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人工智能在直肠癌外科精准化诊疗中的应用价值

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中华胃肠外科杂志 2024年第6期27卷 574-578页

作者：付占威蔡正昊马君俊上海交通大学医学院附属瑞金医院胃肠外科、上海市微创外科临床医学中心上海200025

结直肠癌是最为常见的消化道恶性肿瘤,我国结直肠癌的发病特点尤以中低位直肠癌居多。近年来,随着计算机科学的进步,人工智能技术迅猛发展,并已经在医学领域取得了大量的应用成果。目前,人工智能技术已经覆盖了直肠癌的早期筛查、个体... 详细信息

结直肠癌是最为常见的消化道恶性肿瘤,我国结直肠癌的发病特点尤以中低位直肠癌居多。近年来,随着计算机科学的进步,人工智能技术迅猛发展,并已经在医学领域取得了大量的应用成果。目前,人工智能技术已经覆盖了直肠癌的早期筛查、个体化评估、辅助诊疗决策、精细化手术以及预后判断等各个阶段,为直肠癌的精准化和个体化治疗提供了帮助。然而,缺乏标准化、系统化、可推广化的人工智能模型仍是该领域面临的主要痛点。因此,必须针对人工智能模型开展大型前瞻性临床研究,以进一步证实其在直肠癌临床诊疗中的应用价值。

关键词：直肠肿瘤人工智能精准医学医学影像困难骨盆

Transforming growth factor-β(TGF-β)signaling pathway-related genes in predicting the prognosis of colon cancer and guiding immunotherapy

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Cancer Pathogenesis and Therapy 2024年第4期2卷 299-313页

作者： Jie Chen Chao Ji Silin Liu Jin Wang Che Wang Jue Pan Jinyu Qiao Yu Liang Mengjiao cai Jinlu ma Department of Radiation Oncology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China

Background:Colon cancer is a malignant tumor with high malignancy and a low survival rate whose heterogeneity limits systemic *** growth factor-β(TGF-β)signaling pathway-related genes are associated with multiple tumors,but their role in prognosis prediction and tumor microenvironment(TME)regulation in colon cancer is poorly *** bioinformatics,this study aimed to construct a risk prediction signature for colon cancer,which may provide a means for developing new effective treatment ***:Using consensus clustering,patients in The Cancer Genome Atlas(TCGA)with colon adenocarcinoma were classified into several subtypes based on the expression of TGF-βsignaling pathway-related genes,and differences in survival,molecular,and immunological TME characteristics and drug sensitivity were examined in each *** genes that make up a TGF-β-related predictive signature were found by least absolute shrinkage and selector operation(LASSO)regression using colon cancer data from the TCGA database and confirmed using a Gene Expression Omnibus(GEO)dataset.A nomogram incorporating risk scores and clinicopathologic factors was developed to stratify the prognosis of patients with colon cancer for accurate clinical diagnosis and ***:Two TGF-βsubtypes were identified,with the TGF-β-high subtype being associated with a poorer prognosis and superior sensitivity to *** analyses showed a high incidence of gene mutations in the TGF-β-high *** completing signature construction,patients with colon cancer were categorized into high-and low-risk subgroups based on the median risk score of the TGF-β-related predictive *** risk score exhibited superior predictive performance relative to age,gender,and stage,as evidenced by its AUC of *** in the high-risk subgroup had higher levels of immunosuppressive cell infiltration and immune checkpoints in the TME,suggesting that these patients ha

关键词： Colon cancer Prognosis Risk signature Immune microenvironment Immunotherapy

Altered oceanic crust source for the alkaline rocks with superchondritic Nb/Ta ratios due to the steep subduction

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Journal of Earth Science 2024年

作者： Xu Zhao Ning-Bo Li He-cai Niu Shu-Cheng Tan Department of Geology， School of Earth Sciences， Yunnan University CAS Key Laboratory of Mineralogy and Metallogeny， Guangzhou Institute of Geochemistry， Chinese Academy of Sciences CAS Center for Excellence in Deep Earth Science

