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Chinese Journal of Integrative Medicine 2019年第4期25卷 292-297页

作者： CUI Tian-wei QIN mao LIU Bao-xing GAO Yun-xiao ma wen-jing ZHANG Xiu-ping Department of Andrology China-Japan Friendship HospitalBeijing(100029)China Department of Andrology Chongqing Health Center for Women and ChildrenChongqing(400013)China

Objective: To assess the effect of electroacupuncture(EA) on expression of cytoskeletal proteins from Sertoli cells(SCs) and spermatogenesis in rats with oligozoospermia of insufficiency of Shen(Kidney)essence syndrome(OIKES).Methods: Twenty healthy male Sprague-Dawley rats were randomly assigned to four groups using a random number table: control,tripterygium glycosides(TG) treatment,sham and EA groups(n=5 in each group).A rat model of OIKES was established by oral gavage with *** EA group was treated with TG and received EA at Shenshu(BL 23) and Zusanli(ST 36) acupoints for 20 min,once daily for 30 days,while the sham group received EA at identical acupoints with skin penetration without *** 30 days,the ?nal body weight and coef?cients for the testis and epididymis were calculated and sperm parameters were *** analyses were performed to detect expression of vimentin and α-tubulin in SCs and proliferating cell nuclear antigen(PCNA) immunoreactivity in germ *** in germ cells was quanti?ed by the transferase biotin-dUTP nick end labeling ***: Compared with the control group,the final body weight and testis/epididymis coefficients of rats in the TG-treated group were not significantly different,but the sperm count and motility were lower(Pmarkedly,and signi?cantly enhanced PCNA immunoreactivity with decreased apoptosis in germ cells(Pmatogenesis in rats with *** effect seems to

关键词： electroacupuncture Sertoli cells cytoskeletal proteins oligozoospermia insufficiency of Shen(Kidney)essence syndrome

Luteolin prevents f MLP-induced neutrophils adhesion via suppression of LFA-1 and phosphodiesterase 4 activity

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Journal of Integrative Agriculture 2015年第1期14卷 140-147页

作者： JIANG Dai-xun LIU Shu-rong ZHANG Mei-hua ZHANG Tao ma wen-jing MU Xiang CHEN Wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Luteolin is an active ingredient found early from Fofium perillae and Flos Ionicerae, and has a specific inhibition on phosphodiesterase 4 （PDE4） activity in vitro. Researches show luteolin has pharmacological effects of anti-inflammation, anti-anaphylaxis, antitumor, antioxidant, protection of nervous system and so on, and has mainly been used for the treatment of respiratory inflammatory diseases, cancer and cardiovascular disease in clinic. PDE4, specific to hydrolyze cyclic AMP （cAMP）, is considered to be a new anti-inflammatory target due to the decisive role on cAMP signal in inflammatory cells such as neutrophils. In order to explore the anti-inflammatory mechanism, we further studied the effects of luteolin on the activity and expression of PDE4, the expression of lymphocyte function-associated antigen-1 （LFA-1） and macrophage-1 （maC-l） in neutrophils, and the adhesion of neutrophils and endothelial cells. The results showed that luteolin had a dose-dependent inhibition on both bare PDE4 activity and PDE4 in cultured neutrophils, and had an obviously promotive effect on gene expressions of PDE4A, 4B and 4D in later period. Luteolin had a significant inhibitory effect on neutrophils adhesion and LFA-1 expression in early stage, and had no obvious effect on maC-1 expression. Therefore, luteolin can inhibit LFA-1 expression of neutrophils, then inhibit the adhesion of neutrophils and endothelial cells, and the mechanism is at least related with the inhibition of PDE4 activity.

关键词： luteolin neutrophils phosphodiesterase 4 LFA-1 maC-1 adhesion swine

Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-α and rat arthritis model

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Journal of Integrative Agriculture 2015年第4期14卷 758-764页

作者： JIANG Dai-xun ZHANG Mei-hua ZHANG Qian CHEN Yi-shan ma wen-jing WU Wei-peng MU Xiang CHEN Wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Our previous studies showed that the anti-inflammatory effects of Paeonia lactiflora roots extract may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in part by an inhibition on c AMP-phosphodiesterase（PDE）. To explore the anti-inflammatory effect and mechanism, the influence of gallic acid on neutrophils PDE4 activity and expression, TNF-α and IL-6 content and rat arthritis model were further studied. PDE4 activity and gene express were calculated respectively by substrate c AMP change examined with HPLC and real-time RT-PCR. The concentration of IL-6 and TNF-α in supernatant were assayed by ELISA method. Model of rat arthritis was caused by complete Freund＇s adjuvant. Results showed that gallic acid had a dose-dependent restraint on PDE4 activity of neutrophils in vitro, promoted significantly PDE4 A expression（P〈0.01）, and had no influence on the expressions of PDE4 B and 4D. However, PDE4 C expression was not detected. Gallic acid could promote IL-6 release（P〈0.05）, and inhibit TNF-α release of neutrophils（P〈0.05）. The experiment in vivo showed that gallic acid had obvious restraint on local inflammation of animal model（P〈0.05）. Therefore, the anti-inflammatory effect of gallic acid may be mediated in part through an inhibition on PDE4 activity and further an increase of IL-6 and a decrease of TNF-α of neutrophils, and this effect seemed to have no relationship with PDE4 expression.

