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Three-dimensional gravity and magnetic data acquisition and study on its joint gradient Euler deconvolution method

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Applied Geophysics 2020年第2期17卷 297-305,317页

作者： ma guo-qing Yong Xiao-Yu Li Li-Lit guo Hua College of Geoexploration Science and Technology Jilin UniversityChangchun 130021China China Aero Geophysical Survey and Remote Sensing center for Land and Resources Beijing 100083China

Three-dimensional(3 D)gravitational and magnetic exploration is performed using aerial measurement tools,however,this has difficulties with measuring-height design and the construction of a joint-interpretation *** present,the height in such experiments is set according to the measurement scale,and the distribution characteristics of anomalies are not fully ***,we present the idea of using the attenuation characteristics of a singular-value spectrum to evaluate the contributions of various measurement heights and multi-height combinations for inversion to correctly and reasonably design appropriate measuring heights and the number of various measurement heights to be *** jointgradient Euler-deconvolution method can accurately obtain the distribution of geological bodies from 3 D gravitational and magnetic data at an improved resolution,and experimental tests confirm these ***,an actual 3 D aeromagnetic-data-acquisition and inversion test were carried out in the vicinity of the Zhurihe Iron Mine in Inner *** fl ight-height diff erence was set to 60 m,and the specifi c distribution of lodes was obtained by the joint-gradient Euler-deconvolution *** provides a reliable basis for future detailed exploration and proves that the methods presented in this paper have good practicalapplication eff ects and prospects.

关键词： Three-dimensional gravity and magnetic exploration singular value gradient Euler deconvolution

Modified arthroscopic transfer of the long head of the biceps tendon to the conjoint tendon

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Chinese Medical Journal 2009年第6期122卷 745-747页

作者： ma Yong CUI guo-qing AO Ying-fang XIAO Jian YAN Hui YANG Yu-ping XIE Xing Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

The long head of the biceps tendon （LHBT） pathology has been implicated as a common source of shoulder pain. The patients may be more resistant to conservative treatment than those with isolated subacromial impingement. Even though, the surgical options of this disease remain controversial. It has been reported that tenotomy and tenodesis of the biceps tendon were usually utilized. However, persistent pain, deformity, and muscle cramping were frequently observed. Transfer of the LHBT to the conjoint tendon was originally described by Post and Benca in 1982.4 Verma et all has performed the transfer under arthroscopy since 2004. Eighty percent of their patients reported good results with a minimum 2 years of follow-up. However, there was a steep learning curve to become proficient in their technique. We devised a more convenient transfer compared with O＇Brien＇s technique. Six patients received our modified arthroscopic transfers from may 2006 to may 2007. All of them obtained good results.

关键词： arthroscopic long head of the biceps tendon conjoint tendon tenodesis

The molecular genetics of PI3K/PTEN/AKT/mTOR pathway in the malformations of cortical development

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Genes & Diseases 2024年第5期11卷 252-271页

作者： qing ma Guang Chen Ying Li Zhenming guo Xue Zhang NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Urology The Fourth Hospital of Harbin Medical UniversityHarbinHeilongjiang 150000China Department of Child and Adolescent Health School of Public HealthHarbin Medical UniversityHarbinHeilongjiang 150000China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200120China

malformations of cortical development(MCD)are a group of developmental disorders characterized by abnormal cortical structures caused by genetic or harmful environmental *** kinds of MCD are caused by genetic *** is the common cause of intellectual disability and intractable *** rapid advances in imaging and sequencing technologies,the diagnostic rate of MCD has been increasing,and many potential genes causing MCD have been successively ***,the high genetic heterogeneity of MCD makes it challenging to understand the molecular pathogenesis of MCD and to identify effective targeted ***,in this review,we outline important events of cortical *** we illustrate the progress of molecular genetic studies about MCD focusing on the PI3K/PTEN/AKT/mTOR ***,we briefly discuss the diagnostic methods,disease models,and therapeutic strategies for *** information will facilitate further research on *** the role of the PI3K/PTEN/AKT/mTOR pathway in MCD could lead to a novel strategy for treating MCD-related diseases.

关键词： Epilepsy Gene mutation Genetics malformations of cortical development PI3K/PTEN/AKT/mTOR pathway

Deterministic and Robust Volt-var Control Methods of Power System Based on Convex Deep Learning

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 719-729页

作者： qing ma Changhong Deng the School of Electrical Engineering and Automation Wuhan UniversityWuhanChina

Volt-var control(VVC)is essentially a non-convex optimization problem due to the non-convexity of power flow(PF)constraints,resulting in the difficulty in obtaining the optimum without convexity *** existing second-order cone method for the convexity conversion often leads to a sharp increase in PF constraints and optimization variables,which in turn increases the optimization difficulty or even leads to optimization *** paper first proposes a deterministic VVC method based on convex deep learning power flow(DLPF).This method uses the input convex neural network(ICNN)to establish a single convex mapping between state parameters and node voltage to complete the convexity conversion while the optimization variables only correspond to reactive power equipment,which can ensure the global optimum with extremely fast computation *** cope with the impact brought by the uncertainty of distributed energy and omit the additional worst scenario search of traditional robust VVC,this paper proposes robust VVC method based on convex deep learning interval power flow(DLIPF),which continues to adopt ICNN to establish another convex mapping between state parameters and node voltage *** DLIPF with DLPF,this method decreases the modeling and optimization difficulty of robust VVC *** results on 30-bus,118-bus,and 200-bus systems prove the correctness and rapidity of the proposed methods.

