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Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome

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World Journal of Stem Cells 2021年第8期13卷 1134-1150页

作者： maría B monzón-Nomdedeu Karl J morten Elisa Oltra School of Biotechnology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Nuffield Department of Women's and Reproductive Health The Women CentreUniversity of OxfordOxford OX39DUUnited Kingdom Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

BACKGROUND Fibromyalgia(Fm)and myalgic encephalomyelitis/chronic fatigue syndrome(mE/CFS)are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific *** patient heterogeneity linked to patient subgroups and variation in disease severity,anomalies are found in the blood and plasma of these patients when compared with healthy control *** seeming specificity of these“plasma factors”,as recently reported by Ron Davis and his group at Stanford University,CA,United States,and observations by our group,have led to the proposal that induced pluripotent stem cells(iPSCs)may be used as metabolic sensors for Fm and mE/CFS,a hypothesis that is the basis for this indepth *** To identify metabolic signatures in Fm and/or mE/CFS supporting the existence of disease-associated plasma factors to be sensed by *** A PRISmA(Preferred Reported Items for Systematic Reviews and meta-analysis)-based systematic review of the literature was used to select original studies evaluating the metabolite profiles of Fm and mE/CFS body *** meSH terms“metabolomic”or“metabolites”in combination with Fm and mE/CFS disease terms were screened against the Pubmed *** original studies applying omics technologies,published in English,were *** data obtained were tabulated according to the disease and type of body fluid *** across studies were searched and P-values reported by the original studies were gathered to document significant differences found in the disease *** Eighteen previous studies show that some metabolites are commonly altered in mE/CFS and Fm body *** vitro cell-based assays have the potential to be developed as screening platforms,providing evidence for the existence of factors in patient body fluids capable of altering morphology,differentiation state and/or growth ***,they can be further develo

关键词： myalgic encephalomyelitis/chronic fatigue syndrome Fibromyalgia Induced pluripotent stem cells Plasma factor Conditioned medium Sensor system

Platelet rich plasma(PRP)induces autophagy in osteoblast precursor 3T3-L1

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BIOCELL 2018年第1期42卷 13-16页

作者： SERGIO ANDRES CARmINATI marÍA CAROLINA BARBOSA CLAUDIO marCELO FADER Universidad Nacional de Cuyo Facultad de OdontologíaMendozaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET).Instituto de Histología y Embriología(IHEm) Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina

Autophagy is an essential cellular homeostatic mechanism by which intracellular components are delivered into the lysosomes for degradation and *** has been related with a diversity of pathological or physiological dentary processes such as bone remodeling,skeletal aging,osteoclastogenesis,osteoblastogenesis and different types of oral ***-rich plasma(PRP),isolated from autologous blood,is a plasma preparation containing a higher concentration of platelets which contains numerous different growth factors and cytokines that activate several cellular signaling *** purpose of this study is to investigate the effect of PRP on autophagy stimulation in both osteoblast precursor 3T3-L1 and non-related osteoblastic *** results showed that PRP can increase the number of autophagic structures in 3T3-L1 and HeLa(cervical cancer cells)***,we have determined by Western blot a rise in the lipidated form of the autophagic protein LC3(***3-II)upon PRP *** together,our results suggest that PRP is able to induce a strongly autophagy response in osteoblast precursor and,to a lesser extent,in non-related osteoblastic cells,suggesting that PRP could be a potential therapeutic tool for some autophagy-related diseases associated with bone homeostasis.

关键词： Autophagy 3T3-L1 Platelet rich plasma Odontology

Determination of L-norvaline and L-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11- dihydroquinidine-silica hybrid monolithic column

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Journal of Pharmaceutical Analysis 2020年第1期10卷 70-77页

作者： Dongsheng Xu Elena Sanchez-Lopez Qiqin Wang Zhengjin Jiang maría Luisa marina Departamento de Química Analítica Química Física e Ingeniería QuímicaUniversidad de AlcalaCtra.Madrid-Barcelona Km.33.60028871Alcala de Henares(Madrid)Spain Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou510632China Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese medicine&New Drug Research Jinan UniversityGuangzhou510632China Instituto de Investigacion Química“Andres m.del Río”(IQAR) Universidad de AlcalaCtra.Madrid-Barcelona Km.33.60028871Alcala de Henares(Madrid)Spain

An analytical methodology based on an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine(mQD)-silica hybrid monolithic column was developed for the enantioseparation of 9-fluorenylmethoxycarbonyl(FmOC)derivatized amino acids by nano-liquid *** mobile phase was optimized including the apparent pH,content of ACN,and concentration of the buffer to obtain a satisfactory enantioresolution performance.27 FmOC derivatized amino acids including 19 protein and 8 non-protein amino acids were tested,and 19 out of them were enantiomerically discriminated obtaining baseline separation for 11 of *** characteristics of the method were evaluated for norvaline and tryptophan in terms of linearity,precision,accuracy,limits of detection(LOD)and quantitation(LOQ)showing good performance to be applied to the enantiomeric determination of these amino acids in dietary *** and LOQ values were 9.3 and 31 mm for norvaline enantiomers and 7.5 and 25 mm for tryptophan enantiomers,*** contents of D-norvaline and D-tryptophan were below their respective LODs in all the analyzed *** of L-tryptophan and L-norvaline showed good agreement with the labeled contents except for one sample which did not show presence of L-norvaline,contrary to the label indication.

