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Chinese Journal of Cancer Research 2022年第4期34卷 415-421页

作者： Limin Zou Yueli qi Ling Tang Yu Du Meiyi Xiang Xiaoming Chen Jun ma Zhimin Yang Office of Clinical Evaluation 1 Center for Drug EvaluationNational Medical Products AdministrationBeijing 100022China Office of management and Communication Center for Drug EvaluationNational Medical Products AdministrationBeijing 100022China Harbin Institute of Hematology and Oncology Harbin 150010China

Several phosphoinositide 3-kinase(PI3 K) inhibitors are currently approved to treat hematolymphatic malignant diseases worldwide, and many drugs that have the same target are in the clinical research stage. In march 2022,duvelisib became the first PI3 K inhibitor approved in China indicated for the treatment of hematolymphatic malignant diseases. Meanwhile, linperlisib and copanlisib have almost completed the technical review of the clinical specialty. The Center for Drug Evaluation(CDE) of the China National Medical Products Administration(NMPA) found that class I PI3 K inhibitors can cause various degrees of immune-related adverse events, which are associated with action mechanisms, affecting the benefit-risk assessment of the drugs. On April 21, 2021, the United States Food and Drug Administration(FDA) convened the Oncologic Drugs Advisory Committee(ODAC)meeting to discuss the safety of PI3 K inhibitors indicated for hematolymphatic malignancies and their related risk of death. The hematological tumor group of CDE of the China NMPA summarized and combined the data on PI3 K inhibitors listed or under technical review for marketing authorization applications and found that such products may have unique efficacy and safety characteristics in Chinese patients with malignant lymphoma.

关键词： Class I PI3K inhibitors efficacy hematolymphatic malignancies safety

Analyses of microRNAs and transcriptomes in the midgut of Spodoptera litura feeding on Brassica juncea

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Insect Science 2021年第2期28卷 533-547页

作者： Xiao-Peng Zou Yi-Guang Lin Yong-Jie Cen Kang ma Bin-Bin qiu qi-Li Feng Si-Chun Zheng School of Life Sciences South China Normal UniversityGuangzhouChina

Spodoptera litura is a destructive agricultural pest in tropical and subtropical *** the molecular mechanisms of *** adaptation to its preferred host plants may help identify target genes useful for pest *** used high-throughput sequencing to characterize the expression patterns of messenger RNAs(mRNAs)and microRNAs(miRNAs)in the midgut of *** fed on Brassica juncea for 6 h and 48 h.A total of 108 known and 134 novel miRNAs were identified,29 miRNAs and 237 mRNAs were differentially expressed at 6 h of *** feeding,26 miRNAs and 433 mRNAs were differentially expressed at 48 *** the mRNAs,the up-regulated genes were mostly enriched in detoxification enzymes(cytochrome P450,esterase,glutathione^-transferase,uridine diphosphate-glucuronosyl transferase),while the down-regulated genes were mostly enriched in proteinases and immune-related ***,most detoxification enzymes begin to up-regulate at 6 h,while most digestion and immunerelated genes begin to up-or down-regulate at 48 *** and 37 differently expressed transcription factors were identified at 6 h and 48 h,which may regulate the functional *** acquired 136 and 41 miRNA versus mRNA pairs at 6 h and 48 h,*** down-regulated and up-regulated miRNAs were predicted to target detoxification enzymes and proteinases,***-time quantitative polymerase chain reaction of nine randomly selected miRNAs and 28 genes confirmed the results of *** analyses of miRNA and mRNA transcriptomes provides useful information about the molecular mechanisms of *** response to ***.

