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GB 9706.202-2021《医用电气设备第2-2部分:高频手术设备及高频附件的基本安全和基本性能专用要求》主要条款解读

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中国医疗器械信息 2024年第15期30卷 36-41页

作者：左鹏飞马小建魏胜深圳迈瑞生物医疗电子股份有限公司广东深圳518057 杭州迈瑞医疗科技有限公司浙江杭州311501

阐述GB 9706.202-2021《医用电气设备第2-2部分:高频手术设备及高频手术附件的基本安全和基本性能专用要求》中高频手术附件的条款解读。重点对高频电解质强度中的预处理、高频泄漏、高频介电强度、工频介电强度条款进行了详细解读。

关键词：高频附件手术附件绝缘高频泄漏高频介电强度工频介电强度

Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with Upper Respiratory Tract Infections:A Multicenter Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第5期28卷 387-393页

作者： LUO Hui SONG Gui-Hua ma xiao-jian SUN Meng-meng ZHANG man XIE jian-rong PENG Shao Institute for Tibetan Medicine China Tibetology Research CenterBeijing(100101)China Department of Pediatrics the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou(450000)China Department of Pediatrics Huaihe Hospital of Henan UniversityZhengzhou(450000)China Department of Pediatrics the First Affiliated Hospital of Zhengzhou UniversityZhengzhou(475000)China School of Statistics Renmin University of ChinaBeijing(100872)China

Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in ***:The study was a multicenter,randomized,open-label,controlled trial.A total of 142 children aged 2 to 14 years old,with URTIassociated cough within 48 h of onset,were randomly assigned to two groups at a 1:1 ratio by computer-generated randomization *** were treated with JWZH(1 to 1.5 g,twice to thrice daily)in the treatment group or conventional treatment(Pediatric Paracetamol,Artificial Cow-bezoar and Chlorphenamine maleate Granules,0.25 to 1 g,thrice daily)in the control group for 5 *** primary endpoints were the time to cough resolution and 4-day cough resolution *** secondary endpoints were the daily improvement in symptom scores and cough resolution rate during the study ***:A total of 138 children were included in the intention-to-treat analysis,with 71 cases in the treatment group and 67 cases in the control *** with the conventional treatment,the children receiving JWZH had a shorter time to cough resolution[hazard ratio,2.10;95%confidence interval(CI),1.29-3.40;P=0.003].The median time to cough resolution for children receiving JWZH was shorter than that of the conventional treatment(2 days vs.3 days;P0.05).Adverse events was reported in 5.6%(4/71)and 4.5%(3/67)in participants of JWZH and PPACCM groups(P>0.05),respectively,which were all mild and resolved without ***:JWZH seemed to be a safe and effective therapy for URTI-associated cough in children.(Trial registration *** CTR2000039421)

关键词： child cough upper respiratory tract infection Jiuwei Zhuhuang Powder randomized controlled trial Tibetan medicine

Exploring binding mode for styrylquinoline HIV-1 integrase inhibitors using comparative molecular field analysis and docking studies

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Acta Pharmacologica Sinica 2004年第7期25卷 104-112页

作者： xiao-hui ma, xiao-yi ZHANG, jian-jun TAN, Wei-zu CHEN, Cun-xin WANG2 College of LifeScience and Bioengineering, Beijing University of Technology, Beijing 100022, China College of Life Science and Bioengineering Beijing University of Technology Beijing 100022 China

AIM: To understand pharmacophore properties of styrylquinoline derivatives and to design inhibitors of HIV-1 integrase. METHODS: Comparative molecular field analysis (CoMFA) was performed to analyze three-dimen- sional quantitative structure-activity relationship (3D-QSAR) of styrylquinoline derivatives. Thirty-eight compounds were randomly divided into a training set of 28 compounds and a test set of 10 compounds. The stability of 3D- QSAR models was proved by the analysis of cross-validated and non-cross-validated methods. Moreover, the binding mode of these compounds and integrase was constructed by AutoDock program. RESULTS: The CoMFA model of the training compounds was reasonably predicted with cross-validated coefficient (q2) and conventional (r2) values (up to 0.696 and 0.754). Then the model was validated by the test set. The resulting CoMFA maps visualized structural requirements for the biological activity of these inhibitors. Docking results showed that a carboxyl group at C-7 and a hydroxyl group at C-8 in the quinoline subunit, bound closely to the divalent metal cofactor (Mg2+) around the integrase catalytic site. Moreover, there is a linear correlation between the binding energy of the inhibitors with integrase and their inhibitory effect. CONCLUSIONS: The present study indicated that the CoMFA model together with docking results could give us helpful hints for drug design as well as interpre- tation of the binding affinity between these inhibitors and integrase.

