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Progress in Natural Science:materials International 2015年第5期25卷 419-424页

作者： Imran Sadiq Shahzad Naseem muhammad Naeem Ashiq m.A.Khan Shanawer Niaz m.u.rana Centre of Excellence in Solid State Physics University of the Punjab Institute of Chemical Sciences Bahauddin Zakariya University Department of Physics BUITEMS 4. Department of Physics University of Sargodha

The sol-gel auto-combustion method was adopted to synthesize nanomaterials of single-phase X-type hexagonal ferrites with the composition of Sr;Gd;Ni;Fe;Cd;O;（x=0.00,0.02,0.04,0.06,0.08,0.10 and y = 0,0.1,0.2,0.3,0.4,0.5）.The structural properties were carried out by XRD analysis and the lattice parameters show variation with the doping of *** average particle size measured by TEm was in the range of 8-10 nm which is beneficial in obtaining suitable signal-to-noise ratio in recording media and biomedical *** room temperature resistivity enhanced with the increase of the dopant *** increase in resistivity indicates that the synthesized materials can be considered good for the formation of the multilayer chip inductors（mLCIs） as well as for the reduction of eddy current *** dielectric constant decreased with the increase in the frequency which is the general reported trend of the hexagonal ferrites and can be explained on the basis of Koop’s theory and maxwell-Wagner *** abnormal dielectric behavior indicates the formation of small polarons in the *** maximum value of tangent loss at low frequencies reflects the application of these materials in medium frequency devices（mF）.

关键词： Sol–gel Nanocrystalline materials Thermal properties Electrical properties Dielectric properties

Cross Section of Heavy Ion Reaction （14.5 meV/u） ^132Xe ＋ Bi

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Chinese Physics Letters 2006年第3期23卷 572-575页

作者： G. Sher m.I. Shahzad m. Hussain m. A. rana E. u. Khan Physics Research Division PINSTECH P.O Nilore Islamabad Pakistan Department of Physics University of the Punjab Lahore Pakistan

We investigate the cross section of the heavy ion reaction （14.5 meV/u） ^132Xe ＋ Bi by using a CR-39 plastic track detector. The target-detector assembly is exposed at uNILAC beam facility of GSI, Germany. After etching under appropriate etching conditions, the detector is scanned for multipronged events produced as a result of interactions of projectile ions with target atoms. The elastic events are separated from binary events and used for the determination of the quarter-point angle. The quarter-point angle obtained is used to determine the total reaction cross section. The total experimental reaction cross section is determined by using statistics of inelastic events of two-pronged and higher multiplicity events. The experimental reaction cross sections determined by using elastic and inelastic data observed in the reaction under study are found to be in good agreement with the theoretically calculated value of reaction cross section using a sharp cutoff model.

关键词： SEQuENTIAL FISSION COuLOmB BARRIER TRACK DETECTORS NuCLEAR SCATTERING PB-208

Fallopian tube assessment of the peristaltic-ciliary flow of a linearly viscous fluid in a finite narrow tube

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Applied mathematics and mechanics(English Edition) 2018年第3期39卷 437-454页

作者： H.ASHRAF A.m.SIDDIQuI m.A.rana Department of mathematics and Statistics Riphah International University Department of mathematics York CampusPennsylvania State University

The present theoretical assessment deals with the peristaltic-ciliary trans- port of a developing embryo within a fallopian tubal fluid in the human fallopian tube. A mathematical model of peristalsis-cilia induced flow of a linearly viscous fluid within a fallopian tubal fluid in a finite two-dimensional narrow tube is developed. The lubrica- tion approximation theory is used to solve the resulting partial differential equation. The expressions for axial and radial velocities, pressure gradient, stream function, volume flow rate, and time mean volume flow rate are derived. Numerical integration is performed for the appropriate residue time over the wavelength and the pressure difference over the wavelength. moreover, the plots of axial velocity, the appropriate residue time over wavelength, the vector, the pressure difference over wavelength, and the streamlines are displayed and discussed for emerging parameters and constants. Salient features of the pumping characteristics and the trapping phenomenon are discussed in detail. Yhrther- more, a comparison between the peristaltic flow and the peristaltic-ciliary flow is made as the special case. Relevance of the current results to the transport of a developing embryo within a fallopian tubal fluid from ampulla to the intramural in the fallopian tube is also explored. It reveals the fact that cilia along with peristalsis helps to complete the required mitotic divisions while transporting the developing embryo within a fallopian tubal fluid in the human fallopian tube.

