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Identification and validation of stable and novel quantitative trait loci for pod shattering in soybean[Glycine max(L.)Merr.]

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Journal of Integrative Agriculture 2022年第11期21卷 3169-3184页

作者： JIA Jia WANG Huan CAI Zhan-dong WEI Ru-qian HUANG Jing-hua XIA qiu-ju XIAO Xiao-hui ma qi-bin NIAN Hai CHENG Yan-bo The State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources South China Agricultural UniversityGuangzhou 510642P.R.China The Key Laboratory of Plant Molecular Breeding of Guangdong Province College of AgricultureSouth China Agricultural UniversityGuangzhou 510642P.R.China Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology South China Agricultural UniversityGuangzhou 510642P.R.China Beijing Genomics Institute(BGI)Education Center University of Chinese Academy of SciencesShenzhen 518083P.R.China

Pod shattering is an important domesticated trait which can cause great economic loss of crop yield in cultivated *** this study,we utilized two recombinant inbred line populations(RILs,CY,Huachun 2×Wayao;GB,Guizao 1×B13)to identify quantitative trait loci(QTLs)associated with pod shattering in soybean across multiple environments.A total of 14 QTLs for pod shattering were identified in the two RIL populations,which had LOD scores ranging from 2.64 to 44.33 with phenotypic variance explanation(PVE)ranging from 1.33 to 50.85%.One QTL qPS16-1,located on chromosome 16,included a well-known functional gene Pod dehiscence 1(Pdh1)that was reported *** new putative QTLs were validated in two RIL populations,and their LOD scores were between 2.55 and 4.24,explaining 1.33 to 2.60%of the phenotypic *** which four novel QTLs(qPS01-1,qPS03-2,qPS05-1,and qPS07-1)could be detected in two environments where nine genes had specific changes in gene *** the nine genes may have significant effects on pod shattering of soybean,their detailed functions still need to be further explored in the *** results of this study will facilitate a better understanding of the genetic basis of the pod shattering-resistant trait and benefit soybean molecular breeding for improving pod shattering resistance.

关键词： soybean pod shattering QTL mapping candidate genes

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Clinical outcomes and predictive model of platelet reactivity to clopidogrel after acute ischemic vascular events

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Chinese Medical Journal 2019年第9期132卷 1053-1062页

作者： qi ma Guang-Zhong Chen Yu-Hu Zhang Li Zhang Li-An Huang Department of Neurology The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510632China Guangdong Geriatrics Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Neurosurgery Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Neurology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China

Background:High on-treatment platelet reactivity (HTPR) has been suggested as a risk factor for patients with ischemic vascular *** explored a predictive model of platelet reactivity to clopidogrel and the relationship with clinical ***:A total of 441 patients were *** reactivity was measured by light transmittance aggregometry after receiving dual antiplatelet *** was defined by the consensus cutoff of maximal platelet aggregation >46% by light transmittance ***2C19 loss-of-function polymorphisms were identified by DNA microarray *** data were compared by binary logistic regression to find the risk *** primary endpoint was major adverse clinical events (maCEs),and patients were followed for a median time of 29 *** curves were constructed with Kaplan-Meier estimates and compared by logrank tests between the patients with HTPR and ***:The rate of HTPR was 17.2%.Logistic regression identified the following predictors of HTPR:age,therapy regimen,body mass index,diabetes history,CYP2C19^*2,or CYP2C19^*3 *** area under the curve of receiver operating characteristic for the HTPR predictive model was 0.793 (95% confidence interval:0.738–0.848).Kaplan-Meier analysis showed that patients with HTPR had a higher incidence of maCE than those with non-HTPR (21.1% vs.9.9%;χ^2 = 7.572,P = 0.010).Conclusions:Our results suggest that advanced age,higher body mass index,treatment with regular dual antiplatelet therapy,diabetes,and CYP2C19^*2 or CYP2C19^*3 carriers are significantly associated with HTPR to *** predictive model of HTPR has useful discrimination and good calibration and may predict long-term maCE.

