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World Journal of Transplantation 2024年第1期14卷 72-83页

作者： maurizio Salvadori Giuseppina rosso Department of Renal Transplantation Careggi University HospitalFlorence 50139TuscanyItaly Division of Nephrology San Giovanni di Dio HospitalFlorence 50143ToscanaItaly

Gut microbiota is often modified after kidney *** principally happens in the first period after *** and,most of all,immunosuppressive drugs are the main *** relationship between immunosuppressive drugs and the gut microbiota is *** one side immunosuppressive drugs modify the gut microbiota,often generating dysbiosis;from the other side microbiota may interfere with the immunosuppressant pharmacokinetics,producing products more or less active with respect to the original *** phenomena have influence over the graft outcomes and clinical consequences as rejections,infections,diarrhea may be caused by the dysbiotic ***,calcineurin inhibitors such as tacrolimus and cyclosporine,mycophenolate mofetil and mTOR inhibitors are the immunosuppressive drugs whose effect on the gut microbiota is better *** contrast is well known how the gut microbiota may interfere with glucocorticoids,which may be transformed into *** may be transformed by microbiota into a product called m1 that is 15-fold less active with respect to *** pro-drug mycophenolate mofetil is normally transformed in mycophenolic acid that according the presence or not of microbes producing the enzyme glucuronidase,may be transformed into the inactive product.

关键词： Immunosuppressive therapy Kidney transplantation Gut microbiota Dysbiosis Pathobionts Graft outcomes

对“Archer”大豆中瓜果腐霉引起的腐霉猝倒病抗性遗传基因图谱研究

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大豆科技 2015年第1期 39-39页

作者：向新华 m.luciana rosso John C.Rupe Pengyin Chen Leandro A.mozzoni Dep. of Plant Pathology 217 Plant Sciences Bldg. Univ. of Arkansas Fayetteville AR 72701 Dep. of Crop Soil and Environmental Sciences 115 Plant Sciences Bldg. Univ. of Arkansas Fayetteville AR 72701

腐霉猝倒和根腐病引起大豆出苗率严重减少,因此造成减产。有报道认为大豆品种Archer对由腐霉菌引起的苗期病害具有抗性,并描述了与之相关的Rps1k基因对疫霉菌具有抗逆性。为了描述大豆品种Archer抗腐霉猝倒病的遗传特性,并且确定该抗性... 详细信息

腐霉猝倒和根腐病引起大豆出苗率严重减少,因此造成减产。有报道认为大豆品种Archer对由腐霉菌引起的苗期病害具有抗性,并描述了与之相关的Rps1k基因对疫霉菌具有抗逆性。为了描述大豆品种Archer抗腐霉猝倒病的遗传特性,并且确定该抗性是否与Rps1k基因相关,Archer和Hutcheson（感病亲本）进行杂交,F2：4体（子二代）产生。

关键词：大豆品种基因图谱抗性遗传腐霉菌猝倒病瓜果苗期病害遗传特性

Long COVID and gut candidiasis:What is the existing relationship?

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World Journal of Gastroenterology 2024年第37期30卷 4104-4114页

作者： Filippo Bistagnino Davide Pizzi Filippo mantovani Jacopo rosso Antonino marcos Roberto Tovani-Palone Department of medical Biotechnology and Translational medicine International Medical SchoolUniversitàdegli Studi di MilanoMilan 20054Italy Department of Biomedical Sciences for Health Universitàdegli Studi di MilanoMilan 20133Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Since the beginning of the coronavirus disease(COVID)2019 pandemic,thou-sands of articles on the topic have been published,and although there is a growing trend of research on another associated condition,long coronavirus disease,important points still remain to be clarified in this *** evidence has suggested a relevant link between new clinical discoveries and molecular mechanisms that could be associated with the manifestations of different signs and symptoms involving cases of long ***,one of the existing gaps that requires further investigation concerns a possible rela-tionship between gut candidiasis and long *** recent studies also suggest an interplay between the occurrence of these two conditions,it is not yet fully clear how this may happen,as well as the specifics regarding the possible pathophysiological mechanisms *** this connection and with the advent of a potential strengthening of the body of evidence supporting the hypothesis of a link between gut candidiasis and long COVID,a better understanding of the clinical presentation,pathophysiology and clinical management of such a relationship should be essential and useful for both,additional advances towards more targeted research and appropriate case *** more about the signs,symptoms,and complications associated with cases of long COVID is essential in order to more effectively mitigate the related burden and provide a higher quality of care and life for the affected *** light of this and the need for better outcomes,here we review and discuss the content on different aspects of long COVID,including its pathophysiology and the existing evidence of a potential relationship between such a condition and gut candidiasis,as well as suggest propositions for future related *** Long coronavirus disease(COVID)is a condition characterized by the emergence of new symptoms or the persistence of existing symptoms for at least two months,

