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Real-world effectiveness and safety of goserelin 1..8-mg depot in Chinese patients with localized or locally advanced prostate cancer

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Cancer Biology & Medicine 2023年第12期20卷 1047-1059页

作者： Nanhui Chen Zengjun Wang Ming Chen Qi ma Yi He Yujie Wang Xin Li Mingxing Qiu Lei {1. Shaoxing Zhu Qun Xie Xiuheng Liu Benkang {1. Guowen Lin Weizhong Yang Yongbin Liao Haibin Zhang Shusheng Wang Jiexian Li Shaogang Wang Lijun Dong Hui Chen Jiaju Lu YongyiCheng Xiaoping Zhang Lulin ma Liqun Zhou He Wang Shen Li Dingwei ye Department of Urology Meizhou People’s HospitalMeizhou 514089China Department of Urology Jiangsu Province HospitalNanjing 210029China Department of Urology Zhongda Hospital Southeast UniversityNanjing 210009China Translational Research Laboratory for Urology Ningbo First HospitalNingbo 315016China Department of Urology First Affiliated Hospital of JiaxingJiaxing 314050China Department of Urology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830091China Department of Urology Baotou Cancer HospitalBaotou 014016China Department of Urology The People’s Hospital of Sichuan ProvinceChengdu 610032China Department of Urology Yantai Yuhuangding HospitalYantai 264008China Department of Urology Cancer Hospital of The University of Chinese Academy of SciencesHangzhou 310022China Department of Urology Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China Department of Urology Tongji HospitalTongji Medical CollegeHUSTWuhan 430032China Department of Urology Qilu Hospital of Shandong UniversityJinan 250012China Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Urology Huizhou Third People’s HospitalHuizhou 516002China Department of Urology Jiangmen Central HospitalJiangmen 529030China Department of Urology Foshan First People’s HospitalFoshan 528041China Department of Urology Guangzhou Province Traditional Chinese Medical HospitalGuangzhou 510120China Department of Urology Guangzhou Panyu Central HospitalGuangzhou 511489China Department of Urology Renmin Hospital of Wuhan UniversityWuhan 430064China Department of Urology Hebei Petro China Central Hospital(China National Petroleum Corporation Central Hospital)Langfang 065099China Department of Urology Harbin Medical University Cancer HospitalHarbin 150086China Department of Urology Shandong Provincial HospitalJinan 250014China Department of Urology Shaanxi Provincial People’s HospitalXi’an 710021China Department of Urology Union Hospital Tongji Medical

Objective:Real-word data on long-acting luteinizing hormone-releasing hormone(LHRH)agonists in Chinese patients with prostate cancer are *** study aimed to determine the real-world effectiveness and safety of the LHRH agonist,goserelin,particularly the long-acting 1..8-mg depot formulation,and the follow-up patterns among Chinese prostate cancer ***:This was a multicenter,prospective,observational study in hormone treatment-na?ve patients with localized or locally advanced prostate cancer who were prescribed goserelin 1..8-mg depot every 1. weeks or 3.6-mg depot every 4 weeks with or without an *** patients had follow-up evaluations for 26 *** primary outcome was the effectiveness of goserelin in reducing serum testosterone and prostate-specific antigen(PSA)*** secondary outcomes included testosterone and PSA levels,attainment of chemical castration(serum testosterone1. and December {1.,a total of 294 eligible patients received≥1.dose of goserelin;287 patients(97.6%)were treated with goserelin 1..8-mg *** week 24±2,the changes from baseline[standard deviation(95%confidence interval)]in serum testosterone(n=99)and PSA(n=1.1.were-401.0 ng/d L[308.4 ng/d L(-462.5,-339.5 ng/d L)]and-35.4 ng/m L[1.4.4 ng/m L(-53.5,-1..4 ng/m L)],*** 1.2 evaluable patients,1.0(90.2%)achieved a serum testosterone level1.and 1..2%of patients,*** mean testing frequency(standard deviation)was 1.6(1.5)for testosterone and 2.{1.6)for ***:Goserelin 1..8-mg depot effectively achieved and maintained castration and was well-tolerated in Chinese patients with localized and locally advanced prostate cancer.

