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Relationship between Two Blood Stasis Syndromes and Inflammatory Factors in Patients with Acute Coronary Syndrome

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Chinese Journal of Integrative Medicine 2017年第11期23卷 845-849页

作者： ma Cai-yun LIU Jing-hua LIU Jian-xun shi Da-zhuo XU Zhen-{2. WANG Shao-ping JIA Min ZHAO FU-hai JIANG YUE-rong ma Qin PENG Hong-yu LU Yuan ZHENG Ze REN Feng-xue Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing(100029)China Institute of Basic Medical Sciences Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Cardiology Aviation General HospitalBeijing(100016)China

Objective： To investigate the relationship between inflammatory factors and two Chinese medicine（CM） syndrome types of qi stagnation and blood stasis（QSBS） and qi deficiency and blood stasis（QDBS） in patients with acute coronary syndrome（ACS）. Methods： Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2.groups： 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1（ICAM-1）, chitinase-3-like protein 1（YKL-40） and lipoprotein-associated phospholipase A2.Lp-PLA2.. Results： Compared with the QSBS group, Lp-PLA2.and YKL-40 levels in the QDBS group showed no-significant difference（P〉0.05）; ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS（P〈0.05）. Conclusion： Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.

关键词： coronary heart disease Chinese medicine qi deficiency and blood stasis syndrome qi stagnation and blood stasis syndrome inflammation intracellular adhesion molecule-1 chitinase-3-like protein 1 lipoprotein-associated phospholipase A2

Rechargeable Aqueous Zinc-Ion Batteries in MgSO4/ZnSO4 Hybrid Electrolytes

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Nano-Micro Letters 2020年第5期12卷 33-48页

作者： Yingmeng Zhang Henan Li Shaozhuan Huang Shuang Fan Lingna Sun Bingbing Tian Fuming Chen ye Wang Yumeng shi Hui Ying Yang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongPeople’s Republic of China International Collaborative Laboratory of 2. materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060People’s Republic of China Engineering Technology Research Center for 2. material Information Function Devices and Systems of Guangdong Province ShenzhenPeople’s Republic of China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060People’s Republic of China Pillar of Engineering Product Development Singapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore School of Physics and Telecommunication Engineering South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of material Physics of Ministry of Education School of Physics and EngineeringZhengzhou UniversityZhengzhou 450052People’s Republic of China

MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2.5·nH2.//ZnSO4//*** with different concentration ratios of ZnSO4 and MgSO4 are *** batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mah g^-1 at a current density of 100 ma g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mah g^-1 at 5 A g^-*** study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.

关键词： Aqueous zinc-ion batteries Hybrid electrolytes Electrolyte additives magnesium ions Vanadates

青海地区成年藏族活动性肺结核患者与汉族活动性肺结核患者肠道菌群差异研究

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临床肺科杂志 2024年第9期29卷 1315-1320页

作者：王玉清姚杰王玲马晓磊冶赓祉程国栋史发鹏郑立恒青海省第四人民医院青海西宁810007 青海大学医学院青海西宁810001 首都医科大学附属北京胸科医院检验科北京101149

目的分析青海地区成年藏族活动性肺结核患者与汉族活动性肺结核患者肠道菌群特点。方法选取2.2.年12.至2.2.年6月在青海省第四人民医院诊断为活动性肺结核的患者12.,其中藏族8例,汉族4例。本研究采用16S rDNA测序技术,对两组研究对... 详细信息

目的分析青海地区成年藏族活动性肺结核患者与汉族活动性肺结核患者肠道菌群特点。方法选取2.2.年12.至2.2.年6月在青海省第四人民医院诊断为活动性肺结核的患者12.,其中藏族8例,汉族4例。本研究采用16S rDNA测序技术,对两组研究对象的粪便样本进行16S rDNA测序,分析不同种群的肠道微生物群落结构及差异。使用线性判别分析(Linear Discriminant Analysis Effect Size, LefSe)探索特定菌群是否可以作为区分藏族与汉族肺结核患者的差异菌。结果 (1)α多样性分析结果表明,藏族与汉族肺结核患者的肠道菌群物种丰富度(Chao1指数,ACE指数)和多样性(Shannon指数,Simpson指数)差异无统计学意义(P>0.05);β多样性分析显示,藏族与汉族肺结核患者肠道菌群的多样性差异无统计学意义(P>0.05)。(2.未发现有差异菌门,但存在一定的属之间的差别。藏族与汉族肺结核患者在属级别中相比,粪芽孢菌属(1.031%vs 0.061%,P=0.003)、帕拉普氏菌属(0.175%vs 0.009%,P=0.011)、优杆菌属(0.2.8%vs 0.011%,P=0.004)、链型杆菌属(2.668%vs 0.007%,P=0.007)、霍尔德曼氏菌属(1.2.9%vs 0.011%,P=0.016)、芽殖菌属(0.511%vs 0.078%,P=0.035)、厌氧菌属(0.381%vs 0.008%,P=0.038)、多尔氏菌属(1.017%vs 0.305,P=0.046)和斯莱克氏菌属(0.100%vs 0,P=0.044)等菌属相对丰度的差异有统计学意义。(3)LefSe显示,肠道菌群在藏族肺结核患者组中富集的为优杆菌属、梭状芽孢杆菌属和厚壁菌门等,而肠道菌群在汉族肺结核患者组中富集的菌为双歧杆菌目、双歧杆菌属和双歧杆菌科等。结论青海地区成年藏族与汉族肺结核患者的菌群多样性与丰富度可能无差异,但菌群组成及优势菌群可能存在差异性。

关键词： 16S rDNA基因测序汉族藏族肠道菌群肺结核

老年代谢相关脂肪性肝病与结直肠腺瘤的相关性研究

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老年医学与保健 2024年第4期30卷 915-919页

作者：马一鸣王姣锋施佳恒叶丹王静姜静文徐菁恽胡晓娜复旦大学附属华东医院全科医学科上海200040 上海市老年医学临床重点实验室上海200040 复旦大学附属华东医院消化内科上海200040

目的探讨老年人群代谢相关脂肪性肝病(maFLD)、肝纤维化程度与结直肠腺瘤(CRA)的相关性。方法回顾性分析2.2.年6月—2.2.1}月于复旦大学附属华东医院接受腹部超声和电子结肠镜检查的老年患者1583例,其中男性772.、女性811例,CRA组78... 详细信息

目的探讨老年人群代谢相关脂肪性肝病(maFLD)、肝纤维化程度与结直肠腺瘤(CRA)的相关性。方法回顾性分析2.2.年6月—2.2.1}月于复旦大学附属华东医院接受腹部超声和电子结肠镜检查的老年患者1583例,其中男性772.、女性811例,CRA组786例、对照组797例。收集患者的一般资料、血液生化指标和腹部超声结果,二元多因素Logistic回归分析CRA的危险因素,探讨肝纤维化程度与CRA发生风险的相关性。结果CRA患者maFLD患病率高于非CRA者(62.98%vs 52.2.%)。二元多因素Logistic回归分析显示,男性、增龄和maFLD是CRA发生的危险因素(P2.0是CRA发生的独立危险因素(PmaFLD比例较高,随着肝纤维化程度加重,CRA患病风险可能增加。

关键词：老年代谢相关脂肪性肝病结直肠腺瘤肝纤维化

Real-world effectiveness and safety of goserelin 10.8-mg depot in Chinese patients with localized or locally advanced prostate cancer

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Cancer Biology & Medicine 2023年第12期20卷 1047-1059页

作者： Nanhui Chen Zengjun Wang Ming Chen Qi ma Yi He Yujie Wang Xin Li Mingxing Qiu Lei shi Shaoxing Zhu Qun Xie Xiuheng Liu Benkang shi Guowen Lin Weizhong Yang Yongbin Liao Haibin Zhang Shusheng Wang Jiexian Li Shaogang Wang Lijun Dong Hui Chen Jiaju Lu YongyiCheng Xiaoping Zhang Lulin ma Liqun Zhou He Wang Shen Li Dingwei ye Department of Urology Meizhou People’s HospitalMeizhou 514089China Department of Urology Jiangsu Province HospitalNanjing 210029China Department of Urology Zhongda Hospital Southeast UniversityNanjing 210009China Translational Research Laboratory for Urology Ningbo First HospitalNingbo 315016China Department of Urology First Affiliated Hospital of JiaxingJiaxing 314050China Department of Urology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830091China Department of Urology Baotou Cancer HospitalBaotou 014016China Department of Urology The People’s Hospital of Sichuan ProvinceChengdu 610032China Department of Urology Yantai Yuhuangding HospitalYantai 264008China Department of Urology Cancer Hospital of The University of Chinese Academy of SciencesHangzhou 310022China Department of Urology Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China Department of Urology Tongji HospitalTongji Medical CollegeHUSTWuhan 430032China Department of Urology Qilu Hospital of Shandong UniversityJinan 250012China Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Urology Huizhou Third People’s HospitalHuizhou 516002China Department of Urology Jiangmen Central HospitalJiangmen 529030China Department of Urology Foshan First People’s HospitalFoshan 528041China Department of Urology Guangzhou Province Traditional Chinese Medical HospitalGuangzhou 510120China Department of Urology Guangzhou Panyu Central HospitalGuangzhou 511489China Department of Urology Renmin Hospital of Wuhan UniversityWuhan 430064China Department of Urology Hebei Petro China Central Hospital(China National Petroleum Corporation Central Hospital)Langfang 065099China Department of Urology Harbin Medical University Cancer HospitalHarbin 150086China Department of Urology Shandong Provincial HospitalJinan 250014China Department of Urology Shaanxi Provincial People’s HospitalXi’an 710021China Department of Urology Union Hospital Tongji Medical

Objective:Real-word data on long-acting luteinizing hormone-releasing hormone(LHRH)agonists in Chinese patients with prostate cancer are *** study aimed to determine the real-world effectiveness and safety of the LHRH agonist,goserelin,particularly the long-acting 10.8-mg depot formulation,and the follow-up patterns among Chinese prostate cancer ***:This was a multicenter,prospective,observational study in hormone treatment-na?ve patients with localized or locally advanced prostate cancer who were prescribed goserelin 10.8-mg depot every 12.weeks or 3.6-mg depot every 4 weeks with or without an *** patients had follow-up evaluations for 2. *** primary outcome was the effectiveness of goserelin in reducing serum testosterone and prostate-specific antigen(PSA)*** secondary outcomes included testosterone and PSA levels,attainment of chemical castration(serum testosterone2.1. and December 2.1.,a total of 2.4 eligible patients received≥1 dose of goserelin;2.7 patients(97.6%)were treated with goserelin 10.8-mg *** week 2.±2.the changes from baseline[standard deviation(95%confidence interval)]in serum testosterone(n=99)and PSA(n=131)were-401.0 ng/d L[308.4 ng/d L(-462.5,-339.5 ng/d L)]and-35.4 ng/m L[104.4 ng/m L(-53.5,-17.4 ng/m L)],*** 112.evaluable patients,100(90.2.)achieved a serum testosterone level1%and 10.2.of patients,*** mean testing frequency(standard deviation)was 1.6(1.5)for testosterone and 2.2.1.6)for ***:Goserelin 10.8-mg depot effectively achieved and maintained castration and was well-tolerated in Chinese patients with localized and locally advanced prostate cancer.

