检索结果-南通市图书馆

现代预防医学 2024年第6期51卷 1032-1035+1056页

作者：刘文慧陈俊杰马春花广州医科大学护理学院

多重慢性病患者自我管理相较于单一慢性病而言有着更为复杂的特点和需求，在疾病健康转归方面发挥着核心作用。本文重点分析了多重慢性病患者自我管理的特点、现状、存在的障碍和挑战，提示应以动态、发展的眼光看待多重慢性病患者的自... 详细信息

多重慢性病患者自我管理相较于单一慢性病而言有着更为复杂的特点和需求，在疾病健康转归方面发挥着核心作用。本文重点分析了多重慢性病患者自我管理的特点、现状、存在的障碍和挑战，提示应以动态、发展的眼光看待多重慢性病患者的自我管理。在给患者提供自我管理支持时，应基于他们复杂的自我管理需求，识别自我管理过程中具体障碍，建立多种慢性病之间自我管理的联系，制定基于患者偏好、目标和可用资源的个性化自我管理支持内容和方法，提高患者的自我管理能力，改善其健康结局。

关键词：多重慢性病自我管理自我管理支持障碍挑战

ma huang Tang ameliorates asthma though modulation of Th1/Th2 cytokines and inhibition of Th17 cells in ovalbumin-sensitized mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第5期12卷 361-366页

作者： ma chun-hua ma Zhan-Qiang FU Qiang ma Shi-Ping Department of Pharmacology of Chinese materia Medica China Pharmaceutical University

AIM： ma huang Tang （Ephedra decoction, MHT） is a famous classical formula from Shang Han Lun by Zhang Zhongjing in the Han Dynasty. The anti-asthmatic effects of MHT and the possible mechanisms were tested. METHOD： An asthma model was established by ovalbumin （OVA）-induction in mice. A total of forty-eight mice were randomly assigned to six experimental groups： control, model, dexamethasone （2 mg·kg^-1） and MHT （5, 10, and 20 mg·kg^-1）. Airway resistance （Raw） was measured by the forced oscillation technique, histological studies were evaluated by hematoxylin and eosin （HE） staining, Thl/Th2 and Th17 cytokines were evaluated by enzyme-linked immunosorbent assay （ELISA）, and Thl7 cells were evaluated by flow cytometry （FCM）.RESULTS： This study demonstrated that MHT inhibited OVA-induced increases in Raw and eosinophil cotmt; interleukin （IL）-4 and IL-17 levels were recovered in bronchoalveolar lavage fluid, increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that MHT substantially inhibited OVA-induced eosinophilia in lung tissue. Flow cytometry studies demonstrated that MHT substantially inhibited Thl 7 ***： These findings suggest that MHT may effectively ameliorate the progression of asthma, and could be further investigated for potential use as a therapy for patients with allergic asthma,

关键词： ma huang Tang Asthma Thl/Th2 Thl7 cells

Ginkgo biloba extracts attenuate lipopolysaccharide-induced inflammatory responses in acute lung injury by inhibiting the COX-2 and NF-κB pathways

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2015年第1期13卷 52-58页

作者： YAO Xin CHEN Nan ma chun-hua TAO Jing BAO Jian-An CHENG Zong-Qi CHEN Zu-Tao MIAO Li-Yan Department of Pharmacy First Affiliated Hospital of Soochow University Medical College of Soochow University Department of Pharmacology of Chinese materia Medica China Pharmaceutical University Department of Infectious Diseases First Affiliated Hospital of Soochow University

In the present study, we analyzed the role of Ginkgo biloba extract in lipopolysaccharide（LPS）-induced acute lung injury （ALl）. ALI was induced in mice by intratracheal instillation of LPS. G. biloba extract （12 and 24 ***^-1） and dexamethasone （2 ***^-1）, as a positive control, were given by i.p. injection. The cells in the bronchoalveolar lavage fluid （BALF） were counted. The degree of animal lung edema was evaluated by measuring the wet/dry weight ratio. The superoxidase dismutase （SOD） and myelop- eroxidase （MPO） activities were assayed by SOD and MPO kits, respectively. The levels of inflammatory mediators, tumor necrosis factor-a, interleukin-1/3, and interleukin-6, were assayed by enzyme-linked immunosorbent assay. Pathological changes of lung tissues were observed by H＆E staining. The levels of NF-κB p65 and COX-2 expression were detected by Western blotting. Compared to the LPS group, the treatment with the G. biloba extract at 12 and 24 *** ^-1 markedly attenuated the inflammatory cell numbers in the BALF, decreased NF-κB p65 and COX-2 expression, and improved SOD activity, and inhibited MPO activity. The histological changes of the lungs were also significantly improved. The results indicated that G biloba extract has a protective effect on LPS-induced acute lung injury in mice. The protective mechanism of G. biloba extract may be partly attributed to the inhibition of NF-κB p65 and COX-2 activation.

