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国际医学放射学杂志 2024年第1期 126-126页

作者： W.H.T.Teunissen A.Lavrova m.van den bent A.van der Hoorn E.A.H.Warnert m.Smits 武鑫宏

摘要目的动脉自旋标记（ASL）灌注mRI是一种用于脑肿瘤监测的高级mRI技术之一。研究定量脑血流（CBF）与非定量灌注加权成像（ASL-PWI）测量之间的相关性。并研究

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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.Jansen Sandra m.C.Schoenmakers Bas van Genabeek marle E.J.Vleugels Bart W.L.van den Bersselaar E.W.meijer Ghislaine vantomme Institute for Complex molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.m.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(mAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(mRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University medical Center Groningen(UmCG)Genetics Lifelines Initiative(UGLI).meta-analysis of GWASs of mRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCm1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,Tm6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between mRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel mRI-PDFF genetic signals(CREB3L1 and GCm1)were replicated in the FLI *** identified two novel genes for mRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between mRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content mAFLD Genome-wide association study Fatty liver index magnetic resonance imaging proton density fat fraction

Systolic and Diastolic Strain measurements Show Left Ventricular Dysfunction in Women with Turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： Allard T.van den Hoven Sultan Yilmazer Lidia R.Bons Roderick W.Jvan Grootel L.W.Geenen An m.van Berendoncks Anthonie L.Duijnhouwer Hans-marc J.Siebelink Jolien W.Roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:This study aimed to describe the systolic left ventricular global longitudinal strain(LvGLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with Turner syndrome(TS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult TS women underwent an electrocardiogram,transthoracic echocardiogram(TTE)and cardiopulmonary exercise test(CPET)on the same *** and Sre were measured using 2D speckle tracking analysis(STE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with TS and 32 healthy age-matched female controls were *** with TS had a significantly impaired/reduced systolic LvGLS(–17.82±2.98%vs.–21.80±1.85%,p0.001),compared to healthy female ***,TS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(pme(p=0.006),and a higher E/E’-ratio(pmen with TS also had a significantly reduced maximal workload(p=0.033),reduced oxygen uptake(pmaximal heart rate(pmen compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional TTE parameters and baseline characteristics were found.

关键词： Turnersyndrome speckletracking echocardiography strain exercise capacity

Staying home or leaving for a party:tissue-dependent choices of tissue-resident memory T cells

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Cellular & molecular Immunology 2022年第6期19卷 651-652页

作者： Klaas P.J.m.van Gisbergen Joke m.m.den Haan Department of Hematopoiesis Sanquin Research and Landsteiner LaboratoryAmsterdam UMCUniversity of Amsterdam1066CXAmsterdamThe Netherlands Department of molecular Cell Biology and Immunology Cancer Center AmsterdamAmsterdam Institute for Infection and ImmunityAmsterdam UMCVrije Universiteit AmsterdamAmsterdamThe Netherlands

CD8+T cells differentiate into different types of memory T cells after priming in the lymphoid *** memory T cells selectively express lymph node homing markers and recirculate between the blood and the secondary lymphoid *** memory T cells lack lymph node homing capacity,mainly circulate in the blood,and may enter peripheral *** third subset consists of tissue-resident memory T(Trm)cells that express CD69 and adhesion molecules such as CD11a,CD103,and CD49a that prevent tissue egress.

关键词： organs lymphoid CD69

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预报“接近正常”,为何常失误

气象科技 1992年第2期20卷 1-9页

作者： HUUG m.van den DOOL ZOLTAN TOTH 张瑞雪马里兰大学气象系

许多研究表明当把分级预报的得分分解为单个级别时,N 级(“接近正常”级)的得分即使不为负值或零,往往也低。我们看到许多对接近正常天气预报困难的讨论,但文献中还没有令人满意的解释。在此给出几个新的实例,通过一些统计学分析和得分... 详细信息

