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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： m.K.maksimov P.B.Ermolinskiy O.n.Scheglovitova n.n.Sklyankina A.v.muravyov A.E.Lugovtsov A.v.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Epidemiology and microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(nO),which is mainly produced by endothelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced nO on RBC aggregation and adhesion to endothelium;(2)the nO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the *** RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and myrenne *** con¯rmed that nO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only nO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of nO production by ***,data related to L-arginine accumulation by endothelium were obtained:necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,nO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers myrenne flow chamber

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Lithium:A review of applications,occurrence,exploration,extraction,recycling,analysis,and environmental impact

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Geoscience Frontiers 2024年第5期15卷 1-46页

作者： v.Balaram m.Santosh m.Satyanarayanan n.Srinivas Harish Gupta CSIR-national Geophysical Research Institute(nGRI) Hyderabad 500007India School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA 5005Australia Department of Environmental Studies GITAM Institute of ScienceGandhi Institute of Technology&Management(GITAM)Visakhapatnam 530045India Department of Civil Engineering Osmania UniversityHyderabad 500007India

The energy transition challenges faced by modern civilization have significantly enhanced the demand for critical metals like lithium resulting in improved methods to explore,extract,and utilize these *** this comprehensive review,we discuss the different types of lithium resources,factors,and mechanisms controlling lithium enrichment in various geological settings including terrestrial and marine *** exploration strategies including geological,geophysical,mineralogical,geochemical,and remote sensing techniques including drone-based techniques for lithium exploration studies in different terranes are *** overview of the mining techniques,including beneficiation and extraction,and their principles,mechanisms,operations,and comparison of the various approaches and compatibility with different types of lithium deposits for obtaining maximum yield are *** isotopic studies are useful in understanding geological processes such as past weathering events and riverine input into the oceans,as well as in understanding the source of lithium in diverse types of *** also highlight the recent developments in other areas such as recycling,environmental impact,and state-of-the-art analytical techniques for determining lithium in different lithium ore deposits and other geological *** overview provides the latest developments and insights in the various sectors related to lithium and prompt further developments to meet the growing demand for this valuable metal as the world transforms to clean energy.

关键词： Lithium minerals Pegmatite Lithium brine deposits Lithium sedimentary deposits Exploration techniques

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nanomotion of bacteria to determine metabolic profile

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nanotechnology and Precision Engineering 2024年第1期7卷 1-9页

作者： S.n.Pleskova E.v.Lazarenko n.A.Bezrukov R.n.Kriukov A.v.Boryakov m.E.Dokukin S.I.Surodin Research Laboratory of Scanning Probe microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov Physics and Technology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to their visible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitive instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFm detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sense the metabolic activity of bacteria because the oscillations are sensitive to the food preferences of the bacteria and the type of surrounding medium.

关键词： nanomotion Bacteria Cantilever Oscillation Atomic force microscopy metabolism

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： v.A.KRUPIn m.R.nURGALIEv A.R.nEmETS I.A.ZEmTSOv S.D.SUnTSOv T.B.mYALTOn D.S.SERGEEv n.A.SOLOvEv D.v.SARYCHEv D.v.RYJAKOv S.n.TUGARInOv n.n.nAUmEnKO national Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman moscow State Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan n vinayakumar Ravi v Sowmya Center for Computational Engineering and networking(CEn) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAn)is used as a standard communication method because of its efficient and reliable ***,CAn is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy C-means(FCm).The proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the mL35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WnS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UnSW_nB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor CAn traffic in vehicles and proactively alert during attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

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Effect of proton irradiation on the optical properties of thermal control coating based on polystyrene with silica filler

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Propulsion and Power Research 2024年第1期13卷 1-11页

作者： n.I.Cherkashina v.I.Pavlenko m.m.mikhailov A.n.Lapin S.A.Yuriev R.v.Sidelnikov D.S.Romanyuk Belgorod State Technological University named after v.G.Shoukhov Kostyukov Str.46Belgorod 308012Russia Tomsk State University of Control Systems and Radioelectronics 40Prospect LeninaTomsk 634050Russia

