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中药调控mTOR信号通路治疗缺血性脑卒中的研究进展

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中国实验方剂学杂志 2024年第11期30卷 265-272页

作者：马玉刚王兴臣王学斌李雅慧山东中医药大学济南250014 山东中医药大学第二附属医院济南250001

缺血性脑卒中(IS)是临床上较为常见的一类严重的脑血管疾病。针对其缺血损伤发生机制,通过静脉溶栓以恢复血流仍是临床上最主要最有效的治疗手段,但因静脉溶栓存在增加出血风险、治疗窗口狭窄、禁忌证多等弊端,使其在临床的应用受到限... 详细信息

缺血性脑卒中(IS)是临床上较为常见的一类严重的脑血管疾病。针对其缺血损伤发生机制,通过静脉溶栓以恢复血流仍是临床上最主要最有效的治疗手段,但因静脉溶栓存在增加出血风险、治疗窗口狭窄、禁忌证多等弊端,使其在临床的应用受到限制。在未达到完全有效复流的同时,对缺血脑组织进行有效保护事关IS预后。研究发现,改善IS导致的脑损伤存在诸多通道机制,哺乳动物雷帕霉素靶蛋白(mTOR)信号通路就是其中之一。中医在治疗IS,尤其在改善缓解患者症状和提高生活质量方面,具有丰富的干预手段和独特优势。在IS发病后,中医药尽早介入其治疗、康复和预防复发的全过程可以充分发挥中西医协同治疗优势,保证患者获益最大化,对IS后的神经功能和运动功能恢复具有重要临床意义。诸多研究表明,中药干预手段通过调控激活mTOR信号通路,以干预和调节细胞自噬、抑制神经细胞凋亡、抑制氧化应激和炎症反应等方式有效减轻IS导致的脑损伤,对实现脑保护、改善IS预后具有积极作用,为IS的防治提供了新的治疗策略和思路。该文基于此,对mTOR信号通路在IS发病中的作用机制及近年来中药调控mTOR信号通路治疗IS的研究进展进行综述,以期为IS的中医药治疗提供新的治疗思路和系统的科学参考。

关键词：缺血性脑卒中哺乳动物雷帕霉素靶蛋白(mTOR) 信号通路自噬中医药研究进展

New opportunities for nuclear and atomic physics on the femto-to nanometer scale with ultra-high-intensity lasers

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matter and Radiation at Extremes 2022年第2期7卷 1-7页

作者： Changbo Fu Guoqiang Zhang yugang ma Key Laboratory of Nuclear Physics and Ion-Beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

There are a number of puzzles concerning physics on the scale of nanometers to femtometers,including the neutron lifetime,the proton charge radius,and the possible existence of the deep Dirac *** the development of high-intensity laser technology,lasers today can induce extremely strong electromagnetic *** in the deep shells of atoms as well as the atomic nucleus itself can be affected by these *** may provide a new experimental platform for studies of physical processes on the femto-to nanometer scale,where atomic physics and nuclear physics *** this paper,we review possible new opportunities for studying puzzles on the femto-to nanometer scale using highintensity lasers.

关键词： intensity atomic shells

machine learning in nuclear physics at low and intermediate energies

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Science China(Physics,Mechanics & Astronomy) 2023年第8期66卷 1-19页

作者： Wanbing He Qingfeng Li yugang ma Zhongming Niu Junchen Pei Yingxun Zhang Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China School of Science Huzhou UniversityHuzhou 313000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 73000China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China

machine learning(ML)is becoming a new paradigm for scientific research in various research fields due to its exciting and powerful capability of modeling tools used for big-data processing *** this review,we first briefly introduce the different methodologies used in ML algorithms and *** a snapshot of many applications by ML,some selected applications are presented,especially for low-and intermediate-energy nuclear physics,which include topics on theoretical applications in nuclear structure,nuclear reactions,properties of nuclear matter,and experimental applications in event identification/reconstruction,complex system control,and firmware ***,we present a summary and outlook on the possible directions of ML use in low-intermediate energy nuclear physics and possible improvements in ML algorithms.

关键词： machine learning nuclear physics low and intermediate energies

基于影响模型设计的基坑降水对邻近建筑影响研究

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陶瓷 2024年第1期 215-217页

作者：沈勇方汉中马玉刚孙志强浙江潮远建设有限公司杭州311200 杭州水电建筑集团有限公司杭州310000 浙江南业建设有限公司杭州310015 浙江同济科技职业学院杭州311200 宁海县路康交通工程试验检测有限公司浙江宁波315600

由于采用传统模型对深基坑降水进行分析研究,其对周围建筑环境影响得到的结果较差,所以笔者进一步对深基坑降水问题如何影响周边的建筑环境进行深入探索研究。考虑土壤保持水的容重等相关参数,进行不同土壤分层计算对应土层的湿密度;利... 详细信息

由于采用传统模型对深基坑降水进行分析研究,其对周围建筑环境影响得到的结果较差,所以笔者进一步对深基坑降水问题如何影响周边的建筑环境进行深入探索研究。考虑土壤保持水的容重等相关参数,进行不同土壤分层计算对应土层的湿密度;利用分层总和法,将建筑物四周土层按不同性质分为4个不同的土层进行分析计算;引入FLAC方法,对基坑降水可能引起的影响进行模拟,计算由此引发的地面沉降量,建立主要影响因子的周边环境建筑物影响模型。

关键词：基坑开挖降水量建筑物基础影响因素实验模型

Directed flow of isospin sensitive fragments within a modified clusterization algorithm in heavy-ion collisions

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Nuclear Science and Techniques 2013年第5期24卷 44-49页

作者： KUmaR Sanjeev ma yugang Amity Institute of Nuclear Science and Technology Amity University Shanghai Institute of Applied Physics Chinese Academy of SciencesJiading Campus

By extending the minimum spanning tree(MST)clusterization algorithm for the binding energy cut,the isospin asymmetry dependence of directed flow for isospin sensitive isobar pairs(neutrons-protons,3H-3He) is studied from low towards high incident *** modified clusterization method(MSTB) has the advantage to identify the fragments at quite early *** enhances(reduces) the production of free nucleons(fragments) over MST *** directed flow of isobaric pair3H-3He is more sensitive towards isospin asymmetry caused by MSTB than isobaric pair *** sensitivity becomes quite strong towards the high incident energy and neutron-rich reaction *** conclusion,the inclusion of binding energy in clusterization method for the flow studies has been uniquely important for understanding the isospin physics,especially for high density behavior of symmetry energy.

