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一线使用帕博利珠单抗联合化疗的晚期非小细胞肺癌：肿瘤缓解动态作为生存的标志物

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国际医学放射学杂志 2023年第6期 756-756页

作者： m.nishino X.N.Wang B.Ricciuti S.C.Tseng H.Park J.V.Alessi 齐晓莹

摘要目的研究晚期非小细胞肺癌（NSCLC）病人在帕博利珠单抗联合化疗期间CT扫描的肿瘤负荷动力学，为预测总生存期（OS）提供影像学标志物。方法纳入133例接受

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原发性胃间质瘤肿瘤体积估计的准确性及可行性:127例病人使用半自动技术验证

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国际医学放射学杂志 2016年第2期 209-209页

作者： S.H.Tirumani A.B.Shinagare A.C.O 'Neill m.nishino m.H..Rosenthal N.H.Ramaiya 牟文莹 Department of Imaging Dana Farber Cancer Institute Harvard Medical School

摘要目的采用半自动容量法验证原发性胃间质瘤肿瘤体积估计方法的可靠性。方法经伦理委员会批准,选择2000—2013年间在本学院的127例原发性胃间质瘤病人(女52例,男75例,平均年龄61岁)的CT影像行回顾性研究。在CT影像上,测量了肿瘤X轴、... 详细信息

摘要目的采用半自动容量法验证原发性胃间质瘤肿瘤体积估计方法的可靠性。方法经伦理委员会批准,选择2000—2013年间在本学院的127例原发性胃间质瘤病人(女52例,男75例,平均年龄61岁)的CT影像行回顾性研究。在CT影像上,测量了肿瘤X轴、Y轴及Z轴3个方向的

关键词：胃间质瘤肿瘤体积原发性病人

晚期高级别的浆液性卵巢癌:胸部转移的频率和时间以及胸部影像随访的意义

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国际医学放射学杂志 2016年第1期 76-76页

作者： A.B.Shinagare A.C.O'Neill S.C.Cheng B.Somarouthu S.H.Tirumani m.nishino 辛小燕 Department of Radiology Brigham and Women ’s Hospital/Dana-Farber Cancer Institute Harvard Medical School

摘要目的研究晚期(Ⅲ期和Ⅳ期)高级别浆液性卵巢癌(HGSC)胸部转移的频率、时间及其相关性,使胸部横断面成像应用最优化。材料与方法本研究得到机构伦理委员会批准,将186例放弃知情同意权并经病理证实为晚期HGSC的病人按序排列,这186例病... 详细信息

摘要目的研究晚期(Ⅲ期和Ⅳ期)高级别浆液性卵巢癌(HGSC)胸部转移的频率、时间及其相关性,使胸部横断面成像应用最优化。材料与方法本研究得到机构伦理委员会批准,将186例放弃知情同意权并经病理证实为晚期HGSC的病人按序排列,这186例病人,年龄(60±9.7)岁,经初步细胞减瘤术后在三级癌症机构进行影像检查,从2012年1月—12月,经过至少1年的随访,排除胸部转移和死亡的病人。回顾这些病人的电子病案和现有影像以记录病人和肿瘤

关键词：浆液性卵巢癌胸部躯干高级别

Expression of Interleukin-26 is upregulated in inflammatory bowel disease

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World Journal of Gastroenterology 2017年第30期23卷 5519-5529页

作者： makoto Fujii Atsushi Nishida Hirotsugu Imaeda masashi Ohno Kyohei nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba masahiro Kawahara Tomoharu Shimizu Akira Andoh Department of medicine Shiga University of Medical Science Department of Surgery Shiga University of Medical Science

To investigate interleukin (IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and the function of IL-26. mETHODSHuman colonic subepithelial myofibroblasts (SEmFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by real-time polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering (si) RNA transfection. RESULTSThe mRNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEmFs in vivo and in vitro. IL-26 stimulated the mRNA expression of IL-6 and IL-8 in colonic SEmFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and siRNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the mRNA expression of IL-6 and IL-8 induced by IL-26. CONCLUSIONThese results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators.

关键词： Inflammatory bowel disease Interleukin-26 myofibroblasts

Observation of Edge Plasma Fluctuations with a Fast Camera in Heliotron J

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Plasma Science and Technology 2013年第3期15卷 213-216页

作者：臧临阁 m.TAKEUCHI N.nishino T.mIZUUCHI S.OHSHImA K.KASAJImA m.SHA K.mUKAI H.Y.LEE K.NAGASAKI H.OKADA T.mINAmI S.KOBAYASHI S.YAmAmOTO K.HANATANI Y.NAKAmURA S.KONOSHImA F.SANO Graduate School of Energy Science Kyoto University Naka Fusion Institute Japanese Atomic Energy Agency Graduate School of Engineering Hiroshima University Institute of Advanced Energy Kyoto University

A fast video camera is verified to be a powerful t0ol for observation of filaments/blobs near the last closed flux surface （LCFS）. In order to extract the fluctuation component from the raw data of the fast camera, a pre-processing technique, sliding time window averaging subtraction （STWAS） has been developed to remove the background of slowly varying emission from the bulk plasma. By using this pre-processing technique, the fast camera data are analyzed. A method to identify the filaments in the pre-processed image is also discussed.

