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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

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Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang muyuan ma Shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

Evaluation of Ecosystem Services Value of the Zoigê Wetland Nature Reserve by Multiple Criteria

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湿地科学 2016年第2期14卷 145-156页

作者： CUI Lijuan SUN Baodi LI Wei PANG Bingliang LEI Yinru ma muyuan ma Qiongfang Institute of Wetland Research Chinese Academy of Forestry Beijing 100091 P.R.China Beijing Key Laboratory of Wetland Services and Restoration Beijing 100091 P.R.China Shunyi Branch of Beijing Municipal Public Security Bureau Beijing 101300 P.R.China Jilin Academy of Forestry Changchun 130031 Jilin P.R.China

Understanding the value of ecosystem services is useful for the decision making and sustainable management of the wetlands. It would be better to integrate ecological, economic and social factors into ecosystem service valuation. The general value of the Zoigê Wetland Nature Reserve in the southwest China by integrating a social welfare weight, which is determined by a three-level analytic hierarchy process, was calculated. Through analyzing the functions, stakeholders and ecosystem services of the Zoigê Wetland Nature Reserve, the six main services, including substance production, flood control, gas regulation, climate regulation, recreation, and biodiversity conservation,were selected; and a three-level hierarchical structure model was established. The top(goal) level of the model refers to the total ecosystem services value of the Zoigê Wetland Nature Reserve, the middle level(stakeholder level) refers to stakeholders at different scales, and the bottom level(service level) refers to individual services provided by the Zoigê Wetland Nature Reserve. The results indicated that the ecosystem services value of the Zoigê Wetland Nature Reserve was 320.38×10~8yuan RMB in 2011. If including the social welfare, the value increased to 2258.68×10~8yuan RMB. The value of biodiversity conservation accounted for the largest proportion, which were 53% without the social welfare and 75% with it. And without the social welfare, flood control, gas regulation, climate regulation of the Zoigê Wetland Nature Reserve accounted for 26%, 11% and 8% of the total value, while the proportion that substance production and recreation values were of the total value were very small. Meanwhile, with the social weight,flood control, gas regulation, climate regulation, recreation of the Zoigê Wetland Nature Reserve accounted for 10%,13%, 1% and 1% of the total value, then the weight of substance production value was also the smallest.

关键词： ecosystem services value stakeholders analytic hierarchy process(AHP) Zoigê Wetland Nature Reserve

Aboveground biomass and its spatial distribution pattern of herbaceous marsh vegetation in China

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Science China Earth Sciences 2021年第7期64卷 1115-1125页

作者： Xiangjin SHEN Ming JIANG Xianguo LU Xingtu LIU Bo LIU Jiaqi ZHANG Xianwei WANG Shouzheng TONG Guangchun LEI Shengzhong WANG Chuan TONG Hangqing FAN Kun TIAN Xiaolong WANG Yuanman HU Yonghong XIE muyuan ma Shuwen ZHANG Chunxiang CAO Zhichen WANG Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China Key Laboratory of Ecological Protection in the Yellow'River Basin of National Forestry and Grassland Administration School of Ecology1 andConservationBeijing Forestry UniversityBeijing 100083China School of Geographical Sciences Northeast Normal UniversityChangchun 130024China School of Geography Fujian Normal UniversityFuzhou 350007China Guangxi mangrove Research Center Guangxi Academy of SciencesBeihai 536000China National Plateau Wetlands Research Center Southwest Forestry UniversityKunming 650224China Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Institute of Wetland Research Chinese Academy of ForestryBeijing 100091China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Academy of Inventory and Planning National Forestry and Grassland AdministrationBeijing 100714China

