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Observations on the Formation of Ultrafine Ferrite Grain Size in Steels by Physical Simulation Routes

Journal of materials Science & Technology 2003年第z1期19卷 112-114页

作者： L.X. Pan L.P. Karjalainen m. C. Somani University of Oulu Department of Mechanical Engineering P.O. Box 4200 FIN-90014 Oulu Finland University of Oulu Department of Mechanical Engineering P.O. Box 4200 FIN-90014 Oulu Finland University of Oulu Department of Mechanical Engineering P.O. Box 4200 FIN-90014 Oulu Finland

Some observations are reported on the simulation of two thermomechanical routes to produce ultrafine ferrite grainsize in steels. One C-mn grade and Nb, Nb-Ti and Nb-high Ti bearing steels were used in the tests performed ona Gleeble simulator and a laboratory rolling mill. The routes included severe hot deformation of prior grain-refinedaustenite at the temperature close to Ar3 (DIF) and static recrystallization of fine-grained cold-rolled martensite(SRm). It was observed that the hot deformation induces the formation of ferrite above the Ar3 temperature of thesteel, but severe reductions are required for the complete transformation. Strain of 1.2 can result in about 70% offerrite with the grain size of about 1.4～2μm in all the studied steels. Similarly, in short annealing of cold-workedmartensite, the static recrystallization can also lead to a grain size of about 1.5 μm. The distribution of carbonvaries in the microstructures, carbon being in the second phase in the DIF route and in carbide particles in the SRmroute, which may have a significant influence on the mechanical properties and the thermal stability of ultrafine grainstructure.

关键词： Ultrafine grain size, Steels, Physical simulation, Strain-induced ferrite, Cold rolling and annealing

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同时性数字化乳腺X线摄影与数字化乳腺断层成像对乳腺癌辨识度的比较

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国际医学放射学杂志 2019年第5期 607-607页

作者： K.E.korhonen E.F.Conant E.A.Cohen m.Synnestvedt E.S.mcDonald S.P.Weinstein 罗骁 Department of Radiology Division of Breast ImagingHospital of the University of Pennsylvania

摘要既往研究证明数字乳腺断层成像(DBT)较数字化乳腺X线摄影(Dm)能有效改善筛查的结果,但少有研究探索Dm和DBT在乳腺肿瘤辨识度上的优劣。目的比较Dm

关键词：乳腺癌 mLO CC 乳腺肿瘤同时性断层成像

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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja malm Xiaobo mao Joaquim miguel Oliveira mike m.modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou marietta Zille Colin L.masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-macao Institute of CNS Regeneration(GHmICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and mind Centre&School of medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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menopausal transition alters female skeletal muscle transcriptome

Translational Exercise Biomedicine

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Translational Exercise Biomedicine 2024年第1期1卷 43-59页

作者： Hanna-Kaarina Juppi Tia-marje korhonen Tero Sievänen Vuokko Kovanen Urho m.Kujala Pauliina Aukee Neil Cronin Sarianna Sipilä Sira Karvinen Eija K.Laakkonen Gerontology Research Center and Faculty of Sport and Health Sciences University of JyväskyläJyväskyläFinland Faculty of Sport and Health Sciences University of JyväskyläJyväskyläFinland Wellbeing Services County of Central Finland JyväskyläFinland Neuromuscular Research Center Faculty of Sport and Health SciencesUniversity of JyväskyläJyväskyläFinland School of Sport and Exercise University of GloucestershireCheltenhamUK

Objectives Although skeletal muscle is a target of hormonal regulation,the muscle transcriptome,including messenger-RNA(mRNA),long non-coding RNAs(lncRNAs),and microRNAs(miRNAs)has not previously been studied across the menopausal ***,we took a multi-RNA-omics approach to get insight into transcriptome-wide events of *** We included baseline and follow-up muscle samples from seven early(EarlymT)and 17 late perimenopausal(LatemT)women transitioning to early postmenopause during the *** RNA was sequenced and differential expression(DE)of the transcriptome was *** functions were investigated with pathway analyses and protein level expression with Western *** We found 30 DE mRNA genes in EarlymT and 19 in LatemT participating in pathways controlling cell death,growth,and interactions with the external *** of protein level changes may indicate a specific role of the regulatory RNAs during menopause.10 DE lncRNA transcripts but no DE lncRNA genes were *** DE miRNAs were *** identified putative regulatory networks likely to be affected by estradiol *** in gene expression were correlated with changes in body composition variables,indicating that muscularity and adiposity regulators are affected by menopausal *** also found correlations between gene expression and physical activity *** The observed DE genes and their regulatory networks offer novel mechanistic insights into factors affecting body composition during and after *** results imply that physiological deteriorations orchestrated by the muscle transcriptome likely depend on the magnitude of hormonal change and are influenced by physical activity.

关键词： estrogen menopause muscle transcriptome female physiology non-coding RNA multi-omics

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A role for mitogen-activated protein kinase phosphatase 1(mKP1) in neural cell development and survival

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Neural Regeneration Research 2015年第11期10卷 1748-1749页

作者： André Toulouse Yvonne m.Nolan Department of Anatomy and Neuroscience University College Cork

The mitogen-activated protein kinase（mAPK）pathways are a group of conserved intracellular signalling pathways present in most cells including neurons and *** pathways respond to a variety of stimuli including growth factors,cytokines and oxidative stress to generate appropriate cellular responses such as modulation of gene expression,cell proliferation,differentiation and survival as well as the stress response（korhonen and moilanen,2014）.

关键词： mKP1 A role for mitogen-activated protein kinase phosphatase 1 in neural cell development and survival cell

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癌症患儿的兄弟姐妹需要早期的支持治疗:诊断后第1年的随访研究

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 23-23页

作者： Lhteenmki P. m. Sjblom J. korhonen T. Salmi T. T. 王一飞 Dr.Department of Pediatrics Turku University Hospital Kiinamyllynkatu 4-8 FIN-20520 Turku Finland

背景和方法:在1年的随访研究中,笔者评估了33例癌症患儿的兄弟姐妹和357名健康对照者的生活状况。假设诊断癌症后患儿的兄弟姐妹有更多的行为问题和健康相关的问题出现。笔者采用了有效的评估方法。结果:在诊断癌症后3个月进行的评估发... 详细信息

背景和方法:在1年的随访研究中,笔者评估了33例癌症患儿的兄弟姐妹和357名健康对照者的生活状况。假设诊断癌症后患儿的兄弟姐妹有更多的行为问题和健康相关的问题出现。笔者采用了有效的评估方法。结果:在诊断癌症后3个月进行的评估发现,学龄前的兄弟姐妹倾向于有举止。

关键词：随访研究支持治疗混合性生活状况 assessed 学龄期抑郁评分 Depression anxiety illness

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