检索结果-南通市图书馆

Exosomes:the next-generation therapeutic platform for ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin ma Yang Qu Jiaxin ren yingying Sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Prediction of recurrence and prognosis in patients with hepatocellular carcinoma after resection by use of CLIP score

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2002年第2期8卷 237-242页

作者： Wen He Zhao Zhi-Min ma Xing-ren Zhou yi-Zheng Feng Bao-Shan Fang,Department of Oncosurgery,the First Affiliated Hospital,Zhejiang University,Medical College,Hangzhou 310003,Zhejiang Province,China Department of Oncosurgery the First Affiliated Hospital Zhejiang University Medical College 79 Qingchun Hangzhou 310003 Zhejiang Province China. zhaowh@***

AIM: The survival time of patients with hepatocellular carcinoma (HCC) after resection is hard to predict. Both residual liver function and tumor extension factors should be considered. A new scoring system has recently been proposed by the Cancer of the Liver Italian Program (CLIP). CLIP score was confirmed to be one of the best ways to stage patients with HCC. To our knowledge, however, the literature concerning the correlation between CLIP score and prognosis for patients with HCC after resection was not published. The aim of this study is to evaluate the recurrence and prognostic value of CLIP score for the patients with HCC after resection. METHODS: A retrospective survey was carried out in 174 patients undergoing resection of HCC from January 1986 to June 1998. Six patients who died in the hospital after operation and 11 patients with the recurrence of the disease were excluded at 1 month after hepatectomy. By the end of June 2001, 4 patients were lost and 153 patients with curative resection have been followed up for at least three years. Among 153 patients, 115 developed intrahepatic recurrence and 10 developed extrahepatic recurrence, whereas the other 28 remained free of recurrence. Recurrences were classified into early (3 year) recurrence. The CLIP score included the parameters involved in the Child-Pugh stage (0-2), plus macroscopic tumor morphology (0-2), AFP levels (0-1), and the presence or absence of portal thrombosis (0-1). By contrast, portal vein thrombosis was defined as the presence of tumor emboli within vascular channel analyzed by microscopic examination in this study. Risk factors for recurrence and prognostic factors for survival in each group were analyzed by the chi-square test, the Kaplan-Meier estimation and the COX proportional hazards model respectively. RESULTS: The 1-, 3-, 5-, 7-,and 10-year disease-free survival rates after curative resection of HCC were 57.2%, 28.3%, 23.5%, 18.8%, and 17.8%, respect

关键词： Neoplasm Recurrence, Local Adolescent Adult Aged Carcinoma, Hepatocellular Child Disease-Free Survival Female Humans Liver Neoplasms male Middle Aged Neoplasm Staging Predictive Value of Tests Prognosis Retrospective Studies Risk Factors

运用热泵提高低温地热采暖系统能源利用率的分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天津大学学报 1982年第4期 1-8页

作者：吕灿仁马一太

本文探讨我国京津市区丰富的低温地热资源有效利用的方法。文中着重分析有热泵参与的各种地热采暖系统的负荷分配和节能效果,论证热泵系统是提高低温能源利用率和城市采暖的有效方式。本文还介绍了地热热泵模拟试验和所得到的某些结果... 详细信息

本文探讨我国京津市区丰富的低温地热资源有效利用的方法。文中着重分析有热泵参与的各种地热采暖系统的负荷分配和节能效果,论证热泵系统是提高低温能源利用率和城市采暖的有效方式。本文还介绍了地热热泵模拟试验和所得到的某些结果。在经济性分析中指出我国电和燃料比价与国外有很大不同,所以电动热泵直接经济效果还不明显。提议城市地区可用燃气机拖动热泵,并建议要有合理的能源政策促进热泵节能技术的发展。

关键词：热泵系统负荷分配采暖系统低温地热能源利用率

持续干旱对侧柏和祁连圆柏叶片水分状况及光合作用的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

干旱区研究 2010年第1期27卷 88-96页

作者：马仁义张茜张强赵长明兰州大学生命科学学院干旱与草地教育部重点实验室甘肃兰州730000

以侧柏(Platycladus orientalis)和祁连圆柏(Juniperus przewalskii)2年生幼苗为材料,用盆栽实验比较持续干旱对两者叶片水分及光合生理特性的影响。研究发现:侧柏水势(ψ)、叶片相对含水量(RWC)、净光合速率(Pn)、最大光化学效率(Fv/Fm... 详细信息