关键词： Brassica juncea midgut miRNAs RNA-Seq Spodoptera litura

Transcription Factor WRKY70 Displays Important but No Indispensable Roles in Jasmonate and Salicylic Acid Signaling

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Journal of Integrative Plant Biology 2008年第5期50卷 630-637页

作者： Chun-Mei Ren qi Zhu Bi-Da Gao Shao-Ying Ke Wan-Cong Yu Dao-Xin Xie wen Peng College of Bioscience and Biotechnology Hunan Agncultural University Changsha 410128 China Crop Gene Engineering Key Laboratory of Hunan Province Hunan Agncultural University Changsha 410128 China College of Horticulture and Gardening Hunan Agncultural University Changsha 410128 China College of Bio-Safety Science and Technology Hunan Agricultural University Changsha 410128 China Department of Biological Sciences Tangshan Normal College Tangshan 063000 China Ministry of Education Key Laboratory of Bioinformatics Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China

The transcription factor WRKY70 was previously reported to be a common component in salicylic acid （SA） and jasmonate （JA） mediated signal pathways in Arabidopsis. Here, we present that the inactivation of the WRKY70 gene in wrky70-1 mutant does not alter the responses of both JA and SA, and that wrky70 mutation is unable to restore the coil mutant in JA responses. However, overexpression of WRKY70 reduces JA responses such as expression of JA-induced genes and JA-inhibitory root growth, and activates expression of SA-inducible PR1. These data indicate that the WRKY70 is important but not indispensable for JA and SA signaling, and that other regulators may display the redundant role with WRKY70 in modulation of JA and SA responses in Arabidopsis. Furthermore, we showed that JA inhibits expression of WRKY70 and PR1 by both COi1-dependent and COi1-independent pathways.

关键词： Arabidopsis COl 1 jasmonate salicylic acid signaling WRKY70.

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本科生工程实践能力培养与提升

教育教学论坛 2024年第25期 157-160页

作者：韦善阳徐述祺郑禄林孙文吉斌贵州大学矿业学院贵州贵阳550025

随着我国经济的飞速发展,社会各行各业对本科生的要求逐渐提高,应届本科生的素质与能力已无法满足市场的需求,如何提升本科生的实践能力已成为目前高校亟待解决的问题。基于前人的研究成果和存在的问题,针对本科生工程实践能力的不足,... 详细信息

随着我国经济的飞速发展,社会各行各业对本科生的要求逐渐提高,应届本科生的素质与能力已无法满足市场的需求,如何提升本科生的实践能力已成为目前高校亟待解决的问题。基于前人的研究成果和存在的问题,针对本科生工程实践能力的不足,从加强基础条件和综合提升实践能力等方面开展本科人才实践能力提升的研究,为进一步明确本科生的培养目标、提高学生的积极性、提升本科生的实践和应用能力,更好地满足社会的需要并实现教育质量的良性循环提供理论支撑。

关键词：本科生教育实践能力工程实践校企联合

Pulmonary embolism and deep vein thrombosis caused by nitrous oxide abuse: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4057-4062页

作者： wen Sun Ji-Ping Liao Yan Hu Wei Zhang Jing ma Guang-Fa Wang Department of Pulmonary and Critical Care Medicine Peking University First Hospital

BACKGROUND Nitrous oxide(N2O)has gained increasing popularity as a recreational drug,causing hallucinations,excitation,and psychological ***,side effects have been reported in recent *** case report proposes a correlation among N2O,pulmonary embolism(PE),and deep vein thrombosis(DVT)and emphasizes the role of homocysteine(Hcy)in thrombotic *** SUMmaRY A 29-year-old man with long-term N2O abuse sought evaluation after acute chest pain.A diagnostic workup revealed PE,DVT,and *** patient was successfully treated with thrombolytic and anticoagulant ***,his Hcy level decreased and returned to normal after Hcy-lowering *** Chronic N2O abuse might increase the risk of PE and DVT,although there have been few studies previously.

