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Prenatal and pubertal testosterone exposure imprint permanent modifications in the prostate that predispose to the development of lesions in old mongolian gerbils

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Asian Journal of Andrology 2017年第2期19卷 160-167页

作者： manoel F Biancardi Ana PS perez Cassia RS Caires Luiz R Falleiros Jr Rejane m Goes Patricia SL Vilamaior Diogenes R Freitas Jr Fernanda CA Santos Sebastiao R Taboga Department of Structural and Functional State University of Campinas Av. Bertrand Russel s/n Campinas Sao Paulo 13084864 Brazil 2Department of Histology Embryology and Cell BiologyFederal University of Goias Samambaia II Goiania Goias 74001970 Brazil University Estadual Paulista - UNESP Department of Biology Laboratory of Microscopy and Microanalysis Rua Cristovao Colombo 2265 Sao Jose do Rio Preto Sao Paulo 15054000 Brazil medical School Federal University of Goias Colemar Natal e Silva Goiania Goias 74001970 Brazil

The prostate is an accessory sex gland that develops under precise androgenic control. It is known that hormonal imbalance may disrupt its development predisposing this gland to develop diseases during aging. Although the hypothesis regarding earlier origins of prostate diseases was proposed many years ago, the mechanisms underlying this complex phenomenon are poorly understood. Therefore, the aim of this study was to evaluate the prostates of old male gerbils exposed to testosterone during intrauterine and postnatal life using morphological, biometrical, stereological, Kariometric, immunohistochemical, and immunofluorescence analyses. Our findings demonstrate that prenatal and pubertal exposure to testosterone increases the susceptibility to the development of prostate diseases during aging. The presence of a more proliferative gland associated with foci of adenomatous hyperplasia in animals exposed to testosterone during the prenatal and pubertal phase show that the utero life and the pubertal period are important phases for prostatic morphophysiology establishment, which is a determinant for the health of the gland during aging. Therefore, these findings reinforce the idea that prostate disease may result from hormonal disruptions in early events during prostate development, which imprint permanently on the gland predisposing it to develop lesions in later stages of life.

关键词： adenomatous hyperplasia endocrine-disrupting chemicals gerbil prostate development testosterone

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Species diversity of thrips (Thysanoptera) in selected avocado orchards from mexico based on morphology and molecular data

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Journal of Integrative Agriculture 2018年第11期17卷 2509-2517页

作者： Daniel Bravo-perez ma. Teresa Santillbn-Galicia Roberto m. Johansen-Naime Hector Gonzalez-Hernandez Obdulia L. Segura-Leon Daniel L, Ochoa-martinez Stephanie Guzman-Valencia Posgrado en Fitosanidad-Entomologia y Acarologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico Instituto de Biologia de la Universidad Nacional Autonoma de mexico (IBUNAm) Circuito exterior s/n Ciudad Universitaria Coyoacan Ciudad de Mexico 04510 Mexico Posgrado en Fitosanidad-Fitopatologia Colegio de Postgraduados Km 36.5 Carretera Mexico-Texcoco Montecillo Texcoco Estado de Mexico 56230 Mexico

Avocado is one of the most important crops in the world, and mexico is the largest producer of this fruit. Several insect pests affect its production, and thrips are amongst the most important. A key step in the design of control methods is accurate species identification. Despite this, formal reports on species diversity of thrips in mexico are very scarce. morphological identification can sometimes be time-consuming and inconclusive. Therefore, we explored the species diversity of thrips in mexican avocado orchards （michoacan state） based on partial sequences of the mitochondrial gene cytochrome oxidase subunit I （COl）. Forty-four specimens were analysed, which represented approximately 8% of all individuals collected from five localities distributed in three municipalities. All specimens were analysed using the COl marker, and specimens within the genera Frankliniella were also analysed using a marker within the D2 domain of the 28S （28SD2） nuclear ribosomal DNA. molecular identifications were confirmed using morphological taxonomy. Overall, six genera were found （Neohydatothrips, Scirtothrips, Frankliniella, Arorathrips, Caliothrips and Leptothrips）. AII genera contained only one species, except Frankliniella, for which there were six species. Data from the two molecular markers suggest the existence of cryptic species within mexican F. occidentalis populations.