关键词： High on-treatment platelet reactivity Clopidogrel CYP2C19 Light transmittance aggregometry Ischemic vascular events

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MDM2 antagonist Nutlin-3a protects wild-type p53 cancer cells from paclitaxel

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Chinese Science Bulletin 2012年第7期57卷 1007-1012页

作者： SHEN HongChang DONG Wei GAO DongWei WANG GuangHui ma GuoYuan LIU qi DU JiaJun Department of Thoracic Surgery Provincial Hospital Affiliated to Shandong University Shandong University Jinan 250021 China

The p53 pathway has an important role in cell cycle arrest and *** levels of p53 have been shown to increase resistance to the cytotoxic effects of chemotherapy or ***2(murine double minute 2) is able to bind p53 and modulate its transcriptional activity and *** studied the effect of Nutlin-3a,an MDM2 antagonist,on the response of non-small cell lung cancer cell lines,A549(p53+/+) and H1299(p53-/-),to paclitaxel(Taxol).A549 cells treated with Nutlin-3a plus paclitaxel showed a significant increase in MDM2 and wild-type p53 protein,a marked increase in the number of cells in the G0-G1 and G2-M phases,and a significant decrease in the percentage of cells in the S *** percentage of apoptotic A549 cells treated with 10 μmol/L Nutlin-3a plus 10 nmol/L paclitaxel was significantly lower than those treated with paclitaxel alone,and was also lower than that observed in H1299 *** assays demonstrated that Nutlin-3a plus paclitaxel also significantly reduced the sensitivity of A549 cells to paclitaxel compared with that of H1299 *** conclusion,Nutlin-3a mediates the cytotoxic effect of paclitaxel depending on p53 *** may also protect wild-type p53 cells from mitotic chemotherapeutics.

关键词： p53蛋白 MDM2 紫杉醇癌细胞野生型拮抗剂保护 A549细胞

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Hip Squeaking after Ceramic-on-ceramic Total Hip Arthroplasty

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Chinese Medical Journal 2016年第15期129卷 1861-1866页

作者： Guo-Liang Wu Wei Zhu Yan Zhao qi ma Xi-Sheng Weng Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Objective： The present study aimed to review the characteristics and influencing factors of squeaking after ceramic-on-ceramic （CoC） total hip arthroplasty （THA） and to analyze the possible mechanisms of the audible noise. Data Sources： The data analyzed in this review were based on articles from PubMed and Web of Science. Study Selection： The articles selected for review were original articles and reviews found based on the following search terms： “total hip arthroplasty”, “ceramic-on-ceramic”, “hip squeaking”, and “hip noise.” Results： The mechanism of the squeaking remains unknown. The possible explanations included stripe wear, edge loading, a third body, fracture of the ceramic liner, and resonance of the prosthesis components. Squeaking occurrence is influenced by patient, surgical, and implant factors. Conclusions： Most studies indicated that squeaking after CoC THA was the consequence of increasing wear or impingement, caused by prosthesis design, patient characteristics, or surgical factors. However, as conflicts exist among different articles, the major reasons for the squeaking rernain to be identified.

关键词： Ceramic-on-ceramic Squeaking Total Hip Arthroptasty

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一类耦合非线性振子同步混沌Hopf分岔及其电路仿真

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物理学报 2005年第3期54卷 1064-1070页

作者：马文麒杨承辉北华大学理学院物理系吉林132013

对于一类同时存在扩散耦合和梯度耦合的非线性振子系统 ,通过空间傅里叶变换 ,得到具有不同波矢的各运动模式的相互独立的运动方程 .计算各横截模的Lyapunov指数 ,可在耦合参数平面上确定同步混沌的稳定区域 .在稳定区域边界 ,一对共轭... 详细信息

对于一类同时存在扩散耦合和梯度耦合的非线性振子系统 ,通过空间傅里叶变换 ,得到具有不同波矢的各运动模式的相互独立的运动方程 .计算各横截模的Lyapunov指数 ,可在耦合参数平面上确定同步混沌的稳定区域 .在稳定区域边界 ,一对共轭横截模式失稳 ,导致同步混沌的Hopf分岔 .对耦合Lorenz振子系统进行了数值模拟 ,并设计了耦合Lorenz振子系统的电路 ,进行耦合振子系统同步混沌Hopf分岔的电路仿真实验 .计算和仿真的结果表明 ,Hopf分岔的特征频率等于失稳横截模式的振荡频率 .