关键词： Nitrous oxide Pulmonary embolism Deep vein thrombosis Homocysteine Case report

西部高校外语研究生培养新探索和新实践:院长笔谈

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外国语文 2024年第2期40卷 158-173页

作者：赵永峰文旭王欣刘全国莫启扬陈向京俞森林马刚四川外国语大学英语学院重庆400031 西南大学外国语学院重庆400715 四川大学外国语学院四川成都610207 陕西师范大学外国语学院陕西西安710062 重庆大学外国语学院重庆401331 西安交通大学外国语学院陕西西安710054 西南交通大学外国语学院四川成都610031 西安电子科技大学外国语学院陕西西安710119

四川外国语大学、西南大学和四川大学积极发扬外语学科“资源共享”传统,主动服务“成渝双城经济圈”建设和西部大开发国家战略,形成了“区域联动、思政铸魂、学科交叉、创新引领”的外语高层次人才培养新理念,着力培养能讲好中国故事... 详细信息

四川外国语大学、西南大学和四川大学积极发扬外语学科“资源共享”传统,主动服务“成渝双城经济圈”建设和西部大开发国家战略,形成了“区域联动、思政铸魂、学科交叉、创新引领”的外语高层次人才培养新理念,着力培养能讲好中国故事、参与全球治理的高素质复合型创新人才,成果于2023年获国家级教学成果二等奖。2023年11月在四川外国语大学召开了“国家级教学成果奖获奖成果推广交流暨西部地区外语研究生教育教学改革研讨会”,会上四川外国语大学、西南大学、四川大学、陕西师范大学、重庆大学、西安交通大学、西北工业大学、西南交通大学、西安电子科技大学等外国语学院分享西部外语学科研究培养新探索和新实践,乘风破浪,砥砺前行,不断完善和丰富“区域联动、思政铸魂、学科交叉、创新引领:西部外语学科研究生培养新实践”的内涵要求,更好地服务国家和社会对外语高端人才的新需求。

关键词：外语学科研究生区域联动思政铸魂学科交叉

基于LURR的前震分析方法及其在川滇地区的应用

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地球物理学报 2024年第6期67卷 2248-2271页

作者：李泽平余怀忠晏锐刘杰陈界宏张小涛苑争一郭菲马玉川杨文贾东辉赵彬彬李盛乐张致伟洪敏中国地震局地震预测研究所北京100036 中国地震台网中心北京100045 成都理工大学成都610059 新疆维吾尔自治区地震局乌鲁木齐830011 湖北省地震局武汉430071 四川省地震局成都610041 云南省地震局昆明650224

加卸载响应比(Load-Unload Response Ratio,LURR)是基于岩石介质本构关系动态变化提出的一种中短期地震预测方法,然而,在实践应用中存在构造剪应力方向难以确定的问题.本文以前震为研究对象,发展了一种确定构造剪切应力方向的新思路.当... 详细信息

加卸载响应比(Load-Unload Response Ratio,LURR)是基于岩石介质本构关系动态变化提出的一种中短期地震预测方法,然而,在实践应用中存在构造剪应力方向难以确定的问题.本文以前震为研究对象,发展了一种确定构造剪切应力方向的新思路.当4级以上地震发生后,通过沿该地震滑动方向计算库仑破坏应力(CFS)的变化,判断其固体潮加卸载状态,探测后续强震发生的可能性.以川滇地区(20°N—35°N,96°E—106°E)为研究区域,分析2000年以来所有6级以上地震的4级以上前震的加卸载状态发现,大部分4级以上前震发生在加载阶段.进一步分析近10年来所有4级以上地震的加卸载状态发现,非前震则更易发生在卸载阶段.结合概率增益分析可知,(1)若原震区连续发生至少2个4级以上地震,且均位于固体潮加载过程,后续发生强震的可能性较大;(2)当地震位于卸载过程,原震区发生更强地震的可能性要低于平时的背景地震活动水平.此外,对2022年11月以来的4级以上地震加卸载状态分析推测,川东南、滇南、滇西北地区应力积累水平较高,需要重点关注强震危险性.

