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The Pathogenic Characteristics of the Initial Three Mpox Cases in Hunan Province, China

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Biomedical and Environmental Sciences 2023年第12期36卷 1167-1170页

作者： LIU Rong Jiao XIANG Xing Yu HE Zi Xiang SUN Qian Lai LIU Fu Qiang ZHOU Shuai Feng HUANG Yi Wei LI Fang Cai HUANG Chao Yang WANG Juan HE Fang ling OU Xin Hua LI Shi Kang LU Yu Ying ZHANG Fan CAI Liang ma hai ling ZHAN Zhi Fei Hunan Province Center for Disease Control and Prevention Changsha 410153HunanChina Changsha Center for Disease Prevention and Control Changsha 410004HunanChina

Mpox virus (MPXV) belongs to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus,which also includes Variola virus(VARV),Cowpox virus (CPXV),and Vaccinia virus(VACV).Clinical symptoms of mpox are similar to smallpox but are relatively milder^([1]).MPXV was first isolated from crab-eating monkeys in the tropical rainforests of Africa in 1958^([2]).The first human case of MPXV infection was reported in the Congo in1970^([3]).Following the eradication of smallpox in1977,mpox has emerged as one of the prominent viral members of the Poxviridae family,significantly impacting public health^([4]),mainly prevalent in Central and West *** from may 2022.

关键词： Hunan Africa belongs

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钢轨表面瞬态传热系数的实验研究

工程热物理学报 2016年第12期37卷 2668-2673页

作者：马海玲谢建斌王良璧兰州交通大学机电工程学院铁道车辆热工教育部重点实验室兰州730070

随着列车高速化、重载化,轮轨间的接触疲劳越来越严重。列车运行时产生的摩擦热也大大增加。巨大的摩擦热使钢轨表面产生很大的温升,如果钢轨表面温度过高,会使钢轨表面的磨损加速,甚至发生裂纹、剥离等破坏。而车轮通过瞬间钢轨表面瞬... 详细信息

随着列车高速化、重载化,轮轨间的接触疲劳越来越严重。列车运行时产生的摩擦热也大大增加。巨大的摩擦热使钢轨表面产生很大的温升,如果钢轨表面温度过高,会使钢轨表面的磨损加速,甚至发生裂纹、剥离等破坏。而车轮通过瞬间钢轨表面瞬态传热系数的大小直接影响钢轨表面的散热程度。因此,本文通过实验方法获得了钢轨表面的瞬态传热特性,从而为准确分析钢轨表面的瞬态传热提供依据。

关键词：车轮通过钢轨瞬态传热对流换热系数

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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化学实验教学与学生创新意识的培养

青海师专学报 2005年第6期25卷 48-49页

作者：马海玲青海湟川中学二分校青海西宁810000

化学实验是学习和研究化学的重要手段.通过化学实验,可以培养学生的创新意识,让学生在学习中亲身经历从实验中发现问题到解决问题的过程,展示学生的聪明才智、独特个性.从而激发学生的学习兴趣,培养学生的主动性、独立性和独特性等.

关键词：化学实验创新意识

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某种电话机消毒液杀菌效果及稳定性试验观察

预防医学论坛 2006年第4期12卷 450-451页

作者：马海玲湖南省邵阳市疾病预防控制中心湖南邵阳422000

[目的]了解某电话机消毒液的杀菌效果及其稳定性。[方法]按照卫生部《消毒技术规范》[1]中方法进行载体浸泡定量杀菌试验、现场消毒试验和稳定性试验。[结果]该电话机消毒液在使用浓度下,作用3min,对布片上大肠杆菌杀灭率达99.96%,对白... 详细信息

[目的]了解某电话机消毒液的杀菌效果及其稳定性。[方法]按照卫生部《消毒技术规范》[1]中方法进行载体浸泡定量杀菌试验、现场消毒试验和稳定性试验。[结果]该电话机消毒液在使用浓度下,作用3min,对布片上大肠杆菌杀灭率达99.96%,对白色念珠菌杀灭率达99.99%;作用5min,对金黄色葡萄球菌杀灭率达99.99%,对电话机听筒表面的自然菌杀灭率达99.99%。在54℃存放14d,有效浓度下降4.51%。[结论]该电话机消毒液杀菌效果及稳定性均良好。

关键词：电话机消毒液杀菌效果稳定性

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血红素氧合酶及其在神经系统疾病中的作用

中华神经医学杂志 2009年第12期8卷 1286-1290页

作者：马海玲沈霞崔桂云徐州医学院研究生部徐州221002 徐州医学院附属医院神经内科徐州221002

血红素氧合酶（heme ***）是生物体内血红素降解的催化酶，它催化血红素降解为等摩尔的胆绿素、一氧化碳（carbonmonoxide，co）和铁。近年来发现它除了具有降解血红素的功能外．还在许多生理和病理过程中起重要的作用，与神经系统疾病... 详细信息

血红素氧合酶（heme ***）是生物体内血红素降解的催化酶，它催化血红素降解为等摩尔的胆绿素、一氧化碳（carbonmonoxide，co）和铁。近年来发现它除了具有降解血红素的功能外．还在许多生理和病理过程中起重要的作用，与神经系统疾病如脑血管病、脊髓病变、帕金森病、阿尔茨海默病等亦有很大关系，故如何从药理学水平、分子水平及基因水平调节HO的表达，并应用到神经系统疾病的研究或临床，将会引起越来越多的关注。本文对H0及其在上述几种疾病中的作用综述如下。

关键词：血红素氧合酶神经系统疾病

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

PaCLR介导PaLECT2激活脂多糖刺激的香鱼(Plecoglossus altivelis)单核巨噬细胞功能

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海洋与湖沼 2017年第3期48卷 583-588页

作者：史雨红马海玲梁亚芳陈航陈炯宁波大学海洋学院生物化学与分子生物学实验室宁波315211

香鱼(Plecoglossus altivelis)白细胞衍生趋化因子2(leukocyte cell-derived chemotaxin 2,PaLECT2)可以激活香鱼头肾来源的单核巨噬细胞(monocytes/macrophages,MO/MΦ),提高细菌感染后香鱼存活率。进一步研究显示,PaLECT2与香鱼C型凝集素受体(C-type lectin receptor,PaCLR)相互作用可激活静息状态下香鱼MO/MΦ,增强其免疫活性。在前期基础上,本研究通过抗体封闭实验检测PaCLR是否介导PaLECT2激活LPS刺激的MO/MΦ功能。结果显示,重组PaLECT2成熟肽(rPaLECT2m)显著提高了LPS刺激的香鱼MO/MΦ细胞因子的表达,并增强了其吞噬能力和杀菌活性。封闭PaCLR显著抑制了rPaLECT2m激活LPS刺激的香鱼MO/MΦ细胞因子表达、吞噬和杀菌功能。因此,PaCLR介导PaLECT2可以激活病理状态香鱼MO/MΦ。这一认识进一步揭示了LECT2在病理状态的鱼类巨噬细胞调控和炎症反应中的作用及机制。

关键词： LECT2 C型凝集素受体单核巨噬细胞功能脂多糖刺激