关键词： Goserelin hormone-sensitive luteinizing hormone-releasing hormone prostate cancer china real-world

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A Single-Component Supramolecular Organic Framework with Efficient Ultralong Phosphorescence

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CCS Chemistry 2021年第11期3卷 466-472页

作者： Lulu Song Xiao Wang Meng Zhang Wenyong Jia Qian Wang Wenpeng ye He Wang Anqi Lv Huili ma Long Gu Huifang {1. Zhongfu An Wei Huang Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)Nanjing 211816 Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical UniversityXi’an 710072

Supramolecular organic frameworks(SOFs),due to the atomically precise integration of the repeated building units,exhibit intriguing properties and consequently potential applications in chemical and materials science ***,it remains a great challenge to achieve SOFs with ultralong organic phosphorescence(UOP)in a singlecomponent ***,we report metal-free organic compound 9,9′-(6-(2-bromophenethoxy)-1.3,5-triazine-2,4-diyl)bis(9H-carbazole)(DCzPO)with UOP *** to the combination of multiple supramolecular interactions,DCzPO formed a SOF structure with regular hexagonal holes,which shows an ultralong emission lifetime of 398 ms and a phosphorescence efficiency of 3%.So far as we know,among the reported luminescent SOFs,this one is the most highly *** single-component SOF with ultralong phosphorescence will provide a new platform to rationally combine UOP and porous materials.

关键词： ultralong organic phosphorescence noncovalent interactions solid-state structure Haggregation πinteraction

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Implantation-decay method to study the β-delayed charged particle decay

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Nuclear Science and Techniques 2018年第7期29卷 145-151页

作者： Yu-Ting Wang De-Qing Fang Xin-Xing Xu Li-Jie Sun Kang Wang Peng-Fei Bao Zhen Bai Xi-Guang Cao Zhi-Tao Dai Bing Ding Wan-Bing He Mei-Rong Huang shi-Lun Jin Cheng-Jian Lin Ming Lu Long-Xiang Liu Yong Li Peng {1. Jun-Bing {1. Jian-Song Wang shi-Tao Wang Shao-Qiang ye Yan-Yun Yang Cheng-Long Zhou Ming-Hui Zhao Huan-Qiao Zhang Yu-Gang {1. Wen-Qing Shen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China university of the Chinese Academy of Sciences Beijing 100049China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201203China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

In this paper,the implantation-decay method is introduced to study the β-delayed charged particle decay.A silicon detector array was used for the implantation of the incident beams and for the detection of the emitted *** experimental measurement on the β-delayed particle emission from ^(22)Al was used to demonstrate the *** half-life value,charged particle spectroscopy,γ ray spectrum,and γ particle coincidence for the decay process were obtained and compared with previous experimental results for ^(22)*** results show that the implantation-decay method,using a silicon detector array,is a suitable experimental method to study the β-delayed charged particle decay for proton-rich nuclei.

关键词：腐烂粒子培植学习试验性光谱学半衰期原子核

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Identification and validation of novel loci associated with wheat quality through a genome-wide association study

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Journal of Integrative Agriculture 2022年第11期21卷 3131-3147页

作者： PU Zhi-en ye Xue-ling LI Yang shi Bing-xin GUO Zhu DAI Shou-fen {1. Jian LIU Ze-hou JIANG Yun-feng LI Wei JIANG Qian-tao CHEN Guo-yue WEI Yu-ming ZHENG You-liang College of Agronomy Sichuan Agricultural UniversityChengdu 611130P.R.China Triticeae Research Institute Sichuan Agricultural UniversityWenjiang 611130P.R.China Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural Affairs/College of Food and Biological EngineeringChengdu UniversityChengdu 610106P.R.China Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066P.R.China

