检索结果-南通市图书馆

Design and current progress of the Apollon 10 PW project

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2015年第1期3卷 32-35页

作者： J.P.Zou C.Le Blanc D.N.Papadopoulos G.Chériaux P.Georges G.mennerat F.Druon L.Lecherbourg A.Pellegrina P.Ramirez F.Giambruno A.Fréneaux F.Leconte D.Badarau J.m.Boudenne *** T.Valloton J.L.Paillard J.L.Veray m.pina P.monot J.P.Chambaret P.martin F.mathieu P.Audebert F.Amiranoff Laboratoire pour l’Utilisation des Lasers Intenses CNRSEcole Polytechnique Laboratoire d’Optique Appliquée ENSTA Paris TechCNRS Laboratoire Charles Fabry UMR 8501Institut d’OptiqueCNRSUniversité Paris Sud CEA IramisSPAM

The objective of the Apollon project is the generation of 10 PW peak power pulses of 15 fs at 1 shot/minute. In this paper the Apollon facility design, the technological challenges and the current progress of the proj... 详细信息

关键词： titanium lasers PW class facilities

Osteogenic lithium-doped brushite cements for bone regeneration

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive materials 2022年第10期7卷 403-417页

作者： K.Hurle F.R.maia V.P.Ribeiro S.pina J.m.Oliveira F.Goetz-Neunhoeffer R.L.Reis GeoZentrum Nordbayern MineralogyFriedrich-Alexander University Erlangen-Nürnberg(FAU)91054ErlangenGermany B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciˆencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimar˜aesPortugal ICVS/3B’s–PT Government Associate Laboratory BragaGuimar˜aesPortugal

This study investigated the osteogenic performance of new brushite cements obtained from Li+-dopedβ-tricalcium phosphate as a promising strategy for bone ***(Li+)is a promising trace element to encourage the migration and proliferation of adipose-derived stem cells(hASCs)and the osteogenic differentiation-related gene expression,essential for ***-situ X-ray diffraction(XRD)and in-situ 1H nuclear magnetic resonance(1H NmR)measurements proved the precipitation of brushite,as main phase,and monetite,indicating that Li+favored the formation of monetite under certain ***+was detected in the remaining pore solution in significant amounts after the completion of *** calorimetry results showed an accelerating effect of Li+,especially for low concentration of the setting retarder(phytic acid).A decrease of initial and final setting times with increasing amount of Li+was detected and setting times could be well adjusted by varying the setting retarder *** cements presented compressive mechanical strength within the ranges reported for cancellous *** vitro assays using hASCs showed normal metabolic and proliferative *** immunodetection and gene expression profile of osteogenic-related markers highlight the incorporation of Li+for increasing the in vivo bone *** osteogenic potential of Li-doped brushite cements may be recommended for further research on bone defect repair strategies.

关键词： Lithium doping β-tricalcium phosphate Brushite cements Alkaline phosphatase activity Collagen expression Osteogenic expression Bone regeneration

Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and manufacturing 2019年第4期2卷 225-241页

作者： Joao BCosta Joana Silva-Correia Sandra pina Alain da Silva morais Sílvia Vieira Hélder Pereira Joao Espregueira-mendes Rui LReis Joaquim m.Oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:murcia-madrid FIFA medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 mPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 mPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 mPa and dynamical mechanical properties ranging from 1.03 ± 0.08 mPa to 1.56 ± 0.13 mPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hmCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking meniscus

Case Report: A Long Survivor Patient with Stage IV Gastric Adenocarcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2020年第6期11卷 357-364页

作者： marta pina maria Leitão manuela machado medical Oncology Department Portuguese Institute of Oncology of Porto Porto Portugal

Gastric cancer (GC) is the fifth most common malignancy of the world and third leading cause of cancer death. At diagnosis, 35% of GC patients have distant metastases and in these cases the survival rate is very poor with a median overall survival (OS) inferior to 1 year. We report a case of a 67-year-old woman with gastric carcinoma initially deemed limited stage on diagnosis (cT2N0m0), treated surgically with radical subtotal gastrectomy with Billroth II reconstruction. In the staging CT scan, the patient presented a liver image that was considered benign. Three months later, due to abdominal pain, the patient performed another CT scan and the diagnostic of a large single liver metastasis was made;retrospectively it was observed that the lesion was present at diagnosis and that it had increased. A biopsy was performed which confirmed the metastatic origin. In a multidisciplinary team, the lesion was considered unresectable. She was proposed for first line (1st L) palliative chemotherapy (ChT) with FOLFIRI, with partial response as best response. After 30 cycles of FOLFIRI, bone metastases were diagnosed. The patient was submitted to a cementoplasty of D11-12 and L1-2. Afterwards, she started 2nd L ChT with mFOLFOX6 and at the same time she started zoledronic acid every 28 days. The best response to mFOLFOX6 was stable disease. Since November 2018, the patient has been treated with zoledronic acid every 28 days alone and maintains stable disease without ChT.