以侧柏(Platycladus orientalis)和祁连圆柏(Juniperus przewalskii)2年生幼苗为材料,用盆栽实验比较持续干旱对两者叶片水分及光合生理特性的影响。研究发现:侧柏水势(ψ)、叶片相对含水量(RWC)、净光合速率(Pn)、最大光化学效率(Fv/Fm)、实际光化学效率(Φ_(PSII))、电子传递速率(ETR)和叶绿素含量(Chl a,Chl b,Chl a+b)的下降幅度均大于祁连圆柏,且游离脯氨酸含量(Pro)和叶绿素原初荧光值(Fo)上升幅度大于后者,但两者胞间CO_2浓度(Ci)和气孔限制值(Is)变化相反。这些结果表明,侧柏对干旱胁迫敏感度明显高于祁连圆柏,祁连圆柏对干旱胁迫的抵抗力更高;侧柏净光合速率的下降主要是叶绿素组分和光合器官功能的破坏等非气孔因素引起的,而祁连圆柏净光合速率的下降主要是气孔因素引起的。另外,持续干旱处理后祁连圆柏仍保持较高的瞬时水分利用效率(WUEi)和电子传递速率(ETR),表明它能够通过提高水分利用效率和光呼吸速率来减小干旱胁迫产生的伤害。这将为黄土高原区生态恢复中造林绿化树种的选择提供理论依据和实践指导。

关键词：干旱胁迫叶片水分净光合速率气体交换叶绿素荧光侧柏(Platycladus orientalis) 祁连圆柏(Juniperus przewalskii)

三峡移民任务与资金“双包干”匹配分析方法研究

在线全文

学校读者我要写书评

暂无评论

人民长江 2007年第12期38卷 21-23页

作者：王承云马奕仁长江水利委员会长江工程监理咨询有限公司湖北武汉430010

三峡移民实行移民任务与移民资金"双包干"政策,适应了三峡移民管理的需要,对控制移民工程建设规模、确保移民补偿政策的落实、发挥移民补偿资金的效益起到了良好的作用。为了对"双包干"政策落实情况进行量化分析,并发现研究存在的问题,... 详细信息

三峡移民实行移民任务与移民资金"双包干"政策,适应了三峡移民管理的需要,对控制移民工程建设规模、确保移民补偿政策的落实、发挥移民补偿资金的效益起到了良好的作用。为了对"双包干"政策落实情况进行量化分析,并发现研究存在的问题,为上级部门决策服务,综合监理在多年的实践中创造了匹配分析方法。通过阐述三峡移民资金特点及"双包干"政策内容,重点总结归纳了匹配分析方法中的移民工程完成实物量的量测、移民补偿投资完成数量的量测,以及匹配分析的基本原理与评价指标,并对造成移民工程实施中部分项目不匹配的原因进行了分析。匹配分析法已作为三峡移民稽察的重要技术手段,作为一种较为成熟的"双包干"政策技术分析方法,对国内其它实行包干政策的水库移民工程也具有重要的借鉴意义。

关键词：移民工程 “双包干”政策匹配分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

高线集卷站双芯棒旋转定位可靠性分析与改进

冶金设备管理与维修 2013年第5期31卷 49-50,56页

作者：马仁义重庆钢铁集团股份有限公司高速线材轧钢厂重庆400080

分析了双芯棒旋转定位螺栓频繁损坏的原因，通过双芯棒旋转程序的优化和旋转定位螺栓结构的改进，彻底消除了冲击力，使得双芯棒定位更加可靠，大幅度减少了故障。

关键词：双芯棒定位螺栓旋转程序

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Hydration, Microstructure, and Properties of Sulphoaluminate Cement in Pure Water and Simulated Seawater

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 187-193页

作者： ma Jie China Railway Design Corporation Tianjin 300250China

Paste and mortar specimens were prepared with sulfoaluminate cement(SAC),P⋅O 42.5 ordinary Portland cement(OPC),and standard sand,and mixed and cured with pure water and artificial seawater,*** mechanical properties of mortar specimens were *** and microstructure of paste specimens were also investigated using X-ray diffraction(XRD),scanning electron microscope(SEM),and 27Al nuclear magnetic resonance(NMR),*** results indicate that SAC mortar samples mixed and cured by seawater have faster strength growth before 28 d and higher compressive strength than OPC mortar *** to curing in deionized water,the hydration products of SAC are somewhat coarser when cured in simulated *** evolution of aluminum phase hydration products during the hydration process of SAC mixed and cured in simulated seawater is quite different from that of *** 3 to 28 d,the content of each aluminum phase hydration product in SAC paste cured in simulated seawater changed little,while that in OPC paste changed significantly;for example,from 7 to 28 d,the content of ettringite(AFt)in OPC paste increased *** type of AFt formed loosely,harming the mortar's microstructure.

关键词： sulfoaluminate cement seawater mixing and curing 27Al NMR AFt

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng Qian ma Da Han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood