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中国综合临床 2017年第1期33卷 90-93页

作者：焦福德马骁宋劭晨王志涛孟令玲王亚军吉林大学第二医院创伤外科长春130041

桡骨远端骨折常发生于老年人群，目前，临床上采取有效措施治疗尚未达成共识，其治疗方法较多，但疗效不一。我们通过对相关文献的总结，就桡骨远端骨折的流行病学特征、治疗、内固定物选择、手术方式、并发症及预防进行综述，旨在为临... 详细信息

桡骨远端骨折常发生于老年人群，目前，临床上采取有效措施治疗尚未达成共识，其治疗方法较多，但疗效不一。我们通过对相关文献的总结，就桡骨远端骨折的流行病学特征、治疗、内固定物选择、手术方式、并发症及预防进行综述，旨在为临床治疗提供参考。

关键词：桡骨远端骨折闭合手法复位老年人

基于游戏的脑电神经反馈训练对认知功能改善作用的研究

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诊断学理论与实践 2022年第1期21卷 41-45页

作者：马少辰郭昕王铭维王惠君余启军苏文月王华龙马芹颖河北医科大学第一医院神经内科河北石家庄050031 河北省脑老化与认知神经科学重点实验室河北石家庄050031 秦皇岛市惠斯安普医学系统股份有限公司河北秦皇岛066000

目的:采用基于游戏的脑电神经反馈系统训练认知障碍患者,观察其认知功能的改善状况。方法:纳入以记忆力下降为主的认知障碍患者52例,先对其进行简易精神状态检查量表(Mini-Mental State Examination,MMSE)、蒙特利尔认知评估量表(Montre... 详细信息

目的:采用基于游戏的脑电神经反馈系统训练认知障碍患者,观察其认知功能的改善状况。方法:纳入以记忆力下降为主的认知障碍患者52例,先对其进行简易精神状态检查量表(Mini-Mental State Examination,MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)、阿尔茨海默病评定量表-认知量表(Alzheimer′s Disease Assessment Scale-Cognitive section,ADAS-cog)评估。5 d后,对其进行连续10 d的脑电神经反馈“意念力蚂蚁”游戏训练,每天训练30 min。在训练前、训练第10天采集患者的脑电图,训练完成后,再次评估患者的MMSE、MoCA、ADAS-cog评分。结果:经过训练,患者的MMSE、MoCA、ADAS-cog量表总分提高,训练前得分分别为(23.10±2.82)分、(18.63±4.10)分、(14.76±5.30)分,训练后分别为(26.06±2.95)分、(21.88±3.94)分、(12.15±5.15)分。患者的认知功能总体改善,其中记忆力改善最为明显,训练前MMSE、MoCA、ADAS-cog量表记忆力部分得分分别为(1.55±0.77)分、(1.33±1.28)分、(4.35±1.11)分,训练结束后的MMSE、MoCA、ADAS-cog量表记忆力部分得分分别为(2.16±0.80)分、(2.29±1.34)分、(3.93±1.30)分,训练前、后差异有统计学意义(P<0.001),同时对患者的脑电复杂度进行计算分析,发现其脑电复杂度提高,以左侧前额叶改善为主。结论:基于游戏的脑电神经反馈系统训练可显著提高认知障碍患者的认知功能,并能提高其左侧前额叶的脑电复杂度。

关键词：脑电神经反馈记忆力下降认知障碍

Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3139-3155页

作者： Qichao Yang Xianbin ma Yao Xiao Tian Zhang Leilei Yang shaochen Yang Mengyun Liang Shuo Wang Zhizhong Wu Zhigang Xu Zhijun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China

Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the antitumor immune ***,single blockade of these pathways is usually ineffective because of the complex crosstalk and feedback among oncogenic signaling *** enhanced toxicity of free small molecule inhibitor combinations is considered an insurmountable barrier to their clinical *** circumvent this issue,we rationally designed an effective tumor microenvironment-activatable prodrug nanomicelle(PNM)for cancer *** was engineered by integrating the PI3K/m TOR inhibitor PF-04691502(PF)and the broad spectrum CDK inhibitor flavopiridol(Flav)into a single nanoplatform,which showed tumor-specific accumulation,activation and deep penetration in response to the high glutathione(GSH)tumoral *** codelivery of PF and Flav could trigger gasdermin E(GSDME)-based immunogenic pyroptosis of tumor cells to elicit a robust antitumor immune ***,the combination of PNM-induced immunogenic pyroptosis with antiprogrammed cell death-1(a PD-1)immunotherapy further boosted the antitumor effect and prolonged the survival time of ***,these results indicated that the pyroptosis-induced nanoplatform codelivery of PI3K/m TOR and CDK inhibitors can reprogram the immunosuppressive tumor microenvironment and efficiently improve checkpoint blockade cancer immunotherapy.