关键词： Gastric Cancer metastatic Gastric Cancer Palliative Surgery Palliative Chemotherapy Survival

2017年全球新药研发报告——第一部分：新药和生物制剂（Ⅲ）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药学进展 2018年第6期42卷 466-477页

作者： Granl A I pina P Stnnger m 科睿唯安

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂，其中有7种为首创药物（first—inclass），即该药物具有全新作用机制并在全球首次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新... 详细信息

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂，其中有7种为首创药物（first—inclass），即该药物具有全新作用机制并在全球首次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新制剂等）;以及2017年首次获批,但2017年12月31日前尚未上市的25种产品。美国是全球新药研发最活跃的市场，肿瘤是最为活跃的治疗领域。在制药和生物技术领域年度报告的第一部分中，将深入报道这些新药和生物制剂的相关信思。

关键词：新上市药物新批准药物延伸性新药首创药物

2017年全球新药研发报告——第一部分：新药和生物制剂（Ⅳ）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药学进展 2018年第7期42卷 554-560,I0001-I0004页

作者： Graul A I pina P Stringer m 科睿唯安

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂，其中有7种为首创药物（first—in—class），即该药物具有全新作用机制并在全球首次获批并上市;36种产品线拓展产品（即新适应证、新联合用药和... 详细信息

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂，其中有7种为首创药物（first—in—class），即该药物具有全新作用机制并在全球首次获批并上市;36种产品线拓展产品（即新适应证、新联合用药和新制剂等）;以及2017年首次获批，但2017年12月31日前尚未上市的25种产品。美国是全球新药研发最活跃的市场，肿瘤是最为活跃的治疗领域。在制药和生物技术领域年度报告的第一部分中将深入报道这些新药和生物制剂的相关信息。

关键词：新上市药物新批准药物延伸性新药首创药物

EUV ablation of organic polymers at a high fluence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2014年第3期2卷 86-90页

作者： Chiara Liberatore Klaus mann matthias mller Ladislav pina Libor Juha Jorge J.Rocca Akira Endo Tomas mocek Hi LASE Centre Institute of Physics ASCRv.v.i.Za Radnicí 82525241 Dolní BezanyCzech Republic Czech Technical University Thkurova 2077/7160 00 Prague 6Czech Republic Laser Laboratorium Gttingen (LLG) 37077 GttingenGermany Department of Electrical and Computer Engineering Colorado State UniversityFort CollinsCO 80523USA

A preliminary investigation on short-wavelength ablation mechanisms of poly(methyl methacrylate)(PmmA) and poly(1,4-phenylene ether ether-sulfone)(PPEES) by extreme ultraviolet(EUV) radiation at 13.5 nm using a table-top laserproduced plasma from a gas-puff target at LLG(Gttingen) and at 46.9 nm by a 10 Hz desktop capillary discharge laser operated at the Institute of Physics(Prague) is *** of polymer materials is initiated by photoinduced polymer chain *** ablation occurs due to the formation of volatile products by the EUV radiolysis removed as an ablation plume from the irradiated material into the *** general,cross-linking of polymer molecules can compete with the chain *** processes may influence the efficiency and quality of micro(nano)structuring in polymer *** is a critical parameter to be taken into account when an EUV ablation process occurs,because different wavelengths result in different energy densities in the near-surface region of the polymer exposed to nanosecond pulses of intense EUV radiation.

关键词： EUV ablation organic polymer photo-erosion mechanisms wavelength effect

2017年全球新药研发报告——第一部分：新药和生物制剂（Ⅰ）

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

药学进展 2018年第4期42卷 309-313页

作者： Graul A I pina P Stringer m 科睿唯安

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂．其中有7种为首创药物（first-inclass），即该药物具有全新作用机制并在全球酋次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新... 详细信息

2017年全球首次获批或上市的新药和生物制剂共113种，包括首次上市的52种新药和生物制剂．其中有7种为首创药物（first-inclass），即该药物具有全新作用机制并在全球酋次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新制剂等）；以及2017年首次获批，但2017年12月31日前尚未上市的2S种产品。美国是全球新药研发最活跃的市场，肿瘤是最为活跃的治疗领域。在制药和生物技术领域年度报告的第一部分中，将深入报道这些新药和生物制剂的相关信息。

关键词：新上市药物新批准药物延伸性新药首创药物

2017年全球新药研发报告——第一部分：新药和生物制剂（Ⅱ）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药学进展 2018年第5期42卷 394-398页

作者： Graul A I pina P Stringer m 科睿唯安

2017年全球首次获批或上市的新药和生物制剂共113种，包括酋次上市的52种新药和生物制剂，其中有7种为首创药物（first-inclass），即该药物具有全新作用机制并在全球首次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新... 详细信息

2017年全球首次获批或上市的新药和生物制剂共113种，包括酋次上市的52种新药和生物制剂，其中有7种为首创药物（first-inclass），即该药物具有全新作用机制并在全球首次获批并上市：36种产品线拓展产品（即新适应证、新联合用药和新制剂等）：以及2017年首次获批、但2017年12月31日前尚未上市的25种产品。美国是全球新药研发最活跃的市场，肿瘤是最为活跃的治疗领域。在制药和生物技术领域年度报告的第—部分中，将深入报道这些新药和生物制剂的相关信息。

关键词：新上市药物新批准药物延伸性新药首创药物