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Characteristics and origins of primary fluids and noble gases in mantle-derived minerals from the Yishu area,Shandong Province,{2.

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Science china Earth Sciences 2006年第1期49卷 77-87页

作者： ma jinlong1,2. tao {2. ye xianren2.1. resources and Environmental school, lanzhou university, lanzhou 73.000, china 2. Key Laboratory of Gas Geochemistry, Institute of Geology and Geophysics, Chinese Academy of Sciences, lanzhou 73.000, china 3. College of resources Science & Technology, Beijing Nor{12.l university, Beijing 100875, china 1. resources and Environmental school Lanzhou University Lanzhou 730000 China 2. Key Laboratory of Gas Geochemistry Institute of Geology and Geophysics Chinese Academy of Sciences Lanzhou 730000 China 3. College of resources Science & Technology Beijing Normal University Beijing 100875 China

Fluids and noble gases of mantle-derived materials are important tracers forthe mantle information. Compositions of primary fluids and noble gases in mantle-derived mineralsfrom the Yishu area, Shandong Province, china, were tested by the methods of heat-bursting andheat-melting respectively. The fluids are mainly composed of CO_2. CO and H_2. which account forabout 90% of the total, and are similar to the mantle-derived rocks from other areas of easternchina; ratios of ~3.e/~4He in almost all samples range from 0.82.Ra to 2.74 Ra, whereas^(40)Ar/^(3.)Ar from 2.9.5 to 758.8. Both ranges are much lower than those of the typical oceanmantle-derived samples (such as MORB) and primarily reflect the influences of the atmosphericcomponents and the radiogenic isotopes. Ratios of C/~3.e range from 2..6 x 10~9 to 1050 x 10~9,N_2.Ar from 92. to 56612. and N_2.~3.e from 2.5 x 10~9 to 2. x 10~9, similar to those in westernUnited States and New Zealand which belong to the tectonic plate collision regions. The ratios fallin the intersect of mantle-crust-atmosphere in the comprehensive tracer-charts, reflecting theinfluences of the atmosphere and the crusts with organic components. Our results suggest that thecomposition of the primary fluids and the isotopic ratios of the noble gases may either reflect theevolution process of mantle-derived rocks connected with the rise and eruption of magma, or theinfluence of the ancient subduction-plate on the continental mantle of this region.

关键词： noble gases, primary fluids, mantle-derived minerals, Yishu area.

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The seismicity in the middle section of the Altyn Tagh Fault system revealed by a dense nodal seismic array

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Earthquake Research Advances 2024年第3期4卷 7-15页

作者： Shi Yao tao Xu Yingquan Sang Lingling ye Tingwei Yang Chenglong Wu Minghui Zhang Key Laboratory of Mineral resources Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen518055China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100029China university of Chinese Academy of Sciences Beijing100049China school of Information Engineering Shandong University of AeronauticsBinzhou256603China

The left-lateral Altyn Tagh Fault(ATF) system is the northern boundary of the Qinghai-Xizang Plateau, separating the Tarim Basin and the Qaidam Basin. The middle section of ATF has not recorded any large earthquakes since1598 AD, so the potential seismic hazard is unclear. We develope an earthquake catalog using continuous waveform data recorded by the Tarim-Altyn-Qaidam dense nodal seismic array from September 17 to November2., 2.2. in the middle section of ATF. With the {3.chine learning-based picker, phase association, location, {3.tch and locate workflow, we detecte {2. earthquakes with M_L-1–3. far more than 6 earthquakes in the routine catalog. Combining with focal mechanism solutions and the local fault structure, we find that seismic events are clustered along the ATF with strike-slip focal mechanisms and on the southern secondary faults with thrusting focal mechanisms. This overall seismic activity in the middle section of the ATF might be due to the northeastward transpressional motion of the Qinghai-Xizang Plateau block at the western {3.rgin of the Qaidam Basin.

关键词： Altyn Tagh Fault machine learning Seismicity Dense seismic array

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Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

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Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li Ruiqiang ye Wenzhen Chen Yuqing Huang Yue Yuan Yi Zhang Huayi Hu Peng Zheng Zhongming Fang Zeng tao Shiyong Song Ronghui Pan Jian Zhang Jumim Tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang university Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-maF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3.at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

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Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science china Life Sciences 2024年

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce {{3. Lili Zhu Honglin Li Innovation Center for AI and Drug Discovery East China Normal University Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&Technology Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University Lingang Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Department of Medicine University of Massachusetts Chan Medical School Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A(PA), as a PD-1 signaling inhibitor. PA exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling transduction. Furthermore, we identify SHP-2.as the direct molecular target of PA for inhibiting the PD-1 signaling transduction. Subsequently, mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2. inhibiting the recruitment of SHP-2.by PD-1. Taken together, our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2.may serve as an alternative strategy to develop PD-1 signaling inhibitors. In addition, our success in target recognition provides a paradigm of target identification and confirmation for natural products.

