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International Journal of mining science and Technology 2016年第5期26卷 745-752页

作者： A.soofastaei s.m.Aminossadati m.s.kizil P.Knights school of mechanical and mining Engineering The University of Queensland

Data collected from truck payload management systems at various surface mines shows that the payload variance is significant and must be considered in analysing the mine productivity,energy consumption,greenhouse gas emissions and associated *** variance causes significant differences in gross vehicle *** loaded trucks travel slower up ramps than lightly loaded *** trucks are slowed by the presence of slower trucks,resulting in‘bunching’,production losses and increasing fuel *** paper simulates the truck bunching phenomena in large surface mines to improve truck and shovel systems’efficiency and minimise fuel *** study concentrated on completing a practical simulation model based on a discrete event method which is most commonly used in this field of research in other *** simulation model has been validated by a dataset collected from a large surface mine in Arizona state,*** results have shown that there is a good agreement between the actual and estimated values of investigated parameters.

关键词： Discrete-event model simulation Truck bunching Payload variance Cycle time Fuel consumption

A comparison of strategic mine planning approaches for in-pit crushing and conveying, and truck/shovel systems

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International Journal of mining science and Technology 2018年第2期28卷 205-214页

作者： m.Nehring P.F.Knights m.s.kizil E.Hay school of mechanical and mining Engineering The University of Queensland

In a global environment where energy and labor are becoming increasingly expensive, continuous mining systems such as In-Pit Crushing and Conveying(IPCC) systems have been advanced as offering a real alternative to conventional truck haulage systems. The implementation of IPCC systems in hard rock operations in open pit mines however requires different and more comprehensive planning approaches in order to adequately reflect the practical aspects associated with these. This paper investigates the impact that these approaches may have on the implementation of IPCC systems on a basic metalliferous deposit amenable to open pit exploitation. A strategic life of mine plan to provide numerous economic indicators for each approach is analyzed and compared to traditional truck haulage systems. The mine planning and evaluation process highlights the increased overall resource recovery that may accompany the use of IPCC systems. This investigation also provides insights into the issues associated with IPCC and the scale and type of operation and orebody that is likely to provide a feasible alternative to truck haulage.

关键词： In pit crusher conveyor systems strategic mine planning Resource recovery surface metalliferous mining mine optimization Truck and shovel

A comprehensive investigation of loading variance influence on fuel consumption and gas emissions in mine haulage operation

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International Journal of mining science and Technology 2016年第6期26卷 995-1001页

作者： soofastaei A. Aminossadati s.m. kizil m.s. Knights P. school of mechanical and mining Engineering University of Queensland

The data collected from haul truck payload management systems at various surface mines show that the payload variance is significant and must be considered in analysing the mine productivity, diesel energy consumption, greenhouse gas emissions and associated costs. The aim of this study is to determine the energy and cost saving opportunities for truck haulage operations associated with the payload variance in surface mines. The results indicate that there is a non-linear relationship between the payload variance and the fuel consumption, greenhouse gas emissions and associated costs. A correlation model, which is independent of haul road conditions, has been developed between the payload variance and the cost saving using the data from an Australian surface coal mine. The results of analysis for this particular mine show that a significant saving of fuel and greenhouse gas emissions costs is possible if the standard deviation of payload is reduced from the maximum to minimum value.

关键词： Energy consumption Haul truck surface mine Greenhouse gas emissions Cost

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Development of a multi-layer perceptron artificial neural network model to determine haul trucks energy consumption

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International Journal of mining science and Technology 2016年第2期26卷 285-293页

作者： soofastaei Ali Aminossadati saiied m. Arefi mohammad m. kizil mehmet s. school of mechanical and mining Engineering.CRC mining The University of Queensland Department of Power and Control Engineering School of Electrical and Computer EngineeringShiraz University

The mining industry annually consumes trillions of British thermal units of energy,a large part of which is *** fuel is a significant source of energy in surface mining operations and haul trucks are the major users of this energy *** vehicle weight,truck velocity and total resistance have been recognised as the key parameters affecting the fuel *** this paper,an artificial neural network model was developed to predict the fuel consumption of haul trucks in surface mines based on the gross vehicle weight,truck velocity and total *** network was trained and tested using real data collected from a surface mining *** results indicate that the artificial neural network modelling can accurately predict haul truck fuel consumption based on the values of the haulage parameters considered in this study.