关键词： Post-acute COVID-19 syndrome COVID-19 Candidiasis Gastrointestinal microbiome Pandemics

Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

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World Journal of Orthopedics 2024年第3期15卷 204-214页

作者： Dayane maria Braz Nogueira marcelie Priscila de Oliveira rosso Daniela Vieira Buchaim mariana Schutzer Ragghianti Zangrando Rogério Leone Buchaim Department of Prosthodontics and Periodontics Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate DepartmentUniversity of MaríliaMarília 17525-902Brazil

Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive *** research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is *** achieve this,we conducted a comprehensive search on Pub-med/mEDLINE,focusing on English articles published in the last *** search used the keywords“bioglass 45S5 AND bone defect”in *** found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed *** of these studies compared 45S5 BG with other cement or scaffold *** comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic ***,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关键词： Biocompatible materials Bioglass Bone regeneration

Update on the gut microbiome in health and diseases

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World Journal of methodology 2024年第1期14卷 18-32页

The Human microbiome Project,Earth microbiome Project,and next-generation sequencing have advanced novel genome association,host genetic linkages,and pathogen *** microbiome is the sum of the microbes,their genetic information,and their ecological *** study will describe how millions of bacteria in the gut affect the human body in health and *** gut microbiome changes in relation with age,with an increase in Bacteroidetes and *** and environmental factors affecting the gut microbiome are diet,drugs,age,smoking,exercise,and host *** addition,changes in the gut microbiome may affect the local gut immune system and systemic immune *** this study,we discuss how the microbiome may affect the metabolism of healthy subjects or may affect the pathogenesis of metabolism-generating metabolic *** to the high number of publications on the argument,from a methodologically point of view,we decided to select the best papers published in referred journals in the last 3 *** we selected the previously published *** major goals of our study were to elucidate which microbiome and by which pathways are related to healthy and disease conditions.

关键词： Gut microbiome Dysbiosis Pathobionts Gut-brain axis Heart-brain axis metabolic diseases Omics techniques

modelling Strategy and Parametric Study of metal Gaskets for Automotive Applications

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Computer modeling in Engineering & Sciences 2020年第10期125卷 51-64页

作者： Fabio Bruzzone Cristiana Delprete Carlo rosso Politecnico di Torino Corso Duca degli Abruzzi 24Torino10129Italy

This paper is focused on finite element simulation of cylinder head *** element codes support several methodologies,each of which has its own strengths and *** of the key points lies in the influence of the gasket geometry on its final *** a contribution can come from the detailed modelling of the gasket or by defining a global non-linear behaviour in which material and geometry non-linearities are *** approaches were used to simulate the gasket *** first one consists in using a 2D approach,which allows to model through-thickness non-linear behaviour of *** second one consists in using conventional 3D finite element *** numerical methods have been discussed and compared in relation to the accordance with experimental data,amount of information supplied and computational time ***,a parametric study shows how some geometric parameters influence the compressive load and the elastic recovery of a single-layer steel gasket.

关键词： Gaskets finite elements parametric study

Preparation and Structural Characterization of Rapidly Solidified Al-Cu Alloys

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Journal of materials Science & Technology 2014年第4期30卷 394-400页

作者： Iuliana Lichioiu Ildiko Peter Bela Varga mario rosso Department of materials Science Transilvania University of Brasov Department of Applied Science and Technology Institute of Science & Engineering of Materials for the Innovative Technologies

Rapidly solidified Al100-x-Cux alloys （x = 5, 10, 15, 25, 35 wt%） were prepared and analyzed. High cooling rate increased the Cu solubility in α-AI matrix. The influence of the cooling rate on Cu solubility extension in AI was experimentally simulated. Thus the pouring was performed in metallic die and by melt spinning-low pressure （mS- LP） technique. melt processing by liquid quenching was performed using a self-designed melt spinning set-up which combined the cooling technology of a melt jet on the spinning disc with the principle of the mold feeding from low pressure casting technology. The thickness of the melt-spun ribbons was in the range of 30-70 μm. The cooling rate provided by mS-LP was within 105-106 K/s after the device calibration. The obtained alloys were characterized from structural, thermal and mechanical point of view. Optical microscopy and scanning electron microscopy were employed for the microstructural characterization which was followed by X-ray analysis. The thermal properties were evaluated by dilatometric and differential scanning calorimetric measurements. Vickers microhardness measurements were performed in the study. In the case of the hypereutectic alloy with 35 wt% Cu obtained by mS-LP method, the microhardness value increased by 45% compared to the same alloy obtained by gravity casting method. This was due to the extended solubility of the alloying element in the α-AI solid solution.

