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Heterogeneity of mature oligodendrocytes in the central nervous system

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.r.Groh moein yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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multiple exp-function method for soliton solutions of nonlinear evolution equations

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Chinese Physics B 2017年第7期26卷 20-26页

作者： yakup yιldιrιm Emrullah yasar Department of mathematics Faculty of Arts and Sciences Uludag University

We applied the multiple exp-function scheme to the（2＋1）-dimensional Sawada-Kotera（SK） equation and（3＋1）-dimensional nonlinear evolution equation and analytic particular solutions have been deduced. The analytic particular solutions contain one-soliton, two-soliton, and three-soliton type solutions. With the assistance of maple, we demonstrated the efficiency and advantages of the procedure that generalizes Hirota＇s perturbation scheme. The obtained solutions can be used as a benchmark for numerical solutions and describe the physical phenomena behind the model.

关键词： (2+1)-dimensional Sawada-Kotera(SK) equation (3+1)-dimensional nonlinear evolution equation(NLEE) multiple exp-function method multiple wave solutions

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A Collocation Technique via Pell-Lucas Polynomials to Solve Fractional Differential Equationmodel for HIV/AIDS with Treatment Compartment

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Computer modeling in Engineering & Sciences 2024年第10期141卷 281-310页

作者： Gamze yıldırım Suayip yüzbası Department of mathematics Faculty of ScienceAkdeniz UniversityAntalya07058Turkey Department of mathematics Faculty of Basic ScienceGebze Technical UniversityKocaeli41400Turkey Department of mathematics Faculty of ScienceBartın UniversityBartın74100Turkey

In this study,a numerical method based on the Pell-Lucas polynomials(PLPs)is developed to solve the fractional order HIV/AIDS epidemic model with a treatment *** HIV/AIDS mathematical model with a treatment compartment is divided into five classes,namely,susceptible patients(S),HIV-positive individuals(I),individuals with full-blown AIDS but not receiving ArV treatment(A),individuals being treated(T),and individuals who have changed their sexual habits sufficiently(r).According to the method,by utilizing the PLPs and the collocation points,we convert the fractional order HIV/AIDS epidemic model with a treatment compartment into a nonlinear system of the algebraic ***,the error analysis is presented for the Pell-Lucas approximation *** aim of this study is to observe the behavior of five populations after 200 days when drug treatment is applied to HIV-infectious and full-blown AIDS *** demonstrate the usefulness of this method,the applications are made on the numerical example with the help of *** addition,four cases of the fractional order derivative(p=1,p=0.95,p=0.9,p=0.85)are examined in the range[0,200].Owing to applications,we figured out that the outcomes have quite decent ***,we understand that the errors decrease when the value of N *** figures in this study are created in *** outcomes indicate that the presented method is reasonably sufficient and correct.

关键词： Collocation method fractional differential equations HIV/AIDS epidemic model Pell-Lucas polynomials

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On m-theory on real toric fibrations

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Communications in Theoretical Physics 2021年第8期73卷 67-74页

作者： A Belhaj H Belmahi m Benali S-E Ennadifi y Hassouni y Sekhmani Equipe des Sciences de la matière et du rayonnement ESMaRDépartement de Physique Facultédes SciencesUniversitéMohammed V de RabatMorocco LHEP-mS Département de PhysiqueFaculte des SciencesUniversitéMohammed V de RabatMorocco

Borrowing ideas from elliptic complex geometry, we approach m-theory compactifications on real fibrations. Precisely, we explore real toric equations rather than complex ones exploited in F-theory and related dual models. These geometries have been built by moving real toric manifolds over real bases. Using topological changing behaviors, we unveil certain data associated with gauge sectors relying on affine lie symmetries.

关键词： real fibrations m-theory toric real manifolds affine lie symmetries

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First Detailed Photometric Investigation on the Nature of Contact Binary System AA Cet

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research in Astronomy and Astrophysics 2023年第7期23卷 154-163页

作者： m.F.yıldırım F.Soydugan Çanakkale Onsekiz mart University Astrophysics Research Center and Ulupınar Observatory17020ÇanakkaleTurkey Çanakkale Onsekiz mart University Faculty of SciencesDepartment of Physics17020ÇanakkaleTurkey

The TESS light curve(LC)of the marginal contact binary A A Cet was analyzed simultaneously with the radial velocity and the orbital period(OP)change of the system was *** physical parameters of the system were obtained by analyzing the LC of A A Cet with the Wilson-Devinney method,and the absolute parameters of the components were calculated using the results *** the components of AA Cet,the masses and radii were calculated as m_(1)=1.39±0.04 m_⊙,m_(2)=0.48±0.02 m_⊙,and r_(1)=1.64±0.03 r_⊙,r_(2)=1.01±0.04 r_⊙,*** Cet is a marginal contact binary with a temperature difference of 1305 K between its components.A total of 14 eclipse times were obtained from the TESS data and used in the OP analysis together with those collected from the *** has been observed that the change in the OP of AA Cet is in the form of a decreasing *** mass transfer between the components has been interpreted as the reason for this *** OP decrease amount of A A Cet was obtained as dP/dt=0.0062±0.0006 s yr^(-1).and the reason for this decrease was attributed to a 3.3(9)×10^(-8)m_⊙.mass transfer per year from the more massive component to the less massive *** age of A A Cet has been estimated as 7 Gyr,as the age of contact systems helps us to understand their evolution.

关键词： (stars:)binaries:eclipsing stars:fundamental parameters stars:individual(AA Cet)

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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHArI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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An electron moir■ method for a common SEm

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Acta mechanica Sinica 2006年第6期22卷 595-602页

作者： y. m. Xing S. Kishimoto y. r. Zhao Department of Applied mechanics Inner Mongolia University of Technology Hohhot 010051 China National Institute for materials Sciences Tsukuba Ibaraki 305-0047 Japan

In the electron moiré method, a high-frequency grating is used to measure microscopic deformation, which promises significant potential applications for the method in the microscopic analysis of materials. However, a special beam scanning control device is required to produce a grating and generate a moiré fringe pattern for the scanning electron microscope （SEm）. Because only a few SEms used in the material science studies are equipped with this device, the use of the electron moiré method is limited. In this study, an electron moiré method for a common SEm without the beam control device is presented. A grating based on a multi-scanning concept is fabricated in any observing mode. A real-time moiré pattern can also be generated in the SEm or an optical filtering system. Without the beam control device being a prerequisite, the electron moiré method can be more widely used. The experimental results from three different types of SEms show that high quality gratings with uniform lines and less pitch error can be fabricated by this method, and moiré patterns can also be correctly generated.

关键词： Electron moiré Grating multi-scanning Electron beam moiré

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Charaeterizability of the Group ~2D_p(3) by its Order Components,Where p≥5 is a Prime Number Not of the Form 2~m+1

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Acta mathematica Sinica,English Series 2008年第7期24卷 1117-1126页

作者： m.r.DArAFSHEH School of mathematics College of ScienceUniversity of TehranTehranIran

The author will prove that the group ^2Dp（3） can be uniquely determined by its order components, where p ≠ 2^m ＋ 1 is a prime number, p ≥ 5. more precisely, if OC（G） denotes the set of order components of G, we will prove OC（G） = OC（^2Dp（3）） if and only if G is isomorphic to ^2Dp（3）. A main consequence of our result is the validity of Thompson＇s conjecture for the groups under consideration.

关键词： prime graph order component linear group

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CTP Synthase Is required for Optic Lobe Homeostasis in Drosophila

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Journal of Genetics and Genomics 2015年第5期42卷 261-274页

作者： Öm.r.y.Tastan Ji-Long Liu medical research Council Functional Genomics Unit Department of PhysiologyAnatomy and GeneticsUniversity of Oxford

CTP synthase （CTPsyn） is a metabolic enzyme responsible for the de novo synthesis of the nucleotide CTE Several recent studies have shown that CTPsyn forms filamentous subcellular structures known as cytoophidia in bacteria, yeast, fruit flies and humans. However, it remains elusive whether and how CTPsyn and cytoophidia play a role during development. Here, we show that cytoophidia are abundant in the neuroepithelial stem cells in Drosophila optic lobes. Optic lobes are underdeveloped in CTPsyn mutants as well as in CTPsyn rNAi. moreover, overexpressing CTPsyn impairs the development of optic lobes, specifically by blocking the transition from neuro- epithelium to neuroblast. Taken together, our results indicate that CTPsyn is critical for optic lobe homeostasis in Drosophila.

关键词： CTP synthase Cytoophidium Drosophila Central nervous system Neuroepithelial stem cell

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