关键词： edge plasma fluctuation fast camera Heliotron J

Effects of Lithium and Valproic Acid on the Production of Brain-Derived Neurotrophic Factor in Astrocytoma

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Open Journal of Psychiatry 2014年第3期4卷 261-268页

作者： Koji Ohtomo Satoshi nishino masatake Kurita Hirobumi mashiko Shin-ichi Niwa Department of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan Department of Cellular Signaling Graduate School of Pharmaceutical Sciences Tohoku University Sendai Japan School of medicine Department of Neuropsychiatry Fukushima Medical University Fukushima Japan

No systematic investigation considering BDNF and its receptor TrkB has been conducted on the effects of mood-stabilizing drugs. We therefore decided to quantify BDNF production and the expression of TrkB-T1 receptor and PLCγ in astrocytoma. 1321N human astrocytoma cells were grown to a sufficient quantity in 5% fetal calf serum (FCS). The mood-stabilizing drugs Li and VPA were added to the therapeutic concentrations of 1 mm and 600 μm, respectively. The production of BDNF was determined by an enzyme-linked immunosorbent assay. The expressions of TrkB-T1 and PLCγ were determined by Western blot. The production of BDNF was significantly higher on Day 7 in the VPA samples (P mples (P mples (P γ expression did not change. Li and VPA seem differently affect BDNF production and TrkB-T1 (BDNF receptor) expression.

关键词： BDNF Bipolar Disorder Lithium PLCγ TrkB Valproic Acid

根据日本乡村绝经后妇女腰椎骨密度的随访研究制定骨质疏松的护理卫生方针(英文)

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内蒙古医学院学报 2006年第5期28卷 359-370页

作者：梶田悦子 Iki m.nishino H mitamura S 名古屋大学医学部保健学科看护学专攻

为了检测妇女绝经后发生骨量减少的相关指标进而倡导依据生活方式的特点对绝经后妇女骨质疏松的发生采取相应的预防和护理方针,我们对日本乡村的绝经后妇女(末次月经后六个月或更长时间算起)进行了为期4a的随访。我们运用双能X线骨密度... 详细信息

为了检测妇女绝经后发生骨量减少的相关指标进而倡导依据生活方式的特点对绝经后妇女骨质疏松的发生采取相应的预防和护理方针,我们对日本乡村的绝经后妇女(末次月经后六个月或更长时间算起)进行了为期4a的随访。我们运用双能X线骨密度仪(DXA)对腰椎骨密度(BmD)进行检测并对各种变量,包括年龄、绝经时的年龄、骨折史、日常摄奶量以及吸烟习惯进行多元分析,结果表明这些因素对于腰椎骨密度(BmD)的恢复是不相关联的。在这些变量中,骨折史被证明对于相关人群是最具危险性的,这些对象有高比例的骨量减少(6.6%),其次是不规律的摄奶(13.6%)和吸烟(9.3%)。在护理中使用的作用于足跟骨的检测骨密度的设备被证实与作用于腰椎的DXA设备可以相互替代。依据这些结果,针对居住在日本乡村的绝经后妇女制订了相应的预防骨质疏松的方针。这些卫生指导方针依据特定区域的生活方式而制定并可适用于其他的人群和区域。在本文中,作者列出了不同的有助于预防绝经后妇女出现骨质疏松的方法并进行了调查。

关键词：护理卫生方针骨质疏松生活方式

Two Dimensional Density FlUCtuation measurements During the Non-Inductive Current Ramp-up Phase in the Compact Plasma Wall Interaction Experimental Device CPD

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Plasma Science and Technology 2009年第4期11卷 397-401页

作者： H.ZUSHI T.RYOUKAI K.KIKUKAWA T.mORISAKI R.BHATTACHARYAY T.YOSHINAGA K.HANADA T.SAKImURA H.IDEI K.DONO N.nishino H.HONmA S.TASHImA T.mUTOH S.KUBO K.NAGASAKI m.SAKAmOTO Y.NAKASHImA Y.HIGASHIZONO K.N.SATO K.NAKAmURA m.HASEGAWA S.KAWASAKI H.NAKASHImA A.HIGASHIJImA RIAm Kyushu University IGSES Kyushu University National Institute for Fusion Science Hiroshima University Kyoto University University of Tsukuba

Two-dimensional structure of density fluctuations is examined during the current jump phase, indicating a change from the open magnetic fields to the closed ones. During the smooth current ramp-up phase the two-dimensional contour of the LiI intensity shows vertically alignment, consistent with the magnetic surfaces. At the inflection point in Ip ramp-up the LiI intensity contour becomes flat in the observation regime and then suddenly a steep gradient and higher intensity regime are formed in the vertical direction. This higher intensity corresponds to a burst of LiI waveform. According to these changes in the contour, it is found that, within ~1 ms around the burst of LiI, a low frequency coherent wave with a long wavelength rapidly grows. The relations with other signals （magnetic flux and microwave stray power） are discussed with respect to the topological change in the magnetic configuration and mode conversion of the incident electromagnetic waves.

关键词： Li sheet beam density fluctuations current ramp-up spherical tokamak

Progress in Physics and Technology Developments for the modification of JT-60

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Plasma Science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai m.matsukawa G.Kurita N.Hayashi K.Urata Y.m.miura K.Kizu K.Tsuchiya A.morioka Y.Kudo S.Sakurai K.masaki T.Suzuki m.Takechi Y.Kamada A.Sakasai S.Ishida K.Abe A.Ando T.Cho T.Fujii T.Fujita S.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane m.Ichimura Tsuji-Iio S.Itoh m.Katsurai m.Kikuchi A.Kohyama H.Kubo m.Kuriyama m.matsuoka Y.miura N.miya T.mizuuchi K.Nagasaki H.Ninomiya N.nishino Y.Ogawa K.Okano T.Ozeki m.Saigusa m.Sakamoto m.Satoh m.Shimada R.Shimada m.Shimizu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yamamoto K.Yatsu K.Yoshikawa Japan Atomic Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion Science Kanazawa University National Institute of Advanced Industrial Science and Technology

Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the mHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 physics design technology developments