关键词： AI-Cu alloy melt spinning Fractographs Extended solubility

Fission-fusion dynamics of a pelagic delphinid in the arctic:the white-beaked dolphin(Lagenorhynchus albirostris)

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Integrative Zoology 2021年第4期16卷 512-526页

作者： Chiara G.BERTULLI marianne H.RASmUSSEN massimiliano rosso Department of Life and Environmental Sciences University of IcelandReykjavikIceland Sea Watch Foundation New QuayUK Húsavík Research Centre University of IcelandHúsavíkIceland CImA Research Foundation SavonaItaly

Delphinids exhibit great variability in their social *** is therefore important to document lesser known species,in extreme changing habitats,to compare and contrast mechanisms driving ***,we describe the first long-term assessment of social structure of white-beaked dolphins(Lagenorhynchus albirostris)using a compiled version of SOCPROG 2.8 and an 11-year photo-identification dataset(2002–2013)collected from whalewatching vessels at 2 sites(Faxaflói and Skjálfandi bays)off *** identified a total of 487 dolphins which are suggested to be part of an open population as shown by the discovery curve obtained analyzing photo-id *** social analyses were restricted to 35 adults which were sighted on≥5 different *** mean residency time of white-beaked dolphins in our 2 study areas was of 95 days(SE=35.63;95%CI:23-171),with the“migration-full interchange”model best describing movements of dolphins in and out of our 2 study *** differentiation in this population was high(Likelihood:S=0.87,SE=0.04;r=0.31,SE=0.03)indicating diverse,non-random social *** associations best fit the model of“casual acquaintances”against the standardized lagged association rates with the majority of white-beaked dolphin associations being short-term,but with a few long-term across *** for preferred companionship,long-term associations are favored over *** this study,associations among white-beaked dolphins are short-term but with desirably long-term associations fitting into a society with fission-fusion *** information expands the latitudinal range for which social structure has been described for oceanic dolphin species.

关键词： association patterns Iceland Lagenorhynchus albirostris social structure white-beaked dolphin

How to deal with right hepatic artery coming from the superior mesenteric artery during minimally invasive pancreaticoduodenectomy: A systematic review

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 121-127页

作者： Andrea Chierici Antonio Castaldi mohamed El Zibawi Edoardo rosso Antonio Iannelli Service de Chirurgie Digestive Centre Hospitalier d’Antibes Juan-les-PinsAntibesFrance Department of Digestive Surgery and Liver Transplantation University Hospital Center of NiceNiceFrance Department of Radiology University Hospital Center of NiceNiceFrance Department of Surgery Centre Hospitalier de LuxembourgLuxembourgLuxembourg Faculty of medicine UniversitéCôte d’AzurNiceFrance Inserm U1065Team 8’Hepatic Complications of Obesity and Alcohol’NiceFrance

Background: Anatomical variations in the liver arterial supply are quite common and can affect the surgical strategy when performing a minimally invasive pancreaticoduodenectomy(mIPD). Their presence must be preemptively detected to avoid postoperative liver and biliary complications. Data sources: Following the PRISmA guidelines and the Cochrane protocol we conducted a systematic review on the management of an accessory or replaced right hepatic artery(RHA) arising from the superior mesenteric artery when performing an mIPD. Results: Five studies involving 118 patients were included. The most common reported management of the aberrant RHA was conservative(97.0%);however, patients undergoing aberrant RHA division without reconstruction did not develop liver or biliary complications. No differences in postoperative morbidity or long-term oncological related overall survival were reported in all the included studies when comparing mIPD in patients with standard anatomy to those with aberrant RHA. Conclusions: mIPD in patients with aberrant RHA is feasible without increase in morbidity and mortality. As preoperative strategy is crucial, we suggested planning an mIPD with an anomalous RHA focusing on preoperative vascular aberrancy assessment and different strategies to reduce the risk of liver ischemia.

关键词： Pancreatic cancer Pancreaticoduodenectomy Hepatic artery Superior mesenteric artery

Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2016年第41期22卷 9096-9103页

作者： Carla melisa Chackelevicius Sabrina Eliana Gambaro Claudio Tiribelli Natalia rosso Italian Liver Foundation Area Science Park

The nonalcoholic fatty liver disease(NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-alcoholic steatohepatitis(NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes(Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a na?ve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies.

关键词： Th17 Interleukin-17 Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Inflammation