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Emerging role of autophagy in colorectal cancer:Progress and prospects for clinical intervention

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 979-987页

作者： Tian-Fei ma Yue-ren Fan yi-Hang Zhao Bin Liu Department of Breast Internal MedicineⅡ Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042Liaoning ProvinceChina

Autophagy is a physiological mechanism in which cells degrade themselves and quickly recover the degraded cell *** studies have shown that autophagy plays an important role in the occurrence,development,treatment,and prognosis of colorectal *** the early stages of colorectal cancer,autophagy can inhibit the production and development of tumors through multiple mechanisms such as maintaining DNA stability,inducing tumor death,and enhancing immune ***,as colorectal cancer progresses,autophagy may mediate tumor resistance,enhance tumor metabolism,and other pathways to promote tumor ***,intervening in autophagy at the appropriate time has broad clinical application *** article summarizes the recent research progress of autophagy and colorectal cancer and is expected to provide new theoretical basis and reference for clinical treatment of colorectal cancer.

关键词： Autophagy Self-degradation Colorectal cancer Phosphatidylinositol-3-phosphate Immune cells

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao Jingli Sun Yong Yuan Lingwei ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long march Vehicle Beijing 100076China National materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

Distribution and invasion of Spartina alterniflora within the Jiaozhou Bay monitored by remote sensing image

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Acta Oceanologica Sinica 2022年第6期41卷 31-40页

作者： Jianbu Wang Zhaoyang Lin Yuanqing ma Guangbo ren Zijun Xu Xiukai Song yi ma Andong Wang Yajie Zhao Laboratory of marine Physics and Remote Sensing First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China School of Information and Electrics Beijing Institute of TechnologyBeijing 100081China Shandong marine Resources and Environment Research Institute Shandong Provincial Key Laboratory of Restoration for Marine EcologyYantai 264006China North China Sea Environmental Monitoring Center State Oceanic AdministrationQingdao 266033China Shandong Yellow River Delta National Nature Reserve Administration Committee Dongying 257091China

Spartina alterniflora as an alien invasive plant,poses a serious threat to the ecological functions of the coastal wetland of the Jiaozhou *** of 2019,the distribution area of *** in the Jiaozhou Bay has reached more than 500 hm^(2).For this reason,combined with field surveys,remote sensing monitoring of the invasion *** in the Jiaozhou Bay has been carried *** accurately identify *** within the Jiaozhou Bay coastal wetland,we used a new method which is an implement of deep convolutional neural network,and by which we got a higher accuracy than the traditional *** on distribution of *** extracted by the proposed method,the temporal and spatial distribution characteristics of *** were *** then combined with environmental factors,the invasion mechanism of *** in the Jiaozhou Bay was analyzed in *** the monitoring results,it can be seen that *** in Jiaozhou Bay is mainly distributed in the beaches near the Yanghe River Estuary and its southern side,the Dagu River Estuary and the Nü*** alterniflora first broke out near the Yanghe River Estuary and gradually spread to the tidal flats near the Nü*** Dagu River Estuary is dominated by ***,whose area has not changed much over the years,and a small amount of *** has invaded later.

关键词： Spartina alterniflora remote sensing coastal wetland deep residual network

Yeast-Controlled Double-Shelled CacO_(3)/CaF_(2)Hollow Nanospheres with Hierarchically Porous for Sustained pH-Sensitive Drug Release

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Chinese Journal of Chemistry 2024年第15期42卷 1713-1720页

作者： Xinhe Liu yi Chang Guanglei ma Tingting Liu Penghui Song Heng Yu Xueqing ren Yuming Guo Xiaoming ma School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 453007China Collaborative Innovation Center of Henan Province for Green manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistryof EducationHenan Normal UniversityXinxiangHenan 453007China

Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of ***,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great ***,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast *** biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable *** double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical ***,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor *** in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic ***,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.

关键词： Biomimetic synthesis Hierarchically porous Sustained pH-sensitive drug release Antitumor agents Drug delivery Calcium Cancer therapy/Hollow structures

Scientific and technological innovations of wastewater treatment in China

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 43-48页

作者： Hui Huang Rui ma Hongqiang ren State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China

The“dual-carbon”strategy promotes the development of the wastewater treatment sector and is an important tool for leading science and technology *** on the global climate change and the new policies introduced by China,this paper described the new needs for the development of wastewater treatment science and *** offered a retrospective analysis of the historical trajectory of scientific and technological advancements in this *** bibliometrics,it delineated the research hotspots within wastewater treatment,notably highlighting materials genomics,artificial intelligence,and synthetic ***,it posited that,in the future,the field of wastewater treatment should follow the paths of technological innovations with multi-dimensional needs,such as carbon reduction,pollution reduction,health,standardisation,and *** purpose of this paper was to provide references and suggestions for scientific and technological innovations in the field of wastewater treatment,and to contribute to the common endeavor of moving toward a Pollution-Free Planet.

关键词： Wastewater treatment Dual-carbon strategy Technological innovation Carbon reduction

Minimum eigenvalue based adaptive fault compensation for hypersonic vehicles

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Journal of Systems Engineering and Electronics 2023年第2期34卷 492-500页

作者： ma Yajie JIANG Bin ren Hao College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The attitude tracking control problem is addressed for hypersonic vehicles under actuator faults that may cause an uncertain time-varying control gain *** adaptive compensation scheme is developed to ensure system stability and asymptotic tracking properties,including a kinematic control signal and a dynamic control *** deal with the uncertainties of the control gain matrix,a new positive definite one is *** minimum eigenvalue of such a new control gain matrix is *** results of application to an X-33 vehicle model verify the effectiveness of the proposed minimum eigenvalue based adaptive fault compensation scheme.