关键词： HIV integrase inhibitors quinolines comparative molecular field analysis AutoDock

THE EFFECT OF WAVE GROUPINESS ON A MOORED SHIP STUDIED BY NUMERICAL SIMULATIONS

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Journal of Hydrodynamics 2011年第2期23卷 145-153页

作者： ma xiao-jian SUN Zhao-chen ZHANG Zhi-ming YANG Guo-ping ZHOU Feng State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China China Communications Planning and Design Institute for Water Transportation Beijing 100007 China

Waves with the same wave parameters, such as significant wave height and period, but with different wave groupiness factors are simulated, to study the motion behavior of a moored ship under the action of waves with different Groupiness Factors of Height （GFH） and Group Length Factors （GLF）. The numerical results show that both the sway and heave motions increase with an increase in GFH. In contrast, the influence of GLF on the motions of a moored ship is weak.

关键词： wave groupiness moored ship Groupiness Factors of Height (GFH) Group Length Factors (GLF)

magnesium-containing pellet regulating blast furnace ferrous burden interaction:softening-melting behavior and mechanism

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Journal of Iron and Steel Research International 2024年第7期31卷 1623-1635页

作者： Li-ming ma jian-liang Zhang Yao-zu Wang xiao-yong ma Gui-lin Wang Zhuo Li Hui-qing jiang Zheng-jian Liu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Lingyuan Iron and Steel Group Co. Lingyuan 122500LiaoningChina

MgO participates in all stages of sintering,pelletizing,and blast furnace ironmaking,and synergistically optimizing the distribution of MgO in ferrous burden can effectively enhance the interaction within the ferrous burdens and optimize the softening-melting properties of the mixed ***-containing pellets mixed with low-MgO sinter or mixed with high-MgO sinter in the blast furnace ferrous burden structure have opposite softening-melting performance *** the structure of the ferrous burden is magnesium-containing pellets mixed with low-MgO sinter,the magnesium-containing pellets can enhance the interaction of the ferrous burden in the process of softening-melting,which can optimize the composition of the slag phase and improve the slag *** the structure of the ferrous burden is magnesium-containing pellets mixed with high-MgO sinter,the magnesium-containing pellets weaken the interaction of the ferrous burden in the process of softening-melting,increase the content of the high melting point solid-phase particles in the slag,lead to an increase in the viscosity of the slag and difficult separation of the slag and iron,and decrease the permeability of the charge ***,to ensure good permeability of the mixed burden,the following measures are suggested:optimizing the MgO distribution of the ferrous burden,reducing the MgO content of the sinter to 1.96 wt.%,increasing the MgO content of the pellets to 1.03-1.30 wt.%,controlling the MgO/Al_(2)O_(3) ratio of the mixed burden within 1.15-1.32,narrowing the position of the cohesive zone,and maintaining an S value(permeability index)of approximately 150 kPa℃.

关键词： Ironmaking Ferrous burden Softening-melting property Interaction Permeability Slag

Biomineralization and mineralization using microfluidics:A comparison study

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 661-669页

作者： Yang xiao Xiang He Guoliang ma Chang Zhao jian Chu Hanlong Liu Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqing400045China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400045China School of Civil Engineering Chongqing UniversityChongqing400045China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore

Biomineralization through microbial process has attracted great attention in the field of geotechnical engineering due to its ability to bind granular materials,clog pores,and seal *** minerals formed by biomineralization are generally the same as that by mineralization,their mechanical behaviors show a significant *** study aims to figure out the differences between biomineralization and mineralization processes by visualizing and tracking the formation of minerals using *** biomineralization and mineralization processes occurred in the Y-shaped sandcontaining microchip that mimics the underground sand *** from different areas in the reaction microchannel of microchips were captured to directly compare the distribution of *** size and numbers from different reaction times were measured to quantify the differences between biomineralization and mineralization processes in terms of crystal *** showed that the crystals were precipitated in a faster and more uncontrollable manner in the mineralization process than that in the biomineralization process,given that those two processes presented similar precipitation *** addition,a more heterogeneous distribution of crystals was observed during the biomineralization *** precipitation behaviors were further explained by the classical nucleation crystal growth *** present microfluidic tests could advance the understanding of biomineralization and provide new insight into the optimization of biocementation technology.

