检索结果-南通市图书馆

高效液相色谱法同时测定镥[^(177)Lu]氧奥曲肽注射液中两种稳定剂的含量

在线全文

学校读者我要写书评

暂无评论

核化学与放射化学 2025年第1期47卷 86-92,I0004页

作者：王勇梁塑孔祥瑞李英范振亚罗田伟王宁付博马红利杨柳李洪玉原子高科股份有限公司北京102413 国家原子能机构核技术(放射性药物工程转化)研发中心北京102413 中国核工业集团有限公司放射性药物工程技术研究中心北京102413

为建立高效液相色谱法(HPLC)测定镥[^(177)Lu]氧奥曲肽注射液中稳定剂(龙胆酸、维生素C)的含量,采用十八烷基硅烷键合有机杂化硅胶填充的色谱柱(4.6 mm×250 mm×5μm),以0.82 g/L醋酸钠溶液(用冰醋酸调pH至3.50)和甲醇为流动相,串联紫... 详细信息

为建立高效液相色谱法(HPLC)测定镥[^(177)Lu]氧奥曲肽注射液中稳定剂(龙胆酸、维生素C)的含量,采用十八烷基硅烷键合有机杂化硅胶填充的色谱柱(4.6 mm×250 mm×5μm),以0.82 g/L醋酸钠溶液(用冰醋酸调pH至3.50)和甲醇为流动相,串联紫外-可见分光检测器(检测波长为295 nm)与放射性流量检测器,柱温为25℃,进样体积为5μL,运行20.0 min,1.00 mL/min进行梯度淋洗,可有效地将龙胆酸和维生素C分离。龙胆酸和维生素C分别在0~1.50 g/L和0~30.0 g/L质量浓度范围内线性关系良好,相关系数r分别为1.000和0.998;改变柱温、流速、流动相pH值等色谱条件时,样品溶液中维生素C和龙胆酸含量的相对标准偏差均满足≤2.0%的要求;龙胆酸的回收率满足90%~108%的要求,维生素C回收率满足92%~105%的要求。该方法简便、快速、灵敏、准确,可用于镥[^(177)Lu]氧奥曲肽注射液中龙胆酸和维生素C含量的准确测定,为该类药物的工艺过程优化提供了指导作用。

关键词：高效液相色谱法镥[^(177)Lu]氧奥曲肽注射液稳定剂龙胆酸维生素C 方法验证

Guanxin Danshen Dripping Pills Improve Quality of life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression(GLAD Study):A Randomized Double-Blind Placebo-Controlled Study

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2023年第3期29卷 195-204页

作者： WANG Cheng-long HUAN Na WANG Pei-li GENG Qing-shan ma Wen-lin ma li-hong JIANG hong-yan MENG Xiao-ping ZHANG Da-wu GOU Xiao-jiang HU Da-yi CHEN Ke-ji Department of Cardiovascular Disease Xiyuan HospitalChinese Academy of Chinese Medical SciencesBeijing(100091)China National Clinical Research Center for Chinese Medicine Cardiology Beijing(100091)China Department of Cardiovascular Disease Guangdong Provincial People’s HospitalGuangzhou(510055)China Department of Cardiovascular Disease Shanghai Tongji HospitalShanghai(200065)China Department of Cardiovascular Disease Fuwai HospitalChinese Academy of Medical SciencesBeijing(100037)China Department of Cardiovascular Disease Beijing First Hospital of Integrated Chinese and Western MedicineBeijing(100020)China Department of Cardiovascular Disease Affiliated Hospital of Changchun University of Chinese MedicineChangchun(130021)China Department of Cardiovascular Disease People’s Hospital of Peking UniversityBeijing(100044)China

Objective:To assess the efficacy and safety of Guanxin Danshen Dripping Pills(GXDS)in the treatment of depression or anxiety in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:From September 2017 to June 2019,200 CHD patients after PCI with depression and anxiety were included and randomly divided into GXDS(100 cases)and placebo control groups(100 cases)by block randomization and a random number *** in the GXDS and control groups were given GXDS and placebo,respectively,0.4 g each time,3 times daily for 12 *** primary outcomes were scores of Patient Health Questionnaire-9(PHQ-9),Generalized Anxiety Scale(GAD-7)and the Seattle Angina Pectoris Scale(SAQ).The secondary outcomes included 12 Health Survey Summary Form(SF-12)scores and the first onset time and incidence of major adverse cardiovascular events(maCEs).Other indices including blood pressure,blood lipids,microcirculation and inflammatory-related indices,*** monitored at baseline,week 4,and week ***:In the full analysis set(200 cases),after treatment,the PHQ-9 and GAD-7 scores in the GXDS group were considerably lower than those in the control group(Pline,the total PHQ-9 scores of the experimental and control groups decreased by 3.97 and 1.18,*** corrected mean difference between the two groups was–2.78(95%CI:–3.47,–2.10;Pline level,while that of the placebo group decreased by 1.13%.The corrected mean difference between the two groups was–2.35(95%CI:–2.95,–1.76;Plin and high-sensitive C-reactive protein levels in the GXDS group were substantially superior than those in the placebo group,and the differences between the two groups were statistically significant(P<0.05).Similar results were obtained in the per protocol population analysis of 177 p