关键词： Pyroptosis Prodrug Stimuli-responsive Immunotherapy Targeted therapy Tumor microenvironment

Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第3期10卷 1-9页

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan Yu Xiaofan Lei Shixiong Li Junsheng Zhai Yuanren ma Long He Qiheng Liu Chenglong Liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi Zhao Zhikang Wang Shuang Sun Wei Guo Min Zheng Shuai Zhang Jia Deng Xiaofeng Liu Xingju Ye Xun Zhang Qian Wang Rong Zhang Yan Zhang Shaosen Wang Chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun Jian Zhou Yujia Shi Zhiyong ma Yonggang Zhou Jianpo Yu shaochen Li Jiaxi Lu Junli Gao Faliang Wang Wenjing Chen Yanming Zhu Xingen Zhang Dong Zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

关键词：

Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 451-466页

作者： Xianbin ma shaochen Yang Tian Zhang Shuo Wang Qichao Yang Yao Xiao Xiaoxiao Shi Peng Xue Yuejun Kang Gang Liu Zhi-Jun Sun Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhan 430079China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death(ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment(ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin(DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels(DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful antitumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines.

关键词： Bioresponsive Prodrug Nanogel Doxorubicin mannose Immunogenic cell death Chemotherapy Immunotherapy

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热连轧机刚度综合评价系统的开发

安徽冶金科技职业学院学报 2024年第2期34卷 13-14页

作者：王会伟王立兵王二化王少晨马钢股份公司安徽马鞍山243000 安徽工业大学安徽马鞍山243000

轧机刚度是热连轧机提高设备管理水平和产品质量的核心内容,轧机刚度技术的应用是稳定生产,提高热轧极限产品生产能力的重要手段。结合轧机刚度的组成部分和影响因素,开发了轧机刚度在线评分系统和监控管理系统,建立了在线评价和实时监... 详细信息

轧机刚度是热连轧机提高设备管理水平和产品质量的核心内容,轧机刚度技术的应用是稳定生产,提高热轧极限产品生产能力的重要手段。结合轧机刚度的组成部分和影响因素,开发了轧机刚度在线评分系统和监控管理系统,建立了在线评价和实时监控体系。实现了刚度信息化、数字化控制,使得轧机刚度水平和轧制稳定性得到大幅提升。

关键词：轧机刚度评分系统设备精度刚度监控

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露井协采下边坡岩体损伤规律与强度特性

煤矿安全 2014年第7期45卷 205-207,211页

作者：李伟李绍臣马明煤炭科学研究总院矿山安全技术研究分院北京100013 煤炭资源高效开采与洁净利用国家重点实验室北京100013

岩体的变形实质上由岩块的弹性变形、岩块的塑性变形和节理裂隙的延展三者产生的变形之和。节理岩体的强度特性与节理裂隙的发育与延展密切相关。根据损伤力学与断裂力学理论,通过模拟岩体节理裂隙在不同开挖条件下的延展而引起损伤张... 详细信息

岩体的变形实质上由岩块的弹性变形、岩块的塑性变形和节理裂隙的延展三者产生的变形之和。节理岩体的强度特性与节理裂隙的发育与延展密切相关。根据损伤力学与断裂力学理论,通过模拟岩体节理裂隙在不同开挖条件下的延展而引起损伤张量的变化,探讨岩体强度与损伤张量之间的关系以表征其岩体强度的时空变化与各向异性。

关键词：边坡岩体露井协采损伤张量损伤规律强度特性

钩藤中钩藤碱对肿瘤坏死因子-α诱导人星型胶质细胞炎症模型作用机制研究

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河南师范大学学报（自然科学版） 2019年第2期47卷 98-104页