关键词： molecular taxonomy morphological identification cytochrome oxidase subunit I 28S nuclear ribosomal DNA.

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Aroma profile of two commercial truffle species from Yunnan and Sichuan,China:inter-and intraspecific variability and shared key compounds

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Food Science and Human Wellness 2021年第2期10卷 163-173页

作者： Bin Lu Jesús perez-moreno Fengming Zhang Andrea C.Rinaldi Fuqiang Yu Yunnan Key Laboratory for Fungal Diversity and Green Development Kunming Institute of BotanyChinese Academy of ScienceKunmingChina Colegio de Postgraduados Campus Montecillo.TexcocoMéxico Key Laboratory for Forest Resources Conservation and Utilisation in the Southwest mountains of China Ministry of EducationSouthwest Forestry UniversityKunmingChina Department of Biomedical Sciences University of CagliariI-09042 Monserrato(CA)Italy

Aroma is central to the worldwide success of truffles as gourmet food and the high prices paid for these edible *** this study,volatile organic compounds(VOCs)from fruiting bodies of two Chinese truffles of commercial relevance,Tuber indicum and Tuber pseudohimalayense,were analyzed using headspace solid-phase microextraction(HS-SPmE)coupled with gas chromatography-mass spectrometry(GC-mS).We aimed to characterize the aroma profile and determine whether it would be influenced by provenance and stage of *** thus collected and analyzed young,middle mature and mature fruiting bodies of each species from different locations in Yunnan and Sichuan provinces,located in southwestern ***,76 VOCs were identified,belonging to different chemical classes,*** and phenols,aldehydes and ketones,benzenes and methoxy compounds,hydrocarbons and amines.A large number of volatiles identified in *** and *** are reported here for the first time for these *** more than 50%of identified VOCs were produced by both truffle species,considerable differences were present in the aroma profiles of fruiting bodies collected at various maturation stages,revealing a dynamic pattern in the biosynthesis of ***,truffles of different provenance had distinct proportions of volatile constituents,suggesting that,besides genetic factors,edaphic and microclimatic conditions influence the synthesis of VOCs in a complex manner.

关键词： Edible mushrooms HS-SPmE Tuber Volatile organic compounds

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Fatty acid oxidation and autophagy promote endoxifen resistance and counter the effect of AKT inhibition in ER-positive breast cancer cells

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Journal of molecular Cell Biology 2021年第6期13卷 433-444页

作者： Lei Duan Sarah Calhoun Daeun Shim Ricardo E.perez Lothar A.Blatter Carl G.maki Department of Cell and molecular medicine Rush University Medical CenterChicagoIL 60612USA Department of molecular Biophysics and Physiology Rush University Medical CenterChicagoIL 60612USA

Tamoxifen(TAm)is the first-line endocrine therapy for estrogen receptor-positive(ER+)breast cancer(BC).However,acquired resistance occurs in∼50%***,although the PI3K/AKT/mTOR pathway is a viable target for treatment of endocrine therapy-refractory patients,complex signaling feedback loops exist,which can counter the effectiveness of inhibitors of this ***,we analyzed signaling pathways and metabolism in ER+mCF7 BC cell line and their TAm-resistant derivatives that are co-resistant to endoxifen using immunoblotting,quantitative polymerase chain reaction,and the Agilent Seahorse XF *** found that activation of AKT and the energy-sensing kinase AmPK was increased in TAm and endoxifen-resistant ***,ERRα/PGC-1βand their target genes mCAD and CPT-1 were increased and regulated by AmPK,which coincided with increased fatty acid oxidation(FAO)and autophagy in TAm-resistant *** of AKT feedback-activates AmPK and ERRα/PGC-1β-mCAD/CPT-1 with a consequent increase in FAO and autophagy that counters the therapeutic effect of endoxifen and AKT ***,our results indicate increased activation of AKT and AmPK with metabolic reprogramming and increased autophagy in TAm-resistant *** inhibition of AKT and FAO/autophagy is necessary to fully sensitize resistant cells to endoxifen.

