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Pro-inflammatory microenvironment and systemic accumulation of CXCR3+cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3033-3044页

作者： Hong-Yi zheng Xiao-yan he Wei li Tian-zhang Song Jian-Bao Han Xiang yang Feng-liang liu Rong-hua Luo Ren-Rong Tian Xiao-li Feng Yu-hua ma Chao liu Ming-hua li Yong-Tang zheng Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of life Science University of Chinese Academy of SciencesKunmingYunnanChina Kunming national High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina national Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Bioland Laboratory(Guangzhou Regenerative Medicine and health Guangdong Laboratory) GuangzhouChina

Understanding the pathological features of severe acute respiratory syn drome coronavirus 2(SARS-CoV-2)infect io n in an animal model is crucial for the treatment of coronavirus disease 2019(COVID-19).here,we compared imnnunopathological changes in young and old rhesus macaques(RMs)before and after SARS-CoV-2 infection at the tissue *** analysis of multiplex immunofluoresce nee staining images of formali n-fixed paraffi n-embedded(FFPE)sections showed that SARS-CoV-2 infectio n specifically induced elevated levels of apoptosis,autophagy,and nuclear factor kappa-B(NF-kB)activation of angiotensirv convert!ng enzyme 2(ACE2)+cells,and increased interferon a(IFN-a)-and interleukin 6(IL-6)-secreting cells and C-X-C motif chemokine receptor 3(CXCR3)+cells in lung tissue of old *** pathological pattern,which may be related to the age-related pro-inflammatory microenvironment in both lungs and spleens,was significantly correlated with the systemic accumulation of CXCR3+cells in lungs,spleens,and peripheral ***,the ratio of CXCR3+to T-box protein expression in T cell(T-bet)+(CXCR3+/T-bet+ratio)in CD8+cells may be used as a predictor of severe *** findings uncovered the impact of aging on the immunopathology of early SARS-CoV-2 infection and demonstrated the potential application of CXCR3+cells in predicting severe COVID-19.

关键词： CXCR3 spleen lung

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magDet:基于地磁的无人机GPS欺骗检测方法

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计算机学报 2024年第4期47卷 877-891页

作者：魏晓敏李兴华孙聪张海宾马建峰西安电子科技大学网络与信息安全学院

GPS是目前最为广泛使用的基于卫星的导航和定位系统,对于无人机而言,它是一个不可或缺的组成部分,提供了关键的精确位置数据,对导航和任务的成功至关重要.然而,GPS欺骗攻击已经逐渐演变成对GPS依赖系统不断增加的威胁.目前,针对无人机的... 详细信息

GPS是目前最为广泛使用的基于卫星的导航和定位系统,对于无人机而言,它是一个不可或缺的组成部分,提供了关键的精确位置数据,对导航和任务的成功至关重要.然而,GPS欺骗攻击已经逐渐演变成对GPS依赖系统不断增加的威胁.目前,针对无人机的GPS欺骗检测方法大多基于仿真数据提出、依赖于多个无人机或者需要专用设备(例如,软件定义无线电平台和高清摄像头).本文提出一种新颖的基于地磁场的无人机GPS欺骗检测方法——mag Det(magnetic field-based Detection method),其基本思想是利用地球内部和周围金属建筑材料不均匀性引起的地磁场异常,通过真实飞行收集位置和磁场强度数据,包括正常和被攻击场景.应用各种机器学习算法来训练这些数据以选择最佳分类器,该分类器可以轻松部署在常见机载计算机中.该方法的检测率超过99.5%,平均错误率(Equal Error Rate,EER)为0.51%,优于现有检测方法.此外,评估了各种因素对mag Det的影响,以证明其鲁棒性.即使在未访问过的地点(距离6 km),准确率也高于95%,EER为0.49%.

