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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang ma Wensheng Yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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Molecular Clouds Associated with HⅡRegions and Candidates within l=106°.65 to 109°.50 and b=-1°.85 to 0°.95

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Research in Astronomy and Astrophysics 2022年第4期22卷 71-105页

作者： chun-Xue Li Hong-chi Wang Yue-Hui ma Miao-Miao Zhang Chong Li Yu-Qing Zheng Purple Mountain Observatory and Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210033China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210023China

We present a large-scale simultaneous survey of the CO isotopologues(^(12)CO,^(13)CO,and C^(18)O)J=1-0 line emission toward the Galactic plane region of l=106°.65 to 109°.50 and b=-1°.85 to 0°.95 using the Purple Mountain Observatory 13.7 m millimeter-wavelength *** for the molecular gas in the solar neighborhood,the emission from the molecular gas in this region is concentrated in the velocity range of[-60,-35]km s^(-1).The gas in the region can be divided into four clouds,with mass in the range of~10^(3)-10^(4)M☉.We have identified 25 filaments based on the^(13)CO *** median excitation temperature,length,line mass,line width,and virial parameter of the filaments are 10.89 K,8.49 pc,146.11 M☉pc^(-1),1.01 km s^(-1),and 3.14,*** these filaments,eight have virial parameters of less than 2,suggesting that they are gravitationally bound and can lead to star *** HⅡregions or candidates have previously been found in the region and we investigate the relationships between these HⅡregions/candidates and surrounding molecular clouds in *** morphology similarity and radial velocity consistency between HⅡregions/candidates and molecular clouds as evidence for association,and raised temperature and velocity broadening as signatures of interaction,we propose that 12 HⅡregions/candidates are associated with their surrounding molecular *** the case of the HⅡregion of S142,the energy of the HⅡregion is sufficient to maintain the turbulence in the surrounding molecular gas.

关键词： ISM:molecules ISM:clouds ISM:structure (ISM:)HⅡregions

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Sintering behavior and thermal conductivity of Y_(2)O_(3) fully stabilized HfO_(2) ceramics

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Rare Metals 2021年第5期40卷 1255-1266页

作者： chun Li Jian He Yue ma School of materials Science and Engineering Beihang UniversityBeijing 100191China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Key Laboratory of High-Temperature Structural materials and Coatings Technology(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China

A series of Y_(2)O_(3) fully stabilized HfO2 ceramics(Hf_(1-x)Y_(x)O_(2-0.5x),x=0.20,0.24,0.28,0.32,0.36 and 0.40)were synthesized by solid-state reaction at 1500℃.The phase composition,thermal conductivity and sintering behavior at 1400℃ of the ceramic bulks were *** Hf_(1-x)Y_(x)O_(2-0.5x) ceramics were comprised of pure cubic phase with disordered fluorite *** phase transformation occurred in the ceramics with Y3+doping concentration ranging from 0.24 to *** Hf_(0.64)Y_(0.36)O_(1.82) and Hf_(0.6)Y_(0.4)O_(1.8) samples revealed the lowest grain growth rate when sintered at 1400℃,indicating good resistance to ***,the Vicker’s hardness and Young’s modulus after annealed for 96 h at 1400℃ for the Hf_(0.64)Y_(0.36)O_(1.82) sample were 8.97 and 200 GPa,respectively,much lower than those of the Hf_(0.6)Y_(0.4)O_(1.8)(14.51 and 237 GPa,respectively).The thermal conductivity of Hf_(1-x)Y_(x)O_(2-0.5x) first decreased and then increased slowly as the Y3+content increased,and the associated mechanism was discussed.

关键词： Yttria fully stabilized hafnia Sintering Mechanical properties Thermal conductivity

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Properties of Nonlinear Transverse-Electric Waves in a Two-Core Optical Waveguide with a Nonlinear Cladding

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chinese Physics Letters 1998年第7期15卷 501-503页

作者： ma chun-sheng Department of Electronic Engineering National Integrated Optoelectronics LaboratoryJilin UniversityChangchun 130023

Expressions of dispersion relation and propagation power are presented for the nonlinear transverse-electric(TE)waves in a two-core optical waveguide with a nonlinear *** properties of the nonlinear TE waves are *** is found that when the total core thickness and the distance between the two cores are sufficiently large,the power curves of the higher odd modes become very sharp in some narrow ranges of the effective refractive index,compared with those of the higher even modes.

关键词： Nonlinear nonlinear adding

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Extant primates and development of primatology in china: Publications, student training, and funding

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Zoological Research 2018年第4期39卷 249-254页

作者： Peng-Fei Fan chi ma School of Life Sciences Sun Yat-Sen University

china supports the richest non-human primate diversity in the northern hemisphere, providing an excellent opportunity for chinese primatologists to take a leading role in advancing the study of primatology Primatology in china began to flourish after 1979. To date, chinese primatologists have published more than 1 000 papers in journals indexed by the chinese Science Citation Database and the Web of Science Core Collection, and universities and academic institutions have trained 107 PhD students and 370 masters students between 1984 and 2016. In total, the National Science Foundation of china has funded 129 primate projects （RMB 71.7 million） supporting 59 researchers from 28 organizations. However, previous research has also shown obvious species bias. Rhinopithecus roxellana, Rhinopithecus bieti, and macaca mulatta have received much greater research attention than other species. Researchers have also tended to continue to study the same species （55.2%） they studied during their PhD training. To promote the development of primatology in china, we suggest （1） the need for a comprehensive primatology textbook written in chinese, （2） continued training of more PhD students, and （3） encouragement to study less well-known primate species.