关键词： endoxifen fatty acid oxidation autophagy AmPK AKT

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Controlled building of CdSe@ZnS/Au and CdSe@ZnS/ Au2S/Au nanohybrids

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Nano Research 2015年第7期8卷 2271-2287页

作者： Raquel E. Galian Pilar Diaz Antonio Ribera Alejandro Rincon-Bertolin Said Agouram Julia perez-Prieto Instituto de Ciencia molecular (ICmol) Universidad de Valencia c/ Catedrdtico Jose Beltran 2 46980 Paterna Valencia Spain Department of Applied Physics and Electromagnetism Dr. Moliner 50 Universidad de Valencia 461 00 Burjassot Valencia Spain

The addition of Au3. to spherical amine-capped CdSe@ZnS nanoparticles in toluene at room temperature and under darkness can lead to ternary CdSe@ZnS/Au nanohybrids. We demonstrate that this happens only when the nanoparticles possess a relatively thin ZnS shell, thus showing that thickness plays a key role in gold deposition on the CdSe@ZnS nanoparticle surface. Our hypothesis is that the amine ligand acts as the reductant of Au3＋ ions into Au＋ ions, whose affinity for sulfur would keep them at the CdSe@ZnS surface. This interaction stabilizes the Au＋ ion, making it less prone to reduction than a non-coordinated Au＋ ion. In CdSe@ZnS with a thin shell, Au＋ ions at the surface of, or most probably within, the ZnS shell cause the transfer of Cd2＋ ions into the solution. Subsequently, the core Se2- anion, which is a better reductant than the shell S2- reduces Au＋ ions to Au（0）, and large gold nanoparticles （AuNPs） are quickly deposited on the CdSe@ZnS surface in room temperature process, leading to ternary CdSe@ZnS/Au nanohybrids. In solution, these ternary nanohybrids progressively transform into quaternary CdSe@ZnS/Au2S/Au nanohybrids due to the reaction of the shell S2- anion with the remaining Au＋ at the CdSe@ZnS surface, thus leading to the growth of Au2S nanoparticles on the CdSe@ZnS surface while Zn concomitantly leaches from the nanohybrid into the solution. Photoirradiation of the heterostructures with visible light enhances their emission efficiency. Comparatively, irradiation of the precursors, i.e., CdSe@ZnS nanoparticles, causes a drastic decrease in their emission accompanied by a blue shift of their emission maximum. The optical properties of these nanohybrids were analyzed by absorption and fluorescence （steady-state and time-resolved） spectroscopy, and the composition of the samples and the chemical states were determined by energy dispersive X-ray spectroscopy （EDX） and X-ray photoelectron spectroscopy （XPS）, respectively. Finally, the structural and m

关键词： heterostructures semiconductor nanoparticle metallic fluorescence time-resolved studies

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High temperature mechanical behaviour of mg-6Zn-1Y alloy with 1 wt.% calcium addition:Reinforcing effect due to I-(mg3Zn6Yi)and mg6Zn3Ca2 phases

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Journal of magnesium and Alloys 2020年第4期8卷 1047-1060页

作者： J.medina G.Garces P.perez A.Stark N.Schell P.Adeva Department of Physical metallurgy National Center for Metallurgical Research(CENIM-CSIC)Avenida Gregorio del Amo 828040 MadridSpain Institute of materials Research Helmholtz-Zentrum GeesthachtMax-Planck-Str.121502 GeesthachtGermany Structural Research on New materials Helmholtz-Zentrum Geesthacht Outstation at DESYNotkestrafie 8522607 HamburgGermany

