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马踏湖猪龙河入湖口人工湿地冬季水质净化效果研究

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广东化工 2021年第10期48卷 142-144页

作者：马义源张克峰苏苗苗刘晓东山东建筑大学市政与环境工程学院山东济南250101 济宁市生态环境技术保障中心(济宁市机动车排气污染监控中心) 山东济宁272000 重庆市环境保护工程设计研究院有限公司广东深圳518000 重庆市环境保护工程设计研究院有限公司深圳分公司广东深圳518000 深港产学研基地(北京大学香港科技大学深圳研修院) 广东深圳518057

针对马踏湖猪龙河入湖口人工湿地冬季去污效果不明确的问题,本试验多次实地取样检测,分析了组合工艺对有机物、氮、磷的去除机理及效果,监测数据显示冬季条件下马踏湖猪龙河人工湿地COD、NH_(3)-N、TN、TP平均去除率分别为47.14%、47.83... 详细信息

针对马踏湖猪龙河入湖口人工湿地冬季去污效果不明确的问题,本试验多次实地取样检测,分析了组合工艺对有机物、氮、磷的去除机理及效果,监测数据显示冬季条件下马踏湖猪龙河人工湿地COD、NH_(3)-N、TN、TP平均去除率分别为47.14%、47.83%、75.66%和73.68%,但出水中除TP外其他水质指标仍不能达到设计标准,需进一步采取措施稳定水质。

关键词：人工湿地冬季去除效果

An improved master-apprentice evolutionary algorithm for minimum independent dominating set problem

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Frontiers of Computer Science 2023年第4期17卷 1-14页

作者： Shiwei PAN Yiming ma yiyuan WANG Zhiguo ZHOU Jinchao JI Minghao YIN Shuli HU School of Computer Science and Information Technology Northeast Normal UniversityChangchun 130117China Key Laboratory of Applied Statistics of MOE Northeast Normal UniversityChangchun 130117China

The minimum independent dominance set(MIDS)problem is an important version of the dominating set with some other *** this work,we present an improved master-apprentice evolutionary algorithm for solving the MIDS problem based on a path-breaking strategy called *** proposed maE-PB algorithm combines a construction function for the initial solution generation and candidate solution *** is a multiple neighborhood-based local search algorithm that improves the quality of the solution using a path-breaking strategy for solution recombination based on master and apprentice solutions and a perturbation strategy for disturbing the solution when the algorithm cannot improve the solution quality within a certain number of *** show the competitiveness of the maE-PB algorithm by presenting the computational results on classical benchmarks from the literature and a suite of massive graphs from real-world *** results show that the maE-PB algorithm achieves high *** particular,for the classical benchmarks,the maE-PB algorithm obtains the best-known results for seven instances,whereas for several massive graphs,it improves the best-known results for 62 *** investigate the proposed key ingredients to determine their impact on the performance of the proposed algorithm.

关键词： evolutionary algorithm combinatorial optimization minimum independent dominating set local search master apprentice path breaking

“单片机原理及应用”课程思政建设探讨与实践

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南阳师范学院学报 2025年第1期24卷 97-101页

作者：程艺苑马世榜刘伟宋玉玲南阳师范学院智能制造与电气工程学院河南南阳473061 南阳师范学院物理与电子工程学院河南南阳473061

对“单片机原理及应用”课程进行了课程思政建设的探讨与实践。结合课程特点,重新设计了课程的教学目标,对课程思政进行了总体设计,深入挖掘思政元素,进行了多种教学方法和实施的改革创新,实现思政教育与课程教学的有机融合。

关键词：单片机课程思政课程建设

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基于聚硅氧烷弹性体的伤口敷料研究进展

弹性体 2017年第6期27卷 68-73页

作者：马一瑗洪雨栋周建达芦麒任杨婧张安强华南理工大学材料科学与工程学院高分子系广东广州510641

聚硅氧烷弹性体是一类具有良好弹性,柔软且生物相容性好,具有一定水汽透过性的高分子材料,在伤口敷料领域有诸多应用。综述了多种基于聚硅氧烷弹性体的伤口敷料的制备方法及其在多种伤口护理(如:压疮、增生性瘢痕、急性创伤和烧伤)中的... 详细信息

聚硅氧烷弹性体是一类具有良好弹性,柔软且生物相容性好,具有一定水汽透过性的高分子材料,在伤口敷料领域有诸多应用。综述了多种基于聚硅氧烷弹性体的伤口敷料的制备方法及其在多种伤口护理(如:压疮、增生性瘢痕、急性创伤和烧伤)中的应用进展。

关键词：聚硅氧烷弹性体伤口敷料伤口护理

APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation

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Protein & Cell 2023年第12期14卷 908-913页

作者： Hongkai Zhao Kuan Yang yiyuan Zhang Hongyu Li Qianzhao ji Zeming Wu Shuai ma Si Wang Moshi Song Guang-Hui Liu Qiang Liu Weiqi Zhang Jing Qu Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Universityof Chinese Academy of Sciences Beijing100049China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical University.Beijing100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Aging Biomarker Consortium Beijing 100101China 12Division of Life Sciences and Medicine Institute on Aging and Brain DisordersThe First Affiliated Hospital of USTCHefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Neurodegenerative Disease Research Center University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Brain Function and Disease University of Science and Technology of ChinaHefei 230026China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

Dear Editor,Cardiovascular diseases(CVDs)are the leading cause of death ***,diagnosing and treating CVD remains at the forefront for clinicians while identifying targetable disease mechanisms in preclinical models are focus areas for researchers and drug developers(Cai et al.,2022a).The polymorphic protein apolipoprotein E(APOE),central to lipid transport and metabolism,is well-recognized for the role of its isoforms as important predictors for human cardiovascular disorders and neurodegenerative diseases(Tudorache et al.,2017).Plasma APOE is generated primarily from liver hepatocytes,accounting for around 75%of the APOE production from the whole body(Getz and Reardon,2009),and plays important functional roles in monocytes/macrophages,adipocytes,and the central nervous system(Kockx et al.,2018).However,despite the fact that APOE is widely expressed in different mammalian cells,studies on the functional roles of APOE mostly focus on its extracellular secreted form,and the specific effects of APOE,particularly intracellular form in cell types closely related to human cardiovascular diseases are therefore still poorly understood.

关键词： cardiovascular metabolism

Spheroids of Endothelial Cells and Vascular Smooth Muscle Cells Promote Cell Migration in Hyaluronic Acid and Fibrinogen Composite Hydrogels

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Research 2020年第1期2020卷 1673-1687页

作者： Xingang Zuo Haolan Zhang Tong Zhou yiyuan Duan Hao Shou Shan Yu Changyou Gao MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China

Cell migration plays a pivotal role in many pathological and physiological *** far,most of the studies have been focused on 2-dimensional cell adhesion and ***,the migration behaviors of cell spheroids in 3D hydrogels obtained by polymerization of methacrylated hyaluronic acid(HA-ma)and fibrinogen(Fg)with different ratios were *** Fg could be released to the medium gradually along with time prolongation,achieving the dynamic change of hydrogel structures and *** types of cell spheroids,i.e.,endothelial cell(EC),smooth muscle cell(SMC),and EC-SMC spheroids,were prepared with 10,000 cells in each,whose diameters were about 343,108,and 224μm,*** composite hydrogels with an intermediate ratio of Fg allowed the fastest 3D migration of cell *** ECs-SMCs migrated longest up to 3200μm at day 14,whereas the SMC spheroids migrated slowest with a distance of only~400μm at the same period of *** addition of free RGD or anti-CD44 could significantly reduce the migration distance,revealing that the cell-substrate interactions take the major roles and the migration is mesenchymal ***,addition of anti-N-cadherin and MMP inhibitors also slowed down the migration rate,demonstrating that the degradation of hydrogels and cell-cell interactions are also largely involved in the cell ***-PCR measurement showed that expression of genes related to cell adhesion and antiapoptosis,and angiogenesis was all upregulated in the EC-SMC spheroids than single EC or SMC spheroids,suggesting that the use of composite cell spheroids is more promising to promote cell-substrate interactions and maintenance of cell functions.

关键词： migration. migrate migration

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

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Protein & Cell 2024年第2期15卷 98-120页

作者： Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng yiyuan Zhang Shuhui Sun Kang Wang jian Yin Shuai ma Si Wang Juan Carlos Izpisua Belmonte Weiqi Zhang Jing Qu Guang-Hui Liu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Xuanwu Hospital Capital Medical University Beijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Aging Biomarker Consortium Beijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Aging increases the risk ofliver diseases and systemic susceptibility to aging-related ***,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ***,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche *** in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during *** particular,hyperactivated sterol regulatory element-binding protein(SREBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SREBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detoxification and accelerated cellular *** study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.

关键词： single-nucleus RNA sequencing liver hepatocytes aging senescence SREBP2

Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging

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Protein & Cell 2023年第4期14卷 279-293页

作者： yiyuan Zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai ma Jing Qu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 10o101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged ***,the cell type-specific changes underlying cardiac aging are far from being ***,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with *** found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional *** transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac ***,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived ***,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases.

关键词： single-nucleus RNA-sequencing primate aging FOxP1 cardiomyocyte

Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis

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Protein & Cell 2019年第9期10卷 649-667页

作者： Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang yiyuan Zhang Xiaojuan He Shuhui Sun Shuai ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing 100101China Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of Biophysics Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin 300071China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing 100069China

RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem ***, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis.

关键词： RAP1 stem cell telomere RELN methylation