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S6A-4 K2P Channels and NMDA Receptor as New Targets of Fast Onset Antidepressants

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神经药理学报 2018年第4期8卷 91-92页

作者： LI Yang GUO Fei ma yu-qin Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of SciencesChina

major depressive disorder(MDD)is a common neuropsychiatric disorder characterized by diverse *** are big limitations of clinic medicine which highlighted an urgent and clear need for more efficacious and faster-acting therapeutic agents to treat patients with MDD,especially those who are refractory to the traditional *** the present study,we assessed a novel compound,YY-21,from timosaponin B-Ⅲderived from sarsasapogenin of Anemarrhenae *** found that YY-21 obviously increased presynaptic glutamate release and enhanced long-term synaptic activity within 10 minutes as determined by excitatory postsynaptic current(EPSC)and field excitatory postsynaptic potential(fEPSP)in medial prefrontal cortex(mPFC)***-21 demonstrated anxiolytic-like effects following acute administration in animals and reversed the depressive-like and anxiety phenotypes induced by chronic unpredictable mild stress(CMS)with a relatively fast therapeutic *** mechanism research reveals that NMDA receptors and K2P(TREK1)channels emerged as new drug targets for faster acting ***-pore domain potassium(K2P)channels generate leak currents that are responsible the maintenance of resting membrane *** are potential targets for the treatment of multiple *** we identify TKDC,an inhibitor of the TREK subfamily,including TREK-1,TREK-2 and TRAAK *** TKDC as a chemical probe,a combined study of computations,mutagenesis,and electrophysiology reveal an allosteric ligand-binding site in the extracellular cap of the *** molecular dynamics simulations suggest that ligand-induced allosteric conformational transitions cause a blockage of the ion conductive *** identification of the extracellular ligand-binding site is confirmed by the discovery of new inhibitors targeting this site using virtual *** results suggest that the extracellular cap of a K2P channel can act as a new allosteric site and may serv

关键词： field excitatory postsynaptic potential(fEPSP) NMDA

K2P channels and NMDA receptor as new targets of fast onset antidepressants

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中国药理学与毒理学杂志 2018年第9期32卷 711-711页

作者： LI Yang GUO Fei ma yu-qin Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of sciences Shanghai 201203 China

major depressive disorder(MDD)is a common neuropsychiatric disorder characterized by diverse *** are big limitations of clinic medicine which highlighted an urgent and clear need for more efficacious and faster-acting therapeutic agents to treat patients with MDD,especially those who are refractory to the traditional *** the present study,we assessed a novel compound,YY-21,from timosaponin B-Ⅲ derived from sarsasapogenin of Anemarrhenae *** found that YY-21 obviously increased presynaptic glutamate release and enhanced long-term synaptic activity within 10 min as determined by excitatory postsynaptic current(EPSC) and field excitatory postsynaptic potential(fEPSP) in medial prefrontal cortex(mPFC) ***-21 demonstrated anxiolytic-like effects following acute administration in animals and reversed the depressivelike and anxiety phenotypes induced by chronic unpredictable mild stress(CMS) with a relatively fast therapeutic *** mechanism research reveals that NMDA receptors and two-pore domain potassium(K2P)(TREK1) channels emerged as new drug targets for faster acting antidepressants.K2 P channels generate leak currents that are responsible the maintenance of resting membrane *** are potential targets for the treatment of multiple *** we identify TKDC,an inhibitor of the TREK subfamily,including TREK1,TREK2 and TRAAK *** TKDC as a chemical probe,a combined study of computations,mutagenesis,and electrophysiology reveal an allosteric ligand-binding site in the extracellular cap of the *** molecular dynamics simulations suggest that ligand-induced allosteric conformational transitions cause a blockage of the ion conductive *** identification of the extracellular ligand-binding site is confirmed by the discovery of new inhibitors targeting this site using virtual *** results suggest that the extracellular cap of a K2P channel can act as a new allosteric site and may ser

关键词： K2P channels NMDA receptors major depressive disorder drug targets

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《怀古录》与江西文法

兰州大学学报（社会科学版） 2021年第4期49卷 121-128页

作者：马茂军马玉琴华南师范大学文学院广东广州510006

宋代江西诗派研究透彻,江西文派却很少有人关注,江西文派的散文思想更少有学者论及。陈模的活动圈子、交游局限于江西,推崇江西本土文人,代表了原生态的江西派散文观。陈模的《怀古录》汇集了江西前贤的散文思想,其中的"高古说""萧散美"... 详细信息

宋代江西诗派研究透彻,江西文派却很少有人关注,江西文派的散文思想更少有学者论及。陈模的活动圈子、交游局限于江西,推崇江西本土文人,代表了原生态的江西派散文观。陈模的《怀古录》汇集了江西前贤的散文思想,其中的"高古说""萧散美""潜气内转说""文好与情好说"体现了江西文派的江西文法。江西文法的研究有利于我们更深刻地认识南宋散文的特点和图景。

关键词：陈模《怀古录》江西文法秦汉派事功派欧阳修苏轼

发酵玉米秸秆对育肥牛生长性能、屠宰性能、肉品质和免疫指标的影响

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饲料研究 2023年第5期46卷 15-18页

作者：马玉勤陶波临夏现代职业学院甘肃临夏731100

试验旨在研究发酵玉米秸秆对育肥牛生长性能、屠宰性能、肉品质和免疫指标的影响。选取45头西门塔尔育肥公牛,随机分成3组,每组3个重复,每个重复5头牛。对照组(C组)育肥牛饲喂基础日粮,T1组、T2组分别饲喂含50%和100%发酵玉米秸秆的基... 详细信息

试验旨在研究发酵玉米秸秆对育肥牛生长性能、屠宰性能、肉品质和免疫指标的影响。选取45头西门塔尔育肥公牛,随机分成3组,每组3个重复,每个重复5头牛。对照组(C组)育肥牛饲喂基础日粮,T1组、T2组分别饲喂含50%和100%发酵玉米秸秆的基础日粮。试验期120 d。结果显示,与C组相比,T2组育肥牛的平均日增重、背膘厚度、pH_(45 min)值、pH_(24 h)值、总抗氧化能力(T-AOC)、超氧化歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活性、免疫球蛋白A(IgA)含量、免疫球蛋白G(IgG)含量、白细胞介素-2(IL-2)含量、干扰素-γ(IFN-γ)含量均显著升高(P<0.05),料重比、剪切力、滴水损失率、蒸煮损失率、丙二醛(MDA)含量均显著降低(P<0.05)。与C组相比,T1组育肥牛滴水损失率、蒸煮损失率均显著降低(P<0.05),SOD活性、GSH-Px活性、IgG含量均显著升高(P<0.05)。研究表明,发酵玉米秸秆完全替代基础日粮中玉米秸秆能够显著改善育肥牛的生长性能、肉品质、抗氧化和免疫指标。

关键词：发酵玉米秸秆育肥牛生长性能屠宰性能肉品质免疫指标

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开放地方公债发行权的探讨

特区经济 2005年第11期 128-129页

作者：袁峰马钦玉江西理工大学经济管理学院江西赣州江西理工大学

从现代政府运行惯例来看,西方发达国家的地方政府往往会利用发行债券的方法筹集公共建设资金.但在我们国家,尽管理论界对地方政府能否发行债券曾经有过激烈探讨,由于现行法律规定不得以地方政府名义发行债券,我国地方政府无法利用该项工... 详细信息

从现代政府运行惯例来看,西方发达国家的地方政府往往会利用发行债券的方法筹集公共建设资金.但在我们国家,尽管理论界对地方政府能否发行债券曾经有过激烈探讨,由于现行法律规定不得以地方政府名义发行债券,我国地方政府无法利用该项工具.随着我国经济的不断增长,仅仅依靠国家财政划拨资金已经远远不能满足不断增长的地方公共建设资金的需要.而由于地方政府经济职能的进一步完善,开放地方公债发行权已经具备了一定的条件和基础.

关键词：地方公债发行权开放西方发达国家政府经济职能地方政府建设资金发行债券政府运行法律规定

加快河南省特色农产品区域化布局的构想与措施

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河南农业科学 2005年第8期34卷 5-7页

作者：何秀芹马玉琴河南省农业厅河南郑州450008

河南地域辽阔,光热水土资源丰富,物种资源多样,特色农产品种类较多.据资料记载,河南有特色农产品30多种,经过多年的发展及近年来农业结构战略性调整,有些特色农产品已有一定的基础,如花卉苗木、中药材、食用菌、茶叶、柞蚕、芝麻、花生... 详细信息

河南地域辽阔,光热水土资源丰富,物种资源多样,特色农产品种类较多.据资料记载,河南有特色农产品30多种,经过多年的发展及近年来农业结构战略性调整,有些特色农产品已有一定的基础,如花卉苗木、中药材、食用菌、茶叶、柞蚕、芝麻、花生等在生产上已初具规模.实践证明,实现特色农产品的区域化布局,能带动区域经济持续健康发展,是实现资源优势、产品优势和市场优势有机结合的最佳选择.为加快河南特色农产品的发展,现提出推进特色农产品区域化布局的构想.

关键词：河南特色农产品区域化布局科技基地建设标准化生产原产地保护龙头企业

magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang ma qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang ma Francesco Lamberti Zhubing He Department of materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DmacPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide magnetron sputter Defect Stability Perovskite solar cell

Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-yu Ye Jun-Ji ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis ma Krystyna Rytel yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro