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Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation

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Chinese Journal of Natural Medicines 2022年第3期20卷 161-176页

作者： JIANG Qi-Xin CHEN Yi-Meng ma jing-jie WANG Yu-Ping LI Ping WEN Xiao-Dong YANG jie State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Simiao Wan(SMW)is a traditional Chinese formula,including Atractylodis Rhizoma,Achyranthis Bidentatae Radix,Phellodendri Chinensis Cortex and Coicis Semen at the ratio of 1:1:2:*** can be used to the treatment of ***,its bioactive compounds and underlying mechanism are *** study was designed to screen the antilipolytic fraction from SMW and investigate its therapeutic mechanisms on hepatic insulin *** fractions of SMW were prepared by membrane separation combined with macroporous resin and their antilipolytic activity was screened in fasted *** effects of 60%ethanol elution(ESMW)on lipolysis were investigated in 3T3-L1 adipocytes stimulated by palmitic acid(PA)and high fat diet(HFD)-fed *** our study,ESMW was the bioactive fraction responsible for the antilipolytic activity of SMW and 13 compounds were characterized from ESMW by UHPLC-QTOF-MS/*** suppressed protein kinase A(PKA)-hormone-sensitive lipase(HSL)related lipolysis and increased AMP-activated protein kinase(AMPK)phosphorylation in PA challenged 3T3-L1 *** knockdown abolished the inhibitory effects of ESMW on IL-6 and HSL pSer-660,revealing that the antilipolytic and anti-inflammatory activities of ESMW are AMPK ***,ESMW ameliorated insulin resistance and suppressed lipolysis in HFD-fed *** inhibited diacylglycerol accumulation in the liver and inhibited hepatic *** medium collected from ESMW-treated 3T3-L1 cells ameliorated insulin action on hepatic gluconeogenesis in liver cells,demonstrating that the antilipolytic activity contributed to ESMW beneficial effects on hepatic glucose *** conclusion,ESMW,as the antilipolytic fraction of SMW,inhibited PKA-HSL related lipolysis by activating AMPK,inhibiting diacylglycerol(DAG)accumulation in the liver and thereby improving insulin resistance and hepatic gluconeogenesis.

关键词： Simiao Wan Insulin resistance Lipolysis AMPK

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Hydration, Microstructure, and Properties of Sulphoaluminate Cement in Pure Water and Simulated Seawater

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 187-193页

作者： ma jie China Railway Design Corporation Tianjin 300250China

Paste and mortar specimens were prepared with sulfoaluminate cement(SAC),P⋅O 42.5 ordinary Portland cement(OPC),and standard sand,and mixed and cured with pure water and artificial seawater,*** mechanical properties of mortar specimens were *** and microstructure of paste specimens were also investigated using X-ray diffraction(XRD),scanning electron microscope(SEM),and 27Al nuclear magnetic resonance(NMR),*** results indicate that SAC mortar samples mixed and cured by seawater have faster strength growth before 28 d and higher compressive strength than OPC mortar *** to curing in deionized water,the hydration products of SAC are somewhat coarser when cured in simulated *** evolution of aluminum phase hydration products during the hydration process of SAC mixed and cured in simulated seawater is quite different from that of *** 3 to 28 d,the content of each aluminum phase hydration product in SAC paste cured in simulated seawater changed little,while that in OPC paste changed significantly;for example,from 7 to 28 d,the content of ettringite(AFt)in OPC paste increased *** type of AFt formed loosely,harming the mortar's microstructure.