关键词： gallic acid phosphodiesterase 4 inflammation IL-6 TNF-α neutrophils

The Studies of Composite Electroless Plating Process on Sintering Ndfeb Permanent magnet

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材料热处理学报 2004年第05B期25卷 1112-1114页

作者： HUJian-wen majing YANDong-qing GAOQing MENGYong-qiang Schoolofmaterial HebeiUniversityofScienceandTechnologyShijiazhuangChina

A reasonable pre-treatment and an ultrasonic pre-plating Cu film were applied for sintering NdFeB permanent magnet. The samples were then plated in neutral bath (PH=7) for 40min and in acidic bath (PH=4.8～5.1) for 2h. A composite electroless plating with different phosphor content was obtained. The results show that the composite plating coatings are dense and have a strong bond with the substrate, which contribute to the excellent corrosion resistance of the plating coating.

关键词： NdFeB永久磁铁预处理无电极电镀耐蚀性

基于能值分析的中国生态经济系统可持续发展评估

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应用生态学报 2020年第6期31卷 2029-2038页

作者：马文静刘娟天津理工大学环境科学与安全工程学院天津300384

本文基于能值理论全面评估了2006—2016年中国的可持续发展水平,并根据一次能源投入比例的不同将各省份分为4组进行比较分析,讨论一次能源投入水平对省域间可持续发展水平的影响。结果表明:2006—2016年,随着经济快速增长,一次能源投入... 详细信息

本文基于能值理论全面评估了2006—2016年中国的可持续发展水平,并根据一次能源投入比例的不同将各省份分为4组进行比较分析,讨论一次能源投入水平对省域间可持续发展水平的影响。结果表明:2006—2016年,随着经济快速增长,一次能源投入比例不断上涨,使得我国整体生态经济系统的环境负荷由2.78升至3.13。同时,受进口增加的影响,能值产出率相对下降,可持续性指标下降至5.40。能值密度变化趋势与一次能源投入比例的变化基本一致,目前大多数省份依旧通过能源消费带动区域经济发展。其中,北京、上海等虽现代化经济高度发达,但环境压力同样高于其他省份,可持续发展水平不容乐观。以江苏为代表的南方省份能源投入较低而能值产出较高,表现出较高的可持续发展活力。因此,提升内陆地区能源利用效率、调整经济发展模式,并适当减缓发展强度,以缓解经济发展与环境保护之间的矛盾,可以令我国稳步实现生态经济的可持续发展。

关键词：能值分析一次能源省域差异时间序列可持续发展

小胸鳖甲热激蛋白基因(Mphsp70)的克隆、序列分析及温度对其表达的影响

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应用昆虫学报 2012年第2期49卷 439-447页

作者：马文静马纪新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室乌鲁木齐830046

采用RACE-PCR技术,从荒漠甲虫小胸鳖甲Microdera punctipennis Kaszab克隆hsp70基因全长cDNA序列,命名为Mphsp70。测序结果表明,序列全长2207bp,该序列覆盖了完整编码区,编码647个氨基酸,分子量大小为70.69ku,理论等电点为5.57(GenBank登录号JF421286.1)。此序列包含142bp的5'端非翻译区和124bp的含有多聚腺苷酸信号序列AATAAA和poly A尾的3'端非翻译区以及1941bp的开放阅读框。该基因无内含子,符合诱导型Hsp70的特征。经BLAST检索分析,由Mphsp70的核苷酸序列推定的氨基酸序列与已知的光滑鳖甲Hsp70高度同源,同源性高达97.22%。通过荧光定量RT-PCR技术研究昆虫受到高温胁迫时该基因的表达,结果表明:经37℃和42℃处理昆虫1h后诱导昆虫体内hsp70的表达,其表达量分别为对照组(25℃)的21.57倍和389.3倍,随着处理时间的延长,表达量降低。该研究结果为深入研究小胸鳖甲的抗逆机理提供了新的思路。