Herbaceous marsh is the most widely distributed type of marsh wetland ecosystem,and has important ecological functions such as water conservation,climate regulation,carbon storage and fixation,and sheltering rare *** carbon sequestration function of herbaceous marsh plays a key role in slowing climate warming and maintaining regional environmental *** biomass is an important index reflecting the carbon sequestration capacity of *** the biomass of marsh vegetation can provide a scientific basis for estimating the carbon storage and carbon sequestration capacity of *** on field survey data of aboveground biomass of herbaceous marsh vegetation and the distribution data set of marsh in China,we analyzed the aboveground biomass and its spatial distribution pattern of herbaceous marsh on a national scale for the first *** results showed that in China the total area of herbaceous marsh was 9.7×10^(4) km^(2),the average density of aboveground biomass of herbaceous marsh vegetation was 227.5±23.0 g C m-2(95%confidence interval,the same below),and the total aboveground biomass was 22.2±2.2 Tg C(1 Tg=1012 g).The aboveground biomass density of herbaceous marsh vegetation is generally low in Northeast China and the Tibetan Plateau,and high in central North China and coastal regions in *** different marsh distribution regions of China,the average biomass density of herbaceous marsh vegetation from small to large was as follows:temperate humid and semi-humid marsh region(182.3±49.3 g C m^(-2))marsh region(243.9±26.6 g C m-2)marsh region(300.5±73.2 g C m-2)marsh region(348.4±59.0 g C m-2)marsh region(675.4±73.8 g C m-2). Due to the different area of herbaceous marsh, the total aboveground biomass of herbaceous marsh vegetation in different marsh distribution regions was the largest in the temperate humid and semi-humid marsh region(9.6±2.6 Tg C)

关键词： Herbaceous marsh Wetland Vegetation Aboveground biomass Spatial distribution China

2013至2018年瓦房店市手足口病流行特征分析

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现代医学 2020年第12期48卷 1545-1550页

作者：马牧原瓦房店市疾病预防控制中心流行病科辽宁瓦房店116300

目的:分析2013至2018年瓦房店市手足口病流行病学特征,探讨疫情变化规律,为手足口病防控提供科学依据。方法:数据来源于中国疾病预防控制信息系统,采用描述流行病学方法对2013至2018年瓦房店市手足口病流行病学特征及病原检测资料进行... 详细信息

目的:分析2013至2018年瓦房店市手足口病流行病学特征,探讨疫情变化规律,为手足口病防控提供科学依据。方法:数据来源于中国疾病预防控制信息系统,采用描述流行病学方法对2013至2018年瓦房店市手足口病流行病学特征及病原检测资料进行统计分析。结果:2013至2018年瓦房店市共报告手足口病7561例,年均发病率为134.47/105,各年度发病率差异有统计学意义(χ2=2257.17,P<0.001)。发病季节性明显,发病高峰集中在6~8月。手足口病年均发病率居前5位的是复州城镇、岗店办事处、文兰办事处、老虎屯镇、共济办事处。城区发病率高于农村,男性发病率高于女性,病例以5岁以下儿童为主,发病职业构成主要为散居儿童、幼托儿童和学生。病原学方面,引起手足口病的不同型别肠道病毒交替流行。送检的415例样本中,肠道病毒核酸检测阳性检出率为90.36%(375/415),其中其他肠道病毒阳性占51.20%,柯萨齐病毒A16型阳性占28.80%,肠道病毒71型(EV71)的占20.00%。70例有实验室检测结果的重症病人中,EV71阳性的有35例,占50%。结论:瓦房店市手足口病疫情呈现每隔2年高发的特征,有明显的季节性、地区性和人群特征。手足口病防控应将夏季作为重点时段,将学龄前儿童作为重点人群,将城区作为重点地区,提高EV71疫苗接种的宣传,预防重症病例的发生。

关键词：手足口病流行病学特征肠道病毒瓦房店

白洋淀养鸭废水对生物膜生物量和胞外酶活性的影响

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水资源保护 2020年第1期36卷 89-96页

作者：马牧源崔丽娟张曼胤于一雷中国林业科学研究院湿地研究所北京100091 湿地生态功能与恢复北京市重点实验室北京100091

为了对应用生物膜进行湖泊的生态监测与评价提供理论依据,通过微宇宙试验研究了不同浓度梯度养鸭废水对生物膜生物量和胞外酶活性的影响。结果表明:养鸭废水会显著增加生物膜的生物量;在短期暴露中,生物膜的生物量与养鸭废水浓度线性相... 详细信息