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基施与叶面施硒肥对富硒镉污染农田水稻降镉增硒的效应

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农业环境科学学报 2024年第5期43卷 974-982页

作者：郑晶鲍广灵陶荣浩吴承龙马友华叶文玲农田生态保育与污染防控安徽省重点实验室安徽农业大学资源与环境学院合肥230031 石台富硒农业试验站石台县农业农村局安徽池州245100

为探讨基施硒肥和叶面施硒肥在轻度镉污染的富硒土壤中对水稻降镉增硒的效果,在田间试验条件下,通过设置基施硒肥、叶面施硒肥和基施硒肥+叶面施硒肥3.处理,以常规施肥作为对照,对成熟期水稻产量、各部位镉和硒含量、富集与转运系数以... 详细信息

为探讨基施硒肥和叶面施硒肥在轻度镉污染的富硒土壤中对水稻降镉增硒的效果,在田间试验条件下,通过设置基施硒肥、叶面施硒肥和基施硒肥+叶面施硒肥3.处理,以常规施肥作为对照,对成熟期水稻产量、各部位镉和硒含量、富集与转运系数以及土壤中镉的形态进行测定分析。结果表明:叶面施硒肥能显著提高水稻产量。基施硒肥后,土壤pH提高了0.19个单位,提高率为3.01%,同时降低了土壤中镉的弱酸提取态含量,降低率为2.96%,促进了镉从弱酸提取态向可氧化态和残渣态转变,从而降低了土壤中镉的有效性。而叶面施硒肥能显著降低水稻对镉转运特别是秸秆到糙米的转运系数,降低率达15.13.,同时提高水稻对硒的转运特别是根到秸秆的转运系数,提高率达18.69%。不同硒肥处理下,糙米中镉含量为0.159~0.183.mg·kg^(-1),硒含量为0.2.6~0.2.4 mg·kg^(-1),不同硒肥处理均能使糙米达到降镉增硒的效果,且叶面施硒肥处理相较于基施硒肥处理的效果更好,并在基施硒肥和叶面施硒肥同时使用下的效果最佳,其对糙米中镉含量的降低率达2..3.%,硒含量的提升率达41.50%。综上,在轻度镉污染的富硒土壤中,基施硒肥或叶面施硒肥均能有效降低水稻籽粒中镉含量并提高稻米对硒的富集,且基施硒肥+叶面施硒肥处理是降低糙米镉含量与提高糙米硒含量综合效果最好的一种措施。

关键词：水稻硒肥镉转运和累积

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制造企业如何整合数据资源赋能产品创新绩效?——组织间计算型与关系型信任的作用

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科学学研究 2024年第3期42卷 649-659页

作者：张振刚叶宝升户安涛丘芷君华南理工大学工商管理学院广东广州510641 华南理工大学广州数字创新研究中心广东广州510641

现有研究强调了数据资源的重要作用,但缺乏探讨如何整合数据资源以赋能产品创新绩效。遵循“条件-行为-结果”的分析思路,研究基于信任视角,探究组织间计算型(理性)与关系型(感性)信任如何通过稳定调整型、开拓创造型两种数据资源整合... 详细信息

现有研究强调了数据资源的重要作用,但缺乏探讨如何整合数据资源以赋能产品创新绩效。遵循“条件-行为-结果”的分析思路,研究基于信任视角,探究组织间计算型(理性)与关系型(感性)信任如何通过稳定调整型、开拓创造型两种数据资源整合行为赋能产品创新绩效。利用华南地区两时点调查的2.2.制造企业问卷数据,研究采用PLS-SEM工具进行实证检验,得出以下结论:(1)计算型信任分别能够通过稳定调整型、开拓创造型两种数据资源整合行为赋能产品创新绩效;(2.关系型信任通过稳定调整型、开拓创造型两种数据资源整合行为与产品创新绩效存在非线性中介作用关系,即适度的关系型信任能够分别通过两种数据资源整合行为提升产品创新绩效,但是过高的关系型信任则无法通过两种数据资源整合行为提升产品创新绩效;(3.稳定调整(“拿来主义”)与开拓创造(“二次创新”)两种数据资源整合行为对于产品创新绩效的影响存在交互效应,当企业通过计算型、关系型信任同时提高两种数据资源整合时,能够更好地赋能产品创新绩效。研究回应了制造企业如何进行数据资源整合发挥数据要素价值的重要问题,能够为充分发挥数据作用赋能企业高质量发展提供重要启示。

