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Off－line　Two－Dimensional　Gas　Chromatography－mass　Spectrometry　for　Analysis　of　Essential　Oil　of　Medicinal　Herb──Use　of　Absorption　Trap

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Chemical Research in Chinese Universities 1994年第4期10卷 291-296页

作者： ma xue-yi PAN Hui-ping and CHEN Yao-zu(iNational Laboratory of Applied Organic Cheniistry and Deparrmentof Chemistry, Lanzhou University, Lanzhou,7300007)(Department of Chemistry , Zhejiang Univer,ity, Hangzhou, 310027)

he use of an absorption trap off-line two-dimensional gas chromatography (2-DGC) in conjunction with a mass spectrometer greatly improved the separation andidefitification of minor constituents of a complex mixture such as a natural essentialoil. The absorption trap device used as an interface of 2-DGC offered the advantageof convenient manipulation.

关键词： Off-line two-dimensional gas chromatography Essential oil Absorp-tion trap Cymbopogon distans

声音创造的生命与情感——浅谈近年来美国动画片中配音对动物角色的塑造

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电影评介 2007年第23期 18-19页

作者：马雪昳上海大学数码艺术学院

近几年,美国动画大片塑造的角色深入人心,而配音在动物角色的塑造上更是起了至关重要的作用。本文以几部颇受欢迎的美国动画片为例,从台词、音色及表演三个方面来讨论近年来美国动画片中的配音模式与特点,并提出对中国动画片发展的启发。

关键词：动画片配音动物角色塑造

关于审理离婚案件如何处理公房居住权承租权问题的思考

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湖北广播电视大学学报 2006年第6期23卷 139-141页

作者：马义学襄樊广播电视大学湖北襄樊441021

在涉及公房居住权、承租权争议的离婚案件中,还包括一个公房居住权、承租权的确认之诉,在立法和法理方面均有与它诉合并审理的依据。在解除当事人婚姻关系同时,在公房使用权问题上也应同时变更租赁关系。

关键词：离婚公房居住权承租权

早期高血糖可致大鼠脑内神经原蛋白质的非酶糖基化反应

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中国临床康复 2006年第34期10卷 95-98,F0003页

作者：胡景胜马学毅盛树力解放军总医院第一附属医院内分泌科北京市100037 首都医科大学宣武医院北京脑老化研究实验室北京市100053

目的:观察早期高血糖对大鼠脑内神经原组织蛋白质非酶糖基化反应的影响。方法:实验于1998年在首都医科大学宣武医院北京脑老化研究实验室完成。选取3月龄雄性Wistar大白鼠35只(Ⅱ级),随机数字表法分为2组,糖尿病模型组20只和正常对照组1... 详细信息

目的:观察早期高血糖对大鼠脑内神经原组织蛋白质非酶糖基化反应的影响。方法:实验于1998年在首都医科大学宣武医院北京脑老化研究实验室完成。选取3月龄雄性Wistar大白鼠35只(Ⅱ级),随机数字表法分为2组,糖尿病模型组20只和正常对照组15只。以10g/L链尿佐菌素60mg/kg腹腔注射制备糖尿病模型,血糖≥15mmol/L时,表明糖尿病模型制备成功,纳入糖尿病模型组。于成模后1,2,3个月分别测定各组大鼠的血糖和体质量。并与实验前比较。自行制备抗牛血清白蛋白的晚期糖化终末产物抗体:①制备牛血清白蛋白的晚期糖化终末产物抗原。②选取纯种无特殊病原体3月龄雄性昆明小鼠11只(Ⅲ级)接种牛血清白蛋白的晚期糖化终末产物。③免疫动物。④抗晚期糖化终末产物多抗初步纯化及检测:采用ELISA方法。于糖尿病成模后1个月行晚期糖化终末产物免疫组织化学检查。结果:糖尿病模型组20只,其中17只在注射链尿佐菌素24～48h后即出现多饮、多食、多尿等症状,测定全血血糖≥15mmol/L,观察1个月内死亡4只。余13只和正常对照组大鼠15只进入结果分析。①糖尿病大鼠成模1,2,3个月时糖尿病模型组平均血糖均显著高于正常对照组犤1个月:(28.8±2.8),(6.2±0.9)mmol/L,P<0.001犦;犤2个月:(23.1±5.5),(6.1±0.8)mmol/L,P<0.001犦;犤3个月:(25.4±5.1),(6.1±0.7)mmol/L,P<0.001犦;其体质量均显著低于正常对照组犤1个月:(250.1±52.2)g,(422.6±36.2)g,P<0.001犦;犤2个月:(263.8±50.0),(462.6±39.0)g,P<0.001犦;犤3个月:(261.5±42.6),(485.0±28.8)g,P<0.001犦。②以不同浓度牛血清白蛋白的晚期糖化终末产物免疫小鼠2次后,测血清抗牛血清白蛋白的晚期糖化终末产物抗体效价,结果显示抗体效价在1∶1000时具有较大的吸光度值。③检测腹水中抗体的最终效价,结果显示5～50mg/L的牛血清白蛋白的晚期糖化终末产物抗原包板液浓度均具有较高吸光度值。④以20mg/L的抗原浓度包板后行ELISA法检测制备腹水抗体效价,显示腹水抗体在1∶4000时有最大吸光度值,1∶20000时还有较大吸光度值。成功制备了牛血清白蛋白晚期糖化终末产物多克隆抗体。⑤晚期糖化终末产物免疫组化染色显示,糖尿病组于糖尿病1个月时即已有免疫组化染色阳性神经元存在,而正常对照组则不明显。免疫组化阳性物质多见于细胞浆。结论:糖尿病大鼠成模1个月后即可在海马、皮质神经元细胞内发现晚期糖化终末产物的表达。糖尿病早期高血糖即可引起脑内神经元蛋白质的糖基化反应,可能在神经元退行性改变发病机制中具有重要作用。