为了对应用生物膜进行湖泊的生态监测与评价提供理论依据,通过微宇宙试验研究了不同浓度梯度养鸭废水对生物膜生物量和胞外酶活性的影响。结果表明:养鸭废水会显著增加生物膜的生物量;在短期暴露中,生物膜的生物量与养鸭废水浓度线性相关;而在长期暴露中则符合Logistic方程,养鸭废水对生物膜生物量的促进具有饱和效应。养鸭废水对生物膜胞外酶活性的效应受暴露时间的影响:短期暴露(24 h)时养鸭废水会促进碱性磷酸酶、β-葡萄糖苷酶和亮氨酸肽酶活性的增加,3种酶活性均随养鸭废水浓度的升高而呈对数增加;长期暴露(60 d)时,养鸭废水对3种酶活性均产生抑制作用,酶活性随养鸭废水浓度升高而呈对数降低。

关键词：生物膜胞外酶活性养鸭废水白洋淀

湿地资源保护经济学分析——以北京野鸭湖湿地为例

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生态学报 2012年第17期32卷 5337-5344页

作者：王昌海崔丽娟马牧源毛旭锋中国林业科学研究院湿地研究所北京100091

湿地资源保护是全球生态保护的核心问题之一。在分析湿地资源保护的经济属性的基础上,以北京市野鸭湖湿地为案例,运用经济学的理论和方法以及清晰的图表重点分析了野鸭湖湿地资源保护过程中的外部性以及资源利用中成本与收益两个问题。... 详细信息

湿地资源保护是全球生态保护的核心问题之一。在分析湿地资源保护的经济属性的基础上,以北京市野鸭湖湿地为案例,运用经济学的理论和方法以及清晰的图表重点分析了野鸭湖湿地资源保护过程中的外部性以及资源利用中成本与收益两个问题。研究结果表明:(1)从正外部性分析,个人收益小于社会收益,个人保护的湿地资源小于社会最优量,会造成湿地资源保护的不足;从负外部性分析,个人成本小于社会成本,个人对湿地资源的利用水平大于社会最优利用水平,造成湿地资源的过度利用;(2)根据湿地资源利用的成本收益分析结果,"搭便车"行为会造成湿地资源的退化甚至恶化;(3)明晰产权有利于湿地资源配置效率的提高。研究结果可以为中国湿地保护过程中出现的资源利用矛盾提供有益的借鉴,特别是为保护北京野鸭湖湿地提供理论支撑和政策建议。

关键词：湿地资源保护外部性成本收益

长链非编码RNA FAM83H-AS1对胃癌细胞周期、增殖和转移的影响及作用机制

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安徽医科大学学报 2020年第9期55卷 1327-1331页

作者：王涛马牧原叶晓锋宁夏医科大学总医院肿瘤外二科银川750001

目的研究长链非编码RNA序列相似性家族83成员H反义RNA 1(lncRNA FAM83H-AS1)对胃癌细胞周期、增殖和转移的影响,并探讨其作用的可能机制。方法qRT-PCR检测FAM83H-AS1在胃癌细胞系MKN-45、SGC-7901、MGC-803和人永生化正常胃上皮细胞GES-... 详细信息

