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Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients

Chinese Medical Journal 2011年第22期124卷 3641-3645页

作者： SUN Jie DOU Jing-tao WANG Xian-ling YANG Guo-qing LU Zhao-hui ZHENG Hua ma fang-ling LU Ju-ming MU Yi-ming Department of Endocrinology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes. This study aimed to analyze the correlation between 1,5-anhydroglucitol （1,5-AG） and glycemic excursions in type 2 diabetic patients. Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People＇s Liberation Army General Hospital. Using a continuous glucose monitoring system （CGMS）, these patients＇ blood glucose levels were monitored for three consecutive days to obtain mean blood glucose （MBG） data. Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions （maGE）, the largest amplitude of glycemic excursions （LAGE）, standard deviation of blood glucose （SDBG） and the M-value. Interday glycemic excursion was assessed by absolute mean of daily difference （MODD）. Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions （PPGE） and postprandial incremental area under the curve （iAUC）. Fasting venous blood samples were collected to measure serum 1,5-AG, whole-blood hemoglobin Alc （HbAlc） and serum glycated albumin （GA）. Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression. Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with maGE, SDBG, M-value, LAGE, PPGE and iAUC （r values were-0.509,-0.430,-0.530,-0.462,-0.416 and-0.435, respectively, P 〈0.01）, especially in moderately and well-controlled patients, based on defined HbAlc levels. Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters, but not HbAlc and GA. Finally, HbAlc and GA were positively correlated with MBG and fasting blood glucose （FBG）. Conclusions 1,5-AG was much better than HbAlc and GA

关键词： 1,5-anhydroglucitol type 2 diabetes mellitus glycemic excursions

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Experimental study on neuroendocrinological and immunological characteristics of the military-trained artillerymen

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Chinese Medical Journal 2012年第7期125卷 1292-1296页

作者： LI Xin HUANG Wen-XU LU Ju-ming YANG Guang ma fang-ling LAN Ya-ting MENG Jun-hua DOU Jing-tao Department of Endocrinology Chinese People’s Liberation Army General HospitalBeijing 100853China

Background Over one million soldiers were treated for battle- or training-fatigue during World War I1. Of all ground combat troops, 37% were discharged for psychiatric reasons due to fatigue. The neuroendocrinological and immunological systems played important roles in the work-related fatigue of military personnel. The aim of this study was to investigate the characteristics of fatigue associated with military operations, and we observed changes in the regulatory functions of the neuroendocrinological and immunological systems that may provide theoretical support for improving the combat effectiveness of armies. Methods A total of 240 soldiers from the Field Artillery regiment were selected as subjects. Researchers and subjects received training before participating in the study. Data of the subjects＇ medical histories, physical examinations, scores on a fatigue assessment scale, and assessments of pituitary-adrenal hormones （adrenal cortical hormone （ACTH）, cortical hormone （F）, and 24-hour urine-free cortisol （UFC））, pituitary-gonadal hormones （luteinizing hormone （LH）, follicle-stimulating hormone （FSH）, testosterone, estradiol （E2）, and prolactin （PRL））, pituitary-thyroid hormones （thyroid-stimulating hormone （TSH）, thyroxine （TT4）, triiodothyronine （TT3）, free thyroxine （FT4）, and free triiodothyronine （FT3））, and cellular immune parameters （CD3~, CD4~, CD8~, CD4~/CD8＋, B, and NK cells） were investigated before and after large-scale and high-intensity field exercises. Data were statistically analyzed with Student＇s t test using SPSS software （version 13.0）, and P values 〈0.05 were deemed to be significant. Results After the high-intensity military training, the scores on the fatigue scale reflected significant increases of feeling of unpleasantness among soldiers. Additionally, the symptom checklist showed notable increases in somatization scores and significant decreases in psychoticism scores. After intensive military work, levels of plasma ACTH, F, and UFC

关键词： training fatigue military operations endocrine hormones immune indices job inventory

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A rigorous real-time acoustic positioning method for ocean bottom seismic exploration

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Satellite Navigation 2024年第1期5卷 168-190页

作者： Jinye ma Shouchuan fang Jianhu Zhao School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079China Institute of marine Science and Technology Wuhan UniversityWuhan430079China Surveying Service Center BGP Inc.CNPCZhuozhou072751HebeiChina

The conventional technique for positioning seafloor geophones in ocean bottom seismic exploration encounters several challenges,including the significant impact of outliers on positioning results,underutilization of high-precision observations,and low efficiency in real-time data *** issues inevitably affect the quality of seismic exploration *** address these challenges and enhance the accuracy of geophone positioning,this paper proposes a rigorous real-time acoustic positioning method for geophones based on sequential adjustment and Baarda's outlier detection *** proposed method comprises three key steps:grouping the original acoustic observations,constructing the intra-group acoustic positioning model,and synthesizing the positioning results across the different *** validity and practicality of this approach are confirmed through a simulation experiment as well as the field experiment conducted in the Bohai Sea,*** results demonstrate that the proposed method effectively eliminates outliers in the original observations and maximizes the utilization of high-quality *** to traditional acoustic positioning methods,it significantly reduces positioning errors from meters to decimeters,and in some cases can achieve centimeter-level *** the sound velocity profile in the operating sea area is measured,the method can attain the posterior standard deviation at the millimeter level and positioning errors within 10 *** the sound velocity profile is unknown,the method can achieve the posterior standard deviation at centimeter-level and positioning errors of approximately 20 cm.

关键词： Ocean bottom seismic exploration Geophone positioning Acoustic positioning method Sequential adjustment Outlier detection

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Effects of a Multivitamin/multimineral Supplement on Young males with Physical Overtraining: A Placebo-controlled, Randomized, Double-blinded Cross-over Trial

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Biomedical and Environmental Sciences 2013年第7期26卷 599-604页

作者： LI Xin HUANG Wen Xu LU Ju Ming YANG Guang ma fang ling LAN Ya Ting MENG Jun Hua DOU Jing Tao Department of Endocrinology Chinese PLA General Hospital

Objective To investigate the effects of vitamin-mineral supplement on young males with physica overtraining. Methods Two hundred and forty male Chinese field artillery personnel who undertook large scale and endurance military training and were on ordinary Chinese diet were randomized to receive a multivitamin/multimineral supplement or a placebo for 1 week. After a 1-week wash-out period, a cross-over with 1 week course of a placebo or multivitamin/multimineral supplement was conducted. Blood and urine samples were analyzed for adrenal, gonadal and thyroid hormones. In addition, cellular immune parameters （CD3＋, CD3＋CD4＋, CD3＋CD8＋, CD4/CD8, CD3-CD56＋, CD3-CD19＋） were examined and psychological tests were performed before and after the training program and nutrition intervention. Results After a large scale and endurance military training, the participants showed significantly increased thyroid function, decreased adrenal cortex, testosterone and immunological function, and significantly increased somatization, anger and tension. Compared to placebo, multivitamin/ multimineral intervention showed significant effects on functional recovery of the pituitary - adrenal axis, pituitary-gonadal axis, pituitary- thyroid axis and immune system as well as psychological parameters. Conclusion High-intensity military operations have significant impacts on the psychology, physical ability and neuroendocrine-immune system in young males. Appropriate supplementation of multivitamin/multimineral can facilitate the recovery of the psychology, physical ability and neuroendocrine-immune system in young males who take ordinary Chinese diet.

关键词： Overtraining Vitamins Intervention Randomized Diet supplement

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Application of three-dimensional electron diffraction in structure determination of zeolites

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结构化学 2024年第4期43卷 39-47页

作者： Yuhang Li Yang ling Yanhang ma School of Physical Science and Technology & Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai201210China

Zeolites have received great attention due to their wide applications in various fields such as catalysis,adsorp-tion/separation,ion exchange,*** the atomic crystal structure of zeolites is crucial to understanding their functions and exploring their *** to the difficulty of synthesizing large single crystals,the structures of many zeolites cannot be solved using conventional single-crystal X-ray diffraction(SCXRD)***-dimensional electron diffraction(3D ED)has witnessed rapid development during the past decade and has shown its powerful ability in the structure determination of *** this review,we will briefly introduce the history of 3D ED and summarize recent advances in the application of 3D ED for the analysis of zeolite structures,along with several typical examples in this research field.

关键词： Electron diffraction Three-dimensional electron diffraction Zeolite Structure solution Electron crystallography

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Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng ma Yanchun Zhu ling Qin Yuan Yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research Center for magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy magnesium alloy Strengthening mechanism

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Causal Analysis Between Rice Growth and Cadmium Accumulation and Transfer under Arbuscular Mycorrhizal Inoculation

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Rice science 2024年第2期31卷 226-236页

作者： ZHAO Ting WANG Li YANG Jixian ma fang State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