关键词： Chinese medicine coronary heart disease percutaneous coronary intervention depression and anxiety state clinical efficacy

在线全文

学校读者我要写书评

暂无评论

生长分化因子15在妇产科疾病中的作用

国际生殖健康/计划生育杂志 2025年第1期44卷 78-83页

作者：石百超马红丽王宇朱梦一刘洋马颖琪吴效科(审校) 黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院妇科

生长分化因子15(growth differentiation factor 15,GDF15)是一种调节全身能量平衡和感应应激的细胞因子。各种器官和组织合成和分泌的GDF15水平在不同的生理和病理状态下有所不同。近年研究发现,GDF15在子宫内膜异位症和妇科恶性肿瘤... 详细信息

生长分化因子15(growth differentiation factor 15,GDF15)是一种调节全身能量平衡和感应应激的细胞因子。各种器官和组织合成和分泌的GDF15水平在不同的生理和病理状态下有所不同。近年研究发现,GDF15在子宫内膜异位症和妇科恶性肿瘤中表达增加,同时在不同时期的多囊卵巢综合征(polycystic ovary syndrome,PCOS)中存在差异,青春期PCOS患者GDF15内源性分泌不足,育龄期PCOS患者GDF15表达增加。除上述情况外,GDF15在胎盘组织中呈特异性高表达,并参与多种病理妊娠过程,如在妊娠早期GDF15过高可使孕妇患妊娠恶心呕吐或妊娠剧吐的风险增加,GDF15过低可导致自然流产;妊娠中晚期GDF15异常高表达与妊娠期高血压疾病、妊娠期糖尿病和妊娠期贫血等关系密切。鉴于此,归纳GDF15在妇产科相关疾病中的作用,为进一步研究GDF15分子机制提供更多参考。

关键词：生长分化因子15 妊娠并发症多囊卵巢综合征子宫内膜异位症生殖器肿瘤女(雌)性

Learner Autonomy in Foreign Language Learning

在线全文

学校读者我要写书评

暂无评论

海外英语 2013年第24期 110-111,116页

作者： ma hong-li Guangzhou Medical University

The paper discusses learner autonomy and its importance in foreign language learning. While human beings are born with a tendency to autonomy, the traditional textbooks and teaching methods hold back the depth, speed and extent of the learn?ers. With it, learners may use this in-born tendency, plus the help from teachers and other learners, to improve the quality of for?eign language education.

关键词： learner autonomy foreign language learning

Ni含量对Co-8.8Al-9.8W合金相影响的热力学

在线全文

学校读者我要写书评

暂无评论

中国有色金属学报 2019年第11期29卷 2533-2539页

作者：徐仰涛马宏利兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050 兰州理工大学材料科学与工程学院兰州730050

为了研究Ni元素对新型钴基高温合金析出相的影响,基于JmatPro热力学模拟计算软件对不同Ni含量下Co-8.8Al-9.8W合金(摩尔分数,%)中平衡相析出的热力学行为进行研究。结果表明:随着Ni含量的增加,合金中γ相的析出温度有降低趋势,析出量减... 详细信息

为了研究Ni元素对新型钴基高温合金析出相的影响,基于JmatPro热力学模拟计算软件对不同Ni含量下Co-8.8Al-9.8W合金(摩尔分数,%)中平衡相析出的热力学行为进行研究。结果表明:随着Ni含量的增加,合金中γ相的析出温度有降低趋势,析出量减少;与0Ni合金相比,25Ni合金γ相析出温度降低了11.63℃,600℃时35Ni合金γ相的析出量较0Ni合金的减少了20.63%。μ-Co7W6相的析出温度升高;与0Ni合金相比,35Ni合金析出温度升高303.73℃,η-Co3Al相则会消失,而γ′相的析出温度升高,析出量增加;与5Ni合金相比,35Ni合金γ′相析出温度升高392.85℃,600℃时35Ni合金析出量较0Ni合金的增加40.9%。从Ni对平衡相中各元素的影响以及各物相的析出角度来看,随着Ni含量的增加,当γ相析出时固相和液相中各元素的含量相差越来越多,要满足γ相的析出和长大,只有通过降低温度或增加过冷度来实现。从而导致γ相的含量越来越少,析出温度也越来越低。合金中加入的Ni元素以形成γ′相的形式抑制η-Co3Al相的形成与生长,从而导致η相最后消失。从γ相中析出的W和Al元素分别为μ-Co7W6和η-Co3Al提供形核及生长的条件,但η-Co3Al相消失以后,从γ相中析出的Al和Ni元素却为γ′相的生成提供了条件,γ′相开始形成并增加。

关键词： JmatPro软件 Co-8.8Al-9.8W合金 γ相二次相

Long-term results of small-diameter proximal splenorenal venous shunt:A retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第29期17卷 3453-3458页

作者： Hao Chen Wei-Ping Yang Ji-Qi Yan Qin-Yu li Di ma hong-Wei li Department of Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

