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Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn

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Chinese Journal of Integrative Medicine 2021年第12期27卷 912-918页

作者： ma li-tian BAI Yang li Jie QIAO Yu liU Yang ZHENG Jin Department of Traditional Chinese Medicine Tangdu Hospitalthe Fourth Military Medical UniversityXi'an(710038)China Department of Gastroenterology Tangdu HospitalAir Force Medical UniversityXi'an(710032)China Department of Anatomy Histology and Embryology&K.K.Leung Brain Research Centrethe Fourth Military Medical UniversityXi'an(710032)China Department of Neurosurgery General Hospital of Northern Theater Command(General Hospital of Shenyang Military Command)Shenyang(110016)China Department of Endocrinology Xijing Hospitalthe Fourth Military Medical UniversityXi'an(710038)China Laser Medical Center Hainan HospitalPeople's Liberation Army General HospitalSanya(572013)Hainan ProvinceChina Health Center of 31658 of the People's liberation Army Xining(810000)China

Objective To investigate the mechanisms underlying elemene-induced analgesia in rats with spared nerve injury(SNI).Methods Sixty-five rats were equally divided into 5 groups using a random number table:naive group,sham group,SNI group,SNI+elemene(40 mg·kg−1·d−1)group and naive+elemene(40 mg·kg−1·d−1)*** SNI rat model was established and the intervention were given respectively for 14 consecutive *** Frey filament tests and elevated plus-maze(EPM)tests were used to evaluate the effect of elemene on the mechanical threshold and anxiety,*** and immunostaining were used to measure the expression of glial fibrillary acidic protein(GFAP)and NMYC downstream-regulated gene 2(NDRG2)within the lumbar spinal dorsal horn(SDH).Results The SNI rat model exhibited a significant decrease in paw withdrawal threshold and exploratory behaviour in the EPM(P<0.05).Consecutive administration of elemene alleviated SNI-induced mechanical allodynia and anxiety in rats(P<0.05).Immunohistochemical data showed that elemene decreased SNI-induced upregulation of NDRG2 within the SDH(P<0.05).Double immunofluorescent staining data further showed that elemene decreased SNI-induced upregulation of the number of GFAP immunoreactive(-ir),NDRG-ir,and GFAP/NDRG2 double-labelled cells within the SDH(P<0.05).Immunoblotting data showed that elemene decreased SNI-induced upregulation of GFAP and NDRG2 within the SDH(P<0.05).Conclusion Elemene possibly alleviated neuropathic pain by downregulating the expression of NDRG2 in spinal astrocytes in a rat model of SNI.

关键词： elemene emulsion injection astrocyte NMYC downstream-regulated gene 2

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ST-elevation myocardial infarction caused by very late stent thrombosis due to drug-eluting stent fracture

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Chinese Medical Journal 2012年第15期125卷 2794-2796页

作者： ma Guo-tian li Lang WU Xiang-hong Department of Cardiology First Affiliated Hospital GuangxiMedical University Nanning Guangxi 530021 China

Although the incidence of coronary stent fracture （SF） is relatively rare, the increasing amount of patients v undergoing percutaneous indicates more cases coronary- intervention （PCI） of SF. The incidence of sirolimus-eluting stent （SES） fracture is reported in 0.89% to 4.4% of patients at 6 to 12 months follow-up 12 anglography post-PCI. Recently, SF has been recognized as a complication that may result in thrombosis, perforation, restenosis, and migration of the stent resulting in morbidity and mortality. Here we describe a rare case presented with ST-elevation myocardial infarction （STEMI）, which was caused by very late stent thrombosis due to SES fracture, in order to help the physicians ensure rapid recognition and treatment of this urgent situation.