关键词： Volt-var control convexity conversion convex deep learning power flow

Improved preconditioned conjugate gradient algorithm and application in 3D inversion of gravity-gradiometry data

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Applied Geophysics 2017年第2期14卷 301-313,324页

作者： Wang Tai-Han Huang Da-Nian ma guo-qing Meng Zhao-Hai Li Ye College of Geo-Exploration Scienceand Technology Jilin University Claangchun 130021 China Tianjin Navigation Instrument Research Institute Tianjin 300131 China Jilin Provincial Electric Power Survey and Design Institute Changchun 130021 China.

With the continuous development of full tensor gradiometer （FTG） measurement techniques, three-dimensional （3D） inversion of FTG data is becoming increasingly used in oil and gas exploration. In the fast processing and interpretation of large-scale high-precision data, the use of the graphics processing unit process unit （GPU） and preconditioning methods are very important in the data inversion. In this paper, an improved preconditioned conjugate gradient algorithm is proposed by combining the symmetric successive over-relaxation （SSOR） technique and the incomplete Choleksy decomposition conjugate gradient algorithm （ICCG）. Since preparing the preconditioner requires extra time, a parallel implement based on GPU is proposed. The improved method is then applied in the inversion of noise- contaminated synthetic data to prove its adaptability in the inversion of 3D FTG data. Results show that the parallel SSOR-ICCG algorithm based on NVIDIA Tesla C2050 GPU achieves a speedup of approximately 25 times that of a serial program using a 2.0 GHz Central Processing Unit （CPU）. Real airbome gravity-gradiometry data from Vinton salt dome （south- west Louisiana, USA） are also considered. Good results are obtained, which verifies the efficiency and feasibility of the proposed parallel method in fast inversion of 3D FTG data.

关键词： Full Tensor Gravity Gradiometry (FTG) ICCG method conjugate gradient algorithm gravity-gradiometry data inversion CPU and GPU

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun Liu Shangde guo Rong Liu Minfang guo qing Wang Zhi Chai Baoguo Xiao Cungen ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

Escape probability for isotropic emitters near Kerr black hole with astrometric

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Communications in Theoretical Physics 2024年第5期76卷 128-133页

作者： Yu-Xuan Han qing-Hua Zhu qing-guo Huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Department of Physics Chongqing UniversityChongqing 401331China School of Fundamental Physics and mathematical Sciences Hangzhou Institute for Advanced Study UCASHangzhou 310024China

The paper investigates the escape probability for isotropic emitters near a Kerr black *** propose a new approach to obtain the escape probability in a general manner,going beyond previous case-by-case *** approach is based on studies of the black hole shadow with astrometric observable and can be applied to emitters with an arbitrary 4-velocities and locations,even to the emitters outside of the equatorial *** also consider representative examples illustrating how escape probabilities vary with distance,velocity,and inclination ***,this new approach provides an effective method for studying escape probabilities near Kerr black holes.

关键词： Kerr black hole photon escape probability isotropic emitters

Research on light dark matter particle from evaporating primordial black hole in CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 172-173页

作者： qing-guo Huang School of Fundamental Physics and mathematical Sciences Hangzhou Institute for Advanced StudyUCAS CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences

Dark matter is an essential component of the universe, accounting for approximately 85% of all matter. However,what the nature of dark matter actually is remains a huge mystery. So far, all evidence for the existence of dark matter has come from gravitational interactions. Since gravitational interactions are universal, it is challenging to reveal the nature of dark matter through gravitational interactions. To unravel the mystery of dark matter, it is essential to directly detect dark matter.

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Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes:A Randomized,Double-Blind,Placebo-Controlled Multicenter Clinical Study

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Chinese Journal of Integrative Medicine 2022年第4期28卷 304-311页

作者： QU Ling LIANG Xiao-chun TIAN guo-qing ZHANG Gai-li WU Qun-li HUANG Xiu-mei CUI Ya-zhong LIU Yu-ling SHEN Zhu-fang ma guo-qing LU Hao LI Yi JIANG Hong YANG Xi-yan ZHANG Guang-de YANG Chen-hua Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Institute of materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Department of Endocrinology the Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHaerbin150001China Department of Endocrinology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Department of Traditional Chinese Medicine Beijing HospitalBeijing10005China Department of Endocrinology the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110034China Department of Geriatrics the First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin300073China Department of Endocrinology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Department of Endocrinology Affiliated Hospital of Henan Academy of Traditional Chinese MedicineZhengzhou450003China

Objective:To assess the efficacy and safety of mulberry twig alkaloids(Sangzhi alkaloids,SZ-A)for treatment of type 2 diabetes in a randomized,double-blind,placebo-controlled multicenter clinical ***:A total of 200 patients were randomized to receive SZ-A(n=100)or placebo(n=100)for 16 *** data analysis system for electronic data capture clinical trial central randomization system was used for randomization and dispensing of *** primary outcome was the change in glycosylated hemoglobin(Hb A1c)*** secondary outcome included the proportions of cases with Hb A1cmass index(BMI).Adverse events(AEs),severe adverse events(SAEs),treatment-related adverse events(TAEs),gastrointestinal disorders(GDs),blood pressure,routine blood tests,and liver and kidney function were ***:Compared with baseline,the change of Hb A1c at week 16 was-0.80%(95%CI:-0.98%to-0.62%)and-0.09%(95%CI:-0.27%to 0.09%)in SZ-A group and placebo group,*** proportion of patients with Hb A1c0.05).The incidence rates of AEs,TAEs,and GDs differed significantly between groups(P=0.010,P=0.005,and P=0.006,respectively),whereas the incidence rates of SAEs showed no significant differences between groups(P=1.000).Conclusion:SZ-A are effective and safe for treatment of type 2 diabetes.

关键词： type 2 diabetes mellitus mulberry twig alkaloids tablets(Sangzhi alkaloids) efficacy safety placebo