关键词： GPS欺骗检测地磁无人机 GPS欺骗攻击机器学习

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低泡型非离子Gemini表面活性剂的合成及性能研究

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高分子学报 2024年第10期55卷 1356-1364页

作者：马杰文张之钧李雅琪胡斌邢攸美尹云舰方伟华吴振王国杰北京科技大学材料科学与工程学院北京100083 杭州格林达电子材料股份有限公司杭州310051

低泡型非离子双子(Gemini)表面活性剂在工业清洗、光刻胶显影等领域有着广泛的应用.以二叔戊基氢醌为母体在碱催化的条件下与环氧乙烷通过开环反应合成了3种(P1、P2和P3)不同聚氧乙烯链长度的非离子Gemini表面活性剂,通过表面张力仪、... 详细信息

低泡型非离子双子(Gemini)表面活性剂在工业清洗、光刻胶显影等领域有着广泛的应用.以二叔戊基氢醌为母体在碱催化的条件下与环氧乙烷通过开环反应合成了3种(P1、P2和P3)不同聚氧乙烯链长度的非离子Gemini表面活性剂,通过表面张力仪、接触角测量仪等研究了不同聚氧乙烯链长度对表面张力、润湿性能、乳化性能、泡沫性能的影响.在相同浓度下,随着聚氧乙烯链长度的增加,表面张力和接触角增加,乳化能力逐渐增强,发泡体积逐渐增加.此外,3种非离子Gemini表面活性剂均具有优异的低泡性能,表面活性剂P1发泡量低于传统表面活性剂Tween-80的1%,在工业清洗、光刻胶显影等领域中具有巨大的应用潜力.

关键词：非离子Gemini表面活性剂低泡性表面张力润湿性能乳化性能

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Higher CO_2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells

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World Journal of Gastroenterology 2009年第22期15卷 2714-2722页

作者： jun-jun ma Bo Feng Yi zhang Jian-Wen li Ai-Guo Lu Ming-liang wang Yuan-Fei Peng Wei-Guo Hu Fei yue Min-hua zheng Department of General Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Minimally Invasive Surgery Center Shanghai 200025 China Shanghai Institute of Digestive Surgery Shanghai 200025 China

AIM： To investigate the influence of CO2-insufflation pressure on adhesion, invasion and metastatic potential of colon cancer cells based on adhesion molecules expression. METHODS： With an/n vitro artificial pneumoperitoneum model, SW1116 human colon carcinoma cells were exposed to CO2-insufflation in 5 different pressure groups： 6 mmHg, 9 mmHg, 12 mmHg, 15 mmHg and control group, respectively for 1 h. Expression of E-cadherin, ICAM-I, CD44 and E-selectin was meas- ured at 0, 12, 24, 48 and 72 h after CO2-insufflation using flow cytometry. The adhesion and invasion capacity of SW1116 cells before and after exposure to CO2-insufflation was detected by cell adhesion/invasion assay in vitro. Each group of cells was injected intraperitoneally into 16 BALB/C mice. The number of visible abdominal cavity tumor nodules, visceral metas-tases and survival of the mice were recorded in each group. RESULTS： The expression of E-cadherin, ICAM-1, CD44 and E-selectin in SWl116 cells were changed significantly following exposure to CO2 insufflation at different pressures （P 〈 0.05）. The expression of E-cadherin, CD44 and ICAM-1 decreased with increasing CO2-insufflation pressure. The adhesive/ invasive cells also decreased gradually with increasing pressure as determined by the adhesion/invasion assay. In animal experiments, the number of abdominal cavity tumor nodules in the 15 mmHg group was also significantly lower than that in the 6 mmHg group （29.7± 9.91 vs 41.7±14.90, P = 0.046）. However, the survival in each group was not statistically different. CONCLUSION： CO2-insufflation induced a temporary change in the adhesion and invasion capacity of cancer cells in vitro. Higher CO2-insufflation pressure inhibited adhesion, invasion and metastatic potential in vitro and in vivo, which was associated with reduced expression of adhesion molecules.