关键词： Gibbon Snub-nosed monkey Leafmonkey macaque Slow Iories

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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

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Advances in single-particle detection for DNA sensing

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Science china Chemistry 2017年第10期60卷 1285-1292页

作者： Fei ma Ming Ren chun-yang Zhang College of Chemistry Chemical Engineering and Materials Science Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano Probes Ministry of Education Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University Jinan 250014 China

Rapid, accurate and sensitive detection of particular DNA sequence is critical in fundamental biomedical research and clinical diagnostics. However, conventional approaches for DNA assay often suffer from cumbersome procedures, long analysis time and insufficient sensitivity. Recently, single-particle detection technology has emerged as a powerful tool in the biosensing area due to its significant advantages of ultrahigh sensitivity, low sample-consumption and rapid analysis time. Especially, the introduction of novel nanomaterials has greatly promoted the development of single-particle detection and its applications for DNA sensing. In this review, we summarize the recent advance in single-particle detection strategies for DNA sensing, and focus mainly on metallic nanoparticle-and semiconductor quantum dot-based single-particle detection. We highlight the emerging trends in this field as well.

关键词： single-particle detection DNA assay quantum dots metallic nanoparticles fluorescence resonance energy transfer

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Cryptanalysis and security enhancement of a remote user authentication scheme using smart cards

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The Journal of china Universities of Posts and Telecommunications 2012年第5期19卷 104-114页

作者： WANG Ding ma chun-guang College of Computer Science and Technology Harbin Engineering University Harbin 150001 China Automobile management Institute of PLA Bengbu 233011 China

With the broad implementations of the electronic business and government applications, robust system security and strong privacy protection have become essential requirements for remote user authentication schemes. Recently, Chen et al. pointed out that Wang et al.＇s scheme is vulnerable to the user impersonation attack and parallel session attack, and proposed an enhanced version to overcome the identified security flaws. In this paper, however, we show that Chen et al.＇s scheme still cannot achieve the claimed security goals and report its following problems：（1） It suffers from the offline password guessing attack, key compromise impersonation attack and known key attack; （2） It fails to provide forward secrecy; （3） It is not easily repairable. As our main contribution, a robust dynamic ID-based scheme based on non-tamper resistance assumption of the smart cards is presented to cope with the aforementioned defects, while preserving the merits of different related schemes. The analysis demonstrates that our scheme meets all the proposed criteria and eliminates several grave security threats that are difficult to be tackled at the same time in previous scholarship.

关键词： cryptanalysis authentication protocol smart card non-tamper resistant forward secrecy

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Fluoro-functionalized plant biomass adsorbent:Preparation and application in extraction of trace perfluorinated compounds from environmental water samples

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Journal of Environmental Sciences 2024年第3期137卷 703-715页

作者： Xi Tan Yan Shi chun-Feng ma Quan chi Yu-Hang Yang Wen-Xiang Zhang Hua-Ming Xiao Xian Wang Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission School of Chemistry and Materials ScienceSouth-Central Minzu UniversityWuhan 430074China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Key Laboratory of Oilseeds Processing of Ministry of Agriculture Hubei Key Laboratory of Lipid Chemistry and NutritionOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Perfuorinated compounds(PFCs)are toxic and widely present in the environment,and therefore effective adsorbents are required to remove PFCs from environmental *** the present study,a new type of fuorinated biomass materials was synthesized via an ingenious fuorosilanization *** adsorbents were applied for the adsorption of 13typical PFCs,including perfuorocarboxylic acids(PFCAs)and perfuorosulfonic acids(PFSAs).By comparing their adsorption performance,Fluorinated cedar slag(FCS)was discovered to have the best absorption efficiency and enabled highly efficient enrichment of *** adsorption recovery of FCS with the investigated PFCs is greater than 90%under the optimal adsorption *** to the high affinity of F-F sorbent-sorbate interaction,FCS had good adsorption capacities of PFCs from aqueous solution,with the maximum adsorption capacity of 15.80 mg/g for PFOS and 10.71 mg/g for PFOA,***,the adsorption time could be achieved in a short time(8 min).Using the FCS absorbent,an innovative FCS-solid phase extraction assisted with high performance liquid chromatography-electrospray-tandem mass spectrometry(FCS-SPE-HPLC-ESI-MS/MS)method was first developed to sensitively detect PFCs in the environmental water *** intra-day and inter-day recovery rates of the 13 compounds ranged from 90.7%-104.3%,with the RSD of 2.1%-4.7%(intra-day)and 2.5%-8.5%(inter-day),*** research demonstrates the potential of the newly fuoro-functionalized plant biomass to adsorb PFCs from environmental water,with the advantages of high adsorption efficiencies,high antiinterference,easy operation and low economic cost.

关键词： Fluoro-functionalized biomass Perfuorinated compounds(PFCs) Adsorption efficiency mass spectrometry(MS) Fluorinated cedar slag(FCS)

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