关键词： actuator fault adaptive compensation hypersonic vehicle minimum eigenvalue

A multi-mechanism numerical simulation model for CO_(2)-EOR and storage in fractured shale oil reservoirs

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Petroleum Science 2024年第3期21卷 1814-1828页

作者： Yuan-Zheng Wang ren-yi Cao Zhi-Hao Jia Bin-Yu Wang Ming ma Lin-Song Cheng College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China John&Willie Leone Department of Energy&Mineral Engineering The Pennsylvania State UniversityUniversity Park16802PA.USA

Under the policy background and advocacy of carbon capture,utilization,and storage(CCUS),CO_(2)-EOR has become a promising direction in the shale oil reservoir *** multi-scale pore structure distribution and fracture structure lead to complex multiphase flow,comprehensively considering multiple mechanisms is crucial for development and CO_(2) storage in fractured shale *** this paper,a multi-mechanism coupled model is developed by *** to the traditional Eclipse300 and maTLAB Reservoir Simulation Toolbox(MRST),this model considers the impact of pore structure on fluid phase behavior by the modified Peng—Robinson equation of state(PR-EOS),and the effect simultaneously radiate to maxwell—Stefan(M—S)diffusion,stress sensitivity,the nano-confinement(NC)***,a modified embedded discrete fracture model(EDFM)is used to model the complex fractures,which optimizes connection types and half-transmissibility calculation approaches between non-neighboring connections(NNCs).The full implicit equation adopts the finite volume method(FVM)and Newton—Raphson iteration for discretization and *** model verification with the Eclipse300 and MRST is *** results show that the interaction between the mechanisms significantly affects the production performance and storage *** effect of molecular diffusion may be overestimated in oil-dominated(liquid-dominated)shale *** well spacing and injection gas rate are the most crucial factors affecting the production by sensitivity ***,the potential gas invasion risk is *** model provides a reliable theoretical basis for CO_(2)-EOR and sequestration in shale oil reservoirs.

关键词： CO_(2)-EOR CO_(2)storage Shale oil reservoir Complex fracture model Multiple mechanisms

Local spatial properties based image interpolation scheme using SVMs

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Journal of Systems Engineering and Electronics 2008年第3期19卷 618-623页

作者： ma Liyong Shen yi ma Jiachen School of Information Science and Engineering Harbin Inst. of Technology Weihai 264209 P. R. China

Image interpolation plays an important role in image process applications. A novel support vector machines （SVMs） based interpolation scheme is proposed with increasing the local spatial properties in the source image as SVMs input patterns. After the proper neighbor pixels region is selected, trained support vectors are obtained by training SVMs with local spatial properties that include the average of the neighbor pixels gray values and the gray value variations between neighbor pixels in the selected region. The support vector regression machines are employed to estimate the gray values of unknown pixels with the neighbor pixels and local spatial properties information. Some interpolation experiments show that the proposed scheme is superior to the linear, cubic, neural network and other SVMs based interpolation approaches.

关键词： image processing interpolation support vector machines local spatial properties support vectorregression.

Understanding the intrinsic synergistic mechanism between Pt-O-Ti interface sites and TiO_(2) surface sites of Pt/TiO_(2) catalysts in Fenton-like reaction

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Science China Chemistry 2022年第12期65卷 2596-2603页

作者： Yawen ma Huibin Ge Siwen yi man Yang Dan Feng Yujing ren Jie Gao Yong Qin Interdisciplinary Research Center of Biology&Catalysis School of Life SciencesNorthwestern Polytechnical UniversityXi’an710072China School of materials Science and Engineering Xi’an University of TechnologyXi’an710048China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan030001China

Identifying the active site of oxide-supported metal catalysts and revealing the intrinsic synergistic mechanism between metal and oxide support remain a large ***,we report the identification and separation of the Pt-O-Ti interface and TiO_(2) surface in Pt-TiO_(2)-based catalysts by depositing different thickness of TiO_(2) shell with∼0.4-nm micropores onto the surface of Pt/TiO_(2) catalyst through atomic layer deposition(ALD).In the oxidation of 3,3′,5,5′-tetramethylbenzidine(TMB)by hydrogen peroxide(H_(2)O_(2))process,the TiO_(2) microporous shells can prevent the contact between TMB and embedded Pt clusters,but not delay the diffusion of H_(2)O_(2).The heterolysis of H_(2)O_(2) to ·OH occurs on the Pt-O-Ti interface,and the generated•OH migrates to the TiO_(2) surface to supplement the surface lattice oxygen,which sequentially oxidizes TMB to *** the synergistic effect between Pt-O-Ti interface active sties and TiO_(2) surface active sites can significantly improve the catalytic *** study provides a guide for the understanding of the intrinsic synergistic mechanism between the metal and oxide support in the metal-oxide catalysts.

关键词： Intrinsic synergistic mechanism Pt-O-Ti interface site TiO_(2)surface site Fenton-like reaction metal-oxide catalyst