关键词： Microbially induced carbonate precipitation (MICP) Biocementation Crystal Calcium carbonate Nucleation

Evaluation of teplizumab's efficacy and safety in treatment of type 1 diabetes mellitus:A systematic review and meta-analysis

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World Journal of Diabetes 2024年第7期15卷 1615-1626页

作者： xiao-Lan ma Dan Ge Xue-jian Hu Department of Endocrinology and Metabolism The Second Affiliated Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Islets of Langerhans beta cells diminish in autoimmune type 1 diabetes mellitus(T1DM).Teplizumab,a humanized anti-CD3 monoclonal antibody,may help *** long-term implications on clinical T1DM development,safety,and efficacy are *** To assess the effectiveness and safety of teplizumab as a therapeutic intervention for individuals with *** A systematic search was conducted using four electronic databases(PubMed,Embase,Scopus,and Cochrane Library)to select publications published in peerreviewed journals written in *** odds ratio(OR)and risk ratio(RR)were calculated,along with their 95%*** assessed heterogeneity using Cochrane Q and I2 statistics and the appropriate P *** There were 8 randomized controlled trials(RCTs)in the current meta-analysis with a total of 1908 T1DM patients from diverse age cohorts,with 1361 patients receiving Teplizumab and 547 patients receiving a *** was found to have a substantial link with a decrease in insulin consumption,with an OR of 4.13(95%CI:1.72 to 9.90).Teplizumab is associated with an improved Cpeptide response(OR 2.49;95%CI:1.62 to 3.81)and a significant change in Glycated haemoglobin A1c(HbA1c)levels in people with type 1 diabetes[OR 1.75(95%CI:1.03 to 2.98)],and it has a RR of 0.71(95%CI:0.53 to 0.95).CONCLUSION In type 1 diabetics,teplizumab decreased insulin consumption,improved C-peptide response,and significantly changed HbA1c levels with negligible side *** appears to improve glycaemic control and diabetes management with good safety and efficacy.

关键词： Type-1 diabetes mellitus Teplizumab Anti-CD3 monoclonal antibody Insulin Glycated haemoglobin A1c Cpeptide

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双主梁非对称斜拉桥施工控制方法与结果分析

建筑机械 2024年第9期 110-114页

作者：童丰华马骁健史先振史言稳孙亭亭中交第二公路工程局有限公司陕西西安710065 江苏恒一岩土工程技术有限公司江苏南通226003 江苏金普工程咨询有限公司江苏徐州221700 南京交通职业技术学院路桥与港航工程学院江苏南京211188

斜拉桥成桥后要求达到合理成桥状态,施工过程控制对成桥状态起到关键作用。文章以某双主梁非对称斜拉桥为背景,该桥施工过程采用悬臂浇筑,分析后给出了该桥施工控制方法,采用有限元计算及现场实测数据对比,对施工过程中桥梁的线形和内... 详细信息

斜拉桥成桥后要求达到合理成桥状态,施工过程控制对成桥状态起到关键作用。文章以某双主梁非对称斜拉桥为背景,该桥施工过程采用悬臂浇筑,分析后给出了该桥施工控制方法,采用有限元计算及现场实测数据对比,对施工过程中桥梁的线形和内力进行监测与控制。结果表明:成桥后线形符合有限元计算预期,截面应力控制良好,未超过混凝土强度设计值,索力与计算吻合,满足设计要求。

关键词：斜拉桥悬臂浇筑施工有限元施工控制

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S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds

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Chinese Chemical Letters 2024年第5期35卷 151-154页

作者： Ze-Yuan ma Mei xiao Cheng-Kun Li Adedamola Shoberu jian-Ping Zou Key Laboratory of Organic Synthesis of jiangsu Province College of Chemistry and Chemical EngineeringSoochow UniversitySuzhou 215123China

An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is ***,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moiety occurs were *** this manner,SDDP underwent facile SP(O)(OEt)_(2) transfer with electron-rich substrates such as ketones,indoles,and thiols to formα-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.

关键词： Electrophilic reagent Phosphorothiolation Electrophilic substitution