关键词： 9-Fluorenylmethoxycarbonyl Amino acids Chiral separation Nano-LC Quinidine-silica hybrid monolithic column

Doped graphene/carbon black hybrid catalyst giving enhanced oxygen reduction reaction activity with high resistance to corrosion in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第5期31卷 143-153页

作者： Zhaoqi Ji Jianuo Chen maría Pérez-Page Zunmin Guo Ziyu Zhao Rongsheng Cai maxwell T.P.Rigby Sarah J.Haigh Stuart m.Holmes School of Automotive Engineering Harbin Institute of TechnologyWeihai264209ShandongChina Department of Chemical Engineering and Analytical Science The University of ManchesterManchester M139PLUK Department of materials The University of ManchesterManchester M139PLUK

Nitrogen doping of the carbon is an important method to improve the performance and durability of catalysts for proton exchange membrane fuel cells by platinum–nitrogen and carbon–nitrogen bonds. This study shows that p-phenyl groups and graphitic N acting bridges linking platinum and the graphene/carbon black(the ratio graphene/carbon black = 2/3) hybrid support materials achieved the average size of platinum nanoparticles with(4.88 ± 1.79) nm. It improved the performance of the lower-temperature hydrogen fuel cell up to 0.934 W cm^(-2) at 0.60 V, which is 1.55 times greater than that of commercial Pt/C. Doping also enhanced the interaction between Pt and the support materials, and the resistance to corrosion, thus improving the durability of the low-temperature hydrogen fuel cell with a much lower decay of 10 mV at 0.80 A cm^(-2) after 30 k cycles of an in-situ accelerated stress test of catalyst degradation than that of 92 mV in Pt/C, which achieves the target of Department of Energy(mV). meanwhile,Pt/Nr EGO_(2)-CB_(3) remains 78% of initial power density at 1.5 A cm^(-2) after 5 k cycles of in-situ accelerated stress test of carbon corrosion, which is more stable than the power density of commercial Pt/C, keeping only 54% after accelerated stress test.

关键词： Nitrogen doped graphene Low-temperature hydrogen fuel cell Catalyst degradation Carbon corrosion

ZnO/eosin-Y混合薄膜的生长机理和形态(英文)

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物理化学学报 2012年第1期28卷 251-256页

作者： marí Bernabé SINGH Krishan-Chander mOLLAR miguel mOYA mónica RANA Ravi Departament de Física Aplicada-IDF Universitat Politècnica de ValènciaCamí de Vera s/n46022ValènciaSpain Department of Chemistry Maharshi Dayanand University

Thin hybrid films of ZnO/eosin-Y were prepared by electrodeposition at-0.8 and-0.9 V in aqueous and non-aqueous baths at temperatures ranging from 40 to 90 ℃ with dye concentrations of 100 and 400 μmol·*** films were characterized by X-ray diffraction (XRD),scanning electron microscopy (SEm),energy-dispersive X-ray analysis (EDX),and absorption *** films prepared in a non-aqueous bath were non-porous and did not adsorb dye molecules on their ***,the films grown in aqueous media were porous in nature and adsorbed dye during the deposition of *** growth of the film along the (002) face was observed,and the highest crystallinity was achieved when the film was deposited at 60 ℃.The maximum absorption was achieved for the films grown at 60 to 70 ℃,a deposition potential of-0.9 V,and a dye concentration of 100 μmol·L-1.

关键词：摘要编辑部编辑工作读者

Enhanced depth OCT imaging of the lamina cribrosa for 24 hours

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 306-309页

作者： Pedro Naranjo Bonilla Rafael Giménez Gómez David Ríos Jiménez maría Luísa Varas Fabra maría del Carmen munoz Villanueva Rocío García Catalán Pilar Font Ugalde maría Soledad Poblador Fernández JoséLuís Lancho Alonso Josémaría Gallardo Galera Department of Ophthalmology Reina Sofia University HospitalCordoba 14004Spain methodological Support to Research Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of medicine UCO Maimonides Institute for Biomedical ResearchReina Sofia University HospitalCordoba 14004Spain Department of morphological Sciences Faculty of MedicineCordoba 14004Spain

The lamina cribrosa thickness（LCT） could be affected by dynamic changes in its *** spectral-domainoptical coherence tomography（SD-OCT）,we have studied the behaviour of the laminar region in 14 young subjects over 24 *** changes in LCT were observed,depending on the time at which the measurement was taken,with the maximum thickness being observed at 7.30 p.m.,and the minimum at 7.30 *** finding could suggests a circadian pattern in the LCT thickness in healthy subjects,which could have implications for the classification,diagnosis and prognosis of both normal and glaucomatous subjects.