This paper presents the results of studying the surface properties changes of a ther-moregulating coating based on polystyrene and silicaﬁller after proton irradiation with an en-ergy of 50 kev at afluence of 3�1015 cm�*** proton irradiation,the values of the contact angle of wetting with water increase by 3.5%and 14.9%for polystyrene and the coating,*** free surface energy(energy of the surface layer)of polystyrene and the coat-ings before and after proton irradiation was calculated using the Owens-Wendt-Rabel-Kaelble *** was a signiﬁcant increase in the polarity of the polystyrene surface(gp increased by a factor of 2.2)after proton *** the coating,an increase in gp by a factor of 3.89 was observed after proton *** changes in the coating were presented by IR Fourier spectroscopy.A slight decrease in the absorption intensity of all characteristic bands compared to the unirradiated sample was *** was found that the irradiation of the coating with protons led to the formation of macromolecules with hydroxyl,carbonyl,and carboxyl bonds,as well as the formation of dimeric and oligomeric siloxane *** was also found that after irradiation of a pure polystyrene sample with protons,the value of the solar absorption as increased by only 4.2%;whereas for the coating with silicaﬁller,the value of as increased by 28.6%.

关键词： Thermal control coating Proton irradiation Hydrophobicity Free surface energy Radiation crosslinking

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Thermo-and pH-sensitive Polymer with Pendant Spacer-linked Imidazole Cycles

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Chinese Journal of Polymer Science 2024年第4期42卷 437-445页

作者： natalya v.Zakharova Stanislav n.Zelinskiy mariya S.Strelova Elena n.Danilovtseva vadim v.Annenkov Institute of macromolecular Compounds of the Russian academy of Sciences Saint Petersburg199004Russia Limnological Institute of Siberian Branch of the Russian academy of Sciences Irkutsk664033Russia

By the reaction of poly(acryloyl chloride) with n-(3-aminopropyl)imidazole, poly(n-(3-(1H-imidazol-1-yl)propyl)acrylamide) was synthesized. The new polymer contains an imidazole ring removed from the main chain by a spacer of five bonds. The structure and purity, molecular weight, hydrodynamic and thermosensitive properties of the obtained sample were studied by1H-and13C-nmR, FTIR spectroscopy, acid-base titration, light scattering, turbidimetry and viscometry. The observed ability of the imidazole-containing polymer to form and destroy associates in water-salt solutions at pH 6.6-7.4 and temperatures of 29-48℃ indicates that these are promising candidates for designing complex biomedical systems. The new polymer is able to form complexes with oligo-DnA more actively than poly(1-vinylimidazole), which is of interest for gene delivery applications. The polymer cross-linked with epichlorohydrin gives micro-relief coatings on the plastic surface, and the modified surface is able to attach negatively charged objects. This thermo-and pH-sensitive polymer modification can be applied to create finely controlled surfaces for cell culturing.

关键词： Imidazole-containing polymer Thermolability pH-sensitivity The modified surface DnA immobilization

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Antibacterial HA-coatings on bioresorbable mg alloy

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Journal of magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.v.nadaraia D.v.mashtalyar m.A.Piatkova A.I.Pleshkova I.m.Imshinetskiy m.S.Gerasimenko E.A.Belov v.v.Kumeiko D.n.Kozyrev K.A.Fomenko v.v.mostovaya B.R.Torpanov A.R.Biktimirov I.S.Osmushko S.L.Sinebryukhov S.v.Gnedenkov Institute of Chemistry FEB RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.v.Zhirmunsky national Scientific Center of marine Biology FEB RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatovenerological Dispensary 18 V St.GamarnikaVladivostok 690033Russia nmIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a mg-mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic vancomycin,widely used in the treatment of infections caused by Staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to SEm,EDS,XRD and XPS data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility mg alloy Plasma electrolytic oxidation Hydroxyapatite vancomycin

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Transition from oceanic subduction to continental collision:Insights from volcanogenic-sedimentary rocks of the Tannuola terrane(northern Central Asian Orogenic Belt)

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Geoscience Frontiers 2024年第4期15卷 41-60页

作者： E.v.vetrov n.I.vetrova v.S.Sobolev Institute of Geology and mineralogy SB RAS Koptyuga ave.3NovosibirskRussia

magmatism associated with oceanic subduction plays a dominant role in crustal growth during the Earth's *** Tannuola terrane,situated in the northern Central Asian Orogenic Belt(CAOB),is a key area to understanding oceanic subduction and initial collision processes in the northern *** order to investigate the switch from subduction to collision settings,detailed field mapping,zircon SHRImP U-Pb geochronological and whole-rock geochemical studies of volcanogenic-sedimentary rocks from the Tannuola terrane were carried *** U-Pb ages indicate multi-stage volcanism lasted at least 30 ma from~540 to~510 ma,that can be divided into three events:the late Ediacaran(before~540 ma),the early Cambrian(~520 ma)and the middle Cambrian(~510 ma).These ages are inter-preted to the initial,main and final stages of oceanic subduction during the late Proterozoic-early *** the late Ediacaran,tholeiitic basalts with highεnd(t)values(from+7.4 to+8.5)were *** forming by the 10%-30%partial melting of spinel-garnet mantle source during slab *** the early Cambrian,transitional from tholeiitic to calc-alkaline basaltic rocks withεnd(t)value(+5.6)and coeval intermediate-felsic volcanic rocks with similarεnd(t)values(+5.9 and+6.5)*** early Cambrian basaltic rocks are interpreted to be derived by 10%-30%partial melt-ing of a depleted mantle source metasomatized by slab-derived fluids released from the subducting ocea-nic *** middle Cambrian calcalkaline basaltic rocks withεnd(t)value of+6.2 might be emplaced as a result of low(5%-10%)degree partial melting of a metasomatized mantle followed by fractional crys-tallization of clinopyroxene and *** intermediate-felsic volcanic rocks withεnd(t)values from+6.0 to+6.8 were formed through fractionation of the juvenile neoproterozoic *** middle Cambrian volcanism is interpreted to be triggered by the slab break-off during the transition to a collisional se

关键词： Island-arc magmatism Ediacaran Cambrian zircon U-Pb dating nd isotopes Central asian orogenic belt

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morphology of crater and caldera lakes in the Far Eastern region of Russia and the features of their development

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Journal of mountain Science 2024年第4期21卷 1246-1258页

作者： Dmitrii n.KOZLOv Ekaterina v.LEBEDEvA Institute of marine Geology and Geophysics Far Eastern Branch of the Russian Academy of SciencesYuzhno-Sakhalinsk 693022Russia Institute of Geography Russian Academy of SciencesMoscow 119017Russia

volcanic lakes in the Kuril-Kamchatka region are difficult to access,and for this reason,they remain poorly studied,with only scattered and brief data *** authors have conducted a study of 10 lake basins using modern digital echolocation survey techniques and have also compiled and summarized published data for 15 lakes in the region,calculating their main morphometric *** has been established that many caldera lake basins are modified by young explosive funnels,extrusive or effusive domes,and exhibit traces of hydrothermal *** lakes of the same genetic type in the Kuril-Kamchatka region are similar in depth and depression forms,the group of caldera lakes shows less homogeneity across all morphometric *** was found that the absolute heights of the reservoirs on Kamchatka Peninsula are generally greater than those on the Kuril Islands,as is often the case with the size of their *** volcanic lakes under study can rapidly change their volume and shape under the influence of endogenous *** the first time for this region,on the base of repeated observations,underwater extrusive dome rate growth and the approximate rates of 2 lake level changes were *** observations of lakes in the Ksudach calderas(Kamchatka)and on Simushir Island indicate approximate rates of level changes:a decrease ranging within 0.5-0.6 m per year(over a 27-year observation interval)and an increase reaching up to 0.26 m per year(over a 48-year interval).The growth rate of the underwater extrusive dome in Lake Shtyubel has averaged 1-1.6 m per year over the past 25 *** analysis has facilitated the first generalization regarding the morphology and developmental features of crater and caldera lakes in the Kuril-Kamchatka region of Russia,representing an important step in their *** results obtained will provide a solid foundation for subsequent research in this region and may be of interest to researchers studying

关键词： volcanic lakes Echolocation survey volcanism Gashydrotherms Kamchatka Kuril Islands

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