关键词：振子 Hopf分岔混沌相互独立耦合稳定区域共轭同步电路仿真振荡频率

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Unfractionated heparin attenuates endothelial barrier dysfunction via the phosphatidylinositol-3 kinase/serine/threonine kinase/nuclear factor kappa-B pathway

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Chinese Medical Journal 2020年第15期133卷 1815-1823页

作者： Sheng-Tian Mu Jie Tang Jian-qi ma Yu Zhong Han-Zhe Liu Xiao-Chun ma Zhen Zheng Department of Intensive Care Unit Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110042China Department of Intensive Care Unit The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

Background::Vascular endothelial dysfunction is considered a key pathophysiologic process for the development of acute lung *** this study,we aimed at investigating the effects of unfractionated heparin(UFH)on the lipopolysaccharide(LPS)-induced changes of vascular endothelial-cadherin(VE-cadherin)and the potential underlying ***::male C57BL/6 J mice were randomized into three groups:vehicle,LPS,and LPS+UFH *** injection of 30 mg/kg LPS was used to induce *** in the LPS+UFH group received subcutaneous injection of 8 U UFH 0.5 h before LPS *** lung tissue of the mice was collected for assessing lung injury by measuring the lung wet/dry(W/D)weight ratio and observing histological *** pulmonary microvascular endothelial cells(HPMECs)were cultured and used to analyze the effects of UFH on LPS-or tumor necrosis factor-alpha(TNF-α)-induced vascular hyperpermeability,membrane expression of VE-cadherin,p120-catenin,and phosphorylated myosin light chain(p-MLC),and F-actin remodeling,and on the LPS-induced activation of the phosphatidylinositol-3 kinase(PI3K)/serine/threonine kinase(Akt)/nuclear factor kappa-B(NF-κB)signaling ***::In vivo,UFH pretreatment significantly attenuated LPS-induced pulmonary histopathological changes(neutrophil infiltration and erythrocyte effusion,alveolus pulmonis collapse,and thicker septum),decreased the lung W/D,and increased protein concentration(LPS ***+UFH:0.57±0.04 vs.0.32±0.04 mg/mL,P=0.0092),total cell count(LPS ***+UFH:9.57±1.23 vs.3.65±0.78×105/mL,P=0.0155),polymorphonuclear neutrophil percentage(LPS ***+UFH:88.05%±2.88%vs.22.20%±3.92%,P=0.0002),and TNF-α(460.33±23.48 vs.189.33±14.19 pg/mL,P=0.0006)in the bronchoalveolar lavage *** vitro,UFH pre-treatment prevented the LPS-induced decrease in the membrane expression of VE-cadherin(LPS ***+UFH:0.368±0.044 vs.0.716±0.064,P=0.0114)and p120-catenin(LPS ***+UFH:0.208±0.018 vs.0.924±0.092,P=0.0

关键词： Acute lung injury Cadherin Capillary permeability Heparin

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快速注意力选择计算及其在图像质量评价中的应用

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计算机辅助设计与图形学学报 2009年第7期21卷 973-983页

作者：马奇张立明复旦大学电子工程系上海200433

针对现有的模拟视觉注意力选择模型计算复杂度高、参数选取困难的问题,提出一种快速的频率域算法.将各频点上的幅度设为同一常数,保留其相位信息;对反变换到空间域的图像滤波后,得到视觉注意力显著图,其效果与现有的模型相似;并将显著... 详细信息

针对现有的模拟视觉注意力选择模型计算复杂度高、参数选取困难的问题,提出一种快速的频率域算法.将各频点上的幅度设为同一常数,保留其相位信息;对反变换到空间域的图像滤波后,得到视觉注意力显著图,其效果与现有的模型相似;并将显著图信息作为权重加入到几种主要的图像质量评价标准中.实验结果表明:带有注意力选择的图像质量评价标准更接近于人的主观评价,便于实时应用.

