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Migration of bisphenol A and its related compounds in canned seafood and dietary exposure estimation

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Food Quality and Safety 2022年第2期6卷 275-286页

作者： Na Lin Derong ma Zhidong Liu Xichang Wang liyan ma East China Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghaiChina Shanghai Ocean University ShanghaiChina

The present study sought to investigate the migration of target bisphenols,such as bisphenol-A(BPA),bisphenol-F(BPA),bisphenol-A diglycidyI ether(BADGE),bisphenol-A(2,3-dihydroxypropyl)glycidyl ether(BADGE.H_(2)O),bisphenol-A bis(2,3-dihydroxypropyl)ether(BADGE.2H_(2)O),and bisphenol F diglycidyl ether(BFDGE)in 102 samples of several canned seafood,namely canned Antarctic krill,scallop,oysters,mussel,clam,and mantis shrimp stored for months at different temperatures through a high-performance liquid chromatographic-fluorescence detector com-bined with a microwave-assisted extraction *** for BFDGE,the other five bisphenols were observed in most of the analyzed *** canned shrimp showed the highest migration of BPA(0.089 mg/kg),exceeding the specific migration limit(SML)of BPA(0.05 mg/kg)specified by the European Union,while the migration levels of BADGE and its derivatives were within their *** migration behavior of bisphenols in the canned seafood was majorly affected by the analytes,storage conditions,and food ***,BADGE.H_(2)O,and BADGE 2H_(2)O were characterized by a rapid migration during the first half of the shelf life,which increased with the increase of temperature,followed by a stabilization or decline of their concentrations for prolonged ***,the migration of target bisphenols was significantly influenced by the storage temperature in some seafood ***,higher migration level of BPA was found in samples with higher fat *** average dietary exposure of Chinese adults to BPA,BPF,BADGE.2H_(2)O,BADGE.H_(2)O,and BADGE of canned seafood was estimated at 11.69,1.21,6.47,8.74,and 4.71 ng/(kg d),*** target hazard quotient values of all the analyzed bisphenols were below 1 for the Chinese adults,suggesting an insignificant exposure to these bisphenols through canned seafood consumption.

关键词： Bisphenol-A(BPA) BPA-related compounds canned seafood migration behavior dietary exposure

QuEChERS结合HPLC检测辣椒及其制品中天然辣椒素、二氢辣椒素和合成辣椒素

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食品科学 2025年第2期46卷 240-247页

作者：成璐瑶温雅君石文婷周子莹马丽艳中国农业大学食品科学与营养工程学院北京100083 北京市农产品质量安全中心北京100029 农业农村部农产品质量检验测试中心(北京) 北京100083

建立一种QuEChERS结合高效液相色谱快速检测辣椒及其制品中的天然辣椒素、二氢辣椒素和合成辣椒素的方法。样品用乙腈提取,无水硫酸镁、十八烷基硅烷(C18)、乙二胺-N-丙基硅烷化硅胶、石墨化炭黑复合吸附剂净化。采用Agilent Eclipse Pl... 详细信息

建立一种QuEChERS结合高效液相色谱快速检测辣椒及其制品中的天然辣椒素、二氢辣椒素和合成辣椒素的方法。样品用乙腈提取,无水硫酸镁、十八烷基硅烷(C18)、乙二胺-N-丙基硅烷化硅胶、石墨化炭黑复合吸附剂净化。采用Agilent Eclipse Plus C18(150 mm×4.6 mm,5μm)分离,以0.4%磷酸水溶液和90%乙腈溶液为流动相进行梯度洗脱,荧光检测器进行检测。结果表明:天然辣椒素、二氢辣椒素和合成辣椒素在0.20~100 mg/L范围内线性关系良好,决定系数(R2)均大于0.999。天然辣椒素的方法检出限为0.014~0.069 mg/kg,定量限为0.046~0.23 mg/kg;二氢辣椒素的方法检出限为0.023~0.12 mg/kg,定量限为0.077~0.39 mg/kg;合成辣椒素的方法检出限为0.018~0.088 mg/kg,定量限为0.059~0.30 mg/kg。在干辣椒、鲜辣椒、香菇酱、辣椒油4种基质中,3个不同添加水平下的加标回收率为91.6%~117.2%,相对标准偏差为0.2%~6.1%。该方法简便、准确,不仅适用于干、鲜辣椒,而且适用于高油、高蛋白等辣椒制品中天然辣椒素、二氢辣椒素和合成辣椒素含量的检测。

关键词： QuEChERS 高效液相色谱辣椒辣椒素合成辣椒素

EFFICIENT BOX-CONSTRAINED TV-TYPE-l^1 ALGORITHMS FOR RESTORING ImaGES WITH IMPULSE NOISE

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Journal of Computational mathematics 2013年第3期31卷 249-270页

作者： liyan ma Michael K. Ng Jian Yu Tieyong Zeng School of Computer and Information Technology Beijing Jiaotong University Beijing 100044 China Department of mathematics Hong Kong Baptist University Hong Kong China

In this paper, we study the restoration of images simultaneously corrupted by blur and impulse noise via variational approach with a box constraint on the pixel values of an image. In the literature, the TV-l^1 variational model which contains a total variation （TV） regularization term and an l^1 data-fidelity term, has been proposed and developed. Several numerical methods have been studied and experimental results have shown that these methods lead to very promising results. However, these numerical methods are designed based on approximation or penalty approaches, and do not consider the box constraint. The addition of the box constraint makes the problem more difficult to handle. The main contribution of this paper is to develop numerical algorithms based on the derivation of exact total variation and the use of proximal operators. Both one-phase and two-phase methods are considered, and both TV and nonlocal TV versions are designed. The box constraint [0, 1] on the pixel values of an image can be efficiently handled by the proposed algorithms. The numerical experiments demonstrate that the proposed methods are efficient in computational time and effective in restoring images with impulse noise.

关键词： Image restoration Impulse noise Total variation Nonlocal total variation Proximal Operators.

Effect of Co substitution on the glass forming ability and magnetocaloric effect of Fe88Zr8B4 amorphous alloys

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Science China(Physics,Mechanics & Astronomy) 2017年第7期60卷 81-84页

作者： LiangHua Gan liyan ma BenZhen Tang Ding Ding Lei Xia Laboratory for Microstructure Institute of Materials Shanghai University Shanghai 200072 China

As greater attention is paid to energy consumption and global warming, magnetic refrigeration （MR） technologies based on the magneto-caloric effect （MCE） have been developed. Systems based on MR are expected to be more compact, energy efficient, and environmentally safe compared with traditional vapor-cycle refrigeration technologies .

关键词： Effect of Co substitution on the glass forming ability and magnetocaloric effect of Fe Co Figure Zr8B4 amorphous alloys

Application of Pb isotopic tracing technique to constraining the source of Pb in the West Lake Longjing tea

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Chinese Journal Of Geochemistry 2011年第4期30卷 554-562页

作者： LU Yuanfa YANG Hongmei ma liyan CHEN Xiqing WANG Qunying Department of Geochemistry Yangtze University Jingzhou 434023 China Key Laboratory of Exploration Technologies for Oil and Gas Resources (Yangtze University) Ministry of Education Jingzhou 434023 China Yichang Institute of Geology and Mmeral Resources Yichang 443003 China

This paper dealt with the Pb contents and Pb isotopic composition of the West Lake Longjing tea. The results showed that in the tea leaves, from young leaf →old leaf →tea limb, the Pb contents tend to increase gradu-ally from 1.63 →4.84 →6.07×10-6, wich revealed that the Pb was accumulated gradually in the tea. After cleaned, the Pb contents of tea leaves were significantly reduced. This indicated that the deposits on the surface of tea leaves made a great contributuion to Pb contents. The survey results for soils in the relevant tea gardens showed that soil from the Longjing tea garden has higher Pb contents, with an average level of 49.6×10-6, two times those of common soils (24×10-6) in China. Results of the systematic analysis for tea, tea garden soil and the samples with the relevant background of the Pb isotopic composition displayed that the Pb isotopic ratio of tea is 206Pb/207Pb=1.164±0.005 (2σ). The ratio of 206Pb/207Pb for the soil gradually decreased from residue phase, soil dilute acid extract phase, and then to urban topsoil, i.e., 1.175 →1.171 →1.170. The 208Pb/(206Pb+207Pb) ratios also show a similar variation trend. 206Pb/207Pb ratios in the samples with the relevant background were: vehicle exhaust, 1.124; coal-combustion, 1.156; atmosphere, 1.168; and water, 1.166. Comparative studies have shown that Pb pollution is popular in the environ-mental media (soil, atmosphere, water) in Hangzhou. With the aggravation of Pb pollution, the Pb isotopic composi-tion gradually changed from the natural background (soil residues) to the direction of automobile exhaust. This phe-nomenon could illustrate that the pollution source was the vehicle exhaust, while the coal-combustion contributed little to environmental pollution in Hangzhou. The Pb of the Longjing tea came mostly from soluble phase Pb in the polluted soil. Moreover, secondary pollution was caused by vehicle exhaust.

关键词：铅同位素组成西湖龙井茶同位素示踪技术茶园土壤汽车尾气应用铅同位素比值土壤残留

Lactate anions participate in T cell cytokine production and function

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Science China(Life Sciences) 2021年第11期64卷 1895-1905页

作者： Jing Wen Shipeng Cheng Yaguang Zhang Ran Wang Jiefang Xu Zhiyang Ling liyan ma Xinghao Ai Bing Sun School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China School of Life Science University of Science and Technology of ChinaHefei 230026China Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

After antigen stimulation, T cells preferentially increase aerobic glycolysis to meet the bioenergetic and biosynthetic demands of T cell activation, proliferation, and effector functions. Lactate, a by-product of glycolysis, has been reported to function as an important energy source and signaling molecule. Here, we found that lactate anions are involved in cytokine production in Tcells after TCR activation. During ex vivo T cell activation, the addition of excess sodium lactate(Na L) increased the production of cytokines(such as IFNγ/IL-2/TNFα) more than the addition of sodium chloride(NaCl). This enhanced cytokine production was dependent on TCR/CD3 activation but not CD28 activation. In vivo, Na L treatment inhibited tumour growth in subcutaneously transplanted tumour models in a T cell-dependent manner, which was consistent with increased T cell cytokine production in the Na L treatment group compared to the Na Cl treatment group. Furthermore, a mechanistic experiment showed that this enhanced cytokine production was regulated by GAPDH-mediated post-transcriptional regulation. Taken together, our findings indicate a new regulatory mechanism involved in glycolysis that promotes T cell function.

关键词： lactate glycolysis TCR activation immunometabolism

Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-inhibitory activity

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Science China Chemistry 2012年第12期55卷 2537-2547页

作者： WANG Meng ma liyan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin LIAO HongZe ma Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN Bing YAO ZhuJun State Key Laboratory of Coordination Chemistry and Nanjing National Laboratory of Microstructures Institute of Chemical Biology and Drug InnovationSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes of BiologicalSciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl sub- stituent have been found to exhibit much more potent TNF-a inhibitory activity than natural sinomenine and other derivatives.

关键词： sinomenine druggability heterocycle tumor necrosis factor-m inhibition

Preparation and characteristics of porous ceramics

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Global Geology 2007年第2期10卷 166-170页

作者： Dongmei SHAO Peiping ZHANG liyan ma Juanjuan LIU College of material Science and Engineering Jilin University Changchun 130026 China

Pyrophyllite is always used for making porous ceramics. In order to design the preparation technics of porous ceramics with pyrophyllite reasonably we must know the classifications, characteristics, properties and applications of porous ceramics. The classification and characteristics of porous ceramics are reviewed in this article; and several common preparations with their advantages and disadvantages are also introduced. The authors discussed the problems existing in researching and developing process for porous ceramics, and forecasted the development prospect of porous ceramics.

关键词： porous ceramics pyrophyllite preparation

A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues

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Cellular & Molecular Immunology 2022年第5期19卷 647-649页

作者： Chunyan Yi Zhiyang Ling Xiao Lu Yadong Fu Zhuo Yang Sonam Wangmo Shuangfeng Chen Yaguang Zhang liyan ma Wangpeng Gu Hongzhou Lu Xiaoyu Sun Bing Sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China National Clinical Center for Infectious Disease The Third People’s Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518112Guangdong ProvinceChina Shanghai Public Health Clinical Center Shanghai Medical CollegeFudan UniversityShanghai201508China

The newly emerged Omicron(B.1.1.529)variant of SARS-CoV-2 is quickly overtaking the Delta variant and becoming the dominant strain around the world due to its enhanced transmissibility and high immune escape potential[1,2].Compared to the Wuhan strain,the Omicron variant carries 37 spike mutations,of which 15 are within the receptor-binding domain(RBD)(Fig.1A).A high mutation rate is associated with remarkable resistance to current vaccines and RBD-specific antibody therapeutics[2,3,4].

关键词： residues becoming Omi