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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

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Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong ma fang-qi XU Yan DONG Jia-huan qiN Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao LIU Li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(Pmain first-line *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

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Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China mathematics 2024年第1期67卷 211-236页

作者： qi Lü Bowen ma School of mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

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Two ABCI family transporters,OsABCI15 and OsABCI16,are involved in grain-filling in rice

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Journal of Genetics and Genomics 2024年第5期51卷 492-506页

作者： Bin ma Xiubiao Cao Xiaoyuan Li Zhong Bian qi-qi Zhang Zijun fang Jiyun Liu Qun Li qiaoquan Liu Lin Zhang Zuhua He Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology Agricultural College of Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhouJiangsu 225009China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China Institute of Biotechnology Hangzhou Academy of Agricultural SciencesHangzhouZhejiang 310024China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhouJiangsu 225009China

Seed development is critical for plant reproduction and crop yield,with panicle seed-setting rate,grain-filling,and grain weight being key seed characteristics for yield ***,few genes are known to regulate grain ***,we identify two adenosine triphosphate(ATP)-binding cassette(ABC)I-type transporter genes,OsABCI15 and OsABCI16,involved in rice *** genes are highly expressed in developing seeds,and their proteins are localized to the plasma membrane and ***,knockout of OsABCI15 and OsABCI16 results in a significant reduction in seed-setting rate,caused predominantly by the severe empty pericarp phenotype,which differs from the previously reported low seed-setting phenotype resulting from failed *** analysis indicates that OsABCI15 and OsABCI16 participate in ion homeostasis and likely export ions between filial tissues and maternal tissues during grain ***,overexpression of OsABCI15 and OsABCI16 enhances the seed-setting rate and grain yield in transgenic plants and decreases ion accumulation in brown ***,the OsABCI15/16 orthologues in maize exhibit a similar role in kernel development,as demonstrated by their disruption in transgenic ***,ourﬁndings reveal the important roles of two ABC transporters in cereal grain filling,highlighting their value in crop yield improvement.

关键词： ABC transporters Rice Grain filling Ion homeostasis Grain yield

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A rigorous real-time acoustic positioning method for ocean bottom seismic exploration

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Satellite Navigation 2024年第1期5卷 168-190页

作者： Jinye ma Shouchuan fang Jianhu Zhao School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079China Institute of marine Science and Technology Wuhan UniversityWuhan430079China Surveying Service Center BGP Inc.CNPCZhuozhou072751HebeiChina

The conventional technique for positioning seafloor geophones in ocean bottom seismic exploration encounters several challenges,including the significant impact of outliers on positioning results,underutilization of high-precision observations,and low efficiency in real-time data *** issues inevitably affect the quality of seismic exploration *** address these challenges and enhance the accuracy of geophone positioning,this paper proposes a rigorous real-time acoustic positioning method for geophones based on sequential adjustment and Baarda's outlier detection *** proposed method comprises three key steps:grouping the original acoustic observations,constructing the intra-group acoustic positioning model,and synthesizing the positioning results across the different *** validity and practicality of this approach are confirmed through a simulation experiment as well as the field experiment conducted in the Bohai Sea,*** results demonstrate that the proposed method effectively eliminates outliers in the original observations and maximizes the utilization of high-quality *** to traditional acoustic positioning methods,it significantly reduces positioning errors from meters to decimeters,and in some cases can achieve centimeter-level *** the sound velocity profile in the operating sea area is measured,the method can attain the posterior standard deviation at the millimeter level and positioning errors within 10 *** the sound velocity profile is unknown,the method can achieve the posterior standard deviation at centimeter-level and positioning errors of approximately 20 cm.

关键词： Ocean bottom seismic exploration Geophone positioning Acoustic positioning method Sequential adjustment Outlier detection

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Adaptive Algorithms on maximizing Monotone Nonsubmodular Functions

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Journal of the Operations Research Society of China 2024年第2期12卷 428-445页

作者： Bin Liu Hui Su Shu-fang Gong qi-Zhi fang School of mathematical Sciences Ocean Universityof ChinaQingdao266100ShandongChina

Submodular optimization is widely used in large *** order to speed up the problems solving,it is essential to design low-adaptive algorithms to achieve acceleration in *** general,the function values are given by a value oracle,but in practice,the oracle queries may consume a lot of ***,how to strike a balance between optimizing them is *** this paper,we focus on maximizing a normalized and strictly monotone set function with the diminishing-return ratio under a cardinality constraint,and propose two algorithms to deal with *** apply the adaptive sequencing technique to devise the first algorithm,whose approximation ratio is arbitrarily close to 1-e^(-γ)in O(logn·log(log(k\γ))adaptive rounds,and requires O(logn^(2)·log(log(k\γ))*** by adding preprocessing and parameter estimation steps to the first algorithm,we get the second *** second algorithm trades a small sacrifice in adaptive complexity for a significant improvement in query *** the same approximation and adaptive complexity,the query complexity is improved *** the best of our knowledge,this is the first paper of designing adaptive algorithms for maximizing a monotone function using the diminishing-return ratio.