The infiuence of small calcium additions on the high-temperature mechanical behaviour in an extruded mg-6Zn-l Y(wt.%)alloy reinforced by the I-phase has been *** promotes the formation of the intermetallic mg6Zn3Ca2 phase instead of 1-phase,which results in a noticeable improvement of the yield strength and ultimate tensile strength of the alloy above 100℃.The strength of the alloys was analysed taking into account the contribution due to the grain size,the crystallographic texture and the volume fraction and nature of second phase *** situ synchrotron radiation diffraction experiments have been used to evaluate the load partitioning between the magnesium matrix and the second phase particles(1-and mgeZgCa?phases)in both *** load transfer from the magnesium matrix towards the mgeZihCa?phase is markedly more effective than that for the I-phase over the entire temperature range,especially at 200°C,temperature at which the reinforcement effect of the I-phase is null.

关键词： magnesium alloys I-phase Synchrotron radiation diffraction High temperature mechanical properties.

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p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a

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Journal of molecular Cell Biology 2018年第4期10卷 331-340页

作者： Text Lei Duan Ricardo E. perez Ling Chen Lothar A. Blatter Carl G. maki Department of Cell & molecular medicine Rush University Medical Center Chicago IL 60612 USA Department of Laboratory medicine Shiyan Taihe Hospital College of Biomedical Engineering Hubei University of Medicine Shiyan 442000 China Department of Physiology & Biophysics Rush University Medical Center Chicago IL 60612 USA

Nutlin-3a is a mDm2 antagonist and preclinical drug that activates p53. Cells with mDm2 gene amplification are especially prone to Nutlin-3a-induced apoptosis, though the basis for this is unclear. Glucose metabolism can inhibit apoptosis in response to Nutlin-3a through mechanisms that are incompletely understood. Glucose metabolism through the pentose phosphate pathway （PPP） produces NADPH that can protect cells from potentially lethal reactive oxygen species （ROS）. We compared apoptosis and glucose metabolism in cancer cells with and without mDm2 gene amplification treated with Nutlin-3a. Apoptosis in mDm2-amplified cells was associated with a reduction in glycolysis and the PPP, reduced NADPH, increased ROS, and depletion of the transcription factor SP1, which normally promotes PPP gene expression. In contrast, glycolysis and the PPP were maintained or increased in mDm2 non-amplified cells treated with Nutlin-3a. This was dependent on p53-mediated AKT activation and was associated with maintenance of SP1 and continued expression of PPP genes. Knockdown or inhibition of AKT, SP1, or the PPP sensitized mDm2-non-amplified cells to apoptosis. The data indicate that p53 promotes AKT and SP1-dependent activation of the PPP that protects cells from Nutlin-3a-induced apoptosis. These findings provide insight into how glucose metabolism reduces Nutlin-3a-induced apoptosis, and also provide a mechanism for the heightened sensitivity of mDm2-amplified cells to apoptosis in response to Nutlin-3a.

关键词： Nutlin p53 mDm2 SP1 glycolysis pentose phosphate pathway

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Self-reported dietary supplement use in deployed United States service members pre-deployment *** deployment,Afghanistan,2013-2014

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military medical Research 2018年第3期5卷 207-215页

作者： Shawn m.Varney Patrick C.Ng Crystal A.perez Allyson A.Arana Edwin R.Austin Rosemarie G.Ramos Vikhyat S.Bebartas University of Texas Health Science Center San Antonio 7709Floyd Curl DrSan AntonioTX 78229USA San Antonio military medical Center 3551Roger Brooke DriveSan AntonioTX 78234USA Rocky mountain Poison and Drug Center Denver Health and Hospital AuthorityDenverCOUSA U.S.Army Institute of Surgical Research USAF En Route Care Research Center3698Chambers Pass STE BJBSA Ft Sam HoustonSan AntonioTX 78234USA Department of Emergency medicine University of Colorado School of Medicine13001E 17th PlaceAuroraCO 80045USA

