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Clinical,biochemical and imaging characteristics of adrenal histoplasmosis in immunocompetent patients in a non-endemic area:A case series

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Asian Pacific Journal of Tropical Medicine 2021年第10期14卷 471-477页

作者： Sharmin Jahan Tahseen mahmood Md Fariduddin Ibrahim Faisal Md Shahed Morshed Anil Yadav Anil Kumar Shah Chomon Abdullah Emran-Ur-Rashid Chowdhury Ferdousi Begum ma hasanat Department of Endocrinology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh Department of Endocrinology Combined Military HospitalDhaka CantonmentDhakaBangladesh Division of Endocrinology Department of Internal MedicineIndira Gandhi Memorial HospitalKanbaa Aisa Rani HigunMale'-20402Republic of Maldives Department of Emergency Kurmitola General HospitalDhakaBangladesh Division of Endocrinology Department of Internal Medicine Birat Medical College Teaching HospitalBiratnagarNepal Division of Endocrinology Department of Internal MedicineChitwan Medical CollegeChitwan 44300Nepal Department of Pathology Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh

Objective:To document the clinical,biochemical and imaging phenotypes of immunocompetent patients with adrenal ***:The clinical,biochemical and radiologic data of 18 immunocompetent patients[age:45.00(39.25,56.25)years,median(IQR),m/f(16/2)]with adrenal histoplasmosis presenting in the Department of Endocrinology,BSMMU between 2014 and 2020 were retrospectively ***:All patients were seronegative for HIV infection,and 27.8%(5/18)had well controlled diabetes *** median duration of the symptoms was 6.00(IQR:4.00,11.25)*** had significant weight loss,anorexia and *** was present in 61.1%(11/18)patients and night sweat was present in 27.8%(5/18)*** and hyperpigmentation were present in 55.6%(10/18)and 66.7%(12/18)cases,*** of 18 patients presented with adrenal *** occurred in 55.6%(10/18)cases,but none had *** of 18 patients had adrenal insufficiency whereas 83.3%(15/18)had high adrenocorticotropic *** scan revealed bilateral adrenal enlargement in all cases with oval shape and regular *** were hypodense having radiodensity 21-90 hounsfield unit,and 11.1%(2/18)were heterogeneous in contrast *** had noticeable calcification whereas 1.1%(2/18)cases had central necrosis with peripheral rim *** was present in 6 cases,splenomegaly in 3 cases and 5 patients had abdominal *** were confirmed by positive fine needle aspiration cytology of adrenal ***:Adrenal histoplasmosis should be considered in the list of differentials of bilateral adrenomegaly in immunocompetent individuals even living in non-endemic areas.

关键词： Histoplasmosis Immunocompetent Nonendemic Adrenal CT

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