作者：安畅张颖马阮昕秦劭晨广州市越秀区光塔街社区卫生服务中心广州510120 中山大学附属第六医院药学部广州510655 山西中医学院附属医院太原030024

目的研究钩藤中钩藤碱对肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)诱导人星型胶质细胞(Human Astrocytes,HA)的炎症模型的作用机制.方法:体外培养HA,用TNF-α诱导HA造模,将细胞分为正常组、模型组、钩藤碱组、依达拉奉组.采用... 详细信息

目的研究钩藤中钩藤碱对肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)诱导人星型胶质细胞(Human Astrocytes,HA)的炎症模型的作用机制.方法:体外培养HA,用TNF-α诱导HA造模,将细胞分为正常组、模型组、钩藤碱组、依达拉奉组.采用噻唑蓝(MTT)法检测钩藤碱对HA增殖能力的影响,用逆转录PCR法(RT-PCR)检测一氧化氮合酶(nitric oxide synthase,NOS)mRNA、白细胞介素-23(interleukin-23,IL-23)mRNA、白细胞介素-6(interleukin-6,IL-6)mRNA的表达,用分光光度法检测一氧化氮(nitric oxide,NO)、超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)的表达,用蛋白免疫印迹法(Western blot)检测p-mTOR,mTOR,p-Stat3和Stat3的蛋白表达.结果与正常组比较,32ng·mL-1的TNF-α对星形胶质细胞有明显抑制作用(P<0.001);400μmol·L^(-1)的钩藤碱对星形胶质细胞活力有明显抑制作用(P<0.001).与模型组相比,200μmol·L^(-1)的钩藤碱对模型细胞有明显的增殖作用(P<0.01);钩藤碱组和依达拉奉组NOS mRNA,NO和SOD都显著上升(P<0.001),IL-23mRNA,IL-6mRNA和MDA都显著下降(P<0.001);钩藤碱组p-mTOR/mTOR和p-Stat3/Stat3都显著下降(P<0.01).结论钩藤有效成分钩藤碱具有抑制TNF-α诱导HA炎症的损伤作用,可能是通过下调mTOR/STAT3信号通路增加氧化相关因子NOS,NO,SOD的表达,减少氧化相关因子MDA以及炎症相关因子IL-23和IL-6的表达.

关键词：钩藤碱人星型胶质细胞炎症 mTOR/STAT3信号通路

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工艺参数对SLA成型制件力学性能的影响

工程塑料应用 2019年第10期47卷 75-79页

作者：李晶晶马世博梁帅李韶臣河北科技大学材料科学与工程学院石家庄050018 河北增材制造产业研究院石家庄050000

为了获得性能优异的立体光固化成型(SLA)制件,以SZUV–W8001P型光敏树脂为打印材料,基于SLA光固化3D打印机制备了不同工艺参数下的标准拉伸、弯曲及冲击试样,探究了打印层厚、填充扫描速度、填充线距及后固化时间等工艺参数对SLA成型试... 详细信息

为了获得性能优异的立体光固化成型(SLA)制件,以SZUV–W8001P型光敏树脂为打印材料,基于SLA光固化3D打印机制备了不同工艺参数下的标准拉伸、弯曲及冲击试样,探究了打印层厚、填充扫描速度、填充线距及后固化时间等工艺参数对SLA成型试样力学性能的影响。结果表明,打印层厚为0.05mm时,拉伸强度、弯曲强度和冲击强度均达到最大值,分别为48.52,68.63MPa和174.76kJ/m^2;填充扫描速度对力学性能影响较小;力学性能随填充线距的增大呈先增大后减小的趋势,在0.04~0.06mm时表现出良好的力学性能;拉伸强度随后固化时间的增加呈先上升后下降的趋势,后固化时间为100min时拉伸强度最大为47.93MPa;当打印层厚为0.05mm,填充扫描速度为6000mm/s,填充线距为0.04~0.06mm以及后固化时间为100min时,有利于SLA制件获得相对最优的力学性能。

关键词：光敏树脂打印参数后固化时间立体光固化成型力学性能

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制氢变压吸附解吸气回收利用方案探讨

石油炼制与化工 2007年第11期38卷 56-59页

作者：黄晓晖杨少臣刘海涛马晓伟新疆克拉玛依石化公司新疆克拉玛依834003

介绍了变压吸附(PSA)解吸气产生的原因,针对其组分特点,提出将其作燃料、作合成甲醇原料、脱二氧化碳后作制氢原料三种利用方案,并对这三种方案的优缺点进行分析。

关键词：制氢燃料甲醇解吸气回收