关键词：集群化同位旋敏感性重离子碰撞流量算法修改入射能量

原子核中的α团簇对核反应与相对论重离子碰撞的影响

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核技术 2023年第8期46卷 1-22页

作者：马余刚复旦大学核科学与技术系/现代物理研究所国家自然科学基金委理论物理专款-上海核物理理论研究中心上海200433

团簇结构可以稳定存在于原子核的内部。研究原子核的α团簇结构及其影响在核物理与天体物理中是一个十分重要的课题。在过去几十年里,原子核的团簇结构效应在重离子核反应中有了较多的研究。本文主要总结了在核反应与相对论重离子碰撞... 详细信息

团簇结构可以稳定存在于原子核的内部。研究原子核的α团簇结构及其影响在核物理与天体物理中是一个十分重要的课题。在过去几十年里,原子核的团簇结构效应在重离子核反应中有了较多的研究。本文主要总结了在核反应与相对论重离子碰撞中对原子核的α团簇结构效应的研究。例如,通过原子核的巨共振来研究原子核的团簇结构。通过核反应中的粒子(包括中子、质子以及光子)的发射与关联、集体流等研究原子核的团簇结构。进一步,我们把原子核的团簇效应延伸推广到相对论重离子碰撞中,比如,对集体流及其涨落、HBT(Hanbury Brown and Twiss)关联、多重性关联、双强子方位角关联、电磁场等的研究。

关键词：原子核内α 团簇巨共振核子-核子关联集体流双强子关联

Hydrogen release of NaBH_(4) below 60 ℃ with binary eutectic mixture of xylitol and erythritol additive

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Chinese Journal of Chemical Engineering 2024年第7期71卷 225-234页

作者： yugang Shu Jiaguang Zheng Chengguo Yan Ao Xia Meiling Lv Zhenxuan ma Zhendong Yao School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced Energy materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China College of materials and Chemistry China Jiliang UniversityHangzhou 310018China

NaBH_(4) was widely regarded as a low-cost hydrogen storage material due to its high-mass hydrogen capacity of approximately 10.8%(mass)and high volumetric hydrogen capacity of around 115 g·L^(–1).However,it exhibits strong stability and requires temperatures above 500℃ for hydrogen release in practical *** this study,two polyhydric alcohols,xylitol and erythritol(XE),were prepared as a binary eutectic sugar alcohol through a grinding-melting *** binary eutectic sugar alcohol was used as a proton-hydrogen carrier to destabilize NaBH_(4).The 19NaBH_(4)-16XE composite material prepared by ball milling could start releasing hydrogen at 57.5℃,and the total hydrogen release can reach over 88.8%(4.45%(mass))of the theoretical *** the 19NaBH_(4)-16XE composite was pressed into solid blocks,the volumetric hydrogen capacity of the block-shaped composite could reach 67.2 g·L^(–1).By controlling the temperature,the hydrogen desorption capacity of the NaBH_(4)-XE composite material was controllable,which has great potential for achieving solid-state hydrogen production from NaBH_(4).

关键词： Hydrogen Desorption Binary mixture NaBH_(4) Xylitol Erythritol

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2023年全国科技馆运行情况分析

自然科学博物馆研究 2024年第2期9卷 5-12页

作者：王美力杨洋宋岳龙王姝婧马宇罡蔡文东赵洋中国科技馆科研管理部北京市100101 中国科技馆网络科普部北京市100101

2023年全国科技馆持续提升服务能力和服务效能,总体建设、教育活动均表现出色,接待观众数量同比更创新高,增长率超90%。本文在2023年全国科技馆调查结果的基础上进行了分析研究,希望为科技馆的规划编制、决策部署、业务发展、项目研究... 详细信息

2023年全国科技馆持续提升服务能力和服务效能,总体建设、教育活动均表现出色,接待观众数量同比更创新高,增长率超90%。本文在2023年全国科技馆调查结果的基础上进行了分析研究,希望为科技馆的规划编制、决策部署、业务发展、项目研究提供参考,从而推动现代科技馆体系高质量发展。

关键词：科技馆现代科技馆体系数据分析

A possible Zpif's law in the nuclear disassembly

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Chinese Science Bulletin 2000年第16期45卷 1459-1464页

作者： Dingding Han yugang ma East China’s Normal University Shanghai China Shanghai Institute of Nuclear Research Chinese Academy of Sciences Shanghai China T. D. Lee-Fudan Physics Laboratory Fudan University Shanghai China

Zpif’s law in the field of linguistics is tested in the nuclear disassembly within the framework of isospin dependent lattice gas model. It is found that the average cluster charge (or mass) of rank n in the charge (or mass) list shows exactly an inverse order to its rank, i.e., Zpif’s law appears at the phase transition temperature. This novel criterion shall be helpful in searching the nuclear liquid gas phase transition.

关键词： lattice gas model liquid gas phase transition /.pil’s law.