Understanding the genetic basis of quality-related traits contributes to the improvement of grain protein concentration(GPC),grain starch concentration(GSC),and wet gluten concentration(WGC)in *** this study,a genome-wide association study(GWAS)based on a mixed linear model(MLM)was performed on 236 wheat accessions,including 1.0 cultivars and 76 landraces,using a 55K single nucleotide polymorphism(SNP)array in multiple environments.A total of 1. stable QTL/SNPs that control different quality traits in this populations in at least two environments under stripe rust stress were *** these 1.,three,seven and two QTLs associated with GPC,GSC and WGC were characterized,respectively,and they were located on chromosomes(chr)1.,1.,2A,2B,2D,3B,3D,5D,and 7D with the phenotypic variation explained(PVE)ranging from 4.2 to 1..7%.Compared with the previously reported QTLs/genes,five QTLs(***-1.L,***-1.S,***-2DL.1.***-2DL.2,and ***-5DL)were potentially *** markers for the SNPs AX-1.8770574 and AX-1.8791.20 on chr5D associated with wet gluten concentration were successfully *** phenotypes of the cultivars containing the A-allele in AX-1.8770574and the T-allele in AX-1.8791.20 were extremely significantly(P1.higher than those of the landraces containing the G-or C-allele with respect to the wet gluten concentration in each of the *** KASP markers developed and validated in this study could be utilized in molecular breeding aimed at improving the quality of wheat.

关键词： cultivars landraces grain protein concentration(GPC) grain starch concentration(GSC) wet gluten concentration(WGC) 55K SNP validation

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ADAM9 decreases in castration resistant prostate cancer and is a prognostic factor for overall survival

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Chinese Medical Journal 2012年第21期125卷 3800-3805页

作者： LIN Guo-wen YAO Xu-dong ye Ding-wei ZHANG shi-lin DAI Bo ZHANG Hai-liang {1. Chun-guang Department of Urology Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Oncology Shanghai Medical College of Fudan UniversityShanghai 200032China

Background A disintegrin and metalloprotease 9 （ADAM9） is a membrane-anchored enzyme which is considered to be involved in some diseases including tumor. However, the role of ADAM9 in castration resistant prostate cancer （CRPC） is not clear. This study aimed to explore the different expressions on protein and messenger RNA （mRNA） level of ADAM9 between hormonal sensitive prostate cancer （HSPC） and CRPC tissue, and find the correlation with prognosis.

关键词： A disintegrin and metalloprotease 9," castration resistant prostate cancer," immunohistochemistry,qR T-PCR prognostic factor

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Application of global variance reduction method to calculate a high-resolution fast neutron flux distribution for TMSR-SF1

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Nuclear Science and Techniques 2019年第8期30卷 66-76页

作者： Pu Yang ye Dai Yang Zou Rui Yan Bo Zhou shi-He Yu Yu-Wen {1. Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China university of Chinese Academy of Sciences Beijing 100049China

The solid fuel thorium molten salt reactor(TMSR-SF1. is a 1.-MWth fluoride-cooled pebble bed reactor. As a new reactor concept, one of the major limiting factors to reactor lifetime is radiation-induced material damage. The fast neutron flux(E > 0.1.MeV) can be used to assess possible radiation damage. Hence, a method for calculating high-resolution fast neutron flux distribution of the full-scale TMSR-SF1.reactor is required. In this study,a two-step subsection approach based on MCNP5 involving a global variance reduction method, referred to as forward-weighted consistent adjoint-driven importance sampling, was implemented to provide fast neutron flux distribution throughout the TMSR-SF1.facility. In addition,instead of using the general source specification cards, the user-provided SOURCE subroutine in MCNP5 source code was employed to implement a source biasing technique specialized for TMSR-SF1. In contrast to the one-step analog approach, the two-step subsection approach eliminates zero-scored mesh tally cells and obtains tally results with extremely uniform and low relative ***, the maximum fast neutron fluxes of the main components in TMSR-SF1.are provided, which can be used for radiation damage assessment of the structural materials.