关键词： sulfoaluminate cement seawater mixing and curing 27Al NMR AFt

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国家与社会理论框架下的民间信仰变迁及现代适应——以青海省贵德县六月会相关民间信仰为例

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青海民族研究 2020年第4期31卷 207-214页

作者：马婧杰中央民族大学民族学与社会学学院北京100081

民间信仰以乡间傩祭和节庆民俗的形式承载了地方社会文化记忆,并自下而上的,折射出国家与社会的关联形式和状态。历史上,贵德凭借黄河天险,自西汉时期起始终处于中原军屯和中央治理边疆的战略要地。因而,国家与地方的互动和交流内容,成... 详细信息

民间信仰以乡间傩祭和节庆民俗的形式承载了地方社会文化记忆,并自下而上的,折射出国家与社会的关联形式和状态。历史上,贵德凭借黄河天险,自西汉时期起始终处于中原军屯和中央治理边疆的战略要地。因而,国家与地方的互动和交流内容,成为了贵德地域间民间信仰重要的基底。文章梳理贵德民间信仰中关于国家社会关系的历史和现代性内容,提出国家与社会关系是一项动态变迁内容,其在民间现代性适应过程中,不断实现着文化再生产,并在文化遗产保护、乡村治理中具有重要的价值和地位。

关键词：民间信仰国家与社会贵德变迁现代性适应

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浅谈道教文化对青海河湟地区民族文化影响——以道教正一派在河湟地区传播影响为例

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青海民族研究 2011年第4期22卷 169-172页

作者：马婧杰中共青海省委党校青海西宁810000

本文在文献资料和田野调查资料的基础上,以道教与河湟多元文化的互动为轴心,对道教正一派在青海的传入、发展、演变的历史脉络进行梳理;通过结合实地调研资料,以河湟地区受道教影响最大的乐都县与民和县为典型个案,解析河湟多元民族文... 详细信息

本文在文献资料和田野调查资料的基础上,以道教与河湟多元文化的互动为轴心,对道教正一派在青海的传入、发展、演变的历史脉络进行梳理;通过结合实地调研资料,以河湟地区受道教影响最大的乐都县与民和县为典型个案,解析河湟多元民族文化模式受道教文化影响的特殊现象。提出如下观点:一,道教与藏传佛教结合;二,道教与北方萨满文化的结合;三,道教对河湟各民族丧葬礼俗的影响等。

关键词：道教传播正一派家道

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Optimal investment, retirement, and life insurance with consumption ratcheting and time-inhomogeneous utility

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Science China mathematics 2025年

作者： jie Xing jingtang ma School of Big Data Application and Economics Guizhou University of Finance and Economics School of mathematics Southwestern University of Finance and Economics

In this paper, we study a portfolio selection problem of an investor with a retirement option, who has possibility to buy life insurance and does not tolerate any decline in consumption. The agent's optimization problem can be viewed as a mixed singular control and optimal stopping problem with time-inhomogeneous utility functions. The closed-form optimal solution is not available in general. We use the dual control method to convert the original problem into two classes of optimal stopping problems in finite and infinite *** show that the optimal consumption strategy and the best retirement time depend on the free-boundary functions which satisfy Fredholm and Volterra integral equations. We derive the closed-form formulas for these two free boundaries for some special cases and develop numerical methods to solve the integral equations of the free boundaries for general cases.

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu jie Mu Yu Leng Lei ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing Guo Qiang Li Wanqi jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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青海河湟地区藏传佛教与道教互动

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青海民族研究 2013年第3期24卷 89-92页

作者：马婧杰马明忠中共青海省委党校青海西宁810000

研究多元民族文化格局形成过程中的各文化间交流、互动和认同对于研究民族文化多元一体的中华文化自觉精神有着重要的意义。青海河湟地区是藏文化与汉文化互相影响、彼此吸收形成互动、互融格局较为典型的区域。本文通过道教与藏传佛教... 详细信息

研究多元民族文化格局形成过程中的各文化间交流、互动和认同对于研究民族文化多元一体的中华文化自觉精神有着重要的意义。青海河湟地区是藏文化与汉文化互相影响、彼此吸收形成互动、互融格局较为典型的区域。本文通过道教与藏传佛教相互影响的个案考察,辨析两者在青海地区传承、发展变迁中的各民族文化间互动交流关系建立的根本动因。

关键词：河湟地区藏传佛教道教动因辨析

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