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Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential m.l.imodal imaging contrast agent

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Journal of Rare Earths 2024年第2期42卷 278-285,I0002页

作者： Yongxiu li Feng Guo Siwei Wei Duofu li Jun Zhang Kai Xu Dongping li Department of Chemistry Nanchang UniversityNanchang330031China Key laboratory of Functional m.l.cule Design and Interface Process Anhui Jianzhu UniversityHefei230601China Department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Nanchang UniversityNanchang330006China

The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination *** from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been *** rein,we introduced a series of lanthanide tetrahedral cages,(Eu_(n)Gd_(4-n)l_(4))(sol)_8(n=0,1,2,3 and 4,where l=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological *** the good luminescent and magnetic properties of Eu^(3+) and Gd^(3+) ions,Eu_(4)l_(4) and Gd_(4)l_(4) com.l.xes show a high luminescence quantum yield of 29% in DmSO and large longitudinal relaxivity(r_(1)) of 11.4(mm.l.l)^(-1)/s at 0.5 T in water containing 1 vol% DmSO,*** heterobimetallic Eu-Gd com.l.xes achieve a dual imaging mode by combining luminescent and magnetic centers in one *** the Gd:Eu ratio increases from 1:3 to 3:1,the r_(1) values increases from 5.33 to 8.64(mmoI/l)^(-1)/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mm.l.l)^(-1)/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the selfassem.l.d Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the m.l.imodal imaging contrast agent.

关键词： lanthanide organic cage luminescence Cell imaging Contrast agents Rare earths

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-li Wang Wen-Jun Huang De-li Gao mOE Key laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear shape is sim.l.fied into three categories according to common mathematical ***,based on the mechano-electrochemical(m-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical sim.l.tion,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show that the existence of wear defects results in a stress concentration and enhanced m-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more than one-third if the m-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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OsPDR20 is an ABCG metal transporter regulating cadmium accum.l.tion in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He li Chao li Di Sun Zhi min Yang Department of Biochemistry and m.l.cular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accum.l.tion in crops and bioremediation of Cd-polluted *** study investigated a functionally uncharacterized ATP binding cassette transporter G fam.l.(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μm.l.l Cd,but led to more Cd accum.l.tion.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed that RNAi plants growth and development were also compromised compared to wild-type(WT),with sm.l.er panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accum.l.tion in rice straw including lower leaves and culm and *** results suggest that OsPDR20 is actively involved in Cd accum.l.tion and homeostasis in rice *** increased Cd accum.l.tion in the RNAi plants has the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accum.l.tion Phytoremediation

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Twenty years of Gendicine?rAd-p53 cancer gene therapy:The first-in-class human cancer gene therapy in the era of personalized oncology

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Genes & Diseases 2024年第4期11卷 234-245页

作者： li Qi Guiqing li Peipei li Hongwei Wang Xiaolong Fang Tongchuan He Jingjing li Affiliated Hospital of Weifang medical University School of Clinical MedicineWeifang Medical UniversityWeifangShandong 262700China Jinming Yu Academician Workstation of Oncology Affiliated Hospital of Weifang Medical UniversityWeifangShandong 262700China Decording Therapeutics Corp Shangha 200000China Yangkun Biogroup Co. LtdNanjingJiangsu 210002China The University of Chicago ChicagoIL 60290USA

Genetic mutations in TP53 contribute to human m.l.gnancies through various *** date,there have been a variety of therapeutic strategies targeting p53,including gene therapy to restore norm.l.p53 function,mutant p53 rescue,inhibiting the mDm2-p53 interaction,p53-based vaccines,and a number of other *** review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of *** human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,has made tremendous progress in cancer gene *** herein discuss the biological mechanisms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical ***,the clinical studies suggest that the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression than gene therapy/chemotherapy ***,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.

