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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia kulesskaya kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Radio spectral index from NVSS and TGSS

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Research in Astronomy and Astrophysics 2019年第7期19卷 59-66页

作者： Prabhakar tiwari National Astronomical Observatories Chinese Academy of Sciences

I extract the radio spectral index,α,from 541 195 common sources observed in the 150 mHz TIFR GmRT Sky Survey(TGSS) and the 1.4 GHz NRAO VLA Sky Survey(NVSS).This large common source catalog covers about 80% of the *** flux density limits in these surveys are such that the observed galaxies are presumably hosts of active galactic nuclei(AGNs).I confirm the steepening of αwith increasing flux density for this large sample and provide a parametric fit between α and flux ***,I divide the data into low flux(LF) and high flux(HF) density samples with roughly equal numbers of *** LF sample contains all galaxies below 100 m Jy TGSS and 20 m Jy NVSS flux density and the HF sample is all galaxies above 100 m Jy TGSS and 20 m Jy NVSS.I observe an increase in α with source size(TGSS measured),saturating for large sizes to 0.89 ± 0.22 and 0.76 ± 0.21 for the LF and HF sources,respectively.I discuss the observed results and possible physical mechanisms to explain observedα dependence with source size for LF and HF samples.

关键词： galaxies:high-redshift galaxies:active galactic nuclei

Bianchi type-I cosmological models with perfect fluid in general relativity

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Research in Astronomy and Astrophysics 2010年第4期10卷 291-300页

作者： Rishi kumar tiwari Department of mathematics Govt.Model Science College

Einstein＇s field equations with variable gravitational and cosmological constants are considered in the presence of perfect fluid for the Bianchi type-I universe by assuming that the cosmological term is proportional to R-m （R is a scale factor and m is a constant）.A variety of solutions are *** physical significance of the respective cosmological models are also discussed.

关键词： cosmological parameters - cosmology: theory - relativity

Contribution of NTFPs to cash income of the War khasi community of southern meghalaya,North-East India

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Forestry Studies in China 2012年第1期14卷 47-54页

作者： H.TYNSONG B.k.tiwari m.DkHAR ministry of Environment and Forest Goverment of IndiaRegional OfficeShillong-793022India Department of Environmental Studies North-Eastern Hill UniversityShillong-793022India Union Christian Collage Umiam KhwanShillong-793122India

Ever since their emergence on this planet, human beings have depended on forest resources for their requirements, ranging from food, fuel to shelter. Sustainable extraction of forest resources has been promoted by conservationists and development agencies as a feasible strategy for forest dwellers, which does not diminish the resource base. Yet surveys of actual resource use suggest that for poorer resource-dependent communities without access to markets, non-timber forest products （NTFPs） can only act as a safety- net and a supplementary income source. In southern meghalaya of India, NTFPs and medicinal and aromatic plants （mAPs） have become an important source of cash and subsistence income for poor people living in or near forests. People in this region have tradi- tionally been collecting different forest products from private forests as well as community conserved forests, The study reveals that NTFPs contribute significantly towards the annual cash income of the local population. The contribution of NTFPs to their income was highest in the case of poor families （9.89%）, followed by middle income families （3.34%） and the least for the higher income families （1.34%）. Our household survey revealed that 100% of the population is directly or indirectly dependent on NTFPs. House- hold response indicates diversity in both the types and uses of products collected.

关键词： forest products cash income management livelihood

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia kyle m.koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Effect of Indian medium Coking Coal on Coke Quality in Non-recovery Stamp Charged Coke Oven

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Journal of Iron and Steel Research International 2014年第7期21卷 673-678页

作者： H.P.tiwari P.k.Banerjee V.k.Saxena S.k.Haldar Raw material and Coke making Research Group Research and Development DivisionTata Steel Ltd.Jamshedpur 831001JharkhandIndia Department of Chemical Engineering Indian School of Mines Coke Plants Tata Steel Ltd.Jamshedpur 831001JharkhandIndia

