检索结果-南通市图书馆

microstructure and thermal properties of dissimilar m300–CuCr1Zr alloys by multi-material laser-based powder bed fusion

在线全文

学校读者我要写书评

暂无评论

International Journal of minerals,metallurgy and materials 2024年第1期31卷 118-128页

作者： Xiaoshuang li Dmitry Sukhomlinov Zaiqing Que Aerosint SA B-4040 HerstalBelgium Aalto University Department of Chemical and Metallurgical EngineeringEspoo 02150Finland VTT Technical Research Centre of Finland Espoo 02044Finland

multi-material laser-based powder bed fusion (PBF-LB) allows manufacturing of parts with 3-dimensional gradient and additional functionality in a single step. This research focuses on the combination of thermally-conductive CuCr1Zr with hard m300 tool *** interface configurations of m300 on CuCr1Zr and CuCr1Zr on m300 were investigated. Ultra-fine grains form at the interface due to the low mutual solubility of Cu and steel. The material mixing zone size is dependent on the configurations and tunable in the range of0.1–0.3 mm by introducing a separate set of parameters for the interface layers. microcracks and pores mainly occur in the transition *** of these defects, the thermal diffusivity of bimetallic parts with 50vol% of CuCr1Zr significantly increases by 70%–150%compared to pure m300. The thermal diffusivity of CuCr1Zr and the hardness of m300 steel can be enhanced simultaneously by applying the aging heat treatment.

关键词： multi-material additive manufacturing laser-based powder bed fusion thermal diffusivity dissimilar metals copper alloy

Picroside Ⅱ promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in mdr2^(−/−)mice by polarizing m1 macrophages and balancing immune responses

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural medicines 2024年第7期22卷 582-598页

作者： JIA Kexin mA Zhi ZHANG Yinhao XIE Kaihong li Jianan WU Jianzhi QU Jiaorong li Fanghong li Xiaojiaoyang School of life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese materia medica Beijing University of Chinese MedicineBeijing 100029China

liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar *** play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune *** Ⅱ(PIC Ⅱ),extracted from Picrorhizae Rhizoma,has demonstrated therapeutic potential for various liver ***,the mechanisms by which macrophage polarization initiates immune cascades and contributes to the development of liver fibrosis,and whether this process can be influenced by PIC Ⅱ,remain *** the current study,RNA sequencing and multiple molecular approaches were utilized to explore the underlying mechanisms of PIC Ⅱ against liver fibrosis in multidrug-resistance protein 2 knockout(mdr2^(−/−))*** findings indicate that PIC Ⅱ activates m1-polarized macrophages to recruit natural killer cells(NK cells),potentially via the CXCL16-CXCR6 ***,PIC Ⅱ promotes the apoptosis of activated hepatic stellate cells(aHSCs)and enhances the cytotoxic effects of NK cells,while also reducing the formation of neutrophil extracellular traps(NETs).Notably,the anti-hepatic fibrosis effects associated with PIC Ⅱ were largely reversed by macrophage depletion in mdr2^(−/−)***,our research suggests that PIC Ⅱ is a potential candidate for halting the progression of liver fibrosis.

关键词： liver fibrosis PicrosideⅡ m1 macrophage Hepatic stellate cell Natural killer cell Neutrophil

Identification and characterization of genes related to m^(6)A modification in kiwifruit using RNA-seq and ATAC-seq

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第5期10卷 1121-1133页

作者： Xiaoli Hu Tong li Changbin Xu Yanna Xu Congjun You Xinyi li Jinli Gong Xiaolong li Xuepeng Sun Collaborative Innovation Center for Efficient and Green Production of Agriculture in mountainous Areas of Zhejiang Province Key Laboratory of Quality and Safety Control for Subtropical Fruit and VegetableMinistry of Agriculture and Rural AffairsCollege of Horticulture ScienceZhejiang A&F UniversityHangzhouZhejiang 311300China

N6-methyladenosine(m^(6)A)RNA modification is a conserved mechanism that regulates the fate of RNA across eukaryotic *** its significance,a comprehensive analysis of m^(6)A-related genes in non-model plants,such as kiwifruit,is ***,we identified 36 m^(6)A-related genes in the kiwifruit genome according to homology and phylogenetic *** performed bioinformatics and evolutionary analyses of the writer,eraser,and reader families of m^(6)A *** of public RNA-seq data collected from samples under various biotic and abiotic stresses indicated that most m^(6)A-related genes were remarkably expressed under different *** construction of gene co-expression networks,we found significant correlations between several m^(6)A-related genes and transcription factors(TFs)as well as receptor-like genes during the development and ripening of ***,we performed ATAC-seq assays on diverse kiwifruit tissues to investigate the regulatory mechanisms of m^(6)A-related *** identified 10 common open chromatin regions that were present in at least two tissues,and these regions might serve as potential binding sites for mADS protein,C2H2 protein,and other predicted *** study offers comprehensive insights into the gene family of m^(6)A-related components in kiwifruit,which will lay foundation for exploring mechanisms of post-transcriptional regulation involved in development and adaptation of kiwifruit.

关键词： Kiwifruit N^(6)-methyladenosine Phylogenetic analysis cis-element Co-expression network

Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan m_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第3期8卷 514-521页

作者： Qiong Wang ShuYu li XinYi li Yue Wu PanPan Zhao Yuan Gao Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

On December 18,2023,an m_(s)6.2 earthquake occurred in Jishishan,Gansu Province,*** earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China *** this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and *** discovered that the location of the earthquake was related to changes in the crustal *** results showed that the Jishishan m_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave *** epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity ***,the source area is flanked by two high-velocity anomalies from the east and *** principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this *** some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal *** features underscore the relationship between the occurrence of the Jishishan m_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic *** NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension *** presence

关键词： Jishishan m_(s)6.2 earthquake crustal structure anisotropy stress and strain seismogenic mechanism northeast margin of the Tibetan Plateau

High-entropy catalysts for electrochemical water-electrolysis of hydrogen evolution and oxygen evolution reactions

在线全文

学校读者我要写书评

暂无评论

Frontiers in Energy 2024年第3期18卷 265-290页

作者： Simiao SHA Riyue GE Ying li Julie m.CAIRNEY Rongkun ZHENG Sean li Bin liU Jiujun ZHANG Wenxian li School of materials Science and Engineering Shanghai UniversityShanghai 200444China School of Chemical and Environmental Engineering Anhui Polytechnic UniversityWuhu 241000China Australian Centre for microscopy and microanalysis School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia School of Physics The University of SydneySydney NSW 2006Australia School of materials Science and Engineering UNSW Materials&Manufacturing Futures InstituteUniversity of New South WalesSydney NSW 2052Australia College of materials Science and Engineering Fuzhou UniversityFuzhou 350108China

High entropy materials (HEms) have developed rapidly in the field of electrocatalytic water-electrolysis for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) due to their unique properties. In particular, HEm catalysts are composed of many elements. Therefore, they have rich active sites and enhanced entropy stability relative to single atoms. In this paper, the preparation strategies and applications of HEm catalysts in electrochemical water-electrolysis are reviewed to explore the stabilization of HEms and their catalytic mechanisms as well as their application in support green hydrogen production. First, the concept and four characteristics of HEms are introduced based on entropy and composition. Then, synthetic strategies of HEm catalysts are systematically reviewed in terms of the categories of bottom-up and top-down. The application of HEms as catalysts for electrochemical water-electrolysis in recent years is emphatically discussed, and the mechanisms of improving the performance of electrocatalysis is expounded by combining theoretical calculation technology and ex-situ/in situ characterization experiments. Finally, the application prospect of HEms is proposed to conquer the challenges in HEm catalyst fabrications and applications.

关键词： high-entropy electrocatalysis synthetic methods water-electrolysis hydrogen and oxygen evolutions

The role of m^(6)A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 252-267页

作者： Yunan Shan Wei Chen Yanbin li The First Clinical medical College Shandong University of Traditional Chinese MedicineJinanShandong 250013China Department of Neurology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qjanfoshan HospitalShandong Institute of NeuroimmunologyShandong Key Laboratory of Rheumatic Disease and Translational MedicineJinanShandong 250013China Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

N6-methyladenosine m^(6)A modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent *** m^(6)A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and *** advances have highlighted that m^(6)A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune *** this re-view,we summarized the regulatory mechanisms of m^(6)A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m^(6)A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immunediseases.

关键词： Adaptive immunity Autoimmune diseases Innate immunity Immune response m^(6)A RNA methylation

mechanical behavior and damage constitutive model of sandstone under hydro-mechanical (H-m) coupling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of mining Science and Technology 2024年第6期34卷 837-853页

作者： Tao Tan Chunyang Zhang Yanlin Zhao Xiaoshuang li School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Safety and Health in metal mines Maanshan 243000China Sinosteel maanshan General Institute of mining Research Co. Ltd.Maanshan 243000China School of Resource&Environment and Safety Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Urban Construction Changzhou UniversityChangzhouJiangsu 213164China

Underground engineering often passes through water-rich fractured rock masses, which are prone to fracture and instability under the long-term coupling of in-situ stress field and pore water(P-W) pressure, ultimately threatening the stability of underground structures. In order to explore the mechanical properties of rocks under H-m coupling, the corresponding damage constitutive(D-C) model has become the focus of attention. Considering the inadequacy of the current research on rock strength parameters,energy evolution characteristics and D-C model under H-m coupling, the mechanical properties of typical sandstone samples are discussed based on laboratory tests. The results show that the variation of characteristic stresses of sandstone under H-m coupling conforms to the normalized attenuation equation and mohr-Coulomb(m-C) criterion. The P-W pressure mechanism of sandstone exhibits a dynamic change from softening effect to H-m fracturing effect. The closure stress is mainly provided by cohesive strength, while the initiation stress, damage stress, and peak stress are jointly dominated by cohesive strength and friction strength. In addition, residual stress is attributed to the friction strength formed by the bite of the fracture surface. Subsequently, the energy evolution characteristics of sandstone under H-m coupling were studied, and it was found that P-W pressure weakened the energy storage capacity and energy dissipation capacity of sandstone, and H-m fracturing was an important factor in reducing its energy storage efficiency. Finally, combined with energy dissipation theory and statistical damage theory, two types of D-C models considering P-W pressure are proposed accordingly, and the model parameters can be determined by four methods. The application results indicate that the proposed and modified D-C models have high reliability, and can characterize the mechanical behavior of sandstone under H-m coupling, overcome the inconvenience of existing D-C models

关键词： H-m coupling Water-saturated sandstone mechanical mechanism Energy evolution D-C model

m^(6)A modification of plant virus enables host recognition by NmD factors in plants

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第1期67卷 161-174页

作者： Hao He linhao Ge Yalin Chen Siwen Zhao Zhaolei li Xueping Zhou Fangfang li State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310029China

N^(6)-methyladenosine(m^(6)A)is the most abundant eukaryotic mRNA modification and is involved in various biological *** evidence has implicated that m^(6)Amodification is an important anti-viral defense mechanism in mammals and plants,but it is largely unknown how m^(6)Aregulates viral infection in *** we report the dynamic changes and functional anatomy of m^(6)Ain Nicotiana benthamiana and Solanum lycopersicum during Pepino mosaic virus(PepmV)infection.m^(6)Amodification in the PepmV RNA genome is conserved in these two *** of the m^(6)Awriters,mRNA adenosine methylase A(mTA),and HAKAI inhibit the PepmV RNA accumulation accompanied by increased viral m^(6)Amodifications,whereas deficiency of these writers decreases the viral RNA m^(6)Alevels but enhances virus *** study reveals that the cytoplasmic YTH-domain family protein NbECT2A/2B/2C as m^(6)Areaders are involved in anti-viral ***-protein interactions indicate that NbECT2A/2B/2C interact with nonsense-mediated mRNA decay(NmD)-related proteins,including NbUPF3 and NbSmG7,but not with NbUPF1.m^(6)Amodification-mediated restriction to PepmV infection is dependent on NmD-related *** findings provide new insights into the functionality of m^(6)Aanti-viral activity and reveal a distinct immune response that NmD factors recognize the m^(6)Areaders-viral m^(6)ARNA complex for viral RNA degradation to limit virus infection in plants.

关键词： m^(6)A Pepino mosaic virus plant defense m^(6)A readers NmD factors

m^(6)A modification in cardiovascular disease:With a focus on programmed cell death

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen li Yao liu Ruiyan Xu Yuan Zong Lu He Jun Hu Guohua li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis