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Spatial and Temporal Change of Habitat Quality of Poyang Lake Basin in China at Small Watershed Scale and Its Multidimensional Response to Landscape Pattern

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Chinese Geographical Science 2023年第3期33卷 565-582页

作者： BI manyu ZHONG Yexi XIAO Zeping FENG Xinghua ma hongzhi School of Geography and Environment Jiangxi Normal UniversityNanchang 330022China Key Laboratory of Poyang Lake Wetland and Watershed Research Ministry of Education(Jiangxi Normal University) Nanchang 330022China

The health and function of ecosystems are largely determined by the quality of habitat,and the optimal regulation of landscape patterns has become an important way to improve regional habitat quality.This article takes the Poyang Lake Basin of China as a case,reveals the spatial and temporal change of its habitat quality at the small watershed scale,and attempts to examine the multidimensional response of habitat quality to landscape pattern changes with respect to landscape compositions and landscape configuration.The results show:1)from 2000 to 2020,the overall landscape fragmentation of the basin decreased,the landscape aggregation in the central small watersheds changed significantly,and the spatial distribution of landscape elements in the central and southern small watersheds were relatively homogeneous.2)The overall habitat quality of the Poyang Lake Basin is at a middle to high level,with significant spatial differentiation,showing the distribution characteristics of‘high in the periphery,low in the center,high in the south and low in the north’.3)Both landscape compositions and landscape configurations influenced habitat quality,but there were obvious differences in the response degree.From the landscape composition and configuration dimension,the influence of landscape composition on habitat quality was greater than that of landscape configuration;from the multilevel landscape configuration dimension,compared to landscape level,landscape configuration at the class level impacted habitat quality more deeply.To the end,this article proposes a differentiated regulation strategy for habitat quality conservation in small watersheds from the perspective of landscape patterns to improve the ecological service level of Poyang Lake Basin.

关键词： landscape watershed Spatial

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基于羧基化单壁碳纳米角的荧光传感体系检测胰蛋白酶

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分析试验室 2024年第1期43卷 24-29页

作者：冯婷婷闫姝竹马洪志杨丽霞王晓华山西中医药大学中药与食品工程学院晋中030619 桂林医学院药学院桂林541004

构建了一种基于羧基化单壁碳纳米角(oxSWCNHs)的简单、灵敏的荧光传感体系用于胰蛋白酶的检测。实验中合成了水溶性的oxSWCNHs,并设计了一段羧基荧光素(FAM)标记肽段作为胰蛋白酶的底物,该底物能与胰蛋白酶进行特异性反应。当体系中没... 详细信息

构建了一种基于羧基化单壁碳纳米角(oxSWCNHs)的简单、灵敏的荧光传感体系用于胰蛋白酶的检测。实验中合成了水溶性的oxSWCNHs,并设计了一段羧基荧光素(FAM)标记肽段作为胰蛋白酶的底物,该底物能与胰蛋白酶进行特异性反应。当体系中没有胰蛋白酶存在时,FAM标记的肽段可以被oxSWCNHs强烈吸附,致使体系具有较低的荧光背景;当体系中有胰蛋白酶存在时,胰蛋白酶可以与其底物肽段发生特异性水解反应,导致FAM标记的肽段水解为单个氨基酸,致使FAM远离oxSWCNHs表面,FAM荧光不能被oxSWCNHs淬灭,体系具有较强的荧光强度,从而实现荧光传感体系对胰蛋白酶的检测。该传感体系线性范围为0~2.5μg/mL,可用于尿液中胰蛋白酶的测定。

关键词：单壁碳纳米角荧光传感体系胰蛋白酶

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管道特性曲线法在注射水储存分配系统的应用

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山西建筑 2024年第4期50卷 116-118,130页

作者：马宁江进马鸿志中电系统建设工程有限公司北京100040 广东工业大学广东广州510006 北京科技大学北京100083

应用管道特性曲线法对制药企业注射水储存分配系统的流量与压力关系进行了分析探讨,提出了简化计算的方法,并结合具体工程案例进行了分析比较。针对系统实际运行调试过程中出现的常见问题,提出了相应的理论依据及措施。