关键词：小胸鳖甲热激蛋白70 高温处理实时定量PCR

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面向异构计算机平台的HPL方案

软件学报 2021年第8期32卷 2329-2340页

作者：孙乔孙家昶马文静赵玉文中国科学院软件研究所并行软件与计算科学实验室北京100190 计算机科学国家重点实验室(中国科学院软件研究所) 北京100190 中国科学院大学北京100049

HPL(high performance Linpack)是一套被广泛用于测评计算机性能的测试程序,几十年来学术界及产业界十分关注对HPL测试程序的定制化优化工作,以充分反应同时代新兴计算机平台的性能.面向当今主流多设备异构计算平台,尝试为HPL的优化工... 详细信息

HPL(high performance Linpack)是一套被广泛用于测评计算机性能的测试程序,几十年来学术界及产业界十分关注对HPL测试程序的定制化优化工作,以充分反应同时代新兴计算机平台的性能.面向当今主流多设备异构计算平台,尝试为HPL的优化工作提供一种解决方案:Hetero-HPL.在Hetero-HPL中,进程与协处理器的对应关系可被改变,因此HPL算法在单节点独立运行情况下可以完全避免进程间数据传输开销.算法各个重要步骤有能力完全利用物理节点的所有资源,如内存容量、CPU核心、协处理器、PCI-e总线等.Hetero-HPL并不引入冗余计算量及通信量,并在任意设备数量下妥善应对锁页内存分配限制,确保多设备负载均衡和设备内高效的大规模同质运算.在实验平台上,Hetero-HPL效率可以达到平台峰值性能的76.5%(其中,dgemm函数效率为84%).进一步的实验结果表明,Hetero-HPL在多节点联机运行情况下也是一种可行的方案.

关键词： HPL(high performance Linpack) 多设备异构平台并行计算

历史的哗变与圣者的遁逸——论新历史小说的革命叙事

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河北学刊 2006年第1期26卷 154-157页

作者：雷鸣马景文河北工程学院文学院河北邯郸056038 保定师范专科学校中文系河北保定071000

时代的差异、西方当代文学与史学观念的介绍与引进,以及作家自身独特的境遇,促使新历史小说作家彻底抛弃了以往革命历史小说的历史观、文学观,颠覆了既往革命叙事的经典模式。革命叙事在新历史小说中呈现出对革命起源神话的终结、革命... 详细信息

时代的差异、西方当代文学与史学观念的介绍与引进,以及作家自身独特的境遇,促使新历史小说作家彻底抛弃了以往革命历史小说的历史观、文学观,颠覆了既往革命叙事的经典模式。革命叙事在新历史小说中呈现出对革命起源神话的终结、革命历史叙述的重组、革命英雄的沉落等截然不同的景象,表现了拓展历史生活扇面的趋势,但对革命历史的随意处理或编制也有取悦、迎合大众文化之弊,革命历史被演绎成纯粹的幻想,其颠覆性破坏给以后的小说创作以警示。

关键词：新历史小说革命叙事历史英雄

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绩效管理系统在煤矿企业的应用

煤炭技术 2012年第1期31卷 273-275页

作者：马文静河北机电职业技术学院河北邢台054048

在现代管理体系中,绩效管理是一种较为先进、现代企业运用较为广泛的管理制度。煤矿企业的绩效管理强调企业员工与企业的管理者一起参与到其中,这项系统工程涉及到管理观念、管理方法与管理技巧等与管理相关的诸多方面。文章从介绍绩效... 详细信息

在现代管理体系中,绩效管理是一种较为先进、现代企业运用较为广泛的管理制度。煤矿企业的绩效管理强调企业员工与企业的管理者一起参与到其中,这项系统工程涉及到管理观念、管理方法与管理技巧等与管理相关的诸多方面。文章从介绍绩效管理的基本概况入手,进而具体探讨了我国煤矿企业中绩效管理存在的问题,再从绩效系统、绩效考核、绩效沟通等方面分析了如何在我国煤矿企业中加强绩效管理。探索出能使煤矿企业取得更高效的绩效管理,切实提高煤矿企业管理水平。

关键词：煤矿企业绩效管理系统现代企业管理

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品牌化是民族职业教育发展的路径选择

民族教育研究 2012年第3期23卷 64-67页

作者：马文静北京大学政府管理学院北京100871

职业教育品牌化有利于促进民族地区职业院校招生与就业的实效性,有利于促进民族职业教育质量的提高。从实际情况出发,走符合民族区域特点的职业教育品牌化发展道路,是民族职业教育可持续发展的必然选择。

关键词：民族职业教育品牌化可持续发展