The cause resulting in alkaline rocks with superchondritic Nb/Ta ratios remains a geochemical enigma. This paper present zircon and apatite geochronology， mineralogy， geochemistry， and Nd-Hf-Zn isotope investigation on the Ejinao nepheline syenite from South China to constrain the petrogenesis of alkaline rocks. The occurrence of alkaline minerals， including alkaline feldspar， arfvedsonite， and nepheline， indicate an alkaline feature of the Ejinao nepheline syenite. Zircon and apatite from the rock show U-Pb concordia age of 135.4±0.9 ma and 137.5±5.8ma， respectively， suggesting generation in the Early Cretaceous. The rock is characterized by low MgO （0.17 wt.%–0.26 wt.%） contents， but high Fe2O3T（4.66 wt.%–6.16 wt.%） and total alkalis (Na2O + K2O = 12.1 wt.%–13.1 wt.%) contents， consistent with the melts from subducting oceanic crust rather than mantle peridotite. The rock has low TiO2（0.13 wt.%–0.21 wt.%） contents and superchondritic Nb/Ta and Zr/Hf ratios， resulting from rutile residue in the source area. The εNd（t）（-1.35 to -1.09）， εHf（t）（-3.03 to -1.52）， and δ66Zn （0.32‰ to 0.34‰） values of the nepheline syenite manifest the involvement of 15%–20% carbonate-bearing sediments in the altered oceanic crust. Geochemical modeling further reveals that the nepheline syenite was sourced from 10%–20% melting of such a source. This superchondritic Nb/Ta nepheline syenite was generated during the steep subduction of the Paleo-Pacific Ocean， which is needed to bring oceanic slab to a hot mantle and resulted in the altered oceanic crust melting. Our study highlights that the altered oceanic crust represents a novel source for superchondritic Nb/Ta alkaline rocks.

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One-dimensional core-sheath Sn/SnO_(x)derived from maX phase for microwave absorption

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Journal of materiomics 2024年第3期10卷 531-542页

作者： Feiyue Hu Peigen Zhang Fushuo Wu Zhihua Tian Haifeng Tang Bingbing Fan Rui Zhang Wenwen Sun Longzhu cai Zheng Ming Sun School of materials Science and Engineering Southeast UniversityNanjing211189China School of materials Science and Engineering Zhengzhou UniversityZhengzhou450001China The State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing210096China

One-dimensional(1D)metals are highly conductive and tend to form networks that facilitate electron hopping and ***,they have tremendous potential as microwave-absorbing(ma)***,1D metals are mainly precious metals such as gold,silver,nickel,and their preparation methods often have low yield and are not environmentally friendly,which has limited the exploration in this ***,the unique nanolaminate structure and chemical bond characteristics of Ti_(2)SnC maX phase is successfully taken advantages for large-scale preparation of Sn whiskers,and then,core-sheath Sn/SnO_(x)heterojunctions are obtained by simply annealing at different *** heterojunction annealed at 500℃possesses favorable ma performance with an effective absorption bandwidth of 5.3 GHz(only 1.7 mm)and a minimum reflection loss value of51.97 dB;its maximum radar cross section(RCS)reduction value is 29.59 dB·m^(2),confirming its excellent electromagnetic wave attenuation ***-axis electron holography is used to visually characterize the distribution of charge density at the cylindrical heterogenous interface,confirming the enhanced interfacial polarization *** the diversity of maX phases and the advantages of the fabrication method(e.g.,green,inexpensive,and easily scalable),this work provides significant guidance for the design of 1D metal-based absorbers.

关键词： Sn/SnO_(x)heterojunctions Ti_(2)SnC maX phase Microwave absorption Interfacial polarization

Enhancing layered perovskite ferrites with ultra-high-density nanoparticles via cobalt doping for ceramic fuel cell anode

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Journal of Energy Chemistry 2024年第9期96卷 39-48页

作者： Shuo Zhai Rubao Zhao Hailong Liao Ling Fu Senran Hao Junyu cai Yifan Wu Jian Wang Yunhong Jiang Jie Xiao Tao Liu Heping Xie State Key Laboratory of Intelligent Construction and Healthy Operation and maintenance of Deep Underground Engineering Shenzhen University&Sichuan UniversityShenzhen 518060GuangdongChina National and Local Joint Engineering Research Center for Lithium-ion Batteries and materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093YunnanChina School of Energy and Environment City University of Hong KongKowloon 999077Hong KongChina