关键词： Adhesion molecule Colorectal cancer Metastasis Pneumoperitoneum Artificial Tumor invasion

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23种常用中成药治疗失眠的临床研究证据图分析

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中国中药杂志 2024年第14期49卷 3952-3962页

作者：马永庆邢畅李巧凤徐征张金生吴承玉南京中医药大学中医学院江苏南京210023 郑州大学第五附属医院福华街院区中医康复科河南郑州450052 河南中医药大学第三附属医院脑病科河南郑州450008

运用证据图系统检索和梳理中成药治疗失眠的临床研究证据,了解该领域证据分布特点,发现中成药治疗失眠相关研究存在的问题。检索3个国家药物目录中明确提及治疗失眠的中成药,检索建库至2023年8月的中、英文文献。采用图、表展示结果。... 详细信息

运用证据图系统检索和梳理中成药治疗失眠的临床研究证据,了解该领域证据分布特点,发现中成药治疗失眠相关研究存在的问题。检索3个国家药物目录中明确提及治疗失眠的中成药,检索建库至2023年8月的中、英文文献。采用图、表展示结果。最终纳入中成药23种,相关文献299篇,包括随机对照试验(RCTs)236篇,非随机对照试验(non-RCTs)35篇,回顾性研究7篇,系统评价/Meta分析17篇,指南和专家建议或共识4篇。文献占比较大的是百乐眠胶囊、乌灵胶囊、养血清脑颗粒;结局指标包括睡眠评定量表、临床有效率、安全性指标、焦虑抑郁评分等。结果表明,中成药治疗失眠研究整体呈增长趋势,但研究证据相对较少,研究以单中心、小样本和短周期为主;临床定位宽泛,中医优势不足;结局指标对生活质量、随访及复发率方面关注度不够;RCT整体偏倚风险偏高,系统评价/Meta分析整体质量较低,回顾性研究总体评分不高,non-RCT均未提及随访时间、失访率及样本量估算,结果可信度降低。建议以中医药临床研究规范来设计治疗失眠的中成药研究方案,将中医证候积分评价作为重要结局指标,多关注患者生活质量、随访及复发情况,提高有效治疗失眠中成药的可及性和经济性,加强医保政策与中成药政策的衔接,合理提升具有明确疗效和安全证据支持的中成药在医保甲类目录中的占比。

关键词：失眠中成药干预性研究系统评价/Meta分析回顾性研究证据图经济性

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Identification and QTL mapping of Z550, a rice backcrossed inbred line with increased grains per panicle

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Journal of Integrative Agriculture 2019年第3期18卷 526-531页

作者： wang shi-ming CUI Guo-qing wang Hui ma Fu-ying XIA Sai-sai li Yun-feng yang zheng-lin liNG Ying-hua zhang Chang-wei he Guang-hua ZHAO Fang-ming Rice Research Institute Academy of Agricultural SciencesSouthwest UniversityChongqing 400715P.R.China

An elite backcrossed inbred line Z550 with increased grains per panicle was identified from advanced backcrosses between Nipponbare and Xihui 18 by simple sequence repeat(SSR) marker-assisted selection(maS). Z550 carries 13 substitution segments distributed on chromosomes 1, 6, 7, 8, 9, 10, and 12, with an average substitution length of 1.68 Mb. Compared with the Nipponbare parental line, plant height, panicle length, spikelets per panicle, grains per panicle, and grain weight for Z550 were significantly increased. While the grain width of Z550 was significantly narrower, and the seed setting ratio(81.43%) was significantly lower than that of Nipponbare, it is still sufficient for breeding purposes. Quantitative trait loci(QTLs) mapping for important agronomic traits was conducted with the F_2 population derived from Nipponbare crossed with Z550 using the restricted maximum likelihood(REML) method. A total of 16, including 12 previously unreported QTLs were detected, with contribution rates ranging from 1.46 to 10.49%. Grains per panicle was controlled by 8 QTLs, 5 of which increased number of grains whereas 3 decreased it. qGPP-1, with the largest contribution(10.49%), was estimated to increase grains per panicle by 30.67, while q GPP-9, with the minimum contribution rate(2.47%), had an effect of increasing grains per panicle by 15.79. These results will be useful for further development of single segment substitution lines with major QTLs, and for research of their molecular functions via QTL cloning.

关键词： rice backcrossed inbred line yield QTL mapping

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A detector setup for the measurement of angular distribution of heavy-ion elastic scattering with low energy on RIBLL

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Nuclear Science and Techniques 2017年第7期28卷 85-89页

作者： Gao-Long zhang Yong-Jin yao Guang-Xin zhang Zhen-Wei Jiao Cheng-Jian lin ya-Zhou Niu Wei-Wei Qu Lei yang nan-Rou ma Lei zheng Hui-Ming Jia li-Jie Sun xing-xing liu Xiao-Tong Chu Jie-Cheng yang Jian-Song wang shi-Wei Xu Peng ma jun-Bing ma shi-Lun Jin Zhen Bai Mei-Rong huang Hong-liang Zang Biao yang yang liu School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China China Institute of Atomic Energy Beijing 102413 China School of Radiation Medicine and Protection Medical College of Soochow University Soochow 215123 China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China

A detector setup for the measurement of angular distribution of heavy-ion elastic scattering at energies around Coulomb barrier on the radioactive ion beam line in Lanzhou at the heavy-ion research facility in Lanzhou is *** beam profile and the scattering angles on the target are deduced by two parallel plate avalanche counters,and four sets of detector telescopes(including doublesided silicon strip detectors) are placed systematically with the beam line,incorporating with Monte Carlo *** data of ^(16)O on ^(89)Y target were analyzed to compare with the simulation *** is found that the simulated distribution is agreeable with the experimental *** assuming the pure Rutherford scattering at small scattering angles,the angular distribution of elastic scattering of^(16)O+^(89)Y at low energies can be reasonably *** indicates that this set of detector setup can be used for the measurement of angular distributions of heavy-ion elastic scattering at energies around Coulomb barrier.

关键词：兰州放射性束流线重离子研究装置探测器望远镜角分布测量弹性散射低能量设置平行板雪崩计数器

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YGL9, encoding the putative chloroplast signal recognition particle 43 kDa protein in rice, is involved in chloroplast development

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Journal of Integrative Agriculture 2016年第5期15卷 944-953页

作者： wang Zhong-wei zhang Tian-quan xing ya-di ZENG Xiao-qin wang ling liU Zhong-xian shi jun-qiong ZHU Xiao-yan ma ling li Yun-feng liNG Ying-hua SANG Xian-chun he Guang-hua Chongqing Key Laboratory of Application and Safety Control of Genetically Modified Crops Rice Research Institute Southwest University Chongqing 400715 P.R. China

The nuclear-encoded light-harvesting chlorophyll a/b-binding proteins（LHCPs） are specifically translocated from the stroma into the thylakoid membrane through the chloroplast signal recognition particle（cp SRP） pathway. The cp SRP is composed of a cp SRP43 protein and a cp SRP54 protein, and it forms a soluble transit complex with LHCP in the chloroplast stroma. here, we identified the YGL9 gene that is predicted to encode the probable rice cp SRP43 protein from a rice yellow-green leaf mutant. A phylogenetic tree showed that an important conserved protein family, cp SRP43, is present in almost all green photosynthetic organisms such as higher plants and green algae. Sequence analysis showed that YGL9 comprises a chloroplast transit peptide, three chromodomains and four ankyrin repeats, and the chromodomains and ankyrin repeats are probably involved in protein-protein interactions. Subcellular localization showed that YGL9 is localized in the chloroplast. Expression pattern analysis indicated that YGL9 is mainly expressed in green leaf sheaths and leaves. Quantitative real-time PCR analysis showed that the expression levels of genes associated with pigment metabolism, chloroplast development and photosynthesis were distinctly affected in the ygl9 mutant. These results indicated that YGL9 is possibly involved in pigment metabolism, chloroplast development and photosynthesis in rice.

