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基于抗体分型的幽门螺杆菌四联疗法治疗效果观察

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临床合理用药 2025年第1期18卷 13-16,20页

作者：毕胜飞赵婧马子豪高学智张辉王仲玉宋歌酒钢医院检验科甘肃省嘉峪关市735100 酒钢医院重症医学科甘肃省嘉峪关市735100 酒钢医院消化科甘肃省嘉峪关市735100

目的基于幽门螺杆菌(Hp)抗体分型,观察Hp四联疗法的治疗效果。方法选取2023年1月—2024年3月就诊于酒钢医院消化内科门诊~(14)C尿素呼气试验阳性的Hp现症感染患者215例为病例组,依据Hp抗体分型分为Ⅰ型亚组146例和Ⅱ型亚组69例。另选取... 详细信息

目的基于幽门螺杆菌(Hp)抗体分型,观察Hp四联疗法的治疗效果。方法选取2023年1月—2024年3月就诊于酒钢医院消化内科门诊~(14)C尿素呼气试验阳性的Hp现症感染患者215例为病例组,依据Hp抗体分型分为Ⅰ型亚组146例和Ⅱ型亚组69例。另选取健康体检者122例为健康对照组。病例组采用四联疗法治疗,总疗程2周。治疗后4周,比较Ⅰ型亚组和Ⅱ型亚组~(14)C尿素呼气试验转阴率,治疗前后Ⅰ型亚组、Ⅱ型亚组与健康对照组的胃肠激素[胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃蛋白酶原比值(PGR)]、炎性因子[白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平及不良反应。结果治疗后4周,Ⅰ型亚组~(14)C尿素呼气试验转阴率为80.82%(118/146),高于Ⅱ型亚组的72.46%(50/69),但差异无统计学意义(χ^(2)=1.916,P=0.166)。治疗前,Ⅰ型亚组和Ⅱ型亚组G-17、PGⅠ、PGⅡ、IL-6、hs-CRP水平高于健康对照组,PGR低于健康对照组,且Ⅰ型亚组G-17、PGⅠ、PGⅡ水平高于Ⅱ型亚组,PGR低于Ⅱ型亚组(P0.05)。治疗前,Ⅰ型亚组和Ⅱ型亚组IL-6、hs-CRP水平高于健康对照组,且Ⅰ型亚组IL-6、hs-CRP水平高于Ⅱ型亚组(P<0.01);治疗后4周,Ⅰ型亚组和Ⅱ型亚组IL-6、hs-CRP水平低于治疗前,但高于健康对照组(P<0.01)。Ⅰ型亚组与Ⅱ型亚组不良反应总发生率比较差异无统计学意义(6.85%vs.5.80%,χ^(2)=0.085,P=0.770)。结论不同抗体分型Hp对胃黏膜的损害程度不同,Ⅰ型菌株对患者胃黏膜损害更大,四联疗法对Ⅰ型Hp感染和Ⅱ型Hp感染的治疗效果均较好,且Ⅰ型感染~(14)C尿素呼气试验转阴率略高于Ⅱ型Hp感染。

关键词：幽门螺杆菌感染抗体分型四联疗法胃肠激素炎性因子

Overview of SMP-CAIL2020-Argmine:The Interactive Argument-Pair Extraction in Judgement Document Challenge

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Data Intelligence 2021年第2期3卷 287-307页

作者： Jian Yuan zhongyu Wei Yixu Gao Wei Chen Yun Song Donghua Zhao Jinglei ma Zhen Hu Shaokun Zou Donghai Li Xuanjing Huang School of Data Science Fudan UniversityShanghai 200433China Heilongjiang University Heilongjiang 150080China School of mathematical Sciences Fudan UniversityShanghai 200433China China Judicial Big Data Institute Beijing 100043China THUNISOFT Co. Ltd.Beijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China School of Computer Science Fudan UniversityShanghai 200433China

In this paper we present the results of the Interactive Argument-Pair Extraction in Judgement Document Challenge held by both the Chinese AI and Law Challenge(CAIL)and the Chinese National Social Media Processing Conference(SMP),and introduce the related data *** task challenged participants to choose the correct argument among five candidates proposed by the defense to refute or acknowledge the given argument made by the plaintiff,providing the full context recorded in the judgement documents of both *** received entries from 63 competing teams,38 of which scored higher than the provided baseline model(BERT)in the first phase and entered the second *** best performing system in the two phases achieved accuracy of 0.856 and 0.905,*** this paper,we will present the results of the competition and a summary of the systems,highlighting commonalities and innovations among participating *** SMP-CAIL2020-Argmine data set and baseline modelshave been already released.