目的研究长链非编码RNA序列相似性家族83成员H反义RNA 1(lncRNA FAM83H-AS1)对胃癌细胞周期、增殖和转移的影响,并探讨其作用的可能机制。方法qRT-PCR检测FAM83H-AS1在胃癌细胞系MKN-45、SGC-7901、MGC-803和人永生化正常胃上皮细胞GES-1中的表达水平,选择表达最高的胃癌细胞系进行FAM83H-AS1小干扰核糖核酸(siRNA)感染,分为si-NC组和si-FAM83H-AS1组。qRT-PCR检测各组细胞中FAM83H-AS1的表达水平;流式细胞仪检测FAM83H-AS1对细胞周期的影响;MTS和平板克隆实验检测FAM83H-AS1对细胞增殖能力的影响;Tran-swell实验检测FAM83H-AS1对细胞转移能力的影响;West-ern blot检测FAM83H-AS1对cyclinD1和细胞周期蛋白依赖激酶4(CDK4)以及上皮间质转化过程(EMT)标志蛋白的表达影响。结果qRT-PCR检测结果显示FAM83H-AS1在胃癌细胞系的表达水平高于在人永生化正常胃上皮细胞GES-1中的表达(P<0.05),选择表达水平最高的胃癌细胞系MKN-45转染FAM83H-AS1 siRNA,qRT-PCR结果显示si-FAM83H-AS1组细胞中FAM83H-AS1的表达降低(P<0.05);si-FAM83H-AS1组MKN-45细胞增殖和转移能力下降,细胞中细胞周期蛋白cyclinD1和CDK4蛋白的表达降低,EMT标志蛋白E钙黏蛋白蛋白表达增加,N钙黏蛋白和波形蛋白蛋白表达降低。结论干扰FAM83H-AS1的表达抑制胃癌细胞增殖和转移能力。FAM83H-AS1可能是胃癌治疗的新型靶标。

关键词：胃癌 lncRNA FAM83H-AS1反义RNA 1 细胞周期增殖转移上皮间质转化

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欧洲和北美地区退化泥炭地修复技术与借鉴

世界林业研究 2020年第6期33卷 92-98页

作者：朱耀军马牧源赵娜娜中国林业科学研究院湿地研究所湿地生态功能与恢复北京市重点实验室北京100091

泥炭地是重要的自然湿地类型,具有固碳、水文调节、生物多样性维护等多种生态系统服务功能。受侵蚀、火灾等自然灾害以及排水疏干、过度放牧和基础建设等强烈的人为干扰,全球泥炭地面积不断缩减,成为全球气候变化背景下的碳源。文中从... 详细信息

泥炭地是重要的自然湿地类型,具有固碳、水文调节、生物多样性维护等多种生态系统服务功能。受侵蚀、火灾等自然灾害以及排水疏干、过度放牧和基础建设等强烈的人为干扰,全球泥炭地面积不断缩减,成为全球气候变化背景下的碳源。文中从水文修复、植被修复和生态监测与评估等方面,综述了欧洲和北美国家退化泥炭地修复技术研究进展,结合若尔盖湿地修复技术现状进行了研究展望,旨在为我国高原退化湿地的生态修复提供参考。

关键词：泥炭地水文修复植被修复生态监测高原湿地欧洲北美

Super-resolution reconstruction of a 3 arc-second global DEM dataset

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Science Bulletin 2022年第24期67卷 2526-2530,M0003页

作者： Bo Zhang Wei Xiong muyuan ma Mingqing Wang Dong Wang Xing Huang Le Yu Qiang Zhang Hui Lu Danfeng Hong Fan Yu Zidong Wang Jie Wang Xuelong Li Peng Gong Xiaomeng Huang Ministry of Education Key Laboratory for Earth System Modeling Institute for Global Change StudiesDepartment of Earth System ScienceTsinghua UniversityBeijing 100084China Key Laboratory of Computational Optical Imaging Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China Huawei Technologies Co.Ltd Hangzhou 310007China Peng Cheng Laboratory Shenzhen 518000China School of Artificial Intelligence OPtics and ElectroNics(iOPEN)Northwestern Polytechnical UniversityXi’an 710072China Department of Geography and Department of Earth Sciences University of Hong KongHong KongChina

Obtaining multi-source satellite geodesy and ocean observation data to map the high-resolution global digital elevation models(DEMs)is a formidable task at *** key theoretical and technological obstacles to fine modeling must be overcome before the geographical ditribution of ocean topography and plate move-ment patterns can be ***.

关键词：迁移学习超分辨率卫星大地测量预训练地形复杂度地球圈层均衡机制弧秒