关键词： Goserelin hormone-sensitive luteinizing hormone-releasing hormone prostate cancer china real-world

High thermal stability of diamond-cBN-B_4C-Si composites

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Chinese Physics B 2017年第1期26卷 521-525页

作者： Hong-Sheng Jia Pin-Wen Zhu Hao ye Bin Zuo Yuan-Long E shi-Chong Xu Ji Li Hai-Bo Li Xiao-Peng Jia Hong-An {2. Key Laboratory of Functional materials Physics and Chemistry of the Ministry of Education Jilin Normal University Siping 136000 China State Key Laboratory of Superhard materials Jilin University Changchun 130012 China

Improving the thermal stability of diamond and other superhard materials has great significance in various applications. Here, we report the synthesis and characterization of bulk diamond–cBN–B4C–Si composites sintered at high pressure and high temperature（HPHT, 5.2.GPa, 162.–1680 K for 3–5 min）. The results show that the diamond, cBN, B4C,BxSiC, SiO2.and amorphous carbon or a little surplus Si are present in the sintered samples. The onset oxidation temperature of 1673 K in the as-synthesized sample is much higher than that of diamond, cBN, and B4C. The high thermal stability is ascribed to the covalent bonds of B–C, C–N, and the solid-solution of BxSiC formed during the sintering process. The results obtained in this work may be useful in preparing superhard materials with high thermal stability.

关键词： high pressure and high temperature diamond–cBN–B4C–Si composites high thermal stability

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论叶燮《原诗》中对沈约人品、诗品的评价

湖北职业技术学院学报 2024年第3期27卷 53-57,106页

作者：马斌山西师范大学文学院山西太原030031

叶燮在《原诗》中批评沈约心胸狭窄,“闻人一善,如万箭攒心”,又对其诗歌极力贬低,“几无一首一语可取”,这样的“英雄欺人之语”过于片面。考察“万箭攒心”之说,最早来源于唐人李冗的《独异志》,其书专记神仙鬼怪,逸闻稗史,实不足信... 详细信息

叶燮在《原诗》中批评沈约心胸狭窄,“闻人一善,如万箭攒心”,又对其诗歌极力贬低,“几无一首一语可取”,这样的“英雄欺人之语”过于片面。考察“万箭攒心”之说,最早来源于唐人李冗的《独异志》,其书专记神仙鬼怪,逸闻稗史,实不足信。至于沈约的诗品,也绝非叶燮所言,历代诗论家多有客观评价,且沈约提出的“四声八病”之说,为近体诗的形成奠定了基础。可见叶燮对于沈约的评价,是有待商榷的。

关键词：叶燮《原诗》沈约

Acrylamide neurotoxicity on the cerebrum of weaning rats

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Neural Regeneration Research 2015年第6期10卷 938-943页

作者： Su-min Tian Yu-xin ma Jing shi Ting-{2. Lou Shuai-shuai Liu Guo-ying Li School of Basic Medicine Guangdong Pharmaceutical University Xiqiao People’s Hospital Clinical Laboratory of First Affiliated Hospital Xinxiang Medical University Guangzhou university of Chinese Medicine

The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated. To explore the neurotoxic effect of acrylamide on the developing brain, weaning rats were gavaged with 0, 5, 15, and 30 mg/kg acrylamide for 4 consecutive weeks. No obvious neurotoxicity was observed in weaning rats in the low-dose acrylamide group （5 mg/kg）. However, rats from the moderateand high-dose acrylamide groups （15 and 30 mg/kg） had an abnormal gait. Furthermore, biochemical tests in these rats demonstrated that glutamate concentration was significantly reduced, and ^-aminobutyric acid content was significantly increased and was dependent on acrylamide dose. Immunohis- tochemical staining showed that in the cerebral cortex, γ-aminobutyric acid, glutamic acid decarboxylase and glial fibrillary acidic protein expression increased remarkably in the moderate- and high-dose acrylamide groups. These results indicate that in weaning rats, acrylamide is positively associated with neurotoxicity in a dose-dependent manner, which may correlate with upregulation of γ-aminobutyric acid and subsequent neuronal degeneration after the initial acrylamide exposure.

关键词： nerve regeneration γ-aminobutyric acid glial fibrillary acidic protein glutamic aciddecarboxylase neurotoxicity weaning organ index cerebrum cortex glutamate neural regeneration

Bridge as well as a natural barrier:clinical significance of renal capsular involvement status in renal cell carcinoma

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Bridge as well as a natural barrier:clinical significance of...