Nanoparticles anchored on the perovskite surface have gained considerable attention for their wide-ranging applications in heterogeneous catalysis and energy conversion due to their robust and integrated structural ***,we employ controlled Co doping to effectively enhance the nanoparticle exsolution process in layered perovskite ferrites *** alloy nanoparticles with ultra-high-density are exsolved on the(PrBa)_(0.95)(Fe_(0.8)Co_(0.1)Nb_(0.1))2O_(5+δ)(PBFCN_(0.1))surface under reducing atmosphere,providing significant amounts of reaction sites and good durability for hydrocarbon *** a reducing atmosphere,cobalt facilitates the reduction of iron cations within PBFCN_(0.1),leading to the formation of CoFe alloy *** formation is accompanied by a cation exchange process,wherein,with the increase in temperature,partial cobalt ions are substituted by ***,Co doping significantly enhance the electrical conductivity due to the stronger covalency of the Cosingle bondO bond compared with Fesingle bondO bond.A single cell with the configuration of PBFCN_(0.1)-Sm_(0.2)Ce_(0.8)O_(1.9)(SDC)|SDC|Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3−δ)(BSCF)-SDC achieves an extremely low polarization resistance of 0.0163Ωcm^(2)and a high peak power density of 740 mW cm^(−2)at 800℃.The cell also shows stable operation for 120 h in H_(2)with a constant current density of 285 ma cm^(−2).Furthermore,employing wet C_(2)H_(6)as fuel,the cell demonstrates remarkable performance,achieving peak power densities of 455 mW cm^(−2)at 800℃and 320 mW cm^(−2)at 750℃,marking improvements of 36%and 70%over the cell with(PrBa)_(0.95)(Fe_(0.9)Nb_(0.1))_(2)O_(5+δ)(PBFN)-SDC at these respective *** discovery emphasizes how temperature influences alloy nanoparticles exsolution within doped layered perovskite ferrites materials,paving the way for the development of high-performance ceramic fuel cell anodes.

关键词： Solid oxide fuel cell Anode Ethane fuel Nanoparticle Exsolution Layered perovskite Ferrites

护理人员导管相关感染防控护理实践知识现况调查

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中国护理管理 2024年第1期24卷 14-18页

作者：孙众马晶淼翁峰霞蔡虻首都医科大学附属北京中医医院院感办北京市100010 天津医科大学总医院妇科浙江大学医学院附属第一医院外科监护室北京医院医院感染管理处/疾病预防控制处

目的:调查护理人员对导管相关感染防控护理实践知识的掌握现况,以期为提高护理人员导管相关感染防控知识水平提供参考。方法 :于2023年7月12日至8月12日,采用自行设计的导管相关感染防控相关知识问卷,通过中华护理学会医院感染管理专业... 详细信息

目的:调查护理人员对导管相关感染防控护理实践知识的掌握现况,以期为提高护理人员导管相关感染防控知识水平提供参考。方法 :于2023年7月12日至8月12日,采用自行设计的导管相关感染防控相关知识问卷,通过中华护理学会医院感染管理专业委员会平台向临床护士、护理管理者及专业为护理的感控专职人员发放问卷。结果 :知识问卷11题中回答正确人数比例达到50%的有5题,达到80%的仅有3题。正确率最高的是输液接头消毒方法(97.49%),正确率较低是吸痰前稀释痰液方式(19.80%)、留置尿管的清洁消毒(19.06%)、气管插管患者不要定时气囊放气(15.51%)、拔出尿管前膀胱无需功能锻炼(9.97%)等。不同级别医院、不同工作年限、职称及所在岗位的护理人员比较,回答正确率差异具有统计学意义(P<0.05)。结论 :护理人员导管相关感染防控护理实践知识掌握水平有待提升,需要加强循证能力及相关知识培训。

关键词：导管相关感染护理实践现况调查医院感染与控制

Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

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World Journal of Clinical Oncology 2024年第3期15卷 434-446页

作者： Hua Li Yi-Po ma Hai-Long Wang cai-Juan Tian Yi-Xian Guo Hong-Bo Zhang Xiao-Min Liu Peng-Fei Liu Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Critical Care Medicine Dingzhou City People’s HospitalDingzhou 073000Hebei ProvinceChina Department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Tianjin marvel Medical Laboratory Tianjin Marvelbio Technology Co.LtdTianjin 300180China Department of Intelligent Technology Tianjin Yunquan Intelligent Technology Co.LtdTianjin 300381China Department of Oncology Tianjin Huanhu HospitalTianjin 300350China