关键词： TMSR-SF1 Fast neutron flux Globalvariance reduction MCNP

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mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism

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Journal of Genetics and Genomics 2022年第2期49卷 145-154页

作者： Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan shi Weichang Chen ye Tian Xiangdong Liu Xiong {1. Zhongsheng Sun Key Laboratory of Developmental Genes and Human Diseases Institute of Life SciencesSoutheast University2 Sipailou RoadNanjingJiangsu 210096China Beijing Institutes of Life Science Chinese Academy of SciencesNo.1 West Beichen RoadChaoyang DistrictBeijing 100101China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Afﬁliated Renji Hospital145 Shandong Middle RoadShanghai 200001China Department of Laboratory Medicine The Third People’s Hospital of Zhenjiang300 DaijiamenZhenjiangJiangsu 212021China Department of Laboratory Medicine The Fifth People’s Hospital of Wuxi1215 Guangrui RoadWuxiJiangsu 214000China Department of Hepatology The Fifth People’s Hospital of SuzhouSoochow University10 Guangqian RoadSuzhouJiangsu 215131China Department of Rheumatology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology Jiangsu University Afﬁliated Kunshan Hospital91 Qianjin West RoadKunshanJiangsu 215300China Department of Gastroenterology Yixing People’s Hospital75 Tongzhenguan RoadYixinJiangsu 214200China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery Hospital700 Moyu North RoadShanghai 201800China Department of Hepatology The Third People’s Hospital of Changzhou300 Lanling North RoadChangzhouJiangsu 213001China Department of Infectious Diseases First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Radiology Second Afﬁliated Hospital of Soochow University1055 Sanxiang RoadSuzhouJiangsu 215004China Institute of Genomic Medicine Wenzhou Medical UniversityUniversity TownChashanWenzhouZhejiang 325035China

Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers.

关键词： Primary biliary cholangitis de novo mutations Whole exome sequencing Transcriptional networks Co-expression

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Concurrent chemoradiotherapy combined with enteral nutrition support:a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant istulae

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Chinese Journal of Cancer 2017年第1期36卷 26-33页

作者： Li ma Guang-Yu Luo Yu-Feng Ren Bo Qiu Hong Yang Chun-Xia Xie Song-Ran Liu {1.-Liang Liu Zhao-Lin Chen Qun Li Jian-Hua Fu Meng-Zhong Liu Yong-Hong Hu Wen-Feng ye Hui Liu Sun Yat-sen university Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Guangdong Esophageal Cancer Research Institute Department of Radiation Oncology Sun Yat-sen University Cancer Center Department of Endoscopy Sun Yat-sen University Cancer Center Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-sen University Department of Thoracic Surgery Sun Yat-sen University Cancer Center Department of Clinical Nutrition Sun Yat-sen University Cancer Center

Background: Concurrent chemoradiotherapy(CCRT) significantly increases the survival rate of esophageal squa?mous cell carcinoma(ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long?term ***: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat?sen university Cancer Center between January 2.1. and December 2.1.. Treatment outcome and toxicity were ret?rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening(NRS) before, during, and after treatment. Twenty?two patients received a nasogastric tube, and 1. underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 21.6 kcal/day. Treatment response was evaluated at 3 months after the completion of ***: With a median follow?up of 1. months(range, 3–39 months), patients' 1.year overall survival(OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score(P n NRS score(P se to treatment(P 1. were sig= 0.003), increase i= 0.024), fistula closure(P = 0.01.), and responnifi?cantly associated with OS. Multivariate analysis showed that tumor response(P = 0.044) and increase in NRS score(P = 0.044) were independent predictors of OS. Grade 3 vomiting was observed in 8 patients(20.0%), grade 3 neutro?penia was observed in 1. patients(27.5%), and grade 3 cough was observed in 1. patients(32.5%); 2 patients(5.0%) died of massive bleeding during ***: CCRT combined with enteral nutrition support is effective for ESCC patients with malignant fistulae. Patients have an increased potential to be