关键词：高血糖症糖尿病免疫组织化学鼠

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糖尿病性神经病变的诊断与治疗

继续医学教育 2005年第1期19卷 42-46页

作者：马学毅解放军总医院第304临床部内分泌科

糖尿病性神经病变可累及中枢神经、周围神经、感觉神经、运动神经、自主神经多种神经系统,是糖尿病最常见、临床症像最复杂、治疗最困难的并发症,不但引起糖尿病人病死率、残疾率升高,而且还带来了护理、医疗等治疗上的复杂性与困难性,... 详细信息

糖尿病性神经病变可累及中枢神经、周围神经、感觉神经、运动神经、自主神经多种神经系统,是糖尿病最常见、临床症像最复杂、治疗最困难的并发症,不但引起糖尿病人病死率、残疾率升高,而且还带来了护理、医疗等治疗上的复杂性与困难性,更是造成病人反复住院、消耗巨大的卫生资源的一个主要原因.

关键词：糖尿病性神经病变诊断与治疗中枢神经周围神经感觉神经运动神经神经系统自主神经糖尿病人反复住院卫生资源临床症并发症病死率残疾率复杂性

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糖尿病性神经病变的诊断与治疗

继续医学教育 2005年第11期19卷 44-48页

作者：马学毅解放军总医院第304临床部内分泌科

关键词：糖尿病性神经病变糖尿病人中枢神经周围神经感觉神经运动神经神经系统自主神经

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang ying Zhu Pu Chen Tong Zhou Zhe-yi Han Jun Xiao Jian-Feng ma Wen ma Peng Zang ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

抗菌药物在连续性肾脏替代治疗患者中的药代动力学特点与剂量调整

维普期刊数据库评论

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维普期刊数据库

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中华临床感染病杂志 2016年第5期9卷 427-432页

作者：马雪李懿蒋刚四川省肿瘤医院药学部成都610041 四川省肿瘤医院重症监护室成都610041

接受连续性肾脏替代治疗（CRRT）的感染患者体内抗菌药物的药代动力学（PK）参数常常受到各种因素的影响而发生变化。PK 参数的改变可导致抗菌药物剂量的改变，从而增加药物的不良反应或直接导致治疗失败和细菌耐药。该文系统综述了抗... 详细信息

接受连续性肾脏替代治疗（CRRT）的感染患者体内抗菌药物的药代动力学（PK）参数常常受到各种因素的影响而发生变化。PK 参数的改变可导致抗菌药物剂量的改变，从而增加药物的不良反应或直接导致治疗失败和细菌耐药。该文系统综述了抗菌药物在 CRRT 患者中 PK 参数体内变化的各种影响因素，并提出 CRRT 患者使用抗菌药物的剂量调整建议，为临床合理使用抗菌药物提供参考。

关键词：抗菌药物连续性肾脏替代治疗药代动力学