关键词： Argumentation mining Judgement documents Natural language understanding Pretrained language model

Remote sensing and its applications using GNSS reflected signals:advances and prospects

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Satellite Navigation 2024年第1期5卷 10-51页

作者： Shuanggen Jin Adriano Camps Yan Jia Feng Wang manuel martin-Neira Feixiong Huang Qingyun Yan Shuangcheng Zhang zhongyu Li Komi Edokossi Dongkai Yang Zhiyu Xiao Zhongmin ma Weihua Bai Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuo454003China Department of Signal Theory and Communications Technical University of CataloniaBarcelona08034Spain Department of Surveying and Geoinformatics Nanjing University of Posts and TelecommunicationsNanjing210023China School of Electronics and Information Engineering Beihang UniversityBeijing100191China European Space Research and Technology Centre(ESTEC) European Space Agency2200-AGNoordwijkThe Netherlands National Space Science Center Chinese Academy of SciencesBeijing100190China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing210044China College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China University of Electronic Science and Technology of China Chengdu611731China

The Global Navigation Satellite Systems(GNSS),including the US’s GPS,China’s BDS,the European Union’s Galileo,and Russia’s GLONASS,offer real-time,all-weather,any-time,anywhere and high precision observations by transmitting L band signals continuously,which have been widely used for positioning,navigation and *** the development of GNSS technology,it has been found that GNSS-reflected signals can be used to detect Earth’s surface characteristics together with other signals of *** this paper,the current status and latest advances are presented on Global Navigation Satellite System-Reflectometry(GNSS-R)in theory,methods,techniques and *** developments and progresses in GNSS-R instruments,theoretical modeling,and signal processing,ground and space-/air-borne experiments,parameters retrieval(*** speed,sea surface height,soil moisture,ice thickness),sea surface altimetry and applications in the atmosphere,oceans,land,vegetation,and cryosphere are given and reviewed in ***,the challenges in the GNSS-R development of each field are also ***,the future applications and prospects of GNSS-R are discussed,including multi-GNSS reflectometry,new GNSS-R receivers,GNSS-R missions,and emerging applications,such as mesoscale ocean eddies,ocean phytoplankton blooms,microplastics detection,target recognition,river flow,desert studies,natural hazards and landslides monitoring.

关键词： GNSS Reflectometry Remote sensing Environmental change

Simulated photo-degradation of dissolved organic matter in lakes revealed by three-dimensional excitation-emission matrix with regional integration and parallel factor analysis

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Journal of Environmental Sciences 2020年第4期32卷 310-320页

作者： Jin Zhang Fanhao Song Tingting Li Kefu Xie Huiying Yao Baoshan Xing zhongyu Li Yingchen Bai School of Environmental and Safety Engineering Changzhou UniversityJiangsu 213164China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Water Sciences Beijing Normal UniversityBeijing 100875China Department of Chemistry Beijing Normal UniversityBeijing 100875China Stockbridge School of Agriculture University of MassachusettsAmherstMA01003USA

Simulated photo-degradation of fluorescent dissolved organic matter(FDOM) in Lake Baihua(BH) and Lake Hongfeng(HF) was investigated with three-dimensional excitationemission matrix(3 DEEM) fluorescence combined with the fluorescence regional integration(FRI),parallel factor(PARAFAC) analysis,and multi-order kinetic *** the FRI analysis,fulvic-like and humic-like materials were the main constituents for both BH-FDOM and *** individual components were identified by use of PARAFAC analysis as humic-like components(C1),fulvic-like components(C2),protein-like components(C3) and unidentified components(C4).The maximum 3 DEEM fluorescence intensity of PARAFAC components C1-C3 decreased by about 60%,70% and 90%,respectively after *** multi-order kinetic model was acceptable to represent the photo-degradation of FDOM with correlation coefficient(Radj2)(0.963-0.998).The photo-degradation rate constants(kn) showed differences of three orders of magnitude,from 1.09 × 10-6 to 4.02 × 10-4 min-1,and half-life of multi-order model(T1/2n)ranged from 5.26 to 64.01 *** decreased values of fluorescence index(FI) and biogenic index(BI),the fact that of percent fluorescence response parameter of Region I(PⅠ,n) showed the greatest change ratio,followed by percent fluorescence response parameter of Region II(PⅡ,n,while the largest decrease ratio was found for C3 components,and the lowest T1/2n was observed for C3,indicated preferential degradation of protein-like materials/components derived from biological sources during *** research on the degradation of FDOM by 3 DEEM/FRI-PARAFAC would be beneficial to understanding the photo-degradation of FD OM in natural environments and accurately predicting the environmental behaviors of contaminants in the presence of FDOM.

关键词： Fluorescent dissolved organic matter Photo-degradation Fluorescence regional integration Parallel factor analysis Three-dimensional excitationemission matrix Multi-order kinetic models

基于DEM与重力场模型的GPS水准高程处理方法研究

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武汉大学学报（信息科学版） 2007年第9期32卷 767-769,795页

作者：马洪滨董仲宇东北大学测绘工程系沈阳市文化路3号巷11号110004

提出了联合使用DEM模型与重力场模型的高程处理方法,用该方法处理了某市8800 km2范围内的15个水准高程数据,并与传统方法进行了比较分析,同时进行了重力场模型的地区匹配试验。试验发现,该方法适用于比高较大、测区范围广,且水准点数目... 详细信息

提出了联合使用DEM模型与重力场模型的高程处理方法,用该方法处理了某市8800 km2范围内的15个水准高程数据,并与传统方法进行了比较分析,同时进行了重力场模型的地区匹配试验。试验发现,该方法适用于比高较大、测区范围广,且水准点数目少、分布情况不好的山区。

关键词： DEM 重力场模型移去-恢复

Efficient full-path optical calculation of scalar and vector diffraction using the Bluestein method

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Light(Science & Applications) 2020年第1期9卷 872-882页

作者： Yanlei Hu zhongyu Wang Xuewen Wang Shengyun Ji Chenchu Zhang Jiawen Li Wulin Zhu Dong Wu Jiaru Chu CAS Key Laboratory of Mechanical Behavior and Design of materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230026China Department of Mechanical Engineering and Department of Civil and Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA State Key Laboratory of Advanced Technology for materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Institute of Industry and Equipment Technology Hefei University of TechnologyHefei 230009China

Efficient calculation of the light diffraction in free space is of great significance for tracing electromagnetic field propagation and predicting the performance of optical systems such as microscopy,photolithography,and ***,existing calculation methods suffer from low computational efficiency and poor ***,we present a fast and flexible calculation method for computing scalar and vector diffraction in the corresponding optical regimes using the Bluestein *** computation time can be substantially reduced to the sub-second level,which is 105 faster than that achieved by the direct integration approach(~hours level)and 102 faster than that achieved by the fast Fourier transform method(~minutes level).The high efficiency facilitates the ultrafast evaluation of light propagation in diverse optical ***,the region of interest and the sampling numbers can be arbitrarily chosen,endowing the proposed method with superior *** on these results,full-path calculation of a complex optical system is readily demonstrated and verified by experimental results,laying a foundation for real-time light field analysis for realistic optical implementation such as imaging,laser processing,and optical manipulation.

关键词： calculation scalar faster

Reply to Comments on “Efficient full-path optical calculation of scalar and vector diffraction using the Bluestein method”

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Light(Science & Applications) 2021年第1期10卷 3-4页

作者： Yanlei Hu zhongyu Wang Xuewen Wang Shengyun Ji Chenchu Zhang Jiawen Li Wulin Zhu Dong Wu Jiaru Chu CAS Key Laboratory of Mechanical Behavior and Design of materials Key Laboratory of Precision Scientific Instrum entation of Anhui Higher Education InstitutesDepartm ent of Precision Machinery and Precision InstrumentationUniversity of Science and Techno logy of China230026 HefeiChina Departm ent of Mechanical Engineering and Departm ent of Civil and Environm ental Engineering Massachusetts Institute of TechnologyCam bridgeMA 02139USA State Key Laboratory of Advanced Technology for materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of Technology430070 WuhanChina Institute of Industry and Equipment Technology Hefei Uniersity of Technology230009 HefeiChina

Dear Editor,In *** present an efficient full-path optical calculation by using the Bluestein method.A real optical apparatus for laser processing,imaging,or optical tweezing normally involves diverse optical lenses with different physical and numerical apertures(NA).In such applications,the optical path is usually tortuous and *** assist in the design,evaluation,and alignment of optical instruments,it is advantageous to retrieve the optical field in an arbitrary position along the entire optical path,which is termed the full-path calculation in our paper,with sufficient accuracy and *** particular,high flexibility is required to accommodate the mismatch between optical apertures of different components in the optical *** present a fullpath optical calculation method by adopting the Bluestein method to address this realistic demand.

关键词： optical calculation method

LncRNA ZFAS1 regulates cardiomyocyte differentiation of human embryonic stem cells

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BIOCELL 2023年第6期47卷 1407-1416页

作者： YANG CAO YINING LIU YANG YU XIAOFEI GUO XIUXIU WANG WENYA ma HANJING LI zhongyu REN XINLU GAO SIJIA LI HAOYU JI HONGYANG CHEN HONG YAN YANAN TIAN XIN WANG BENZHI CAI Department of Pharmacy The Second Affiliated Hospital of Harbin Medical University(Institute of Clinical PharmacyThe University Key Laboratory of Drug ResearchHeilongjiang Higher Education Institutions)Harbin150086China Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Medicine ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during *** non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation ***,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully ***,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from ***:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was *** expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in ***:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and *** of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating *** terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene *** of ZFAS1 could increase the mRNA expression level of ***,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte ***:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent.

关键词： Long non-coding RNAs Cardiomyocyte differentiation ZFAS1 ZNFX1

Dynamics of passive and active rods in external flows:Fluid particle dynamics simulations

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Dynamics of passive and active rods in external flows:Fluid ...