BACKGROUND The ubiquitin-proteasome pathway(UPP)has been proven to play important roles in *** To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these *** In this study,UPP-related E1,E2,E3,deubiquitylating enzyme,and proteasome gene sets were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,aiming to screen the prognostic genes using univariate and multivariate regression analysis and develop a prognosis predictive model based RESULTS Five genes(including autophagy related 10,proteasome 20S subunit alpha 8,proteasome 20S subunit beta 2,ubiquitin specific peptidase 17 like family member 2,and ubiquitin specific peptidase 8)were proven significantly correlated with prognosis and used to develop a prognosis predictive model for liver *** training,validation,and Gene Expression Omnibus sets,the overall survival differed significantly between the high-risk and low-risk *** expression of the five genes was significantly associated with immunocyte infiltration,tumor stage,and postoperative recurrence.A total of 111 differentially expressed genes(DEGs)were identified between the high-risk and low-risk groups and they were enriched in 20 and 5 gene ontology and KEGG *** division cycle 20,Kelch repeat and BTB domain containing 11,and DDB1 and CUL4 associated factor 4 like 2 were the DEGs in the E3 gene set that correlated with *** We have constructed a prognosis predictive model in patients with liver cancer,which contains five genes that associate with immunocyte infiltration,tumor stage,and postoperative recurrence.

关键词： Liver cancer Ubiquitin-proteasome pathway Prognosis prediction Gene expression Immune infiltration

企业数据技术能力对市值和利润的影响——基于大数据专利的机制检验和互补性投入分析

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财贸经济 2024年第1期45卷 106-123页

作者：陈楠蔡跃洲马文君中国社会科学院数量经济与技术经济研究所 100732 中国社会科学院数量经济与技术经济研究所数字经济研究室 100732 国家工业信息安全发展研究中心 100040

数据技术能力是将原始数据资源转化为生产要素的前提和关键所在,直接影响上市企业的市值与利润。本文使用与数据采集、分析和应用相关的专利统计量表征企业数据技术能力,分析其对市值和利润的影响效果与机制。研究发现,企业数据技术能... 详细信息

数据技术能力是将原始数据资源转化为生产要素的前提和关键所在,直接影响上市企业的市值与利润。本文使用与数据采集、分析和应用相关的专利统计量表征企业数据技术能力,分析其对市值和利润的影响效果与机制。研究发现,企业数据技术能力可以带来显著的市场价值提升,但多数企业还无法将潜在价值转化为实际收益,可能对其长期市值产生负面影响。行业异质性分析表明,金融和批发零售企业所获得的市值提升最为显著,而工业企业则可能承受财务收益的负向影响。工业互联网供应商企业能够将数据技术能力转化为盈利手段,并辅之以研发人员投入、研发资本投入、政府补贴、IT基础设施等互补性投入,从而实现市值与利润的同步提升。为继续推动我国各类市场主体的数据开发利用,建议应注重提升企业数据技术能力,加大互补性投入,开发数据技术的应用场景和盈利模式,培育专业化的数据服务机构,推进数据要素市场机制及基础设施建设。

关键词：数据要素数据技术能力互补性投入大数据专利

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非圆形隧洞衬砌支护下应力与位移的新解法

工程地质学报 2024年第1期32卷 206-215页

作者：吕爱钟崔耀启蔡辉马耀财华北电力大学水电与岩土工程研究所北京102206

以往在利用平面弹性复变函数方法进行衬砌支护作用下非圆形隧洞的力学分析时,一般将洞室外域保角映射到象平面的单位圆外域,并认为可以利用同一个映射函数将衬砌截面映射到象平面的圆环域内。当衬砌厚度很薄时,这种方法是可行的,而当衬... 详细信息

以往在利用平面弹性复变函数方法进行衬砌支护作用下非圆形隧洞的力学分析时,一般将洞室外域保角映射到象平面的单位圆外域,并认为可以利用同一个映射函数将衬砌截面映射到象平面的圆环域内。当衬砌厚度很薄时,这种方法是可行的,而当衬砌相对较厚时,利用同一映射函数所得到的衬砌截面形状发生严重失真。为解决此问题,本文引入两套映射函数,分别将洞室外域映射到象平面的单位圆的圆外域,衬砌截面映射到圆环域。这种方法可以适应于不同的衬砌厚度,利用这种方式获得的衬砌截面,在衬砌较厚时仍能保证衬砌厚度相对均匀。在求解解析函数过程中不再采用传统的幂级数解法,而是使用边界配点法,将两套映射函数结合,获得了该问题的应力解和位移解。本文以马蹄形隧洞为例,求解结果与ANSYS软件所得数值解吻合很好,分析了衬砌厚度对隧洞应力和位移的影响。根据本文解答可以方便、快捷地进行相近条件下隧道的初步设计。

关键词：复变函数方法非圆形压力隧洞均匀厚度衬砌两套映射函数边界配点法