关键词： Fuel consumption Haul truck surface mine Artificial neural network

Advances in fibre optic based geotechnical monitoring systems for underground excavations

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International Journal of mining science and Technology 2019年第2期29卷 229-238页

作者： Hongkui Gong mehmet s.kizil Zhongwei Chen moe Amanzadeh Ben Yang saiied m.Aminossadati school of mechanical and mining Engineering The University of Queensland

Geotechnical stability is a major concern for the long-term safety and integrity of underground infrastructures such as tunnels, railway stations, mine shafts and hydraulic power chambers. An effective geotechnical monitoring system is able to provide adequate warning to underground personnel prior to any unexpected major geotechnical failure. This paper reviews the conventional geotechnical monitoring sensors and the emerging Fibre Optic sensing(FOs) techniques, pointing out their unique features and major differences. Recent advances in various FOs based monitoring systems, including Brillouin time domain distributed optical sensors and fibre Bragg grating(FBG) sensors, are investigated through a critical review of the laboratory studies and field applications used for underground geotechnical monitoring. Particular emphasis is given to fibre packaging, temperature compensation, installation methods and instrumentation performance in the underground environment. A detailed discussion of the advantages and limitations of each FOs monitoring system is also presented in this paper.

关键词： Underground geotechnical monitoring Conventional geotechnical instruments Distributed optical fibre sensors Fibre Bragg grating Brillouin optical analysis

Analysis on the multi-phase flow characterization in cross-measure borehole during coal hydraulic slotting

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International Journal of mining science and Technology 2018年第4期28卷 692-696页

作者： Chunshan Zheng Baiquan Lin mehmet s.kizil saiied m.Aminossadati He Li Zhongwei Chen school of mechanical and mining Engineering The University of Queensland school of safety Engineering China University of Mining & Technology

Hydraulic slotting in a gas drainage borehole is an effective method of enhancing gas drainage perfor- mance. However, it frequently occurs that a large amount of slotting products （mainly the coal slurry and gas） intensely spurt out of the borehole during the slotting, which adversely affects the slotting efficiency. Despite extensive previous investigations on the mechanism and prevention-device design of the spurt during ordinary borehole drilling, a very few studies has focused on the spurt in the s Ottlng pro ] ＂ _ cess. The slotting spurt is mainly caused by two reasons： the coal and gas outburst in the borehole and the borehole deslagging blockage. This paper focuses on the second reason, and investigates the hydraulic deslagging flow patterns in the annular space between the drill pipe and borehole wall Results show that there are six deslagging flow patterns when the drill pipe is still： pure slurry flow, pure gas flow, bubble flow, intermittent flow, layering flow and annular flow. When the drill pipe rotates, each of those six flow patterns changes due to the Taylor vortex effect. Outcomes of this study could help to better understand the slotting-spurt mechanism and provide guidance on the anti-spurt strategies through eliminating the borehole deslagging blockage.

关键词： Coal hydraulic slotting Cross-measure borehole Borehole spurt Deslagging flow pattern

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-segura Aleksandra Polishchuk Laura Nadal marta Tomàs Carolina silvera-simón manel m.santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Convergence of COVID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of Virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree V Dhotre Ajay m Gavkare sachin s mumbre Pradnya s Dhotre Department of microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COVID-19-positive patients compared to non-COVID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandemic.

关键词： Recurrent stroke COVID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level

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Neural Regeneration Research 2020年第5期15卷 824-827页

作者： mehmet Ilyas Cosacak Prabesh Bhattarai Caghan kizil German Center for Neurodegenerative Diseases (DZNE) Dresden Helmholtz AssociationDresdenGermany Center for molecular and Cellular Bioengineering (CmCB) CRTDTU DresdenDresdenGermany

Alzheimer’s disease cannot be cured as of *** current understanding on the causes of Alzheimer’s disease is *** develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are *** recent years,Alzheimer’s disease research underwent a paradigm *** to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the *** on every cell type adds an alternative approach and hope for the efforts towards the *** stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy ***,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for ***,this provocative idea requires further evidence and tools for ***,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s *** this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research.

关键词： Alzheimer's disease mouse neural regeneration neural stem cell neurogenesis neuron single cell sequencing zebrafish