关键词：注意力选择显著图图像质量评价

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从经济文化类型角度探寻匈奴的起源地域

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黑龙江民族丛刊 2007年第2期 73-78页

作者：马强内蒙古科技大学包头医学院内蒙古包头014010

匈奴作为秦、汉时期我国北方地区的主要民族,对中华民族的发展和中华统一多民族国家的形成有着深远影响。通过对匈奴经济文化类型及其特点的分析可以看出匈奴的核心生产生活资料———马的驯化起源地域与匈奴及其先民的生存地域存在相关... 详细信息

匈奴作为秦、汉时期我国北方地区的主要民族,对中华民族的发展和中华统一多民族国家的形成有着深远影响。通过对匈奴经济文化类型及其特点的分析可以看出匈奴的核心生产生活资料———马的驯化起源地域与匈奴及其先民的生存地域存在相关性,其使用马种应为蒙古马种系,而蒙古马又是由普氏野马驯化而来。故最后通过研究蒙古马及其野外祖先普氏野马的分布情况,推定出匈奴的起源地域应为蒙古高原。

关键词：匈奴经济文化类型起源地域蒙古马普氏野马

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Study on the Protective Effect and Mechanism of Tibetan Medicine Ershiwuwei Songshi Pill on Acute Alcoholic Liver Injury in Rats

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Medicinal Plant 2020年第2期11卷 61-64页

作者： Ni ma qi ma Baoyu JIN Jian GU Puyang GONG College of Pharmacy Southwest Minzu University Chengdu 610041 China

[Objectives]To investigate the protective effect and mechanism of Ershiwuwei Songshi Pill on acute alcoholic liver injury in rats.[Methods]Sixty male SD rats were randomly divided into normal control group,model group,polyene phosphatidylcholine(82.08 mg/kg)positive control group and Ershiwuwei Songshi Pill high(180 mg/kg),medium(90 mg/kg)and low(45 mg/kg)dose *** rats in each group were given corresponding drugs by intragastric administration for 3 d and fed *** the 4th d,all groups except the normal control group were fed with 15 mL/kg liquor(56%vol)for 7 d after 2 h of *** the last modeling,the levels of AST,ALT,TC,TG,SOD,GSH in serum and IL-1β,IL-6,TNF-αin liver tissue were *** protein expressions of Bax,Bcl-2 and Caspase3 were determined by Western *** staining was used to observe the pathological changes of liver tissue under light microscope.[Results]Compared with the model group,the body weight and the levels of SOD and GSH in the treatment group were significantly higher than those in the model group;liver index,serum ALT,AST,TC,TG,IL-1β,IL-6 and TNF-αlevels decreased significantly(Pmall amount of collagen proliferation and lymphocyte infiltration in connective tissue around the hepatic portal area in the model group,multiple inflammatory foci could be seen in the lobules,and round fat vacuoles could be seen in the cytoplasm;in each administration group,the pathological condition of the liver was mild.[Conclusions]Ershiwuwei Songshi Pill had a certain protective effect on acute alcoholic liver injury in rats,and its mechanism might be related to reducing enzyme,promoting lipid metabolism and anti-inflammation.

关键词： Ershiwuwei Songshi Pill Alcoholic liver injury Mechanism

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Overview of bile acid signaling in the cardiovascular system

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World Journal of Clinical Cases 2021年第2期9卷 308-320页

作者： Rou Zhang Wen-qi ma Meng-Jun Fu Juan Li Chun-Hua Hu Yi Chen Mi-Mi Zhou Zhi-Jie Gao Ying-Li He Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

Bile acids(BAs)are classically known to play a vital role in the metabolism of lipids and in *** is now well established that BAs act as signaling molecules,activating different receptors(such as farnesoid X receptor,vitamin D receptor,Takeda G-protein-coupled receptor 5,sphingosine-1-phosphate,muscarinic receptors,and big potassium channels)and participating in the regulation of energy homeostasis and lipid and glucose *** addition,increased BAs can impair cardiovascular function in liver *** 50%of patients with cirrhosis develop cirrhotic *** to high concentrations of hydrophobic BAs has been shown to be related to adverse effects with respect to vascular tension,endothelial function,arrhythmias,coronary atherosclerotic heart disease,and heart *** BAs in the serum BA pool have relevant through their hydrophobicity,and the lipophilic BAs are more harmful to the ***,ursodeoxycholic acid is a hydrophilic BA,and it is used as a therapeutic drug to reverse and protect the harmful cardiac effects caused by hydrophobic elevated *** order to elucidate the mechanism of BAs and cardiovascular function,abundant experiments have been conducted in vitro and in *** aim of this review was to explore the mechanism of BAs in the cardiovascular system.

关键词： Bile acids Cardiovascular Arteries Receptors Signaling Cirrhosis

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