关键词： Ginkgo biloba extract Lipopolysaccharide Nuclear factor-rd3 Cyclooxygenase

穿心莲内酯磺化物注射液解热镇痛抗炎作用研究

在线全文

学校读者我要写书评

暂无评论

中国兽药杂志 2024年第5期58卷 56-62页

作者：余佳欣吴禹熹章文丽马春花梁歌殷勤董可四川育强本草生物技术有限公司成都611100 四川省畜牧科学研究院成都610066

为探究穿心莲内酯磺化物注射液的解热、镇痛、抗炎作用,将SD大鼠和KM小鼠分别随机分为空白组,阳性药穿心莲注射液组,穿心莲内酯磺化物注射液高、中、低剂量组。通过皮下注射干酵母诱导大鼠发热模型探究其解热作用;通过冰醋酸致小鼠扭体... 详细信息

为探究穿心莲内酯磺化物注射液的解热、镇痛、抗炎作用,将SD大鼠和KM小鼠分别随机分为空白组,阳性药穿心莲注射液组,穿心莲内酯磺化物注射液高、中、低剂量组。通过皮下注射干酵母诱导大鼠发热模型探究其解热作用;通过冰醋酸致小鼠扭体法探究其镇痛作用;通过二甲苯诱导小鼠耳肿胀法及λ-角叉菜胶诱导大鼠足肿胀法探究其抗炎作用。结果表明,穿心莲内酯磺化物注射液可显著抑制干酵母所致发热大鼠的肛温上升;显著抑制冰醋酸所致小鼠疼痛,减少扭体次数;显著降低二甲苯致小鼠耳肿胀,减少肿胀度;显著抑制λ-角叉菜胶致大鼠足肿胀,减少肿胀度。由此可知,穿心莲内酯磺化物注射液具有明显的解热、镇痛、抗炎的作用。

关键词：解热镇痛抗炎穿心莲内酯磺化物注射液

Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2014年第11期12卷 841-846页

作者： ma chun-hua LIU Ji-Ping QU Rong ma Shi-Ping Discipline of Chinese and Western Integrative Medicine Nanjing University of Chinese Medicine Department of Pharmacology of Chinese materia Medica China Pharmaceutical University Department of Pharmacology Shaanxi University of Chinese Medicine

AIM: In a previous study, the anti-inflammatory effects of tectorigenin were disclosed. In this study, the anti-inflammatory effects of tectorigenin on acute lung injury using a lipopolysaccharide(LPS)-induced acute lung injury(ALI) mouse model were investigated. METHOD: The cell-count in the bronchoalveolar lavage fluid(BALF) was measured. The animal lung edema degree was evaluated by the wet/dry weight(W/D) ratio. The superoxidase dismutase(SOD) activity and myeloperoxidase(MPO) activity was assayed using SOD and MPO kits, respectively. The levels of inflammatory mediators, including tumor necrosis factor-α(TNF-α), IL-1β, and IL-6 were assayed using an enzyme-linked immunosorbent assay method. Pathological changes of lung tissues were observed through HE staining. The inflammatory signal pathway related protein nuclear factor NF-κB p65 mR NA expression was measured by real-time PCR, and the protein level of NF-κB p65 was measured using Western blotting analysis. RESULTS: The data showed that treatment with the tectorigenin markedly attenuated the inflammatory cell numbers in the BALF, decreased nuclear factor NF-κB p65 mR NA level and protein level in the lungs, and improved SOD activity and inhibited MPO activity. Histological studies showed that tectorigenin substantially inhibited LPS-induced neutrophils in lung tissue compared with the model group. CONCLUSION: The results indicated that tectorigenin had a protective effect on LPS-induced ALI in mice.

关键词： Tectorigenin Inflammation LPS-induced acute lung injury

Fluoro-functionalized plant biomass adsorbent:Preparation and application in extraction of trace perfluorinated compounds from environmental water samples