关键词： Esophageal squamous cell carcinoma malignant istula Radiotherapy Concurrent chemotherapy Enteral nutrition support

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Collective structures and band terminations in odd-odd 1.2Ⅰ

Collective structures and band terminations in odd-odd 122Ⅰ

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第十四届全国核物理大会暨第十届会员代表大会

作者： Liu Gong-ye, Li Li, Li Xian-feng, ma Ying-jun, Zhao Yan-xin, Yang Dong, Li Cong-bo, Wang ye-wei, ma Ke-yan, Yang Yan-ji, shi Hong Department of Physics, Jilin university, Changchun 1.0021.Zhu Li-hua, Wu Xiao-guag, He Chuang-ye, Wang Lie-lin, Zheng Yun, Hao Xin, Li Guang-sheng china Institute of Atomic Energy, Box 275-1., Bejing 1.2.1.

Nuclei in the mass A20 region are predicted [1.2] to be very soft against deformation and hence significant variations of deformations and shapes with the configuration of the valence quasiparticles can be expected in... 详细信息

关键词： band structures shape coexistence odd-odd nuclues band terminations

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Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson’s disease

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Neural Regeneration Research 2023年第5期18卷 1107-1117页

作者： Chuan-Xi Tang Jing Chen Kai-Quan Shao ye-Hao Liu Xiao-Yu Zhou Cheng-Cheng ma Meng-Ting Liu Ming-Yu {1. Piniel Alphayo Kambey Wei Wang Abiola Abdulrahman Ayanlaja Yi-Fang Liu Wei Xu Gang Chen Jiao Wu Xue Li Dian-Shuai Gao Department of Neurobiology Xuzhou Key Laboratory of NeurobiologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Experinental Teaching Center of Morphology Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Affiliated Suqian Hospital of Xuzhou Medical UniversitySuqianJiangsu ProvinceChina Department of Rehabilitation Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Medicine Jiangnan UniversityWuxiJiangsu ProvinceChina Department of Nursing Care the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Studies have found that the absence of glial cell line-derived neurotrophic factor may be the primary risk factor for Parkinson’s disease. However, there have not been any studies conducted on the potential relationship between glial cell line-derived neurotrophic factor and cognitive performance in Parkinson’s disease. We first performed a retrospective case-control study at the Affiliated Hospital of Xuzhou Medical university between September 2.1. and January 2020 and found that a decreased serum level of glial cell line-derived neurotrophic factor was a risk factor for cognitive disorders in patients with Parkinson’s disease. We then established a mouse model of Parkinson’s disease induced by 1.methyl-4-phenyl-1.2,3,6-tetrahydropyridine and analyzed the potential relationships among glial cell line-derived neurotrophic factor in the prefrontal cortex, dopamine transmission, and cognitive function. Our results showed that decreased glial cell line-derived neurotrophic factor in the prefrontal cortex weakened dopamine release and transmission by upregulating the presynaptic membrane expression of the dopamine transporter, which led to the loss and primitivization of dendritic spines of pyramidal neurons and cognitive impairment. In addition, magnetic resonance imaging data showed that the long-term lack of glial cell line-derived neurotrophic factor reduced the connectivity between the prefrontal cortex and other brain regions, and exogenous glial cell line-derived neurotrophic factor significantly improved this connectivity. These findings suggested that decreased glial cell line-derived neurotrophic factor in the prefrontal cortex leads to neuroplastic degeneration at the level of synaptic connections and circuits, which results in cognitive impairment in patients with Parkinson’s disease.

关键词： cognitive impairment degree centrality dendritic spine dopamine transmission dopamine transporter glial cell line-derived neurotrophic factor Parkinson’s disease prefrontal cortex synaptic plasticity

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