关键词： myocardial infarction drug-eluting stents, fracture coronary angioplasty

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Anti-fibrotic Effects of Salvia miltiorrhiza and ligustrazine Injection on LX-2 Cells Involved with Increased N-myc Downstream-Regulated Gene 2 Expression

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Chinese Journal of Integrative Medicine 2017年第12期23卷 923-928页

作者： zheng jin ma li-tian ren qin-you hu yue bai yang bian huan zhang yi zhou yong-chun yang ming-hui department of traditional chinese medicine chinese pla general hospitalBeijing 100853China department of integrated traditional and western medicine of oncology tangdu hospitalthe fourth military medical universityXi'an 710032China department of gastroenterology bethune international peace hospitalShijiazhuang 050082China department of anatomy and k.k.leung brain research center faculty of basic medicinethe fourth military medical university department of biochemistry and molecular biology the fourth military medical universityXi'an 710032China department of radiotherapy oncology the first affiliated hospitalthe fourth military medical universityXi'an 710032China

Objective: To investigate the effects of Salvia miltiorrhiza and ligustrazine Injection（SML） on proliferation and apoptosis of human hepatic stellate cell LX-2 and the expression of N-myc downstreamregulated gene 2（NDRG2, a tumor suppressor gene）. Methods: HSCs from the LX-2 cell line were cultured in vitro. The proliferative state of different initial LX-2 cell numbers was measured using a 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） colorimetric assay. LX-2 cells were plated in 96-well plates at an approximate density of 2.50×10;cells/mL and cultured for 24 h followed by the application of different concentrations of SML（1, 2, 4 and 8 μL/mL）. Cell proliferation was measured using the MTT assay at 24 and 48 h. Apoptosis was detected by flow cytometry at 24 h. LX-2 cells were treated with different concentrations of SML and extracted with protein lysis buffer. The levels of NDRG2 and β-catenin were measured by Western blot. Results: With the exception of the 1 and 2 μL/mL concentrations, 4 and 8 μL/mL SML inhibited cell proliferation in a concentration-dependent manner at 24 and 48 h（Pmanner. However, the level of β-catenin was unaffected. Conclusion: SML inhibit LX-2 cell proliferation in a concentration-dependent manner, and the mechanism may be associated with NDRG2 over-expression.

关键词： Salvia miltiorrhiza and ligustrazine Injection N-myc downstream-regulated gene 2 hepatic stellate cell proliferation apoptosis

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Anti-fibrotic Effects and Mechanism of Shengmai Injection(生脉注射液)on Human Hepatic Stellate Cells LX-2

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Chinese Journal of Integrative Medicine 2019年第3期25卷 197-202页

作者： ZHANG Yi ma li-tian li Jie QIAO Yu liU Jun-ye WANG Jin REN Qin-you HU Jin-tao ZHENG Jin Department of Traditional Chinese Medicine Tangdu Hospital The Fourth Military Medical University Department of Endocrinology The 986 Hospital of The People's Liberation Army Department of Anatomy and K.K. Leung Brain Research Center The Fourth Military Medical University Student Brigade The Fourth Military Medical University Department of Radiation Medicine The Fourth Military Medical University Department of Immunology The Fourth Military Medical University

Objective: To investigate the effects of Shengmai Injection(生脉注射液, SMI) on the proliferation, apoptosis and N-myc downstream-regulated gene 2(NDRG2, a tumour suppressor gene) expression in varying densities of human hepatic stellate cells LX-2. Methods: LX-2 cells were cultured in vitro. Then, cells were plated in 96-well plates at an approximate density of 2.5×10~4 cells/mL and cultured for 48, 72, 96 or 120 h followed by the application of different concentrations of SMI(0.6, 1.2, 2.4, 4.8 or 6 μL/mL). Cell proliferation was measured after an additional 24 or 48 h using the 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. The effects of SMI on different cell growth states(cultured for 48, 72, 96, or 120 h) were observed by light microscopy at 24 h after treatment. When the cells reached 80% confluence, apoptosis was detected by flow cytometry after 24 h. Lastly, LX-2 cells were treated with different concentrations of SMI and extracted with protein lysis buffer. The levels of NDRG2 were measured by Western blot. Results: When the LX-2 cells grew for 48, 72, 96 and 120 h, 4.8 and 6 μL/m L of SMI significantly inhibited cell proliferation at 24 and 48 h after treatment(Pliferation at 24 h after treatment when cell growth for 48 h(Pliferation of LX-2 cells were related to not only concentration dependent but also cell density. In addition, SMI(2.4, 4.8 and 6 μL/mL) could accelerate apoptosis in LX-2 cells, and the mechanism might be associated with NDRG2 over-expression.