AIM:To investigate recurrent variceal hemorrhage and long-term survival rates of patients treated with partial proximal splenorenal venous ***:Patients with variceal hemorrhage who were treated with small-diameter proximal splenorenal venous shunt in Ruijin Hospital between 1996 and 2009 were included in this *** diameter was determined before operation using Duplex Doppler ***-operative and long-term results in term of rehemorrhage,encephalopathy and mortality were followed ***:Ninety-eight patients with Child A and B variceal hemorrhage received small-diameter proximal splenorenal venous shunt with a diameter of 7-10 *** operation,the patients’mean free portal pressure (Pmain portal vein(Plity were 6.12%(6 cases)and 2.04%(2 cases),***-one patients were followed up for 7 mo-14 years (median,48.57 mo).Long-term rates of rehemorrhage and encephalopathy were 4.40%(4 cases)and 3.30% (3 cases),*** patients(14.29%)died mainly due to progressive hepatic *** ten-year survival rates were 82.12%and 71.24%,***:Small-diameter proximal splenorenal venous shunt affords protection against variceal rehemorrhage with a low occurrence of encephalopathy in patients with normal liver function.

关键词： Partial portacaval shunt Hemorrhage Esophageal varices Shunt diameter Encephalopathy

A Wind Tunnel Experimental Study on the Wake Characteristics of a Horizontal Axis Wind Turbine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2025年第1期34卷 145-158页

作者： GUO Xingduo li Yinran li Rennian ma Yulong WEI Kui College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Key Laboratory of Fluid machinery and Systems Lanzhou 730050China Gansu Provincial Technology Centre for Wind Turbines Lanzhou 730050China

The characteristics of wind turbine wakes are influenced by multiple factors,including the atmospheric boundary layer(ABL)wind and wind turbine operating conditions(e.g.,tip speed ratio and yaw angle).In this study,two types of ABL winds with different velocity gradients and turbulence intensities are generated in a wind tunnel through configurations of spires,baffles,and various numbers of roughness elements.A wind turbine with a rotor diameter of 0.8 m and a hub height of 0.6 m is tested under varying tip speed ratios,yaw angles,and ABL wind *** results indicate that the streamwise velocity deficit in the near-wake region becomes more pronounced with an increase in the tip speed ratio,while the far-wake velocity deficit remains largely unaffected by changes in the tip speed *** the yaw angle increases,the wake deflection becomes more prominent and the wake narrows;the offset of the wake center at various downstream positions grows linearly,reaching a maximum value of approximately half the rotor ***,the turbulence level and influence range in the wake region are reduced when the turbine is *** ABL wind conditions,high turbulence intensity in the incoming flow accelerates wake recovery,and the Reynolds stress at different lateral positions tends to become consistent with increasing longitudinal ***,turbulence has a significant impact on the meandering characteristics of the wind turbine wake,with greater fluctuations in the wake center observed under higher turbulence ***,this study provides insights that could inform the optimal operation of wind farms.

关键词： horizontal axis wind turbine wind tunnel experiment wind turbine wake turbulence

Local magnetic moment oscillation around an Anderson impurity on graphene

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 188-197页

作者： Shuai li Zhen ma Jin-Hua Gao School of Science Hebei University of Science and TechnologyShijiazhuang 050018China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China School of Physics and Wuhan National High magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China

We theoretically investigate the spin resolved Friedel oscillation(FO)and quasiparticle interference(QPI)in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r^(-2) in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as r^(-3).Such spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment(***ález-Herrero et al.,Science 352,437(2016)).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states(FT-LDOS).Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Fracture behavior of sandstone with partial filling flaw under mixed-mode loading: Three-point bending tests and discrete element method

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 291-308页

作者： Dongdong ma Yu Wu Xiao ma Xunjian Hu Wenbao Dong Decheng li lingyu li State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China State Key Laboratory of Structural Health and Safety of Bridges Wuhan430034China Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress *** filling flaws were intermediate between open fractures and filled fractures,the fracture response may be worth *** this work,the effect of the filling property of sandstone with partial filling flaws on the fracture behavior was systematically investigated based on three-point bending tests and the numerical approach of discrete element method(DEM).In the laboratory,semi-circular three-point bending tests were carried out with partial filling flaws of various filling *** on this,numerical simulations were used to further investigate the effect of the filling ratio and the inclination of the partial filling flaw on the mechanical and fracture responses,and the effect of the partial filling flaw under mixed-mode loading on the fracture mechanism was elucidated coupled with acoustic emission(AE)*** obtained results showed that the increase in filling strength and filling ratio of partial filling flaw led to an increase in peak strength,with a decreasing trend in peak strength with the inclination of partial filling *** terms of crack propagation pattern,the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection,with a tortuosity path,while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction,accompanied with a larger AE event source in ***,the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling *** results may provide an application prospective for reservoir stimulation using the natural fracture system.

关键词： Partial filling flaw Mixed-mode loading Semi-circular three-point bending Acoustic emission(AE) b-value