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 703-715页

作者： Xi Tan Yan Shi chun-Feng ma Quan Chi Yu-Hang Yang Wen-Xiang Zhang hua-Ming Xiao Xian Wang Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission School of Chemistry and Materials ScienceSouth-Central Minzu UniversityWuhan 430074China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Key Laboratory of Oilseeds Processing of Ministry of Agriculture Hubei Key Laboratory of Lipid Chemistry and NutritionOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Perfuorinated compounds(PFCs)are toxic and widely present in the environment,and therefore effective adsorbents are required to remove PFCs from environmental *** the present study,a new type of fuorinated biomass materials was synthesized via an ingenious fuorosilanization *** adsorbents were applied for the adsorption of 13typical PFCs,including perfuorocarboxylic acids(PFCAs)and perfuorosulfonic acids(PFSAs).By comparing their adsorption performance,Fluorinated cedar slag(FCS)was discovered to have the best absorption efficiency and enabled highly efficient enrichment of *** adsorption recovery of FCS with the investigated PFCs is greater than 90%under the optimal adsorption *** to the high affinity of F-F sorbent-sorbate interaction,FCS had good adsorption capacities of PFCs from aqueous solution,with the maximum adsorption capacity of 15.80 mg/g for PFOS and 10.71 mg/g for PFOA,***,the adsorption time could be achieved in a short time(8 min).Using the FCS absorbent,an innovative FCS-solid phase extraction assisted with high performance liquid chromatography-electrospray-tandem mass spectrometry(FCS-SPE-HPLC-ESI-MS/MS)method was first developed to sensitively detect PFCs in the environmental water *** intra-day and inter-day recovery rates of the 13 compounds ranged from 90.7%-104.3%,with the RSD of 2.1%-4.7%(intra-day)and 2.5%-8.5%(inter-day),*** research demonstrates the potential of the newly fuoro-functionalized plant biomass to adsorb PFCs from environmental water,with the advantages of high adsorption efficiencies,high antiinterference,easy operation and low economic cost.

关键词： Fluoro-functionalized biomass Perfuorinated compounds(PFCs) Adsorption efficiency mass spectrometry(MS) Fluorinated cedar slag(FCS)

线路避雷器和绝缘子串的伏秒特性配合问题研究

在线全文

学校读者我要写书评

暂无评论

高压电器 2007年第1期43卷 68-69,73页

作者：马春华中国电力投资集团巴公发电厂山西晋城048002

给出了金属氧化物避雷器(MOA)相对其它类型避雷器的优点,并就MOA与被保护的绝缘子串之间的配合应用原则进行了论述,分析计算了MOA与绝缘子串两者的伏秒特性。计算结果显示,当MOA与绝缘子串两者进行合理配合应用时,对线路设备保护的有效... 详细信息

给出了金属氧化物避雷器(MOA)相对其它类型避雷器的优点,并就MOA与被保护的绝缘子串之间的配合应用原则进行了论述,分析计算了MOA与绝缘子串两者的伏秒特性。计算结果显示,当MOA与绝缘子串两者进行合理配合应用时,对线路设备保护的有效性超过了99.993%,从而得出在架空输电线路防雷保护中应用MOA以防止过电压效果显著,最后就合理确定MOA的主要技术参数提出了意见。

关键词：输电线路金属氧化物避雷器绝缘子串配合应用防雷保护

在线全文

学校读者我要写书评

暂无评论

关于复合外套MOA机械强度计算问题的研究

高压电器 2007年第6期43卷 471-473页

作者：马春华中国电力投资集团巴公发电厂山西晋城048002

针对电力系统应用广泛的复合外套金属氧化物避雷器(PMOA)机械强度的计算问题,进行了分析研究,并提出了定量分析公式,即采用PMOA顶端的转角θ和挠度f来衡量载荷对避雷器变形量的大小。分析计算结果表明:在载荷一定的情况下,减少PMOA的长... 详细信息

针对电力系统应用广泛的复合外套金属氧化物避雷器(PMOA)机械强度的计算问题,进行了分析研究,并提出了定量分析公式,即采用PMOA顶端的转角θ和挠度f来衡量载荷对避雷器变形量的大小。分析计算结果表明:在载荷一定的情况下,减少PMOA的长度可以明显减小外部载荷对其产生的变形量,从而提高其机械性能。

关键词：复合外套金属氧化物避雷器机械强度计算定量分析公式

Optimal investment based on relative performance and weighted utility

在线全文

学校读者我要写书评

暂无评论

Applied mathematics(A Journal of Chinese Universities) 2024年第2期39卷 328-342页

作者： WANG Lei DONG Ying-hui hua chun-rong Department of mathematics Suzhou University of Science and TechnologySuzhou 215009China Changshu Institute of Technology Changshu 215500China

This paper studies the optimal portfolio allocation of a fund manager when he bases decisions on both the absolute level of terminal relative performance and the change value of terminal relative performance comparison to a predefined reference point. We find the optimal investment strategy by maximizing a weighted average utility of a concave utility and an Sshaped utility via a concavification technique and the martingale method. Numerical results are carried out to show the impact of the extent to which the manager pays attention to the change of relative performance related to the reference point on the optimal terminal relative performance.

关键词： relative performance weighted utility S-shaped utility concavification