关键词：制药厂房注射水储存分配系统回水流量管道特性曲线

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经皮针状电极在甲状腺术中喉返神经监测的研究

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西安交通大学学报（医学版） 2024年第1期45卷 94-99页

作者：王哓艳钟琦马泓智郭伟丁硕赵延明何雨蓉李齐佳首都医科大学附属北京同仁医院耳鼻咽喉头颈外科学教育部重点实验室北京100730

目的比较经皮针状电极和经口插管表面电极用于甲状腺术中神经监测的异同,并探讨在不适合经口插管或表面电极故障时,如何识别和保护喉返神经和迷走神经。方法收集并分析32例因甲状腺疾病接受手术治疗患者的临床资料,共计监测喉返神经和... 详细信息

目的比较经皮针状电极和经口插管表面电极用于甲状腺术中神经监测的异同,并探讨在不适合经口插管或表面电极故障时,如何识别和保护喉返神经和迷走神经。方法收集并分析32例因甲状腺疾病接受手术治疗患者的临床资料,共计监测喉返神经和迷走神经各40侧,分别使用经口插管表面电极及经皮针状电极对神经进行监测,记录所获取的振幅及潜伏期。采用SPSS 26.0软件进行统计分析,采用配对t检验对潜伏期进行分析比较,采用秩和检验分析经皮针状电极与经口插管表面电极刺激所得振幅是否有差异。结果经皮针状电极用于甲状腺术中神经监测时,所有神经均被识别并获得与经口插管表面电极潜伏期和振幅相似的双相肌电信号,并可通过潜伏期有效鉴别喉返神经和迷走神经[(3.22±0.50)ms vs.(3.85±1.00)ms,P<0.05],与经口插管表面电极的监测效果[(3.04±0.58)ms vs.(3.89±1.07)ms,P<0.05]无明显差异;同时,经皮针状电极可视化操作度及安全性都更高,具有很大优势。结论经皮针状电极可有效辅助识别并保护喉返神经和迷走神经,是经口插管表面电极的重要补充。

关键词：针状电极神经监测甲状腺手术喉返神经迷走神经

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Factors contributing to lymph node occult metastasis in supraglottic laryngeal carcinoma cT2-T4 N0M0 and metastasis predictive equation

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Chinese Journal of Cancer Research 2014年第6期26卷 685-691页

作者： hongzhi ma Meng Lian Ling Feng Pingdong Li Lizhen Hou Xiaohong Chen Zhigang Huang Jugao Fang Department of Otolaryngology-Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Key Laboratory of Otorhinolaryngology Head and Neck Surgery Ministry of Education Beijing Institute of Otorhinolaryngology Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology

Objective： To investigate factors that contribute to lymph node metastasis（LNM） from clinical cT2-T4 N0M0（cN0） supraglottic laryngeal carcinoma（SLC）, and to predict the risk of occult metastasis before surgery.Methods： A total of 121 patients who received surgery were retrospectively analyzed. Relevant factors regarding cervical LNM were analyzed. Multivariate analyses were conducted to predict the region where the metastasis occurred and prognosis. Results： The overall metastatic rate of c N0 SLC was 28.1%. Metastatic rates were 15.4%, 32.5% and 35.7% for T2, T3 and T4, respectively. Metastatic rates for SLC levels II, III and IV were 19.6%, 17.2% and 3.6%, respectively. A regression equation was formulated to predict the probability of metastasis in cN0 SLC as follows： Pn=e（–3.874＋0.749T3＋1.154T4＋1.935P1＋1.750P2）/[1＋e（–3.874＋0.749T3＋1.154T4＋1.935P1＋1.750P2）]. Approximately 0.2% of patients experienced LNM with no recurrence of laryngeal cancer. Comparison of the intergroup survival curves between patients with and without LNM indicated a statistically significant difference（P=0.029）.Conclusions： Cervical lymph node metastatic rates tended to increase in tandem with T stage in patients with LNM in cN0 SLC, and neck dissection is advised for these patients. Moreover, cervical LNM in cN0 SLC showed a sequential pattern and may be predicted.