关键词：加卸载响应比 4级以上显著地震震源机制解潮汐应力加卸载状态

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路堑高边坡工程施工技术及施工管理研究

工程建设与设计 2024年第4期 241-243页

作者：安文富罗云发祁富辉代冬梅吴超西南交通建设集团股份有限公司昆明650000

公路工程具有建设周期长、建设工艺复杂的特点,尤其路堑高边坡工程的施工,极易受到外界因素和施工技术的影响。为了进一步加强路堑高边坡工程的施工管理工作和风险控制工作,论文研究了路堑高边坡工程施工管理的措施以及施工工艺,分析了... 详细信息

公路工程具有建设周期长、建设工艺复杂的特点,尤其路堑高边坡工程的施工,极易受到外界因素和施工技术的影响。为了进一步加强路堑高边坡工程的施工管理工作和风险控制工作,论文研究了路堑高边坡工程施工管理的措施以及施工工艺,分析了路堑高边坡工程施工风险措施与应急预案的制定和应用。

关键词：路堑高边坡工程施工管理措施风险控制

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中国澳门地区旧桩利用与设计研究

建筑技术开发 2024年第2期51卷 147-150页

作者：邓辉卢文汀罗琦董晨阳涂雄龙香港华艺设计顾问(深圳)有限公司深圳518000

中国澳门长者公寓是在原有地基基础上,重新设计重新施工的住宅项目。原有地基存在大量旧桩,如果全部拆除,存在施工难度大,拆除不干净,扰动场地地基等不利因素。综合经济和社会效益,采用原有地基上的旧桩作为新建主体的桩基,同时根据主... 详细信息

中国澳门长者公寓是在原有地基基础上,重新设计重新施工的住宅项目。原有地基存在大量旧桩,如果全部拆除,存在施工难度大,拆除不干净,扰动场地地基等不利因素。综合经济和社会效益,采用原有地基上的旧桩作为新建主体的桩基,同时根据主体承载力要求,补充新的灌注桩和PHC桩满足承载力要求。针对不同类型旧桩利用存在的难点:旧桩检测、旧桩承载力再利用,裂缝处理、桩基础设计等问题,作一个系统的论述,为后续工程提供参考价值和实际案例。

关键词：旧桩检测裂缝处理中国澳门桩基设计

TaARPC5 is required for wheat defense signaling in response to infection by the stripe rust fungus

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The Crop Journal 2022年第1期10卷 88-97页

作者： Jia Guo Huan Peng Tuo qi Sanding Xu Md Ashraful Islam Brad Day qing ma Zhensheng Kang Jun Guo State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection Northwest A&F UniversityYangling 712100ShaanxiChina Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA

Numerous studies using a combination of confocal microscopic-and pharmacological-based approaches have demonstrated that the actin cytoskeleton dynamically responds to pathogen ***,we observed that phalloidin treatment induced actin nucleation,resulting in enhanced resistance of wheat against the stripe rust pathogen Puccinia striiformis ***(Pst).To define the mechanism underpinning this process,we characterized a family of conserved actin-binding proteins,the actin related protein(ARP)family,which controls actin ***,we identified and characterized a wheat ARPC gene(Ta ARPC5),which encodes a 136-amino acid protein containing a P16-Arc domain,the smallest subunit of the ARP2/3 *** ARPC5 m RNA accumulation was induced following the infection of plants with the avirulent Pst strain,and following the elicitation with flagellin(e.g.,flg22)as *** localization analysis revealed that Ta ARPC5 is primarily localized to the cortical actin cytoskeleton,and its precise cellular localizations suggest the proximity to processes correlated with the actin-organelle *** treatment with virulent Pst,Ta ARPC5-knockdown plants exhibited a significant reduction in the expression of PTI-specific m ***,we observed enhanced induction of reactive oxygen species(ROS)accumulation and a decrease in Ta CAT1 expression following infection with an incompatible Pst *** with yeast complementation assays,the current study demonstrates a role for Ta ARPC5 in resistance signaling in wheat against Pst infection by regulating the host actin cytoskeleton.

关键词： ARPC5 Cytoskeleton Wheat Puccinia striiformis f.sp.tritici Virus-induced gene silencing(VIGS)