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A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

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Protein & Cell 2023年第12期14卷 888-907页

作者： Daoyuan Huang Yuesheng Zuo Chen Zhang Guoqiang Sun Ying Jing jinghui Lei Shuai ma Shuhui Sun Huifen Lu Yusheng Cai Weiqi Zhang Fei Gao Andy Peng Xiang Juan Carlos Izpisua Belmonte Guang-Hui Liu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stemcell and Regeneration CAsBeijing100101China China National Center for Bioinformation Beijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China 11Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou510000China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510000China Altos Labs Inc.San DiegoCA 92121USA and Aging Biomarker Consortium China

The testis is pivotal for male reproduction,and its progressive functional decline in aging is associated with ***,the regulatory mechanism underlying primate testicular aging remains largely ***,we resolve the aging-related cellular and molecular alterations of primate testicular aging by establishing a single-nucleus transcriptomic ***-expression patterns along the spermatogenesis trajectory revealed molecular programs associated with attrition of spermatogonial stem cell reservoir,disturbed meiosis and impaired spermiogenesis along the sequential ***,Sertoli cell was identified as the cell type most susceptible to aging,given its deeply perturbed age-associated transcriptional ***,downregulation of the transcription factor Wilms'Tumor 1(WTi),essential for Sertoli cell homeostasis,was associated with accelerated cellular senescence,disrupted tight junctions,and a compromised cell identity signature,which altogether may help create a hostile microenvironment for ***,our study depicts in-depth transcriptomic traits of non-human primate(NHP)testicular aging at single-cell resolution,providing potential diagnostic biomarkers and targets for therapeutic interventions against testicular aging and age-related male reproductive diseases.

关键词： single-nucleus RNA sequencing primate testis aging WT1

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Age of the Miyun dyke swarm:Constraints on the maximum depositional age of the Changcheng System

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Chinese Science Bulletin 2012年第35期57卷 105-110页

作者： PENG Peng LIU Fu ZHAI MingGuo GUO jinghui State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

A group of NE-trending(～30°)mafic dykes,termed Miyun swarm herein,are distributed around the Miyun Reservoir,northe China,and have individual widths of over 40 m,and lengths of up to 8000 *** grains were extracted from a～40 wide *** an isotope dilution thermal ionization mass spectrometry method,these grains yield an average 207Pb/206Pb a of 1731±4 ma(n=4;or 1731±1 ma,n=3).Because this dyke is overlain unconformably by conglomerates of the Changzhoug Formation,the lowermost formation of the Changcheng Group,the maximum depositional age of this group is constrained to no earlier than 1731 *** result also suggests that the Changcheng System,with the Changcheng Group as its standard stra graphic section,is younger than 1731 *** Miyun dykes possibly have distinct petrogenesis from the subsequent anorth site-rapakivi intrusions(1730-1680 ma),which are thought to be responsible for the opening of the Yan-Liao rift,where Changcheng Group was *** it is reasonable to set the initial boundary of the Changchengian Period at 1730 ma slightly younger.

关键词：密云水库长城系年龄岩墙沉积热电离质谱法长城集团谷物产量

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The N^6-adenine methylation in yeast genome profiled by single-molecule technology

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Journal of Genetics and Genomics 2018年第4期45卷 223-225页

作者： Zhe Liang Guoliang Yu Jingrong Liu Yuke Geng jinghui mao Depeng Wang Jiapeng Zhou Xiaofeng Gu Biotechnology Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China Department of Biological Sciences National University of Singapore 117543 Singapore Grandomics Biosciences Beijing 102206 China

The most common and abundant DNA modification is 5-methylcytosine（5mC）,which has been well-established as an epigenetic mark regulating gene expression in eukaryotes（Jones,2012）.Another DNA modification N^6-methyl... 详细信息

关键词： DNA TSS The N~6-adenine methylation in yeast genome profiled by single-molecule technology

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Geochemistry and zircon U-Pb chronology of charnockites in the Yinshan Block,North China Craton:tectonic evolution involving Neoarchaean ridge subduction

Geochemistry and zircon U-Pb chronology of charnockites in t...

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中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Xudong ma Hong-Rui Fan M.Santosh jinghui Guo Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences School of Earth Sciences and Resources China University of Geosciences Beijing State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences

The Yinshan Block,part of the Neoarchaean basement of the Western Block of the North China Craton,is composed of granite-greenstone and granulite-charnockite *** report research on a suite of charnockites from the gran- ulite-charnockite complex and characterize their geochemistry,zircon U-Pb geochronology,and Hf isotopic composition. The charnockites can be divided into intermediate(SiO=59-63 wt.%)and silicic(SiO=69-71 wt.%)groups.U-Pb zircon data yield protolith formation ages of 2524±4 ma.2533±15 ma,followed by metamorphism at 2498±3 ma, 2490±11 ma,respectively,for these *** the intermediate chamockites are characterized by higher AlO, TiO,FeO,MnO,MgO,CaO,PO,KO,Sr,and FREE content than the silicic charnockites,the ages and Hf isotopic composition of zircons and REE patterns of both intermediate and silicic charnockites are remarkably *** indicates that they are genetically *** chamockites are predominantly metaluminous to slightly peraluminous, calc-alkalic to calcic,and magnesian一characteristics generally related to a subduction ***-Sr+Ba granites with low KO/NaO characteristics,shown by these charnockites,imply a mixture of matiic and felsic magmas generated from an enriched mantle+lower *** MgO,Ni,Cr and Mg#,low KO/NaO,and metaluminous to slightly peraluminous natures imply that the source rocks most likely were *** calc-alkaline magmatism and high-T granulitefacies metamorphism under low-HO activity in the area lead us to propose a model involving mid-ocean ridge subduction within a Neoarchaean convergent *** arc-related rocks accreted along the continent margin,and became a barrier when the lithospheric mantle ascended through the slab *** derived from the decompressing mantle mixed with melt derived from the overlying,juvenile lower crust melt,which was warmed and metamorphosed by the ascending lithospheric mantle.

关键词： end of Archaean charnockites Hfisotopes zircon U-Pb geochronology Yinshan Block North China Craton

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Zircon U-Pb ages,trace elements and Nd-Hf isotopic geochemistry of Guyang sanukitoids and related rocks:Implications for the Archean crustal evolution of the Yinshan Block,North China Craton

Zircon U-Pb ages,trace elements and Nd-Hf isotopic geochemis...

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中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Xudong ma jinghui Guo Fu Liu Qing Qian Hongrui Fan Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences

The Yinshan Block is a unique coherent Neoarchean basement terrane of the Western Block of the North China *** this paper,three Archean plutons,namely the Dajitu,Banshentu and Haolaigou plutons, have been *** on the field observations,the major difference among these plutons is that many ultramafic-mafic enclaves are enclosed in the Dajitu and Banshentu plutons,whereas none occurs in the Haolaigou ***,the Dajitu and Banshentu plutons are characterized by low SiO contents(56-67wt%),high MgO(1.9-7.1 wt%),Cr(10-947 ppm),Ni(2-274ppm)and Mg# (44-64)contents,negative Nb,Ta and Ti anomalies,high large ion lithophile elements(LILEs),with no or slightly negative Eu anomalies,similar to a typical Archean *** geochronological data indicate that the Dajitu and Banshentu plutons were emplaced at 2523±7 ma and 2480±20 ma,with inherited ages of 2606±19 ma and 2647±19 ma,*** contrast,the Haolaigou pluton shows high SiO(68-71 wt%),MgO,Mg#(46-55),Cr,and Ni contents,negative Nb,Ta and Ti anomalies,and high LILEs,with strongly positive Eu anomalies,high Sr and Ba concentrations and Sr/Y and La/Yb ratios,and low Y and HREEs *** was emplaced at 2466±15 ma,with an inherited age of 2638±21 ma. The whole-rockε(t)and zirconε(t)values of the Haolaigou pluton are *** whole-rock TDM(Nd)and zircon T(Hf)values range between 2.6 and 2.8 Ga with a peak at～2.7 Ga,indicating that the melt was generated by the partial melting of a subducted slab interacting with the overlying mantle *** Dajitu pluton has Nd and Hf isotope characteristics identical to those of the Haolaigou pluton, implying that the two plutons have similar *** should be noted,however,that the Dajitu pluton displays sanukitoid characteristics,which are the result of interaction with ultramafic-mafic enclaves. The whole-rockε(t)and zirconε(t)values of the Banshentu pluton are mostly *** whole- rock T(Nd)and zircon T(Hf)values of the plu

关键词： Sanukitoid Nd-Hf isotope Zircon U-Pb age Yinshan Block North China Craton

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Chronology and geochemistry of Neoarchean BIF-type iron deposits in the Yinshan Block,North China Craton:Implications for oceanic ridge subduction

Chronology and geochemistry of Neoarchean BIF-type iron depo...

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

The Dongwufenzi iron deposit is a typical Algoma-type Banded Iron Formation(BIF) in the Yinshan block of the North China *** iron orebodies occur as layers interlayered with plagioclase ***-ICP-MS UPb dating of zircons from the plagioclase amphibolite yielded protolith crystallization age of 2538 ± 9 ma(MSWD= 1.01),followed by metamorphism at2452 ± 7 ma(MSWD = 0.68).The geochemical characteristics of the ores including low A1O,TiO and HFSE contents,pronounced positive Eu anomalies,and the Y/Ho ratios(26-37) suggest that the BIFs precipitated from hydrothermal fluids discharged on the *** geochemical features of the plagioclase amphibolite suggest the protolith magma to be high-Fe ***-Nd analyses of the plagioclase amphibolite yielded εNd(t = 2.54 Ga) and single-stage depleted mantie Nd model ages(T)in the range of ca.+ 1.8 to +3.0 and 2.68 to 2.81 Ga,respectively,suggesting an enriched mantle *** link the source of Fe in the BIFs to the komatiitic complex in the same greenstone belt,and the source of Si with the high-Fe *** geochronological and geochemical data from the other Archean rocks in this area suggest that the Dongwufenzi BIF formed at 2.5 Ga,coeval with the other BIFs in the North China Craton(NCC) as well as similar occurrences in other parts of the *** propose a geodynamic model involving ridge subduction and slab window for the formation of the BIFs and the associated rock suites in the greenstone belt.