关键词： Larynx lymph nodes neoplasm metastasis prediction

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Clinical applications of free medial tibial flap with posterior tibial artery for head and neck reconstruction after tumor resection

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Chinese Journal of Cancer Research 2017年第3期29卷 231-236页

作者： Qi Zhong Jugao Fang Zhigang Huang Xiaohong Chen Lizhen Hou Yang Zhang Pingdong Li hongzhi ma Hongbo Xu Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing Institute of Otolaryngology Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University) Ministry of Education

Tumor resection causes damage in the head and neck which creates problems in swallowing, chewing, articulation, and vision, all of which seriously affect patients' quality of life. In this work, we evaluated the application of a free medial tibial flap in reconstruction of head and neck defects after tumor resection. We discussed the anatomy, surgical technique, and the advantages and disadvantages of the flap. We found several benefits for the flap, such as, it is especially effective for the defects that require thin-layer epithelium to cover or the separated soft tissue defect; a two-team approach can be used because the donor site is far away from the head and neck; and the flap is easy to integrate because of the subcutaneous fat layer of the free medial tibial flap is thin and the flap is soft. Thus, the medial tibial flap could replace the forearm flap for certain applications.

关键词： Head and neck free flap posterior tibial artery reconstruction

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Cathode catalyst prepared from bacterial cellulose for ethanol fermentation stillage treatment in microbial fuel cell

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Chinese Journal of Chemical Engineering 2021年第12期34卷 256-261页

作者： Huiyu Li Ming Gao Pan Wang hongzhi ma Ting Liu Jin Ni Qunhui Wang Tien-Chin Chang Department of Environmental Engineering University of Science and Technology BeijingBeijing Key Laboratory of Resource-oriented Treatment of Industrial PollutantsBeijing 100083China Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business UniversityBeijing 100048China Institute of Environmental Engineering and management National Taipei University of TechnologyTaipei 106China

Bacterial cellulose doped with P and Cu was used as a catalyst for a microbial fuel cell(MFC) cathode,which was then used to treat ethanol fermentation stillage from food waste.Corresponding output power,coulombic efficiency(CE),and biological toxicity were detected.Through a series of characterization experiments,the addition of the cathode catalyst was found to improve catalytic activity and accelerate the consumption of the substrate.The resulting maximum output power was 572.16 mW·m^(-2).CE and the removal rate of chemical oxygen demand(COD) in the fermentation stillage by P-Cu-BC reached 26% and 64.5%,respectively.The rate of biotoxicity removal by MFC treatment reached 84.7%.The aim of this study was apply a novel catalyst for MFC and optimize the treatment efficiency of fermentation stillage.

关键词： Microbial fuel cell Oxygen reduction reaction Fermentation Catalyst Biomass Biotoxicity

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Screening of molecular markers of induced chemotherapy in supraglottic laryngeal squamouscell carcinoma

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 34-40页

作者： Guang Yang Jugao Fang Qiang Shi Ru Wang Meng Lian hongzhi ma Ling Feng Xixi Shen Yu Wang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversitBeijing100730China Department of Otorhinolaryngology Head and Neck Surgery Former 263 ClinicalCenter of People's Liberation ArmyGeneral HospitalBeijing Key Laboratory of Head and Neck Molecular Diagnostic PathologyBeijing100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Captical Medical University) Ministry of EducationBeijing100730China