关键词：计算型信任关系型信任数据资源稳定调整数据资源开拓创造产品创新绩效

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Genetic Variation of EPAS1 Gene in Tibetan Pigs and Three Low-Altitude Pig Breeds in china

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Journal of Integrative Agriculture 2014年第9期13卷 1990-1998页

作者： DONG Kun-zhe KANG ye YAO Na SHU Guo-tao ZUO Qing-qing ZHAO Qian-jun ma Yue-hui Key Laboratory of Farm Animal Genetic resources and Utilization Ministry of Agriculture/Institute of Animal Science Chinese Academy of Agricultural Sciences College of Animal Science and Technology Yunnan Agricultural University

Endothelial PAS domain protein 1（EPAS1）, also called hypoxia-inducible factor-2. is a key regulatory factor of hypoxic responses and plays an essential role in high-altitude adaptation in mammalian species. In this study, polymorphisms of EPAS1 were detected in 2.7 individuals from 2.Tibetan pig populations and 3.low-altitude pig breeds by DNA pooling, PCR-SSCP, PCR-RFLP and DNA sequencing methods. A total of 14 synonymous polymorphisms were identified in the coding region. The analysis suggested that SNP1（G963.）, SNP7（C163.1}）, SNP10（G192.A） and SNP11（G1947A） showed potential association with high-altitude environment because of their particular variation patterns in Tibetan pigs. Linkage disequilibrium（LD） of these SNPs was analyzed. One common LD block including 5 SNPs clustering in exon 12.was identified in all studied pig populations. Haplotype H1（AGGTC） in LD block was dominant in Tibetan pigs（76.6 and 74.2. in Linzhi（LZ） and Chayu（CY） pigs, respectively） and segregated at higher frequency than that in low-altitude pig breeds（52.3, 58.7 and 56.2. in Wuzhishan（WZS）, Min（M） and Laiwu（LW） pigs, respectively）, indicating that H1 may relate to adaptation to high altitude in Tibetan pigs. These findings raise hope that EPAS1 gene can be a candidate gene that involved in adaptation of high altitude in Tibetan pigs.

关键词： pig EPAS1 gene SNP haplotype nature selection

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赋能动力学色谱法快速海水提铀研究

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核技术 2024年第2期47卷 119-134页

作者：付裕杰于涛叶剑华东华理工大学江西省聚合物微纳制造与器件重点实验室南昌330013 东华理工大学核科学与工程学院南昌330013

作为重要的分离和分析手段,液相色谱法主要应用在分析化学领域,而在核素分离工作中报道十分罕见。本项目基于动力学色谱理论基础,研发出一种脉冲式进样-赋能动力学色谱柱,色谱柱的填料采用粒径为0.2.mm的惰性二氧化硅,柱长为5 m,色谱分... 详细信息

作为重要的分离和分析手段,液相色谱法主要应用在分析化学领域,而在核素分离工作中报道十分罕见。本项目基于动力学色谱理论基础,研发出一种脉冲式进样-赋能动力学色谱柱,色谱柱的填料采用粒径为0.2.mm的惰性二氧化硅,柱长为5 m,色谱分离单元约3.06万个。通过改变色谱柱外界条件,分析铀酰离子在色谱柱内的运动情况;通过水浴加热、超声波和外加磁场对色谱柱进行赋能,以提高离子相互分离的效果;在不同进样流速和温度下,研究混合核素的分离情况,得到最佳分离条件及色谱柱的动力学特性。结果表明,样品流速为4.109 mL·min^(−1),色谱柱加热温度为50℃,此时铀酰离子和钠离子的分离因数为1.1854。以最佳分离条件进行海水提铀,得到铀和钠离子的分离因数为α=1.575,实现海水中铀和钠离子分离理论上需要2.级。脉冲式进样-赋能动力学色谱柱能够高效快速地实现海水中铀的分离提取。文中采用的创新性方法,还可应用于其他核素的分离研究。