关键词： peristaltic-ciliary flow linearly viscous fluid analytic solution human fal-lopian tube

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNu-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNu-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNu-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNu-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Bulk etch rates of CR-39 at high etchant concentrations:diffusionlimited etching

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Nuclear Science and Techniques 2020年第12期31卷 41-49页

作者： E.m.Awad m.A.rana mushtaq Abed Al-Jubbori Physics Department Faculty of ScienceMenoufia UniversityShebin El-KoomMenoufia 32511Egypt mERADD Instrumentation Control and Computer Complex(ICCC)PARAS Building18-KM Multan RoadP.O.ChungLahorePakistan Department of Physics College of Education for Pure SciencesUniversity of MosulMosul 41001Iraq

Systematic CR-39 bulk etching experiments were conducted over a wide range of concentrations(2–30 N)of NaOH-based *** analysis and a deep discussion of the results are presented.A comprehensive nuclear track chemical etching data bank was *** regimes of CR-39 bulk etching were *** I spans etchant concentrations from 2 to 12 *** II spans concentrations from 12 to 25 *** call this the dynamic bulk etching *** III is for concentrations greater than 25 *** this regime,the bulk etch rate is saturated with respect to the etchant *** classification is discussed and *** role of ethanol in NaOH-based etchants is explored and discussed.A parameter called the “reduced bulk etch rate” is defined here,which helps in analyzing the dependence of bulk etching on the amount of ethanol in the *** bulk etch rate shows a natural logarithmic dependence on the density of ethanol in the etchant.

关键词： CR-39 detector Ethanol Bulk etch rate Reduced bulk etch rate Diffusion-limited etching Concentration-limited etching

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

A Variant of the Classical Von Kármán Flow for a Couple Stress Fluid

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Chinese Physics Letters 2012年第8期29卷 164-167页

作者： A.A.Farooq A.m.Siddiqui m.A.rana T.Haroon Department of mathematics COMSATS University of Science and TechnologyAbbottabadPakistan Department of mathematics York CampusPennsylvania State UniversityYorkPA 17403USA Department of Basic Sciences Riphah International UniversityIslamabadPakistan Department of mathematics COMSATS University of Science and TechnologyIslamabadPakistan

We present an attempt to study the influence of couple stresses on the flow induced by an infinite disk rotating with a constant angular *** governing equations of motion in three dimensions are treated analytically yielding the derivation of exact solutions which differ from those corresponding to the classical Von Kármán's *** analysis reveals that a boundary layer structure develops near the surface of the disk,whose far-field behaviour is distinct from the near-wall *** velocity and vorticity components for various values of the dimensionless parameters,associated with the flow,are presented graphically.

关键词： solution flow Von

Etchability of Latent Fission Fragment Tracks in CR-39

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Chinese Physics Letters 2007年第11期24卷 3107-3110页

作者： mukhtar Ahmed rana Physics Division Directorate of Science PINSTECH P.O. Nilore Islamabad Pakistan

We report the chemical etching behaviour of the CR-39 polymer detector exposed to fission fragments of 252Cf describing etchability of latent tracks, which are like nanocylinders. The fission fragment exposed detectors were etched in 1-7 N NaOH water solutions at temperatures 50-80℃ for 45 min in the case of track length and 180 min in the case of track diameter measurements. The reduced etch rate S （called here etchability） is determined using experimental results for all etching conditions and the etching conditions with the highest reduced etch are obtained. Physics and energetics of bulk and track etching are discussed. Possible effects causing spurious changes in determination of activation energy of etching are investigated.

关键词： coated conductor buffer layer self-epitaxy CeO2