关键词： lamina cribrosa laminar region glaucoma optical coherence tomography twenty-four-hours

Electron Confinement Effect of Laser Dyes within Dendritic Structures

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Journal of Encapsulation and Adsorption Sciences 2011年第1期1卷 1-6页

作者： Francisco márquez maría José Sabater 不详

Dendrimers are a novel class of nanometric-size macromolecules with a regular tree-dimensional like array of branch units.1,2 Their synthetic availability in a wide range of sizes combined with their peculiar architecture makes them versatile building blocks for a wide range of potential applications.3 Some years ago, meijer and co-workers reported that the modification of terminal amine functionalities of a fifth generation poly(propyleneimine) dendrimer (DAB-dendr-(NH2)64) with bulky substituents, (typically N-t-BOC protected phenylalanine), results in the formation of the so-called “dendritic box” (DAB-dendr-(NH-t-BOC-L-Phe)64).4 Within this macromolecular structure it is possible to encapsulate a variety of guest molecules due to the existence of internal cavities in the core. The photophysical properties of the guests can be modulated by the innovative electron confinement effect. In this respect, we wish to report that the emission frequency of organic dyes can be easily modulated by encapsulation in a dendritic box. The emission bands of dye molecules incorporated into a dendrimer can effectively be red shifted with respect to their emission in solution and contrary to other confined spaces of considerable hardness, the magnitude of this shifting can be regulated under appropriate experimental conditions. This peculiar effect could have unprecedented applications in the development of supramolecular devices relating to the frequency tuning of organic laser dyes.

关键词： Dendrimer Confinement Dyes

Acute-on-chronic liver failure:Pathogenesis,prognostic factors and management

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World Journal of Gastroenterology 2015年第42期21卷 12125-12140页

作者： Sara Blasco-Algora José masegosa-Ataz maría Luisa Gutiérrez-García Sonia Alonso-López Conrado m Fernández-Rodríguez Service of Gastroenterology Hospital Universitario Fundación

Acute-on-chronic liver failure(ACLF) is increasingly recognized as a complex syndrome that is reversiblein many cases. It is characterized by an acute deterioration of liver function in the background of a pre-existing chronic liver disease often associated with a high short-term mortality rate. Organ failure(OF) is always associated, and plays a key role in determining the course, and the outcome of the disease. The definition of ACLF remains controversial due to its overall ambiguity, with several disparate criteria among various associations dedicated to the study of liver diseases. Although the precise pathogenesis needs to be clarified, it appears that an altered host response to injury might be a contributing factor caused by immune dysfunction, ultimately leading to a pro-inflammatory status, and eventually to OF. The PIRO concept(Predisposition, Insult, Response and Organ Failure) has been proposed to better approach the underlying mechanisms. It is accepted that ACLF is a different and specific form of liver failure, where a precipitating event is always involved, even though it cannot always be ascertained. According to several studies, infections and active alcoholism often trigger ACLF. Viral hepatitis, gastrointestinal haemorrhage, or drug induced liver injury, which can also provoke the syndrome. This review mainly focuses on the physiopathology and prognostic aspects. We believe these features are essential to further understanding and providing the rationale for improveddisease management strategies.

关键词： Acute on-chronic liver failure Immune dysfunction

Is Vegetarianism a Solution for Obesity and NCDs? A Review

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Food and Nutrition Sciences 2021年第3期12卷 249-261页

作者： Ana maría Zelaya Elisa m. Sinibaldi Universidad Francisco marroquin Guatemala City Guatemala

Purpose of Review: Obesity is defined as an abnormal fat accumulation associated with disease development risk. The prevalence of obesity and non-communicable diseases (NCDs) continues to increase at a concerning pace. The modern lifestyle requires people to rely on processed foods because of their efficiency and low-cost, which are associated with obesity and NCDs. Vegetarian diet refers to the exclusion of meat, fish, seafood and can also exclude animal products such as dairy and eggs. Therefore, the purpose of this review is to explore vegetarianism as a potential solution for obesity and the development of non-communicable diseases. Recent Findings: Meat intake is also related to unhealthy food groups consumption, contributing to overall poor diet quality. In contrast, vegetarian diets are associated with higher satiety, resulting in less food intake, favoring weight reduction. Lowering the prevalence of NCDs should be a priority, and nutritional interventions are pivotal to accomplish this goal. Summary: Vegetarian diets are associated with weight loss due to: fiber content, lower caloric density, microbiota regulation, and the release of gastrointestinal appetite-regulating hormones. Plant-based eating patterns have demonstrated an overall healthier diet and can be a potential solution for obesity and NCDs’ development.

关键词： Vegetarianism Plant-Based Obesity Weight Loss Non-Communicable Diseases