Objective:To investigate the expressions of maPK10,c-Jun and Itga6 in laryngeal carcinoma and its influence on the sensitivity to docetaxel,cisplatin and 5-fluorouracil(TPF)chemotherapy.Methods:Fifty-seven patients with supraglottic squamous cell carcinoma,who were treated by two cycles of TPF induction chemotherapy in our hospital,were enrolled in this study and divided into groups by chemotherapy resistance or chemotherapy sensitivity.The expressions of mRNA and protein of maPK10,c-Jun and Itga6 in tumor tissues were evaluated by immunohistochemistry.The consistency of mRNA and protein expressions was tested,and the relation with the clinicopathological features was analyzed.Results:The positive rates of maPK10 andc-Jun in the tumor tissues of the sensitive group were significantly higher than those of there assistant group,which was 90.48%and 100.00%,respectively.The expression rate of Itga6 was significantly higher in the resistant group,which was 83.33%(PmaPK10 and c-Jun were significantly lower in the resistant group than in the sensitive group,whilethemRNA levelof Itga6was significantly higher in the resistant group(PmaPK10,c-Jun and Itga6 were consistent with their mRNA expressions(PmaPK10,c-Jun and Itga6 were not correlatedwithage,gender and tumor diameter(P>0.05).However,the expressions of maPK10 and c-Jun were negatively correlated withclinical stage and pathological grading(PmaPK 10 and Itga6,and between c-Jun and Itga6in tumor tissues were found by Spearman’srank correlation coefficient(PmaPK10 and c-Jun expressions were down-regulated,while the Itga6 expression was up-regulated in the chemo-resistant laryngeal carcinoma,and the expression levels of different factors were correlated witheach other.These factorsmight be important biomarkers for predicting outcomes of TPF chemotherapy in

关键词： Larynx carcinoma Drug resistance maPK10 c-Jun ltga6

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免疫联合化疗逆转MET D1228E合并EGFR L858R介导的MET 14外显子跳跃突变肺腺癌耐药

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肿瘤药学 2024年第2期14卷 252-255页

作者：张星周玉玲言欢秦浩越陈阳倩张聿达黄哲向思琦马宏志张琳曾亮杨农张永昌南华大学衡阳医学院湖南省肿瘤医院研究生协作培养基地湖南衡阳421001 湖南省肿瘤医院肺胃肠内科湖南长沙410013 湖南省肿瘤医院头颈放疗二科湖南长沙410013 湖南省肿瘤医院胸部放疗一科湖南长沙410013

1例间质-上皮细胞转化因子(MET)14外显子跳跃突变的Ⅳ期肺腺癌患者服用MET酪氨酸激酶抑制剂(TKI)赛沃替尼8.5个月后疾病进展(PD),耐药基因检测提示出现新的MET 19外显子D1228E及表皮生长因子受体(EGFR)21外显子L858R错义突变。遂将治疗... 详细信息

1例间质-上皮细胞转化因子(MET)14外显子跳跃突变的Ⅳ期肺腺癌患者服用MET酪氨酸激酶抑制剂(TKI)赛沃替尼8.5个月后疾病进展(PD),耐药基因检测提示出现新的MET 19外显子D1228E及表皮生长因子受体(EGFR)21外显子L858R错义突变。遂将治疗方案改为EGFR-TKI奥希替尼联合克唑替尼治疗,23天后临床症状加重,复查CT提示PD。经多学科诊疗(MDT)讨论,将三线治疗方案改为以铂类为基础的化疗联合免疫治疗,期间最佳疗效评价为部分缓解(PR),无进展生存期为6.4个月。目前,对于MET-TKIs耐药后新发二次突变合并EGFR突变的患者尚无标准治疗方案,本案例为此类患者提供了一种可供参考的后续治疗方案。

关键词：肺腺癌 MET 14外显子跳跃突变二次突变免疫联合化疗

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依托创新实验室的研究生协同培养模式探索

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教育学术月刊 2022年第11期 78-84页

作者：钟业喜杜竞马宏智江西师范大学地理与环境学院江西南昌330022 江西省教育评估监测研究院江西南昌330038

提高创新能力是研究生培养的重要目标。在研究生招生数量扩张、跨专业报考背景下,地方高校研究生普遍存在“专业基础不扎实、研究方法不熟练、学术资源不充分”现象,学习力、实践力和创造力不足。江西师范大学依托研究生创新中心开展协... 详细信息

提高创新能力是研究生培养的重要目标。在研究生招生数量扩张、跨专业报考背景下,地方高校研究生普遍存在“专业基础不扎实、研究方法不熟练、学术资源不充分”现象,学习力、实践力和创造力不足。江西师范大学依托研究生创新中心开展协同培养模式探索,以地理学科硕士研究生培养为试点,通过多领域打通、多学科融合、多团队协同,显著提高了研究生的科研产出、创新能力和培养质量。

关键词：导学研协同文理工协同产教研协同研究生培养

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