关键词： Gendicine Gene therapy p53 mutation Recombinant p53 adenovirus TP53

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Unconventional Fluorescent and m.l.i-responsive Polyethyleneimine with lCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-ming Yin li-li Wu Shu-Sheng li Xiao-Na Pan Xiao-li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and m.l.i-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAm).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(lCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAm grafting percentage to PEI,polymer concentration,and pH on the lCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stim.l.-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine m.l.i-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

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Emergence of highly pathogenic avian influenza A(H5N8)clade 2.3.4.4b viruses in grebes in Inner mongolia and Ningxia,China,in 2021

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Journal of Integrative Agriculture 2024年第1期23卷 348-353页

作者： Qiuzi Xu Xinru lü Yi li Hua luo Zhen Zhang Xiang li Rongxiu Qin Qing An Fengyi Qu Zhenliang Zhao Chengbo Zhang Weidong Wang Yuecheng li Yajun Wang Xiangwei Zeng Zhijun Hou Jingqiang Ren Yulong Wang Yanbing li Hongliang Chai College of Wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China Harbin Veterinary Research Institute Chinese Academy of Agricultural SciencesHarbin 150040China Wenzhou Key laboratory for Virology and Immunology Institute of VirologyWenzhou UniversityWenzhou 325000China Ordos Forestry and Grassland Administration Ordos 017000China monitoring Center for Terrestrial Wildlife Epidemic Diseases Yinchuan 750000China

Highly pathogenic avian influenza(HPAI)subtype H5Nx viruses have spread globally and are a major concern for poultry,wild birds,mamm.l.,and even humans(de Vries et al.2015;Zeng et al.2022).The hemagglutinin(HA)genes of H5 subtype viruses have evolved into m.l.iple clades and some of these clades have been further divided into subclades(Cui et al.2022).Clade 2.***.4.4H5N8 HPAI viruses(HPAIVs)have caused several waves of disease outbreaks in wild birds and domestic poultry(Wang et al.2022).

关键词： poultry Ningxia influenza

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A single degenerated primer significantly improves COX1 barcoding performance in soil nematode community profiling

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Soil Ecology letters 2024年第2期6卷 31-44页

作者： Yincai Ren Dorota l. Porazinska Quanhui ma Shuhan liu Hongmei li Xue Qing Department of Plant Pathology Nanjing Agricultural UniversityNanjing210095China Department of Entom.l.gy and Nematology University of FloridaGainesvilleFL32611USA Institute of Grassland Science Key Laboratory of Vegetation Ecology of the Ministry of EducationJilin Songnen Grassland Ecosystem National Observation and Research StationNortheast Normal UniversityChangchun130024China

A new COX1 primer for soil nematode metabarcoding was designed,and this primer outperforms other commonly used COX1 primer pairs in species recovery and quantity of PCR products.•The lack of reference database is the main reason that led to the low species recovery in COX1 metabarcoding.•We expanded current NCBI database by adding 51 newly generated COX1 reference *** nematodes play important roles in soil ecosystems and often serve as bioindicators of soil *** identification of soil nematodes is often difficult due to their limited diagnostic characters and high phenotypic *** barcoding and metabarcoding techniques are promising but lack universal primers,especially for mitochondrial COX1 *** this study a degenerated COX1 forward primer COIFGED was *** primer pair(COIFGED/JB5GED)outperforms other four commonly used COX1 primer pairs in species recovery and quantity of polymerase chain reaction(PCR)*** metabarcoding analysis,the reads obtained from the new primer pair had the highest sequencing saturation threshold and am.l.con sequence variant(ASV)diversity in comparison to other COX1 as well as 18S rRNA *** annotation of ASVs suggested the new primer pair initially recovered 9 and 6 out of 25 genera from mock communities,respectively,outperformed other COX1 primers,but underperformed the widely used 18S NF1/18Sr2b primers(16 out of 25 genera).By supplementing the COX1 database with our reference sequences,we recovered an additional 6 mock community species bringing the tally closer to that obtained with 18S *** summary,our newly designed COX1 primers significantly improved species recovery and thus can be supplementary or alternative to the conventional 18S metabarcoding.