Cadmium(Cd)contamination in rice has been a serious threat to human *** investigate the effects of arbuscular mycorrhizal fungi(AMF)on the Cd translocation in rice,a controlled pot experiment was *** results indicated that AMF significantly increased rice biomass,with an increase of up to 40.0%,particularly in root biomass by up to 68.4%.Notably,the number of prominent rice individuals also increased,and their plasticity was enhanced following AMF *** led to an increase in the net photosynthetic rate and antioxidant enzyme activity of *** the AMF treatment group,the Cd concentration in the rice roots was significantly higher(19.1%‒68.0%)compared with that in the control ***,the Cd concentration in the rice seeds was lower in the AMF treatment group,indicating that AMF facilitated the sequestration of Cd in rice roots and reduced Cd accumulation in the *** coefficients varied across different treatments,suggesting that AMF inoculation reduced the direct impact of soil Cd concentration on the total Cd accumulation in *** translocation of Cd was consistently associated with simultaneous growth dilution and compensatory accumulation as a result of mycorrhizal *** study quantitatively analyzed this process through path analysis and clarified the causal relationship between rice growth and Cd transfer under the influence of AMF.

关键词： cadmium transfer dilution effect heavy metal immobilization mycorrhizal effect path analysis phenotypic plasticity

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A Survey of Knowledge Graph Construction Using machine Learning

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 225-257页

作者： Zhigang Zhao Xiong Luo maojian Chen ling ma School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China Shunde Innovation School University of Science and Technology BeijingFoshan528399China Beijing Key Laboratory of Knowledge Engineering for materials Science Beijing100083China

Knowledge graph(KG)serves as a specialized semantic network that encapsulates intricate relationships among real-world entities within a structured *** framework facilitates a transformation in information retrieval,transitioning it from mere string matching to far more sophisticated entity *** this transformative process,the advancement of artificial intelligence and intelligent information services is ***,the role ofmachine learningmethod in the construction of KG is important,and these techniques have already achieved initial *** article embarks on a comprehensive journey through the last strides in the field of KG via machine *** a profound amalgamation of cutting-edge research in machine learning,this article undertakes a systematical exploration of KG construction methods in three distinct phases:entity learning,ontology learning,and knowledge ***,a meticulous dissection of machine learningdriven algorithms is conducted,spotlighting their contributions to critical facets such as entity extraction,relation extraction,entity linking,and link ***,this article also provides an analysis of the unresolved challenges and emerging trajectories that beckon within the expansive application of machine learning-fueled,large-scale KG construction.

关键词： Knowledge graph(KG) semantic network relation extraction entity linking knowledge reasoning

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Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1514-1531页

作者： Yong Pan Yi-Ru Zhang ling-Yun Wang Li-Na Wu Ying-Qiu ma Zhou fang Shi-Bo Li Department of Infectious Disease Zhoushan HospitalWenzhou Medical UniversityZhoushan 316021Zhejiang ProvinceChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in ***,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain *** To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for *** The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal *** expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC *** targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan *** univariate and multivariate analysis were utilized to identify independent prognostic *** CDKN2A was frequently mutated and deleted in *** single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle *** CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully ***5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC *** association between GAS5 expression and methylation,immune infilt-ration was ***,traditional Chinese medicine effective components targeting GAS5 were *** This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and ***,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

关键词： Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker

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Fake News Detection Based on Text-Modal Dominance and Fusing Multiple Multi-Model Clues

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Computers, materials & Continua 2024年第3期78卷 4399-4416页

作者： Li fang Fu Huanxin Peng Changjin ma Yuhan Liu College of Arts and Sciences Northeast Agricultural UniversityHarbin150030China College of Engineering Northeast Agricultural UniversityHarbin150030China

In recent years,how to efficiently and accurately identify multi-model fake news has become more ***,multi-model data provides more evidence but not all are equally ***,social structure information has proven to be effective in fake news detection and how to combine it while reducing the noise information is ***,existing approaches fail to handle these *** paper proposes a multi-model fake news detection framework based on Tex-modal Dominance and fusing Multiple Multi-model Cues(TD-MMC),which utilizes three valuable multi-model clues:text-model importance,text-image complementary,and text-image ***-MMC is dominated by textural content and assisted by image information while using social network information to enhance text *** reduce the irrelevant social structure’s information interference,we use a unidirectional cross-modal attention mechanism to selectively learn the social structure’s features.A cross-modal attention mechanism is adopted to obtain text-image cross-modal features while retaining textual features to reduce the loss of important *** addition,TD-MMC employs a new multi-model loss to improve the model’s generalization *** experiments have been conducted on two public real-world English and Chinese datasets,and the results show that our proposed model outperforms the state-of-the-art methods on classification evaluation metrics.

关键词： Fake news detection cross-modal attention mechanism multi-modal fusion social network transfer learning

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