许多研究表明当把分级预报的得分分解为单个级别时,N 级(“接近正常”级)的得分即使不为负值或零,往往也低。我们看到许多对接近正常天气预报困难的讨论,但文献中还没有令人满意的解释。在此给出几个新的实例,通过一些统计学分析和得分的定义,试图解释此种现象。这里引进均方根误差(rms)和得分(skill)的定义,专指给定的距平的。3级预报中 N 级得分低,原因是(a)当具有准高斯分布的预报量的分级宽度在中心附近很窄时,我们预报方法的 rms 误差与预报振幅关系不大。(b)检验观测值偏离 N 级的机会(其两侧均有偏离机会)比其它级的机会大(半闭合级只有单侧偏离机会)。从另外一层意义上解释是:由于在得分的定义中,所需检验方法以随机预报为参考,因而在均值附近得分低。从 rms 的意义上来说,随机预报在均值附近效果最好。均值附近预报得分低并不只出现在分级预报或任何特定时间。本文不是给出一个解决方法,而是提醒人们不能过分解释等级评分的概念。似乎均值附近预报得分低,主要是定义所造成,因而不需要物理学和动力学方面的解释。当取持续性预报为参考代替随机预报时,所有问题就都迎刃而解了。最后,我们注意到,远在我们对评分作预报之前,在实际中均值附近得分低已应用了预测预报得分的概念。分析表明只要预报距平相对于预报 rms 误差来说比较小,则可以预测距平相关随预报幅度线性增加。这已被 Tracton 等(1989)从经验上发现。

关键词：天气预报观测误差正常

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Biliary drainage of the common bile duct with an enteral metal stent

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World Journal of Gastroenterology 2009年第19期15卷 2423-2424页

作者： Irene m Dek Bram DJ van den Elzen Paul Fockens Erik AJ Rauws Department of Gastroenterology and Hepatology Academic Medical CentreUniversity of Amsterdam1105 AZ AmsterdamThe Netherlands

In this case report we present an elderly patient who was referred to our hospital with recurrent episodes of cholangitis that persisted after placement of fi ve metal stents for a distal common bile duct(CBD) *** metal stents were endoscopically removed from the CBD by forceps after balloon dilatation of the papilla.A profoundly dilated CBD with sludge and concrements was *** ensure adequate bile drainage an enteral metal stent was inserted in the *** case shows that proximally migrated uncovered metal stents in the CBD can be safely removed endoscopically under certain *** suggest that in the case of a CBD drainage problem due to an extremely dilated CBD,placement of an enteral metal stent in the CBD could be considered,especially in patients who are unfi t for surgery.

关键词： Cholangitis Dilated common bile duct Endoscopic retrograde cholangiopancreatography Enteral metal stent metal stent removal

《汉语语气词“了”：汉语的语篇构造和语用标记》介绍

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当代语言学 2009年第1期11卷 69-72页

作者： m.van den Berg Wu Guo 杨素英(译) 黄月圆(译) 不详香港九龙香港浸会大学

《汉语语气词“了”：汉语的语篇构造和语用标记》（The Chinese Panicle Le：Discourse Construction and Pragmatic marking in Chinese）由Routledge于2006年出版，作者marinus van den Berg，Wu Guo（武果）。全书分为9章，共284页。

关键词：语用标记 “了” 语气词汉语构造语篇

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The caudate lobe described by Adriaan van den Spiegel

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 748-748页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Adriaan van den Spiegel[1578-1625]was born in the Flemish city of *** studied medicine in Louvain(Belgium)and Leiden(The Netherlands)and early on showed a keen interest in anatomical dissections(1).Also known as‘Spigelius’in Latin,he was appointed professor of dissection and surgery at the famous medical faculty of the University of Padua in Italy.

关键词： Latin den Netherlands

Evolution of real area of contact due to combined normal load and sub-surface straining in sheet metal

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Friction 2021年第4期9卷 840-855页

作者： meghshyam SHISODE Javad HAZRAT Tanmaya mISHRA matthijn DE ROOIJ Ton van den BOOGAAED Nonlinear Solid mechanics Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 NBThe Netherlands Surface Technology and Tribology Faculty of Engineering TechnologyUniversity of TwenteEnschede 7522 NBThe Netherlands

Understanding asperity flattening is vital for a reliable macro-scale modeling of friction and *** sheet metal forming processes,sheet surface asperities are deformed due to contact forces between the tools and the *** addition,as the sheet metal is strained while retaining the normal load,the asperity deformation increases *** of the asperities determines the real area of contact which influences the friction and wear at the tool-sheet metal *** real area of contact between two contacting rough surfaces depends on type of loading,material behavior,and topography of the contacting *** this study,an experimental setup is developed to investigate the effect of a combined normal load and sub-surface strain on real area of *** and zinc coated steel sheets(GI)with different coating thicknesses,surface topographies,and substrate materials are used in the experimental *** element(FE)analyses are performed on measured surface profiles to further analyze the behavior observed in the experiments and to understand the effect of surface topography,and coating thickness on the evolution of the real area of ***,an analytical model is presented to determine the real area contact under combined normal load and sub-surface *** results show that accounting for combined normal load and sub-surface straining effects is necessary for accurate predictions of the real area of contact.

关键词： asperity flattening real area of contact sub-surface strain zinc coating sheet metal forming

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