关键词： Approximation algorithm Adaptivity Nonsubmodular maximization:Cardinality constraint

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A review on WO_(3)-based composite photocatalysts:synthesis,catalytic mechanism and diversified applications

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Rare Metals 2024年第8期43卷 3441-3459页

作者： Xue Zhang Zi-qi Zhang Yan-Dong Sun Xiao-Jia ma Feng-Xian Jin fang-Yuan Zhang Wei-Guang Han Bo-Xiong Shen Sheng-qi Guo College of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Food and Chemical Engineering Liuzhou Institute of TechnologyLiuzhou 545616China

Photocatalysis as an emerging "green" energy conversion technology has attracted domestic and international *** technology uses semiconductor photocatalysts to convert solar energy into directly usable chemical energy,showing great potential for application in environmental pollutant purification and clean energy production,with broad development *** many semiconductor materials,tungsten trioxide(WO_(3)) is favored by researchers in the field of photocatalysis because of its good visible light response and excellent valence band hole oxidation ***,a large number of photocatalysts based on WO_(3),in particular W03-based composite photocatalysts,have been reported,and their applications cover a wide range of *** order to promote the development of WO_(3)-based photocatalysts and provide a reference for colleagues,we present a systematic summary of the applications and research progress of W03-based composites in the field of photocatalysis in recent *** from the structural properties of WO_(3)itself,this article summarizes the preparation methods and structure-activity relationships of WO_(3)-based composite ***,it introduces the current application status of existing WO_(3)-based composite photocatalysts in CO_(2) reduction,hydrogen production,nitrogen fixation,and pollutant ***,the development prospects were analyzed.

关键词： WO_(3)-based composite photocatalysts Intrinsic characteristic Preparation method Reaction mechanism Applications

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Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang qi Meng Zhi-Ming ma Academy of mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

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Review on heat-to-power conversion technologies for hypersonic vehicles

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Chinese Journal of Aeronautics 2024年第5期37卷 148-179页

作者： Yinke qi Xiaofeng ma Peixue JIANG Yinhai ZHU Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of CO_(2)Utilization and Reduction Technology Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China

Hypersonic vehicles have enormous military and economic value,while their power and thermal protection demands will increase substantially with the rise in mach number and *** the tremendous high-quality heat on the vehicle surface and engine wall into electrical energy through heat-to-power technologies will not only play a role in thermal protection,but also supply power for the *** paper provides a comprehensive review of heat-to-power conversion technologies on hypersonic vehicles,including the indirect conversion of Brayton and Rankine cycles,direct conversion of thermoelectric materials,and combined *** the open Brayton cycle with hydrocarbon fuel as the working fluid,the Power-to-Weight Ratio(PWR)can achieve the highest,at around 1.8,due to the high PWR of the hydrocarbon fuel turbine and the few components of the ***,its work capacity is limited by the flow rate of the supplied *** closed Brayton cycle can maintain a relatively high PWR,ranging from 0.2 to 0.8,while achieving relatively high output power and conversion *** Rankine cycle has a higher PWR,its range is close to that of the closed Brayton cycle,peaking at about *** thermoelectric materials technology has a small power generation level,making it more suitable for scenarios with low power *** review provides a basis for selecting and developing heat-to-power conversion technologies on hypersonic vehicles.

关键词： Hypersonic vehicles Heat-to-power conversion Brayton cycle Rankine cycle Thermoelectric materials

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High-performance wood-based thermoelectric sponges for thermal energy harvesting and smart buildings

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Nano Research 2024年第6期17卷 5349-5357页

作者： Ding Zhang qi Li Yanjie fang Peijia Bai Lili Liu Jiaqi Guo Guangfa Wang Yuetong Zhou Rujun ma School of materials Science and Engineering National Institute for Advanced MaterialsSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China

The development of renewable woods for power generation can help improve the energy efficiency of buildings,and promote the concept design and implementation of“smart buildings”.Here,with specific chemical treatment and hydrothermal synthesis,we demonstrated the practical value of natural wood for thermoelectric power generation in smart *** prepared wood-based thermoelectric sponges show high Seebeck coefficients of 320.5 and 436.6μV/K in the vertical and parallel directions of the longitudinal channel of *** 500 cycles of the compressive strain at 20%,the corresponding Seebeck coefficients increase up to 413.4 and 502.1μV/K,respectively,which is attributed to the improved contact and connection between tellurium thermoelectric *** Seebeck coefficients are much larger than those of most reported inorganic thermoelectric ***,the thermoelectric sponges maintain excellent thermoelectric and mechanical *** further modeled the application value of wood-based thermoelectric sponges in smart buildings for power *** high thermoelectric electricity can be obtained,such as in Beijing with over 1.5 million kWh every year,demonstrating the great potential in thermal energy harvest and energy supply.

关键词： wood thermoelectric effect thermal energy harvesting smart buildings energy supply

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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu Jia Cheng Wang Wenlong Xu Dong ma fangfang qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

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