关键词： Late Archean Greenstone belt Banded iron formation Zircon U-Pb geochronology Oceanic ridge subduction

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T follicular helper cells and T follicular regulatory cells in rheumatic arthritis

T follicular helper cells and T follicular regulatory cells ...

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第十四届全国免疫学学术大会

作者： jinghui Zhan Xiaoqi Yue Tengyao Niu Qiang Gao Runqiu ma Yanli Zhang 宁夏医科大学基础医学院

As a hallmark of autoimmune rheumatoid arthritis,autoantibodies have been used in diagnosis for ***,the immunological mechanism underlying their generation has only become clear following the identification of T follicular helper(Tfh) cells and T follicular regulatory(Tfr) cells.T follicular helper T(Tfh) cells are necessary for germinal center(GC) formation and within the GC,provide key signals to B cells for their differentiation into plasmablasts and plasma cells that secrete high-affinity and isotype-switched antibody(Ab).U nder normal circumstances,the germinal center reaction results in antibodies that precisely target foreign pathogens while limiting autoimmunity and excessive *** order to have this degree of control,the immune system ensures Tfh-mediated B-cell help is regulated locally in the germinal center.T follicular regulatory cells,a newly identified subset of Tregs,have been found in GCs where they control GC responses by acting on both Tfh and GC B *** indicate that patients with autoimmune rheumatoid arthritis have increased numbers of Tfh cells that can be hyperactive,and also potentially have altered numbers of Tfr cells with reduced function,suggesting a conceivable dysregulation in the balance between Tfh cells and Tfr cells in these ***,by identifying the molecular mechanisms underlying the development and function of these cell populations,new opportunities have emerged to develop novel therapeutic *** application will only be achieved by the inclusion of Tfh cells and Tfr cells as part of biomarker discovery in future clinical trials.

关键词： rheumatoid arthritis T follicular helper T follicular regulatory autoantibodies

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Catalyst-Free C-H Bond Functionalization of Benzoxazoles with Chromium（0） Fischer Carbene Complexes

Catalyst-Free C-H Bond Functionalization of Benzoxazoles wit...

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中国化学会第九届全国有机化学学术会议

作者： Fangdong Hu jinghui Yang Ying Xia Chen ma Yang Zhang Jianbo Wang Beijing National Laboratory of Molecular Sciences(BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of ChemistryPeking University School of Chemistry and Chemical Engineering Shandong University

＜正＞Since firstly discovered in 1964,[1]Fischer carbene complexes have been developed into valuable and powerful organometallic reagents for organic synthesis.[2]As the most prevalent members of these organometallic...

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交联型微米级聚苯乙烯粒度标准物质的研制

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强激光与粒子束 2016年第6期28卷 131-134页

作者：范敬辉吴菊英马艳中国工程物理研究院总体工程研究所四川绵阳621900

采用分散聚合法制备了标称粒径为3μm的单分散交联型聚苯乙烯(PS)微球。相对于线型μm级聚苯乙烯而言,交联型μm级聚苯乙烯的耐热性和耐溶剂性明显提高,其玻璃化温度提高了28.6℃,在常用溶剂中保持不溶解状态。采用扫描电子显微镜(SEM)... 详细信息

采用分散聚合法制备了标称粒径为3μm的单分散交联型聚苯乙烯(PS)微球。相对于线型μm级聚苯乙烯而言,交联型μm级聚苯乙烯的耐热性和耐溶剂性明显提高,其玻璃化温度提高了28.6℃,在常用溶剂中保持不溶解状态。采用扫描电子显微镜(SEM)绝对测量法对交联型μm级聚苯乙烯粒度标准物质进行定值,用美国国家标准技术研究院(NIST)的粒度标准物质校正其放大倍数。定值结果为2.84μm,扩展不确定度为0.08μm。采用F检验法和t检验法检验了样品的均匀性和稳定性。定值过程和均匀性、稳定性都符合国家二级粒度标准物质的要求。μm级交联型聚苯乙烯微球粒度标准物质,可用于高温和腐蚀等极端环境下的粒度分析。

关键词：交联型聚苯乙烯 μm级微球标准物质定值

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强度参量双界限凸集模型及双调数值解法

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应用力学学报 2000年第1期17卷 85-90页

作者：张之颖张景绘马强西安交通大学西安710049 中国建筑西北设计研究院西安710003

采用非传统概率方法—凸集方法来考虑地震动强度的不确定性。提出了一个能直接关联反应地震动强度因素的双界限凸集模型 ,介绍了在该模型下求得最不利侧移响应和地震激励的双调数值解法。最后通过实际算例 ,验证了该模型算法的实用性。

关键词：结构地震激励双界限凸集模型强度参量

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