关键词： degenerated primers DNA metabarcoding mitochondrial cytochrome oxidase c subunit I gene phylogeny ribosom.l.RNA gene soil nematodes

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Precise immobilization of metal single atoms into a porphyrinic metal-organic framework for an efficient alkene hydrosilylation

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Nano Research 2024年第7期17卷 5914-5921页

作者： Chun-Ying Chen Qi-Jie mo Fu-Zhen li Hai-li Song li Zhang mOE laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510006China

Alkene hydrosilylation is one of the most concise and atom-economical methods to synthesize organosilicon ***,we reported the precise immobilization of metal single atoms(m-SAs;m=Ru,Rh,Ir,Pd,Pt,and Au)into a porphyrinic metalorganic framework(mOF)of PCN-222(PCN=porous coordination network),and then applied the resultant mOF composites of m-SAs@PCN-222 to alkene *** solvent-free conditions,Pt-SAs@PCN-222 displayed an especially high catalytic efficiency with the turnover frequency up to 119 s−1 and the maximum turnover number of 906,250 at room *** and theoretical studies revealed that there existed strong interactions between Pt-SAs@PCN-222 and the substrates,which helped to condense the substrates in the cavities of the porous *** density functional theory calculations and m.l.cular dynamics sim.l.tions disclosed that PCN-222 could transfer electrons to Pt-SAs to enhance the silane oxidative addition and drive the reaction to proceed smoothly via Chalk–Harrod pathway.

关键词： alkene hydrosilylation single atom catalysts metal-organic frameworks precision chemistry synergistic catalysis

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Unconventional Fluorescent and m.l.i-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第5期42卷 579-590,I0006页

作者： Xiao-Di li Shu-Sheng li Xu-Bao Jiang Xiao-li Zhu Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China College of Chemical Engineering Tianjin UniversityTianjin300072China Foshan(Southern China)Institute for New materials Foshan528200China

Owing to their high significance in fundamental study and diverse applications,stim.l.-responsive and fluorescent polymers,particularly those with cluster-triggered emission(CTE)featured by non-conjugated chromophores,have drawn tremendous attention in recent *** this work,fluorescent and m.l.i-responsive polysiloxane(FRPS)was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane(APmS)with 3-(N-isopropyl propionamide)iminopropyl methyl diethoxysilane(APmS-NIP),which was formed in situ through aza-michael addition between APmS and N-isopropyl *** was not only highly sensitive to temperature,pH and CO_(2) in water,but also showed an enhanced and stim.l.-adjustable fluorescence *** effects of monomer feeding,pH and CO_(2) on its lower critical solution temperature and fluorescent property were *** fluorescence emission was ascribed to CTE *** addition,FRPS was shown to be highly potential as physiological indicator for cell imaging,and for controlled release and trace detection of *** study provides therefore a type of stim.l.-responsive and fluorescent material for potential applications in biomedical fields,and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stim.l.-responsive polymers.

关键词： Polysiloxane m.l.i-responsiveness Cluster-triggered emission Cell imaging Controlled drug release

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Optim.l.pivot path of the sim.l.x method for linear programming based on reinforcement learning

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Science China mathematics 2024年第6期67卷 1263-1286页

作者： Anqi li Tiande Guo Congying Han Bonan li Haoran li School of mathematical Sciences University of Chinese Academy of SciencesBeijing100049China

Based on the existing pivot rules,the sim.l.x method for linear programming is not polynomial in the worst ***,the optim.l.pivot of the sim.l.x method is *** this paper,we propose the optim.l.rule to find all the shortest pivot paths of the sim.l.x method for linear programming problems based on monte Carlo tree ***,we first propose the Sim.l.xPseudoTree to transfer the sim.l.x method into tree search mode while avoiding repeated basis ***,we propose four reinforcement learning models with two actions and two rewards to make the monte Carlo tree search suitable for the sim.l.x ***,we set a new action selection criterion to am.l.orate the inaccurate evaluation in the initial *** is proved that when the number of vertices in the feasible region is C_(n)^(m),our method can generate all the shortest pivot paths,which is the polynomial of the number of *** addition,we experimentally validate that the proposed schedule can avoid unnecessary search and provide the optim.l.pivot ***,this method can provide the best pivot labels for all kinds of supervised learning methods to solve linear programming problems.

关键词： sim.l.x method linear programming pivot rules reinforcement learning

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