved a green and efficient dearomatization for the synthesis of 2,3-functionalized polycyclic indolines in an electrochemical *** avoiding of external oxidants and metals approach allowed various nucleophilic sources(Nu¼anilines,TMSN3 and ROH)to perform the products,representing an environmentally benign ***,the continuous flow electrosynthesis and synthetic transformations also reveal the strong practicality of electrochemistry in organic synthesis.

关键词： Green synthesis Organic electrochemistry Indole Dearomatization Cyclization

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