关键词： Shengmai injection liver fibrosis N-myc downstream-regulated gene 2 LX-2 cell proliferation apoptosis Chinese medicine

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Effect of Phytosulfokine-α on Agrobacterium-Mediated Transformation in Rice

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Rice science 2005年第4期12卷 255-260页

作者： CHEN De-xi Xu Zheng-jun ma Bing-tian li Shi-gui Rice Research Institute Sichuan Agricultural University Wenjiang 611130 China

Phytosulfokine- α （PSK- α ）, a biologically active peptide acting as a growth factor, plays a key role in cellular differentiation and proliferation. To test if PSK- α has some influence on agrobacterium-mediated transformation in rice, PSK-α at a series of concentrations was added into co-culture medium respectively. The results showed that PSK- α indeed affected the recovery of resistant calli and the transformation frequency of rice varieties Taipei 309 and lijiangxintuanheigu, PSK- α at the concentration of 10 nmol/L could increase induction of resistant callus and efficiency of transformation, with a 11% and 4.9% top increase, respectively than the control. However, PSK- αat 200 nmol/L could inhibit the induction of the resistant calli. Further more, the effect of PSK-α on agrobacterium-mediated transformation is related with the concentration of 2, 4-D in selection medium. Higher induction rate of resistant calli was obtained from tissues treated with PSK- α plus 2 mg/L 2, 4-D.

关键词： phytosulfokine rice Agrobacterium-mediated transformation

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu li Yumeng Gao Feng tian Yu Wang Yuan Yao Shaoliang lin Xiang ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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基于不确定模型误差系统的变分贝叶斯STCKF

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控制与决策 2016年第12期31卷 2255-2260页

作者：马天力王新民彭程李婷边琦西北工业大学自动化学院西安710129

强跟踪容积卡尔曼滤波器在对含有模型误差和时变噪声的非线性系统进行滤波时,容易出现性能降低甚至发散.鉴于此,提出一种基于变分贝叶斯的强跟踪容积卡尔曼滤波算法.该算法运用虚拟噪声法补偿模型误差,假设虚拟噪声均值非零,且满足高斯... 详细信息

强跟踪容积卡尔曼滤波器在对含有模型误差和时变噪声的非线性系统进行滤波时,容易出现性能降低甚至发散.鉴于此,提出一种基于变分贝叶斯的强跟踪容积卡尔曼滤波算法.该算法运用虚拟噪声法补偿模型误差,假设虚拟噪声均值非零,且满足高斯分布,虚拟噪声方差服从逆gamma分布,在强跟踪容积卡尔曼滤波器估计状态的同时,采用变分贝叶斯推理估计虚拟噪声参数.仿真结果表明,所提出算法对含模型误差与时变噪声的非线性系统具有较好的估计精度,相比于自适应算法具有更强的鲁棒性.

关键词：强跟踪滤波器容积卡尔曼滤波器模型误差时变噪声虚拟噪声法变分贝叶斯理论

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Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng liu Xin ma Shaojie tian Qinghe Cui Beijing Advanced Innovation Center for materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

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一种改进的输出反馈特征结构配置方法在飞翼飞机增稳系统设计中的应用

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控制与决策 2016年第6期31卷 1111-1117页

作者：彭程王新民马天力何澳西北工业大学自动化学院西安710129 中航工业第一飞机设计研究院飞控与液压研究室西安710089

针对常规输出反馈特征结构配置方法不能完全保证闭环系统稳定性的问题,提出一种改进的输出反馈特征结构配置方法.该改进的算法通过引入二次型性能指标,将闭环系统的稳定性问题转化为线性二次型最优控制问题,从而保证闭环系统的稳定性;... 详细信息

针对常规输出反馈特征结构配置方法不能完全保证闭环系统稳定性的问题,提出一种改进的输出反馈特征结构配置方法.该改进的算法通过引入二次型性能指标,将闭环系统的稳定性问题转化为线性二次型最优控制问题,从而保证闭环系统的稳定性;考虑到采用特征结构配置方法所设计的闭环系统鲁棒性不强,给出保证系统鲁棒性的条件,以解决系统鲁棒性问题.最后,通过在飞翼飞机上的仿真结果验证了所提出算法的有效性.

关键词：飞翼飞机特征结构配置稳定性鲁棒性

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