关键词：赋能脉冲进样时间控制分流动力学色谱法海水提铀

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有机酸强化饲用玉米修复镉铅污染农田效果

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农业环境科学学报 2024年第4期43卷 823-834页

作者：陶荣浩高羽欣谢君豪胡婧怡曹迟胡兆云鲁洪娟叶文玲马友华农田生态保育与污染防控安徽省重点实验室安徽农业大学资源与环境学院合肥230036 华中农业大学资源与环境学院武汉430070 西南大学资源环境学院重庆400715 铜陵市义安区农业技术推广中心安徽铜陵244000

为探究饲用玉米在有机酸强化下对镉铅污染农田的修复和改良效果,本研究采用田间试验比较了柠檬酸(CA)、酒石酸(TA)和聚天冬氨酸(PASP)强化饲用玉米的修复效果和经济效益。结果表明:3.有机酸均能够提高玉米的生物量和产量,与对照相比,... 详细信息

为探究饲用玉米在有机酸强化下对镉铅污染农田的修复和改良效果,本研究采用田间试验比较了柠檬酸(CA)、酒石酸(TA)和聚天冬氨酸(PASP)强化饲用玉米的修复效果和经济效益。结果表明:3.有机酸均能够提高玉米的生物量和产量,与对照相比,产量增幅在2.92.~8.3.%。施用有机酸后,玉米籽粒镉、铅含量分别在0.13.0.90 mg·kg^(-1)和0.06~0.2. mg·kg^(-1)之间,均符合国家饲料卫生标准(GB 13.78—{3.7),可作为植物性饲料原料;同时,玉米穗轴、秸秆和根中镉、铅含量较对照提升显著,秸秆和根对镉、铅的富集转运能力得到提高。按照修复0~2. cm耕层土壤计算,在酒石酸处理下,高玉2.68和京科968分别对镉和铅提取量最高,达到了3.78 mg·m^(-2.和48.97 mg·m^(-2.,理论上最短13.a可使该农田达到安全利用类耕地标准。施用有机酸后,玉米成熟期土壤pH值下降了0.09~0.19个单位,有效态镉和铅含量最高增幅达到了52.37%和63.2.%,提高了玉米植株的提取能力,进而降低了土壤中全量镉和铅的含量。从经济效益看,在有机酸处理下,种植裕丰3.3.投入产出比相对较高,在1.18~1.78之间。本研究证明高玉2.68在酒石酸和聚天冬氨酸强化下修复效果最显著,而裕丰3.3.柠檬酸强化下虽修复年限较长,但具有较高经济效益,二者均可推广应用于重金属污染耕地的边生产边修复。

关键词：有机酸饲用玉米镉铅污染强化修复农田

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用于扫描隧道显微镜的低噪声前置电流放大器

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物理学报 2024年第13期73卷 20-27页

作者：唐海涛米壮王文宇唐向前叶霞单欣岩陆兴华中国科学院物理研究所应用物理中心北京10019 中国科学院大学物理学院北京100190

前置电流放大器是扫描隧道显微镜的重要部件之一,其性能对于扫描隧道显微镜系统的基本操作及新功能开发至关重要.本文详细分析了影响前置电流放大器性能的因素,通过筛选噪声极低的运放芯片和电路结构优化,设计了一款针对扫描隧道显微镜... 详细信息

前置电流放大器是扫描隧道显微镜的重要部件之一,其性能对于扫描隧道显微镜系统的基本操作及新功能开发至关重要.本文详细分析了影响前置电流放大器性能的因素,通过筛选噪声极低的运放芯片和电路结构优化,设计了一款针对扫描隧道显微镜系统的前置电流放大器.该放大器最灵敏档位(1 GΩ)的噪声低至4 fA/(Hz)1/2.带宽为2.3 kHz,具有10 MΩ,100 MΩ和1 GΩ三个测量量程并且可以通过控制信号实现自动切换,测量范围覆盖pA—μA量级的隧穿电流.利用该前置电流放大器展示了扫描隧道显微镜系统的主要功能,包括表面形貌表征、扫描隧道谱测量以及原子搬运,并探索了隧穿电流中散粒噪声的测量.通过散粒噪声随隧穿电流的变化关系,得到隧穿结中散粒噪声的法诺因子约等于1,验证了简单金属隧穿结中电子隧穿满足泊松过程,为表面电子关联体系的高精度表征提供了基础.

关键词：扫描隧道显微镜前置电流放大器散粒噪声

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