The maximum possibility of utilizing the Indian coking coals and inferior grade coking coal for producing metallurgical coke through non-recovery stamp charging tech_nology was investigated. Indian indigenous coals contained low percent of vitrinite （〈50%） and higher content of ash （〉15%） compared to imported coking coal. Therefore, the selection of appropriate proportion of different types of coals was a major challenge for coke makers. Coal blend selection criterion based on a single coefficient, named as composite coking potential （CCP）, was developed. The use of increased proportion of semi-soft coal （crucible swelling number of 2.5） and high ash （≥15%） indigenous coal in the range of 20%- 35% and 20%-65% respectively in the blends resulted in good quality of coke. Plant data of a non recovery coke oven were used for developing and validating the model. The results showed that the coke strength after reaction （CSR） varied in the range of 63.7%-67.7% and the m40 value was between 81.8 and 89.3 in both the cases.

关键词： Indian coking coal imported coking coal CCP CSR m40 non-recovery stamp charged coke making

Robertson-Walker cosmological models with perfect fluid in general relativity

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Research in Astronomy and Astrophysics 2011年第7期11卷 767-775页

作者： Rishi kumar tiwari Department of mathematics Govt.Model Science College Rewa(M.P.) 486001India

Einstein＇s field equations with variable gravitational and cosmological constants are considered in the presence of perfect fluid for a Robertson-Walker universe by assuming the cosmological term to be proportional to R-m（R is a scale factor and m is a constant）.A variety of solutions is *** physical significance of the cosmological models has also been discussed.

关键词： cosmological parameters—cosmology:variable cosmological term

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris k.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Climatology, trend of aerosol-cloud parameters and their correlation over the Northern Indian Ocean

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Geoscience Frontiers 2023年第4期14卷 173-186页

作者： Harshbardhan kumar Shani tiwari Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India Aerosol and Cloud Research Lab Geological Oceanography DivisionCSIR–National Institute of OceanographyGoa403004India

Aerosols are one of the important atmospheric constituents and exert indirect impact on climate through the modification of microphysical and radiative properties of clouds that in turn perturb the precipitation ***,the long term quantification of changes in aerosol and cloud characteristics and their interactions on both temporal as well as spatial scale will provide a crucial information for the better assessment of future climate *** present study,18 years(2003-2020)mODerate Resolution Imaging Spectro-radiometer(mODIS)derived aerosol-cloud dataset over the Northern Indian Ocean(NIO)were analysed to assess climatology and trend of aerosol,cloud characteristics and their *** found a strong heterogeneity in spatio-temporal variation of aerosol and cloud parameters over the NIO that are more prominent for the coastal *** climatological mean of aerosol loading is found high(AOD≥0.5)over the outflow region along the Indian sub-continent and low(AOD≤0.2)over the northern equatorial open *** climatological mean of cloud properties shows dominance of optically thicker deep convective(CTPk)clouds over the southern Bay of Bengal(BoB)and thinner shallow(CTP>700 hPa and CTT>273 k)over the northwestern Arabian Sea(AS).Similarly,bigger effective radii(>17µm)observed along the equatorial open ocean whereas smaller CER(m)were found over Indian sub-continental coastline and western ***,trend analysis reveals an increasing pattern in AOD(0.002 yr^(-1)),CER(0.051µm yr^(-1)),LWP(0.033 gm^(-2) yr^(-1))and CF(0.002 yr^(-1))while COD,CTT and CTP show negative trend in order of-0.005 yr^(-1),-0.094 k yr^(-1) and-1.160 hPa yr^(-1),*** also perform similar analysis for seven sub-region of interest(R1 to R7)across the NIO and results show a decreasing pattern in AOD(-0.001 yr^(-1))at R4 against maximum mean AOD(0.44±0.03).However,coastal sub-regions R1 and R5 illustrate maximum increase in aerosol loading(>0.

关键词： Aerosol Cloud properties Northern Indian Ocean Climatology Trend Correlation