Background: Dietary supplement use(protein/amino acids, weight-loss supplements, performance enhancers) is common among U.S. military members. Reported dietary supplement use in deployed troops is limited and is of concern in settings where troops are exposed to high ambient temperatures, increased physical demands, and dehydration. Our objective was to describe dietary supplement use and adverse events(AEs) among deployed U.S. service members compared with their pre-deployment ***: We conducted an institutional review board(IRB) approved, descriptive study in Afghanistan using a written questionnaire and collected demographic information, dietary supplement use before and during deployment, AEs associated with supplement use, and physical workout routines. Participants were U.S. military personnel of all branches of service deployed to Afghanistan. They were recruited in high-traffic areas in the combat theater. We analyzed the data with descriptive statistics. Paired t-test/Wilcoxon signed-rank test was conducted to examine the before/during deployment changes for continuous data, and mc Nemar's chi-square test was conducted for categorical data. We constructed separate logistic regression models to determine the best predictors of increases or decreases in dietary supplement use, with demographic information, reasons for using supplements, and education requested/received as covariates in each model. All statistical tests were two-sided at a significance level of 5%(Pmy or Air Force. The participants were more likely to work out daily or more than once a day during deployment. Thirty-five percent of the participants reported no supplement use before or during deployment. The remaining 65% of participants reported increased use and increased frequency of use of supplements(e.g., daily) during deployment compared with predeployment. Additionally, more pe

关键词： military Dietary supplement Workout Exercise Adverse events

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management of critically ill patients with diabetes

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World Journal of Diabetes 2017年第3期8卷 89-96页

作者： Livier Josefina Silva-perez mario Alberto Benitez-Lopez Joseph Varon Salim Surani Department of medicine Autonomous University of Baja Cali-fornia School of Medicine Department of medicine Foundation Surgical Hospital the University of Texas Health Science Center at Houston Department of medicine Texas A and M UniversityCorpus Christi

Disorders of glucose homeostasis, such as stress-induced hypoglycemia and hyperglycemia, are common complications in patients in the intensive care unit. Patients with preexisting diabetes mellitus(Dm) are more susceptible to hyperglycemia, as well as a higher risk from glucose overcorrection, that may results in severe hypoglycemia. In critically ill patients with Dm, it is recommended to maintain a blood glucose range between 140-180 mg/d L. In neurological patients and surgical patients, tighter glycemic control(i.e., 110-140 mg/d) is recommended if hypoglycemia can be properly avoided. There is limited evidence that shows that critically ill diabetic patients with a glycosylated hemoglobin levels above 7% may benefit from looser glycemic control, in order to reduce the risk of hypoglycemia and significant glycemic variability.

关键词： Diabetes mellitus Critical care Stress hyperglycemia Hypoglycemia Glycemic control Intensive care unit

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A novel and stretchable carbon-nanotube/Ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of Environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael perez-Gonzalez Christian Gomez-Solis Luis Armando Diaz-Torres Armando Encinas Jorge Oliva Vicente Rodriguez-Gonzalez Consejo Nacional de Ciencia y Tecnología-División de materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de Ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México Grupo de Espectroscopia de materiales Avanzados y Nanoestructurados(GEmANA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CNTs),silicon rubber and Ni@TiO_(2):W nanoparticles(TiWNi NPs) with average size of 37±2 *** images showed that the TiWNi NPs decorated the surface of the CNT fibers,which are oriented in a preferential *** NPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWNi powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CNT composite (stretched at 0%),TiWNi powders,CNT+TiWNi(stretched at 0%),CNT+TiWNi (stretched at 50%) and CNT+TiWNi (stretched at 100%),***,stretching the CNT+TiWNi composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CNT/TiWNi-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

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