关键词： Oryza sativa yellow-green leaf gene cpSRP43 light-harvesting chlorophyll a/b-binding protein

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Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation,deep tumor penetration and augmented synergistic phototherapy

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Journal of materials Science & Technology 2023年第17期148卷 171-185页

作者： Wenjun wang Enhui ma Pengyu Tao Xiaoyu Zhou Yujuan xing liang Chen Yingying zhang Jingjing li Kai Xu Hong wang Shaohui zheng School of Medical Imaging Xuzhou Medical UniversityXuzhou 221006China School of Chemical Engineering&Technology China University of Mining and TechnologyXuzhou 221116China Department of Radiology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China

The complex tumor microenvironment(TME)with the characteristics of severe hypoxia,enriched hydro-gen peroxide(H_(2)O_(2))and dense nature significantly restricted the therapeutic efficacy of nanomedicine in cancer *** micro/nanomotors have shown multiple versatility in modulating the abnor-mal TME and overcoming the limited penetration in solid ***,we constructed a chemical-NIR dual-propelled nanomotor based on CuS/Pt Janus nanoparticles with IR820 encapsulation for hypoxia alle-viation,deep tumor penetration and augmented synergistic photodynamic(PDT)and photothermal ther-apy(PTT).The deposited Pt effectively catalyzed tumor endogenous H_(2)O_(2) into oxygen,which extremely relieved the tumor hypoxia state and allowed the chemical propulsion of *** NIR irra-diation,the Janus nanomotors exhibited more obvious movement via efficient photothermal *** autonomous motion significantly improved the tumoral accumulation of nanomotors and facilitated much deeper penetration inside tumor in *** addition,enriched oxygen also promoted the genera-tion of reactive oxygen species(ROS)for augment of PDT,which achieved satisfied antitumor effect in combination with the PTT ***,this strategy based on CuS/Pt Janus nanomotors would provide an innovative dimension for considerable applications in effective cancer management.

关键词： CuS/Pt Janus nanomotors Chemical-NIR dual-propulsion Deep tumor penetration Hypoxia alleviation Synergistic PDT and PTT

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ACE2-independent infection of T lymphocytes by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1232-1242页

作者： Xu-Rui Shen Rong geng Qian li Ying Chen Shu-Fen li Qi wang Juan Min Yong yang Bei li Ren-Di Jiang Xi wang Xiao-Shuang zheng yan Zhu Jing-Kun Jia xing-Lou yang Mei-Qin liu Qian-chun Gong Yu-Lan zhang Zhen-Qiong Guan Hui-ling li Zhen-hua zheng zheng-li shi Hui-Lan zhang Ke Peng Peng Zhou CAS Key Laboratory of Special Pathogens&State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhanPeople’s Republic of China University of Chinese Academy of Sciences BeijingPeople’s Republic of China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan University200438 ShanghaiChina Center for Organoid and Regenerative Medicine Greater Bay Area Institute of Precision Medicine(Guangzhou)511462 GuangzhouChina Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyJie Fang RoadHan Kou District430030 WuhanChina

SARS-CoV-2 induced marked lymphopenia in severe patients with ***,whether lymphocytes are targets of viral infection is yet to be determined,although SARS-CoV-2 Rna or antigen has been identified in T cells from ***,we confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells(PBCs)or postmortem lung T cells,and the infectious virus could also be detected from viral antigen-positive *** next prove that SARS-CoV-2 infects T lymphocytes,preferably activated CD4+T cells in *** infection,viral Rna,subgenomic Rna,viral protein or viral particle can be detected in the T ***,we show that the infection is spike-ACE2/TMPRSS2-independent through using ACE2 knockdown or receptor blocking ***,we demonstrate that viral antigen-positive T cells from patient undergone pronounced *** vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent ***,we demonstrated that LFA-1,the protein exclusively expresses in multiple leukocytes,is more likely the entry molecule that mediated SARS-CoV-2 infection in T cells,compared to a list of other known ***,this work confirmed a SARS-CoV-2 infection of T cells,in a spike-ACE2-independent manner,which shed novel insights into the underlying mechanisms of SARS-CoV2-induced lymphopenia in COVID-19 patients.

关键词： ACE2 lymphocytes infection

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